「rat」の検索結果

Project gene annotations across genomes using TOGA (Kirilenko 2023 whole-genome-alignment chain-based projection with intactness classification), CESAR 2.0 (Sharma, Schwede & Hiller 2017 codon-aware exon projection), LiftOff (Shumate & Salzberg 2021 reference-based annotation transfer), Liftover (UCSC), GeMoMa (Keilwagen 2019 evidence-based projection), and Comparative Annotation Toolkit (CAT). Use when transferring annotations from a well-annotated reference to query genome(s), classifying gene-loss vs gene-intact across many genomes at scale, building Zoonomia-style comparative annotations across hundreds of mammals or birds (Kirilenko 2023), detecting pseudogenization, projecting alternative isoforms, or selecting between WGA-anchored (TOGA) vs ortholog-based (LiftOff) annotation transfer strategies.

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Identifies essential genes from CRISPR-Cas9 fitness screens using BAGEL2 (Kim & Hart 2021 Genome Med), a Bayesian classifier scoring per-gene Bayes Factors via log-likelihood ratios over per-sgRNA fold changes, calibrated against CEGv2 core-essentials (Hart 2017 G3, ~684 genes) and NEGv1 non-essentials (Hart 2014, ~927 genes). Covers the fc + bf + pr workflow, the linear-extrapolation improvement over BAGEL1 truncation, multi-target off-target correction, tumor-suppressor sensitivity (BAGEL2 detects enrichment), and BF calibration (BF >6 ≈ 90% posterior per Hart 2017; ~5% FDR by BAGEL convention). Use when classifying essential vs non-essential genes, calibrating BAGEL2 thresholds against PR curves, identifying tumor suppressors alongside essentials, comparing BAGEL2 hits to MAGeCK / drugZ, or generating publication-quality essentiality calls.

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Automated cell behavior analysis from microscopy or XR lab recordings. Classifies cell motion phenotypes (migration, proliferation, apoptosis, division, quiescence), computes population-level quantitative metrics (growth rate, migration velocity, directionality index), and emits structured JSON for downstream reporting, plotting, or ELN integration.

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Spec-driven manual QA testing and Playwright E2E code generation. Orchestrates browser skills to navigate apps like a human tester, producing structured test reports or production-ready .spec.ts files. Always prompts user for credentials — never guesses or stores auth. Use for QA testing, E2E generation, login flow testing, or exploratory testing from a URL. NOT for AI-autonomous flows (see mk:agent-browser).

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Use this skill whenever the user asks to generate, edit, inpaint, restyle, or create bitmap images through OpenAI's Responses API image_generation tool from Codex. This skill calls the Responses API, saves generated base64 image results to files, uses no npm or pip dependencies, works on Linux/macOS/Windows with either Node.js 18+ or Python 3, and reuses Codex's configured API base URL, model, and key instead of asking the user for credentials.

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Evaluates basal insulin rates through basal rate testing across different time periods and adjusts as indicated. Triggered by clinician orders to 'Perform basal rate test to verify pump settings' or 'Check basal rates during periodic pump review'.

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In patients with normal preoperative adrenal function, suggests an individualized clinical approach for postoperative glucocorticoid administration until HPA axis evaluation can be performed. Triggers include managing postoperative patient with normal preoperative adrenal function needing glucocorticoid management.

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Generate hand-drawn 16:9 article illustrations with the Grav character IP, sparse annotations, and absurd but clear visual metaphors.

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When the user needs to generate, iterate, or scale ad creative for paid advertising. Use when they say 'write ad copy,' 'generate headlines,' 'create ad variations,' 'bulk creative,' 'iterate on ads,' 'ad copy validation,' 'RSA headlines,' 'Meta ad copy,' 'LinkedIn ad,' or 'creative testing.' This is pure creative production — distinct from paid-ads (campaign strategy). Use ad-creative when you need the copy, not the campaign plan.

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AI-powered presentation generation via the 2slides API — create slides from text, match a reference image style, summarize documents into decks, add AI voice narration, and export pages/audio. Use for any "make slides", "create a deck", or "slides from this document" request.

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Use when planning or upgrading an internal skill/workflow for business operations, especially when turning a messy idea into a structured skill plan, migration plan, acceptance checklist, or packaging decision. Particularly useful for Obsidian knowledge base consolidation, workspace migration, content library cleanup, and integrating multiple workbenches into one operating system.

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Expert-level analytical chemistry knowledge. Use when working with chromatography, spectroscopy, electroanalytical methods, sample preparation, quantitative analysis, calibration, statistics, or instrumental analysis. Also use when the user mentions 'HPLC', 'GC', 'mass spectrometry', 'atomic absorption', 'ICP', 'titration', 'calibration curve', 'detection limit', 'NMR', 'chromatography', 'electrochemistry', 'sample preparation', or 'method validation'.

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Generate beautiful, on-brand HTML artifacts — reports, diagrams, diff reviews, slide decks, plans, recaps, dashboards. Loads on creation intents ("create a plan", "make me an implementation plan", "generate a diagram", "build a slide deck", "draft a recap", "visualize this", "render this as HTML", "make me a status update") and exploration intents ("show me three layouts", "explore document shapes", "compare visual treatments", "explore a new design system", "compare replacement brand directions") and iteration intents ("make this beautiful", "polish this report", "make this less generic", "design this", "theme this", "use my brand", "iterate on this design", "review this artifact", "make this bolder", "make this quieter", "simplify this design", "animate this", "improve the look of", "give this a refresh"). Captures brand from the user's codebase, asking, or live site, then applies it to every artifact.

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Quando o usuário quer planejar, avaliar ou construir uma ferramenta gratuita para fins de marketing — geração de leads, valor em SEO ou conscientização de marca. Use também quando o usuário menciona "engenharia como marketing", "ferramenta gratuita", "ferramenta de marketing", "calculadora", "gerador", "ferramenta interativa", "ferramenta de geração de leads", "construir uma ferramenta para leads" ou "recurso gratuito". Esta competência conecta engenharia e marketing — útil para fundadores e profissionais de marketing técnico.

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AI image generation with OpenAI GPT Image 2, Azure OpenAI, Google, OpenRouter, DashScope, Z.AI GLM-Image, MiniMax, Jimeng, Seedream, Replicate and Agnes APIs. Supports text-to-image, reference images, aspect ratios, and batch generation from saved prompt files. Sequential by default; use batch parallel generation when the user already has multiple prompts or wants stable multi-image throughput. Use when user asks to generate, create, or draw images.

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Analyzes article structure, identifies positions requiring visual aids, generates illustrations with Type × Style × Palette three-dimension approach. Use when user asks to "illustrate article", "add images", "generate images for article", or "为文章配图".

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Scaffolds an xUnit integration test project for validating Oracle-to-PostgreSQL database migration behavior in .NET solutions. Creates the test project, transaction-rollback base class, and seed data manager. Use once per project before writing Oracle-to-PostgreSQL migration integration tests.

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Creates integration test cases for .NET data access artifacts during Oracle-to-PostgreSQL database migrations. Generates DB-agnostic xUnit tests with deterministic seed data that validate behavior consistency across both database systems. Use after the test project is scaffolded, to cover a project's data access code before porting it.

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Cascades strategy from boardroom to individual contributor. Detects and fixes misalignment between company goals and team execution. Covers strategy articulation, cascade mapping, orphan goal detection, silo identification, communication gap analysis, and realignment protocols. Use when teams are pulling in different directions, OKRs don't connect, departments optimize locally at company expense, or when user mentions alignment, strategy cascade, silo, conflicting OKRs, or strategy communication.

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Production-grade Stripe integrations: subscriptions with trials and proration, one-time payments, usage-based billing, checkout sessions, idempotent webhook handlers, customer portal, and invoicing. Covers Next.js, Express, and Django patterns. Use when integrating Stripe for the first time, debugging webhook reliability issues, migrating from a different payment provider, or adding usage-based billing to an existing subscription product.

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Culture assessment and monitoring with three modes — Diagnostic for a deep session surfacing the gap between declared culture and actual culture, Review for periodic check-ins on whether behavior is shifting, and Alert Triggers for setting tripwires around culture-strategy misalignment, regression, and integration risk. Not a culture change programme — a mirror. Updates company-context.md after every run. Triggers on questions about culture, values, team dynamics, how decisions really get made, why change efforts stall, merger integration, or whether the organisation can actually execute its strategy. Based on practice by Eterdis (eterdis.com).

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Wardley Mapping for strategic positioning — map your value chain from customer need to underlying components, plot where each component sits on the evolution curve (novel to commodity), and spot the strategic plays that movement creates. Use this skill when someone wants to understand where their industry is heading, whether they're building things they should be buying, where competitors are vulnerable, what's about to become commoditised, or why their competitive advantage is eroding. Triggers on questions about build-vs-buy, component evolution, value chain analysis, commoditisation risk, or strategic positioning relative to market movement. Three modes — full diagnostic (build a map from scratch), review (update positions and reassess), and alert triggers (set tripwires for when components move). Based on practice by Eterdis (eterdis.com).

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First-principles strategy — strip away conventional assumptions and find the theoretical maximum for your business. Three modes. Diagnostic mode runs a full session (45+ min) to define your theoretical maximum, map the gap honestly, classify constraints, invert for failure modes, set strategic intent, and work backwards to your first intervention. Review mode (15-20 min) checks whether your theoretical maximum has shifted, whether the gap has changed, and whether you're still climbing the right peak. Alert mode defines constraint-shift, peak-shift, and local-peak triggers that tell you when to reassess. Use when someone is stuck optimising incrementally, when conventional wisdom is driving strategy, when a new technology or regulation changes what's physically possible, or when you suspect the business is climbing a local peak. Integrates with company-context.md. Based on practice by Eterdis (eterdis.com).

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Distributed machine learning, data mining, and iterative HPC with Exasol. Covers end-to-end ML pipelines (DISTRIBUTE BY + SET scripts + BucketFS), per-entity federated training with partial_fit and ctx.reset(), batch inference, map-reduce ensemble training, distributed ensemble and SON algorithm for frequent itemset mining (Apriori, FP-Growth, association rules, market-basket analysis), Lua execute script orchestration for iterative algorithms (k-means, SGD, gradient descent), scikit-learn model training, parallel hyperparameter search, per-entity forecasting, anomaly detection, model lifecycle in BucketFS (pickle/joblib/ONNX versioning), GPU acceleration via CUDA SLCs (PyTorch/TensorFlow/RAPIDS), and ML-specific performance tuning (skew, OOM, multi-pass chunking).

日本語の概要は準備中です。原文の説明を表示しています。