「method」の検索結果

End-to-end post-GWAS causal inference pipeline orchestrating heritability partitioning, genetic correlation, Mendelian randomization with CHP-aware sensitivity (CAUSE / LHC-MR), colocalization, fine-mapping with SuSiE / FOCUS, mediation, TWAS triangulation, cis-pQTL drug-target MR, effector-gene prioritization (L2G / PoPS / cS2G), and GenomicSEM common-factor GWAS. Use when triangulating causal inference across multiple complementary methods, prioritizing tissues via stratified LDSC, nominating or de-risking drug targets, mapping a lead SNP to a candidate effector gene, modeling shared genetic architecture across correlated traits, or producing a STROBE-MR-compliant publication-grade evidence battery from GWAS summary statistics.

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Trains and applies base-resolution deep learning models on ChIP-seq / ChIP-nexus / CUT&RUN data. Uses BPNet (Avsec 2021 Nat Genet 53:354; soft motif syntax from ChIP-nexus), chromBPNet (Pampari A et al 2025 Nat Genet; bias-factorized base-resolution profiles), EnFormer (Avsec 2021 Nat Methods 18:1196; 196 kb input, ~100 kb effective receptive field), DeepSEA (Zhou 2015; multi-task CNN), and JASPAR 2026 deep-learning collection (1259 BPNet ChIP models). Performs in silico mutagenesis for variant-effect prediction, DeepLIFT/Grad attribution, and TF-MoDISco motif discovery from attribution scores. Use when predicting variant effects on TF binding, discovering soft motif syntax / cooperativity, integrating ChIP-seq with sequence-only predictions, or applying precomputed JASPAR Deep Learning models to new variants.

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End-to-end clinical trial analysis workflow from CDISC SDTM/ADaM loading through ICH E9(R1) estimand-driven primary analysis to CONSORT 2025 regulatory-compliant reporting. Covers data preparation, FDA 2023 marginal vs conditional logistic regression, categorical tests with Boschloo, modern HTE/subgroup methods, missing-data sensitivity (MMRM, reference-based MI, Permutt tipping point), graphical multiplicity (Bretz-Maurer), survival analysis (Cox/RMST/competing risks) when applicable, and Table 1. Use when performing a complete analysis of clinical trial data.

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Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.

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Calculate TAM/SAM/SOM for market opportunities using top-down, bottom-up, and value theory methodologies. Use this skill when sizing markets, estimating addressable revenue, validating market opportunity for a new venture, or building investor-ready market analysis for a startup pitch or business plan.

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Master problem solver for systematic problem-solving methodologies. Use when the user asks to talk to Dr. Quinn or requests the Master Problem Solver.

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Guide human-centered design processes using empathy-driven methodologies. Use when the user says "lets run design thinking" or "I want to apply design thinking"

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Apply systematic problem-solving methodologies to complex challenges. Use when the user says "guide me through structured problem solving" or "I want to crack this challenge with guided problem solving techniques"

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Guidance for using Generator.Equals — a C# source generator for auto-generating Equals, GetHashCode, operators, and Diff/Inequalities methods via attributes.

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Use when implementing features or fixing bugs with strict Test-Driven Development (TDD). Activate for coding tasks that require new functionality, refactoring, or comprehensive test coverage, especially when the user mentions TDD or Test Driven Development.

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Generate MATLAB Grader assessment items that are suitability-gated, profile-driven, feedback-aware, and validated through MATLAB MCP. Produces Script, Function, Class Definition, Class Inheritance, Object Usage, and Class Methods items with MATLAB Grader assessment setup instructions.

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Seed a fresh (greenfield) repository with the PRD-Driven Context Engineering scaffold — PRD.md, SoT/ knowledge files, EPIC templates, domain-profile config, and agent MEMORY starters. Invoked as /prd-ce:init when the plugin is installed. The framework itself (skills, agents, hooks, scripts) ships LIVE in the plugin; this skill only plants the consumer-owned files the plugin cannot carry as behavior. Triggers on "/prd-ce:init", "set up PRD lifecycle here", "scaffold a new PRD-CE project", "initialize the methodology". Outputs a seeded scaffold + a verification report.

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Implement features and fix bugs test-first, the Canon TDD way (test list → one test → make it pass → refactor → repeat). Use when implementing any new feature, endpoint, model, or method, fixing a bug, or executing a plan — write the test list and a failing test BEFORE production code.

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Write and maintain high-quality Swift DocC documentation for the TMDb package, following its established `///` conventions. Use when adding or changing any public declaration (protocol, class, struct, enum, actor, model, property, initializer, method, typealias) and when keeping the DocC catalog in sync. This is the single source of truth for the project's documentation style — applied inline as you write, and followed by the `documentation-writer` agent for bulk sweeps.

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A/B and multivariate testing methodology. Design experiments, calculate sample sizes, determine statistical significance, avoid common pitfalls, and interpret results. Platform-agnostic framework applicable to landing pages, emails, ads, pricing, and product features. Use when the user asks about A/B testing, split testing, experiment design, statistical significance, or conversion experiments.

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Context7 fetches current, version-specific documentation and code examples for software libraries and hands them to an AI coding agent, so generated code matches the library version in use instead of stale training data. Use when someone says "use context7", "get the latest docs for this library", "look up the current API", "the agent keeps using a deprecated method", "set up Context7 in Claude Code or Cursor", or asks how to call a framework whose API changed recently. Covers the ctx7 CLI, the MCP server and its two tools, library IDs and version pinning, API keys and rate limits, and the REST API.

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Understand essential business finance — profit margins, unit economics, cash flow, LTV/CAC, and the 4 methods to increase revenue. Use when: analyzing business profitability, making pricing decisions, evaluating SaaS unit economics, financial planning.

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Vulnerability audit and dataflow analysis built on the neug CPG engine. file_audit (default, recommended): first builds a function-level summary graph (tier1) over the entire project, then incrementally builds detailed CPGs (tier2) on demand for chosen functions; both tiers coexist in a single neug database (unified schema, cross-layer refines edges; C/Java/Python/Rust). All capabilities are exposed as CLI tool subcommands (audit/overview/build/query/methods/paths), so an agent can drive the audit step by step via shell; the audit subcommand can also run the built-in LLM loop. The same tooling also supports a dataflow analysis mode (Workflow C): no vulnerability hunting, only variable-level dataflow tracing for functions of interest, producing dataflow_analysis.json. repo_audit: multi-round LLM/Cypher audit over a full-repo CPG. Use when the user asks to audit a codebase/project for vulnerabilities, scan a project with CPG/neug, run repo_audit/file_audit, find source-to-sink taint paths, or analyze dataflow inside a function. Supports C, Java, Python, and Rust.

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Design and implement Monte Carlo methods for uncertainty quantification, risk analysis, and probabilistic simulations across scientific and financial domains. Use when "monte carlo, random sampling, uncertainty quantification, risk analysis, stochastic simulation, MCMC, variance reduction, probabilistic, " mentioned.

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World-class level design expertise - spatial storytelling, player flow, blockout methodology, and the invisible hand that guides players without them knowingUse when "level design, blockout, graybox, whitebox, player flow, level layout, combat arena, exploration space, map design, multiplayer map, pacing, weenie, landmark, gating, metroidvania, open world design, linear level, environmental storytelling, teaching through design, playtesting, heatmap, metrics, sightlines, level-design, game-development, spatial-design, blockout, graybox, player-flow, pacing, environmental-storytelling, combat-design, multiplayer-maps, open-world, linear-design, metroidvania" mentioned.

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Formal Design of Experiments (DOE) methodology for maximizing information from experiments while minimizing resources. Covers factorial designs, blocking, randomization, and optimal design strategies. Use when ", " mentioned.

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Patterns for computer-aided drug discovery including virtual screening, molecular docking, ADMET prediction, lead optimization, and integration with AI/ML methods. Covers both structure-based and ligand-based approaches. Use when ", " mentioned.

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Expert in entertainment industry concept art workflows, from initial ideation through final production-ready deliverables. Combines traditional art fundamentals with modern digital workflows used at AAA studios and film production houses. Draws from methodologies of industry masters: Feng Zhu's efficient design process, Scott Robertson's perspective and vehicle design systems, Sparth's graphic shape language, and Syd Mead's industrial design thinking. Use when "concept art, visual development, vis dev, keyframe, color script, production design, mood board, thumbnail sketch, environment concept, character concept, prop design, callout sheet, orthographic views, design exploration, photobash, speedpaint, concept-art, visual-development, game-art, film-art, pre-production, ideation, design" mentioned.

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Expert in designing and structuring online courses - curriculum architecture, learning outcomes, module design, and assessment strategies. Covers backward design methodology, scaffolding content, and creating courses that actually deliver transformation. Use when "create a course, course curriculum, course outline, learning outcomes, course structure, design a course, online course, " mentioned.

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