「orr」の検索結果

Think and work like an expert AI Researcher. Use when a task calls for AI Researcher judgment. Reasons from data generating processes, inductive biases, and compute-data-algorithm trade-offs through train/val/test discipline, seed sweeps, ablation ladders, and standards like NeurIPS reproducibility checklists, model cards, and lm-eval-harness, while treating data leakage (Kapoor & Narayanan taxonomy), benchmark contamination, spurious correlations, and reward-model overoptimization as first-class failure modes.

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Write correct Python code with the official GREEN-API SDK whatsapp-api-client-python (package whatsapp_api_client_python). Use when sending/receiving WhatsApp messages, files, polls, groups, journals, queues, statuses, contacts, partner instances, polling notifications, or configuring a GREEN-API instance in Python. Triggers: GREEN-API, green-api, whatsapp-api-client-python, GreenAPI, GreenApi, sendMessage, receiveNotification.

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An agent makes an animated film of an average session with its own user, beginning to end, told with that user's real messages: whatever their routine is (code, writing, data, design, video). The agent sits at a desk in a room decorated from what it knows about the user, and the monitor shows their kind of work. Requests glide in as paper planes and unfold. Corrections are a 3D cartoon mallet that bonks, then turns to show the words on its face. Praise is a butterfly towing the words on a ribbon. The agent types each reply onto a sheet, folds it and throws it back. The film opens with the agent asleep until the monitor boots: "Initiating session with <name>". The agent composes its own orchestral score, cued to every action. p5.brush watercolour, rendered in HyperFrames. Trigger on: "a video of our session", "animate a session with me", "session story", "show what working with me is like", "make a film about me and my agent".

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A 60 to 75 s hand-drawn ink film of the agent's day with its own user ("a day in my life as <name>'s agent"): one average session from the user's local Claude Code history, beginning to end. The story follows what they actually do (coding, tests, docs, shipping, videos, whatever the history shows), told with their real words (first message, check-ins, corrections, praise, memory titles). It is drawn in two-tone p5.brush strokes that boil at 8 fps and scored for strings composed note-for-note on the film's clock (the typed "claude" is the theme). Trigger on: "day in my life as my agent", "a film about me and my agent", "what is it like to be my agent", "animate your day with me", "make a video of our sessions". Covers harvesting the routine and receipts, the privacy gate, the chapter toolbox, the ink kit, the score, render and QC.

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The Auto 档 scenario — a soft-plan orchestrator for a complete fundamental equity research thesis: understand → financials → valuation → synthesize. The body is a soft plan (stages), not a rigid DAG; correctness is enforced by each referenced skill's own requires: preconditions, never by this plan's rigidity (Q2).

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portfolio hedging, tail risk hedging, options overlay, correlation regime, downside protection, portfolio insurance, risk mitigation strategy, hedge construction, black swan hedging, volatility hedging

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Facilitate a structured conversation to define architecture principles for a repository. Supports multiple architecture styles: clean architecture (default), hexagonal / ports & adapters, modular monolith, or custom. Produces a formal architecture document that the corresponding atom will use. Use when setting up a new project, defining architecture standards, or when the user says 'setup architecture', 'define layers', 'architecture principles', 'help me define my architecture', 'hexagonal architecture', 'modular monolith', 'ports and adapters', or 'define my architecture style'.

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Provider-independent governance workflow for verifying and correcting human- or model-generated video descriptions. Use for pre-caption critique and post-caption revision, aspect-by-aspect factual review, critique precision/recall/constructiveness, second-stage peer review, calibration, appeals, versioned triplets, provenance, and acceptance reporting; not for pixel/audio QA, accessibility captioning, model training, or creative shot direction.

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Provider-independent color grading and finishing direction for generated video, ads, trailers, product films, social clips, explainers, and mixed-source edits. Use when planning, directing, reviewing, or QAing color correction, shot matching, exposure, contrast, saturation, skin/product color protection, look development, LUT/reference use, SDR/HDR color management, delivery constraints, generated-media artifacts, editor/compositor handoff, and finishing QC.

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When the user wants to create sales collateral, pitch decks, one-pagers, objection handling docs, or demo scripts. Also use when the user mentions 'sales deck,' 'pitch deck,' 'one-pager,' 'leave-behind,' 'objection handling,' 'deal-specific ROI analysis,' 'demo script,' 'talk track,' 'sales playbook,' 'proposal template,' 'buyer persona card,' 'help my sales team,' 'sales materials,' or 'what should I give my sales reps.' Use this for any document or asset that helps a sales team close deals. For competitor comparison pages and battle cards, use an available competitor-analysis capability. For marketing website copy, cold outreach, or offer design, use the corresponding capability when available.

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Processes environmental DNA metabarcoding data from raw amplicon reads to species occurrence tables using OBITools3, DADA2, and taxonomic assignment against BOLD, MIDORI2, or MitoFish databases. Handles COI, 12S, rbcL, and ITS barcode regions with primer removal, denoising, chimera detection, and contamination filtering via decontam. Includes occupancy modeling (occumb) for detection probability correction. Use when analyzing eDNA from water, soil, or bulk samples for biodiversity monitoring. Not for 16S human microbiome (see microbiome/amplicon-processing).

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Detect transcription factor binding footprints in ATAC-seq using TOBIAS, HINT-ATAC, Wellington, or scprinter. Use when identifying bound TF sites within accessible regions, correcting Tn5 insertion bias before footprinting, choosing between cleavage-based and aggregate-based footprinters, or comparing differential TF activity between conditions.

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All-in-one read preprocessing with fastp including adapter trimming, quality filtering, deduplication, base correction, and HTML report generation. Use when preprocessing Illumina data and wanting a single fast tool instead of separate Cutadapt, Trimmomatic, and FastQC steps.

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End-to-end CRISPR experiment design from target selection to delivery-ready constructs. Covers guide RNA design, off-target assessment, and specialized editing strategies including knockouts, base editing, and HDR knockins. Use when designing complete CRISPR editing experiments for gene knockout, correction, or tagging.

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Preprocessing and harmonization of multi-omics data before integration. Covers normalization, batch correction, feature alignment, and missing value handling across data types. Use when preparing multi-omics datasets for integration analysis.

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Extract, filter, annotate, and export differential expression results from DESeq2 or edgeR. Use for identifying significant genes, applying multiple testing corrections, adding gene annotations, and preparing results for downstream analysis. Use when filtering and exporting DE analysis results.

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Per-CpG differential methylation testing from bisulfite sequencing count data or beta-value matrices. Covers beta and M-value computation, coverage filtering, statistical tests (Welch t-test, Mann-Whitney, limma, DSS beta-binomial), multiple testing correction, and effect size calculation. Use when comparing methylation at individual CpG sites between experimental groups from WGBS, RRBS, or targeted bisulfite sequencing.

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Sequence-based deep learning for ATAC-seq using chromBPNet, BPNet, scBasset, or EnFormer. Use when correcting Tn5 bias with neural networks beyond k-mer models, predicting per-base accessibility profiles, scoring in silico variant effects at GWAS or rare-variant SNPs, discovering motifs via DeepLIFT/TF-MoDISco from a trained model, or generating cell-type-specific accessibility predictions for unobserved cell states.

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Discover RBP binding motifs from CLIP-seq peaks or single-nucleotide crosslink sites using HOMER, MEME/STREME, kpLogo, mCross (CL-position-registered motifs), PEKA (positional k-mer enrichment), RBPamp (affinity), and RNA Bind-n-Seq (RBNS) cross-validation. Use when characterizing RBP sequence specificity, registering motifs to crosslink positions, validating in vivo CLIP motifs against in vitro RBNS Kd, reconciling motif disagreements across tools, or correcting for the uracil crosslinking bias that contaminates raw CLIP motif logos.

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Spillover compensation and data transformation for flow cytometry. Covers compensation matrix calculation, application, and biexponential/arcsinh transforms. Use when correcting spectral overlap between fluorophores or transforming data for analysis.

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Run remote BLAST searches against NCBI servers using Biopython Bio.Blast.NCBIWWW. Use when identifying unknown sequences, finding homologs, picking the correct BLAST program (blastn/blastp/blastx/tblastn/tblastx/psiblast/megablast/dc-megablast), interpreting Karlin-Altschul E-values, avoiding the max_target_seqs trap (Shah 2019), choosing composition-based statistics, or limiting searches by organism. Covers RID lifecycle, database choice (nt/nr/refseq_select/swissprot), word-size and CBS taxonomy.

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Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.

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Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

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Identifies essential genes from CRISPR-Cas9 fitness screens using BAGEL2 (Kim & Hart 2021 Genome Med), a Bayesian classifier scoring per-gene Bayes Factors via log-likelihood ratios over per-sgRNA fold changes, calibrated against CEGv2 core-essentials (Hart 2017 G3, ~684 genes) and NEGv1 non-essentials (Hart 2014, ~927 genes). Covers the fc + bf + pr workflow, the linear-extrapolation improvement over BAGEL1 truncation, multi-target off-target correction, tumor-suppressor sensitivity (BAGEL2 detects enrichment), and BF-to-FDR calibration (BF >6 ≈ FDR 0.05 from Hart 2017). Use when classifying essential vs non-essential genes, calibrating BAGEL2 thresholds against PR curves, identifying tumor suppressors alongside essentials, comparing BAGEL2 hits to MAGeCK / drugZ, or generating publication-quality essentiality calls.

日本語の概要は準備中です。原文の説明を表示しています。