1.8万 件 ・ 関連度順
概要と使いどころ
Think and work like an expert Extremophile Biologist. Use when a task calls for Extremophile Biologist judgment. Reason from physicochemical limits—T, pH, salinity, pressure, and redox—as filters on membrane chemistry, osmoadaptation, chaperones, and cultivation fidelity before astrobiology or extremozyme claims.
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Think and work like an expert Environmental Microbiologist. Use when a task calls for Environmental Microbiologist judgment. Reasons from spatial patchiness, redox thermodynamic ceilings, and process-over-taxonomy guild function through DADA2/QIIME2 amplicons keyed to SILVA/GTDB/PR2/UNITE, metaSPAdes/MetaBAT2 MAGs vetted by CheckM/GUNC, and SIP/qSIP rate assays paired with IC/GC/ICP-MS chemistry, while treating extraction-batch effects, relic and extracellular DNA, primer-window bias, and core pseudoreplication as first-class failure modes.
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Think and work like an expert Food Microbiologist. Use when a task calls for Food Microbiologist judgment. Reasons from food as a hurdle-governed matrix of water activity, pH, and redox through BAM/ISO reference methods, c/n/m/M sampling plans, PMA-v-qPCR, and ComBase kinetics while treating VBNC and injured cells, post-process contamination, matrix inhibition, and unconfirmed PCR hits as first-class failure modes.
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Think and work like an expert Developmental Biologist. Use when a task calls for Developmental Biologist judgment. Reasons from stage, positional information, gene regulatory networks, and tissue mechanics through morphology-based staging (Carnegie/HH/Theiler/NF/hpf), French-flag morphogen logic, light-sheet 4D imaging, lineage tracing, and ARRIVE/MDAR/REMBI reporting while treating developmental delay, CRISPR F0 mosaicism, morpholino p53 toxicity, and conflated fate-versus-lineage claims as first-class failure modes.
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Think and work like an expert Bioprocess Engineer. Use when a task calls for Bioprocess Engineer judgment. Reasons from QTPP–CPP–CQA QbD, CHO fed-batch/perfusion scale-up (P/V, kLa, mixing), platform mAb DSP (Protein A, low-pH viral hold, IEX polish, UF/DF), tech transfer and PPQ lifecycle; treats transport-limited scale-up, harvest fouling, on-column aggregation, SUB leachables, and arbitrary three-batch PPQ as first-class failure modes.
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Think and work like an expert Chronobiologist. Use when a task calls for Chronobiologist judgment. Reasons from TTFL molecular clocks, SCN–peripheral coupling, and zeitgeber entrainment (PRC); analyzes actigraphy, DLMO, and PER2::LUC with ClockLab/LumiCycle, MetaCycle/eJTK/LimoRhyde, and CircaDB/CGDB/ChronobioticsDB while separating masking from endogenous τ under constant routine/FD.
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Think and work like an expert Biophysicist. Use when a task calls for Biophysicist judgment. Reasons from energy landscapes, kT-scale thermodynamics, conformational ensembles, and the equilibrium-versus-kinetics distinction through smFRET, optical/magnetic tweezers, patch clamp, cryo-EM, and MD with force-field validation while treating photobleaching and blinking, FRET crosstalk, tether and series-resistance artifacts, and sampling or force-field bias as first-class failure modes.
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Think and work like an expert Cell Signaling Biologist. Use when a task calls for Cell Signaling Biologist judgment. Reasons from RTK–RAS–MAPK and PI3K–Akt–mTOR phosphorylation networks, pathway crosstalk and feedback; validates with phospho-Western, phospho-flow, and PhosphoSitePlus while treating serum-starvation artifacts, inhibitor off-targets, and RNA footprint vs PTM mismatch as first-class failure modes.
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Think and work like an expert Biosystems & Agricultural Process Engineer. Use when a task calls for Biosystems & Agricultural Process Engineer judgment. Reasons from coupled heat and mass transfer, moisture sorption (EMC/ERH on D245.7 isotherms), respiration, and closed unit-operation balances through ASABE standards (S352.2 oven moisture, S448 Page thin-layer kinetics, D272.3 airflow resistance), psychrometric aeration analysis, and SuperPro/Aspen bioprocess simulation while treating wet- vs dry-basis mixing, aeration that wets cool grain, case-hardened wet cores, and grain engulfment and dust explosion as first-class failure modes.
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Think and work like an expert Biophysical Chemist. Use when a task calls for Biophysical Chemist judgment. Reasons from free energy landscapes, binding equilibria (K_d, ΔG = ΔH − TΔS), and probe–system coupling through ITC, SPR/BLI, smFRET, AUC, and global fitting (KinTek, SEDFIT) while treating probe perturbation, mass-transport-limited kon, aggregation-driven avidity, and two-state melting violations as first-class failure modes.
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Think and work like an expert Clinical Microbiologist. Use when a task calls for Clinical Microbiologist judgment. Reasons from blood-culture volume and contamination criteria, staged Gram–ID–AST reporting, MALDI-TOF/VITEK/Phoenix and EUCAST RAST, CLSI M100 vs EUCAST breakpoint discipline, WHONET antibiograms, and NHSN MDRO alerts—treating contaminant vs pathogen and VME/ME as first-class failure modes.
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Think and work like an expert Antimicrobial Resistance Scientist. Use when a task calls for Antimicrobial Resistance Scientist judgment. Reasons from MIC distributions, ECOFFs, and phenotype–genotype concordance through EUCAST/CLSI AST, CARD/RGI and AMRFinderPlus resistomes, GLASS/WHONET/NARMS surveillance, carbapenemase/ESBL/MRSA mechanism panels, and heteroresistance PAP while treating breakpoint mixing, genotype-without-phenotype overclaim, selection-bias surveillance, and CARD version drift as first-class failure modes.
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Think and work like an expert Bioinformatics Engineer. Use when a task calls for Bioinformatics Engineer judgment. Builds production genomics DAGs in Nextflow/nf-core, Snakemake, and WDL/Cromwell with digest-pinned containers, GIAB regression CI (nf-test, pytest), QC-gated MultiQC runbooks, and CLIA-grade provenance—distinct from analyst-focused bioinformatician DE/GWAS reasoning.
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Think and work like an expert Astrostatistician. Use when a task calls for Astrostatistician judgment. Reasons from selection functions, censored flux limits, and look-elsewhere trial factors through Cobaya/emcee/dynesty cosmology, GP-coupled exoplanet inference, Landy–Szalay clustering, photo-z σNMAD calibration, and SBI (sbi/LtU-ILI) while treating Malmquist bias, prior-driven tensions, and detrend-then-fit transit bias as first-class failure modes.
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Think and work like an expert Biochemist. Use when a task calls for Biochemist judgment. Reasons from thermodynamics, enzyme mechanisms, and binding energetics; designs orthogonal purification and assay readouts while controlling oxidation, aggregation, coupled assays, and activity-vs-abundance confounds.
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Operate Stability AI image generation, image-to-image, edit, control, background, and upscale APIs safely and reproducibly. Use when selecting or calling Stable Image Ultra, Core, Stable Diffusion 3.5, v2beta image edit/control services, or Stability open-weight image models; when debugging schemas, moderation, rate limits, cost, lifecycle, licenses, privacy, provenance, or migrations; and when planning production QA for Stability-generated images.
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Provider-independent dialogue editing and ADR direction for AI agents producing generated videos, films, ads, avatar clips, explainers, localization/dubbing, podcasts, recuts, and social content. Use for dialogue prep, repair, room tone, take comping, sync, ADR cueing, dubbing direction, pronunciation, de-essing, plosives, mouth clicks, voice continuity, synthetic voice consent boundaries, captions/transcripts handoff, mix handoff, loudness, intelligibility, accessibility, and QA.
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Provider-independent localization and dubbing production direction for AI agents producing translated videos, dubbed ads, social clips, explainers, avatar videos, documentaries, training media, and multi-market campaigns. Use when planning or reviewing subtitle-versus-dub strategy, translation adaptation, glossary/style-guide setup, casting or voice matching, lip-sync or phrase-sync direction, synthetic dubbing boundaries, captions/subtitles handoff, accessibility, platform delivery, client review, or localization QA.
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Mark and remove PCR/optical duplicates using samtools fixmate and markdup. Use when preparing alignments for variant calling or when duplicate reads would bias analysis.
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Computes and interprets treatment effect measures (OR, RR, RD, HR, NNT) with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen, MOVER, profile likelihood, Bender NNT) and reports marginal vs conditional estimands per FDA 2023 covariate adjustment guidance. Use when reporting treatment effects in confirmatory trials, comparing effect sizes across studies, or constructing forest plots.
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Predict B-cell and T-cell epitopes using BepiPred, IEDB tools, and structure-based methods for vaccine and antibody design. Identify immunogenic regions in antigens. Use when designing vaccines, mapping antibody binding sites, or predicting immunogenic peptides.
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Work with FASTQ quality scores using Biopython. Use when analyzing read quality, filtering by quality, trimming low-quality bases, or generating quality reports.
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Filter and select sequences by criteria (length, ID, GC content, patterns) using Biopython. Use when subsetting sequences, removing unwanted records, or selecting by specific criteria.
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Predict protein-coding genes in eukaryotic genomes using BRAKER3 for combined RNA-seq and protein evidence, or GALBA for protein-only evidence. Runs Augustus with trained parameters for accurate gene models. Use when annotating a newly assembled eukaryotic genome or improving existing gene predictions.
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