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概要と使いどころ
Extract and analyze pricing information from competitor websites. Identifies pricing tiers, features per tier, billing models, and positioning relative to market alternatives. Ideal for competitive pricing strategy and market positioning research.
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Find web pages and content similar to a given URL using Exa's neural similarity search. Ideal for competitor discovery, alternative source finding, related content research, and expanding research beyond known sources.
日本語の概要は準備中です。原文の説明を表示しています。
Query the Ensembl REST API for gene/transcript/protein lookup, sequence retrieval, comparative genomics (Compara), variant effect prediction (VEP), regulatory features, and cross-species ortholog/paralog calls. Use when pulling Ensembl-native data (Ensembl Gene IDs, version-pinned releases, archive endpoints for reproducibility), gene/transcript/exon structure with stable IDs, or VEP for variant annotation. Encodes the 15 req/sec rate limit, archive (e110.rest.ensembl.org) for reproducibility, Ensembl divisions (vertebrates / plants / fungi / metazoa / bacteria), and the symbol-vs-ID stability problem.
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Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda window scheduling, soft-core potentials, REST2 enhanced sampling, MBAR/BAR analysis, and cycle closure validation. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.
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Corrects the gene-independent copy-number artifact in CRISPR-Cas9 screens (Aguirre 2016 / Munoz 2016 Cancer Discov) where amplified loci appear essential from DNA-damage burden of simultaneous cuts. Covers the p53-dependent G2-arrest mechanism, CRISPRcleanR (Iorio 2018) unsupervised pre-hoc correction, CERES (Meyers 2017) joint CN + gene-effect model, Chronos (Dempster 2021) DepMap-standard population-dynamics + CN model with lowest residual bias, the decision tree by data availability, the Spearman LFC-vs-CN diagnostic, focal-amplification examples (ERBB2 in HER2+, MYC in colorectal, FGFR1 in head and neck), and CRISPRi/a alternatives that bypass the artifact. Use when screening cancer cell lines, diagnosing essentiality at amplified loci, choosing CRISPRcleanR / CERES / Chronos, deciding whether CN correction is needed before MAGeCK / BAGEL2 / drugZ, or switching from Cas9 to CRISPRi.
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Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.
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Visualize copy number profiles, segments, allele-specific tracks, and cohort patterns from CNVkit, GATK, ASCAT, FACETS, Sequenza, and other callers. Covers genome-wide and per-chromosome log2 scatter plots, B-allele-frequency/minor-allele-fraction tracks, ideograms, cohort heatmaps, circos views, and caller-native plots. Use when creating publication CNV figures, choosing which plot answers a given question, diagnosing a wrong diploid baseline visually, displaying loss of heterozygosity, or deciding what depth-only plots cannot reveal.
日本語の概要は準備中です。原文の説明を表示しています。
Project gene annotations across genomes using TOGA (Kirilenko 2023 whole-genome-alignment chain-based projection with intactness classification), CESAR 2.0 (Sharma & Hiller 2017 codon-aware exon projection), LiftOff (Shumate & Salzberg 2020 reference-based annotation transfer), Liftover (UCSC), GeMoMa (Keilwagen 2019 evidence-based projection), and Comparative Annotation Toolkit (CAT). Use when transferring annotations from a well-annotated reference to query genome(s), classifying gene-loss vs gene-intact across many genomes at scale, building Zoonomia-style comparative annotations across hundreds of mammals or birds (Kirilenko 2023), detecting pseudogenization, projecting alternative isoforms, or selecting between WGA-anchored (TOGA) vs ortholog-based (LiftOff) annotation transfer strategies.
日本語の概要は準備中です。原文の説明を表示しています。
Batch effect correction for CRISPR screens covering ComBat empirical-Bayes, RUV, SVA, control-sgRNA normalization, and the model-based alternative of including batch as a covariate in MAGeCK MLE or Chronos. Covers screen-specific batch sources (passage cohort, library lot, infection day, sequencing run, Cas9 lot, FBS lot), PCA + variance-decomposition diagnostic to decide if correction is needed, when correction harms biology by over-correcting condition into batch, limma removeBatchEffect for visualization-only correction, and relationship to multi-condition design matrices. Use when combining screens for joint analysis, when passage cohort confounds biology, when DepMap-style panels need Chronos with batch covariates, when picking ComBat vs RUV, or when correction harms biology and should be replaced with explicit covariate modeling.
日本語の概要は準備中です。原文の説明を表示しています。
Statistical testing for differentially abundant proteins between conditions. Covers preprocessing (log2 transformation, normalization), limma and DEqMS workflows with empirical Bayes moderation, fold change shrinkage for accurate effect size estimation, and Python alternatives. Use when identifying proteins with significant abundance changes between experimental groups.
日本語の概要は準備中です。原文の説明を表示しています。
Annotate CLIP-seq peaks or crosslink sites to RNA features (5'UTR, CDS, 3'UTR, intron, splice junction, snoRNA, tRNA, ncRNA, repeat elements) with ChIPseeker, RCAS, RBP-Maps (Yeo splicing regulatory maps), and bedtools, applying feature-priority hierarchies, transcript-context resolution, and metagene aggregation. Use when characterizing where in transcripts an RBP binds, comparing peak distribution across regions, generating splicing-regulatory maps relative to alternative-splicing events, or distinguishing exonic vs intronic vs UTR binding.
日本語の概要は準備中です。原文の説明を表示しています。
Boltz-1 / Boltz-2 structure prediction for proteins, complexes, and ligand-aware validation. Use this skill when: (1) Predicting protein complex structures, (2) Validating designed binders, (3) Need open-source alternative to AF2, (4) Predicting protein-ligand complexes, (5) Using local GPU resources. For QC thresholds, use protein-design-qc. For AlphaFold2 prediction, use alphafold2-multimer. For Chai prediction, use chai1-structure-prediction.
日本語の概要は準備中です。原文の説明を表示しています。
Workflow for event-level and isoform-level splicing analysis with sashimi-ready outputs and splice QC.
日本語の概要は準備中です。原文の説明を表示しています。
Structure prediction using Boltz-1/Boltz-2, an open biomolecular structure predictor. Use this skill when: (1) Predicting protein complex structures, (2) Validating designed binders, (3) Need open-source alternative to AF2, (4) Predicting protein-ligand complexes, (5) Using local GPU resources. For QC thresholds, use protein-qc. For AlphaFold2 prediction, use alphafold. For Chai prediction, use chai.
日本語の概要は準備中です。原文の説明を表示しています。
Chai-1 structure prediction for protein complexes and design validation. Use this skill when: (1) Predicting protein-protein complex structures, (2) Validating designed binders, (3) Predicting protein-ligand complexes, (4) Using the Chai API for high-throughput prediction, (5) Need an alternative to AlphaFold2. For QC thresholds, use protein-design-qc. For AlphaFold2 prediction, use alphafold2-multimer. For ESM-based analysis, use esm2-sequence-scoring.
日本語の概要は準備中です。原文の説明を表示しています。
Structure prediction using Chai-1, a foundation model for molecular structure. Use this skill when: (1) Predicting protein-protein complex structures, (2) Validating designed binders, (3) Predicting protein-ligand complexes, (4) Using the Chai API for high-throughput prediction, (5) Need an alternative to AlphaFold2. For QC thresholds, use protein-qc. For AlphaFold2 prediction, use alphafold. For ESM-based analysis, use esm.
日本語の概要は準備中です。原文の説明を表示しています。
Find academic papers across up to 8 sources (OpenAlex / Semantic Scholar / CrossRef / PubMed / arXiv for English, OpenReview for AI venues, plus native-Chinese retrieval via NSSD 国家哲社文献中心 + yiigle 中华医学期刊) with adjustable depth — Quick scan (5 min) to Audit prep (3 hr). Use when the user wants to find papers, run a literature search, gather references, scope a research topic, search Chinese-language / 中文原生 literature (中文文献/中文核心/CSSCI/C刊/国内研究/国内文献/中华××期刊/心理学报/经济研究), or filter results by journal tier (中科院分区/一区/几区, Q1, JCR/SJR quartile, 影响因子/impact factor, 期刊分区, 顶刊/top journal, '按分区筛'), or export paste-ready professional search strategies / 检索式 for external databases (PubMed / WOS / Scopus / Embase / 知网 CNKI / 万方 / SinoMed — '写检索式', '导出检索式', 'WOS 检索式', '知网专业检索', 'search strategy', 'boolean search strategy'). Triggers on search verbs ('find papers', 'literature search', 'papers about X'), review types ('scoping review', 'systematic review', 'SR prep', 'literature review', 'lit review', 'help me write a lit review'), Chinese ('找文献', '找论文', '论文搜索', '学术检索', '文献检索', '文献综述', '综述前期', '求文献', '中文文献', '中文核心', 'CSSCI', 'C刊', '国内研究', '找中文的'). Outputs Shadcn HTML report + BibTeX/RIS/CSV + PRISMA-S log. Do NOT use for: concept explanations ('what is X' / 'X 是什么', e.g. '影响因子怎么算'), writing ('帮我写' / 'help me write a paragraph'), single-paper interpretation or PDF download with metadata (use paper-downloader-portable), or when the user already has a literature set (use literature-set-review).
日本語の概要は準備中です。原文の説明を表示しています。
Internal — for Boundless team members only. Audit native ETH, market deposit, prover collateral, and distributor ZKC reserve balances for every operator-managed address (provers, distributor, order generators, signal). Use when the user wants to know which addresses need topping up, asks about the balance of provers/OGs/distributor/signal signers, says something is "running low" or "out of gas", or wants a periodic operational health check on operator wallets. Defaults to prod env (mainnets + prod testnets) — pass `--all` to also include staging.
日本語の概要は準備中です。原文の説明を表示しています。
Use when the user wants to create/generate/scaffold a new Spring Boot project (Maven or Gradle, REST API / Web App / Spring Boot + Angular full stack). Derives progen CLI inputs from the user's plain-English project description, asks for any missing mandatory info, ensures the progen binary is available, and runs it to generate the project. If the user asks for features progen doesn't support natively, generate the base project first, then add those features on top of the generated code.
日本語の概要は準備中です。原文の説明を表示しています。
Deploy AI models to embedded hardware using MathWorks tools (MATLAB, Simulink, Embedded Coder). Covers two workflow patterns: (1) MathWorks-native or 3P-imported models rebuilt as dlnetwork for lean hardware (Cortex-M, DSP), (2) direct C/C++ code generation from PyTorch and LiteRT models for high-performance hardware (Cortex-A, x86, GPU). Trigger when: user wants to deploy AI to embedded targets; generate C/CUDA from neural networks; compress AI models for MCU/DSP; integrate AI in Simulink for system-level simulation; import PyTorch/ONNX/TensorFlow models for embedded deployment; optimize AI for resource-constrained hardware; or use loadPyTorchExportedProgram, importNetworkFromPyTorch, dlquantizer, exportNetworkToSimulink, or Embedded Coder with AI models.
日本語の概要は準備中です。原文の説明を表示しています。
Break a plan, spec, or the current conversation into a set of tracer-bullet tickets, each declaring its blocking edges, published to the configured tracker (edges as text in one file per ticket locally, or native blocking links on a real tracker).
日本語の概要は準備中です。原文の説明を表示しています。
Design analytics-driven browser test matrices and execute cross-browser tests. Covers BrowserStack/Sauce Labs configuration, Playwright browser channels, common cross-browser CSS/JS divergences, a known-issues documentation log, and progressive enhancement validation. Use when: "cross-browser," "browser matrix," "BrowserStack," "Safari issues," "browser compatibility," "Edge," "works in Chrome but not Safari." Not for: pixel-level baseline strategy and threshold tuning — use visual-testing; device-farm testing of native/hybrid apps — use mobile-testing. Related: visual-testing, playwright-automation, ci-cd-integration, mobile-testing.
日本語の概要は準備中です。原文の説明を表示しています。
Conducts deep technical research for Aha Loop stories. Use before implementing stories involving unfamiliar libraries or architectural decisions. Triggers on: research this, investigate, explore options, compare alternatives.
日本語の概要は準備中です。原文の説明を表示しています。
Map the competitive landscape before positioning your product for PRD v0.2 Market Definition. Triggers on completing v0.1 Spark, analyzing competitors, researching market, or requests like "competitive analysis", "who else solves this", "market landscape", "what alternatives exist", "competitor research", "feature comparison". Outputs CFD- entries for competitive intelligence and BR- entries for positioning rules.
日本語の概要は準備中です。原文の説明を表示しています。