「standard」の検索結果

Produce audio-first podcast episodes with generative tools — design the show and episode format (interview, narrative, news brief, two-host conversational), write scripts for the ear, decide between fully-synthetic and hybrid (recorded human + synthetic) production and meet the disclosure duty each triggers, cast and direct multi-voice TTS for consistency and chemistry, build episode structure (cold open, intro/outro, segments, ad slots), assemble and edit, clear music and SFX rights, hit podcast loudness and delivery standards, ship metadata/chapters/transcripts through RSS, and pass platform AI-content policy and QA before publishing. Use this skill whenever the deliverable is a podcast episode or a podcast show bible, or when an agent must make production, rights, disclosure, or delivery decisions for spoken-word audio. Not for music tracks, single-voice notification prompts, or video where picture leads (route audio-for-video to a video skill).

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Read and manipulate Flow Cytometry Standard (FCS) files. Covers loading data, accessing parameters, and basic data exploration. Use when loading and inspecting flow or mass cytometry data before preprocessing.

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Predict enhancer-gene regulatory connections from ATAC-seq using ABC, ENCODE-rE2G, HiChIP, or Cicero. Use when linking distal enhancers to target genes, choosing between contact-aware (ABC, ENCODE-rE2G), accessibility-only (Cicero), and orthogonal (HiChIP H3K27ac, EpiMap) approaches, validating predictions against CRISPRi-FlowFISH gold-standard, or building cell-type-specific regulatory maps for fine-mapping or therapeutic target discovery.

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Corrects the gene-independent copy-number artifact in CRISPR-Cas9 screens (Aguirre 2016 / Munoz 2016 Cancer Discov) where amplified loci appear essential from DNA-damage burden of simultaneous cuts. Covers the p53-dependent G2-arrest mechanism, CRISPRcleanR (Iorio 2018) unsupervised pre-hoc correction, CERES (Meyers 2017) joint CN + gene-effect model, Chronos (Dempster 2021) DepMap-standard population-dynamics + CN model with lowest residual bias, the decision tree by data availability, the Spearman LFC-vs-CN diagnostic, focal-amplification examples (ERBB2 in HER2+, MYC in colorectal, FGFR1 in head and neck), and CRISPRi/a alternatives that bypass the artifact. Use when screening cancer cell lines, diagnosing essentiality at amplified loci, choosing CRISPRcleanR / CERES / Chronos, deciding whether CN correction is needed before MAGeCK / BAGEL2 / drugZ, or switching from Cas9 to CRISPRi.

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Create portable, standards-based bioinformatics pipelines with Common Workflow Language (CWL). Use when building workflows that need maximum portability across execution platforms, sharing pipelines with collaborators using different systems, or contributing to community workflow registries.

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Generates standardized quality control reports by aggregating metrics from FastQC, alignment, and other tools using MultiQC. Use when summarizing QC metrics across samples, creating shareable quality reports, or building automated QC pipelines.

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ATAC-seq library quality control -- TSS enrichment, FRiP, fragment-size periodicity, library complexity (NRF/PBC1/PBC2), mitochondrial fraction, and ENCODE 4 thresholds. Use when assessing whether an ATAC-seq library passes ENCODE acceptance criteria, diagnosing transposition artefacts, comparing Omni-ATAC vs standard prep quality, or selecting which replicates to drop before peak calling.

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Proteina-Complexa flow-based protein backbone generation with fold-conditioned sampling guidance. Use this skill when: (1) Generating de novo protein backbones with hierarchical fold conditioning, (2) Exploring long-chain backbone generation beyond standard diffusion baselines, (3) Using NVIDIA Proteina-style flow matching workflows for controllable backbone design, (4) Comparing flow-based backbone generation against RFdiffusion or BoltzGen, (5) Prototyping fold-guided backbone campaigns before sequence design. This skill is based on the public NVIDIA Digital Bio Proteina project and uses "Proteina-Complexa" as the BioClaw-facing skill label. For sequence design after backbone generation, use proteinmpnn or solublempnn. For QC thresholds, use protein-design-qc.

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Standard scRNA-seq preprocessing and clustering with Scanpy. Use for QC, normalization, HVG selection, PCA, neighbor graph construction, UMAP, Leiden clustering, and export of an analysis-ready AnnData object.

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Predicts ADMET properties using ADMETlab 3.0 (119 endpoints with uncertainty), ADMET-AI, DeepChem MolNet, and chemprop D-MPNN with explicit handling of OECD QSAR principles, applicability domain assessment, calibration, hERG/CYP/AMES gold-standard endpoints, and PAINS / Lipinski / Ro5 / Veber / BBB druglikeness filters. Use when filtering compounds for drug-likeness, prioritizing leads by predicted safety, or building an in-house ADMET QSAR model.

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Solubility-optimized protein sequence design using SolubleMPNN. Use this skill when: (1) Designing for E. coli expression, (2) Optimizing solubility of designed proteins, (3) Reducing aggregation propensity, (4) Need high-yield expression, (5) Avoiding inclusion body formation. For standard design, use proteinmpnn. For ligand-aware design, use ligandmpnn.

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Ligand-aware protein sequence design using LigandMPNN. Use this skill when: (1) Designing sequences around small molecules, (2) Enzyme active site design, (3) Ligand binding pocket optimization, (4) Metal coordination site design, (5) Cofactor binding proteins. For standard protein design, use proteinmpnn. For solubility optimization, use solublempnn.

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Provisional task skill for organisational plain language implementation (based on ISO/CD 24495-4, committee draft). Activates for plain language gap analysis, policy drafting, review workflow design, and organisational readiness for the future published standard. Does not activate for ordinary writing, rewriting, or reviewing of individual documents.

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Sector-specific Plain Language standard for science and technical writing (ISO 24495-3:2026). Applied during software documentation, architecture specs, and technical analysis.

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Sector-specific Plain Language standard for legal communication (ISO 24495-2:2025). Applied during contract drafting, license review, and legal/compliance writing.

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Core Plain Language standard (ISO 24495-1:2023). Governs all user-facing responses to ensure clear, structured, findable, understandable, and actionable output.

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Provisional sector-specific Plain Language standard for document design (based on ISO/WD 24495-5, under development). Applied when structuring complex documents so readers can find and navigate content through layout, visual hierarchy, and navigation aids.

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Comprehensive guidelines for Obsidian.md plugin development including ESLint rules from eslint-plugin-obsidianmd v0.4.2, TypeScript best practices, memory management, API usage (requestUrl vs fetch), UI/UX standards, popout window compatibility, community.obsidian.md submission process, and Scorecard optimization. Use when working with Obsidian plugins, main.ts files, manifest.json, Plugin class, MarkdownView, TFile, vault operations, or any Obsidian API development.

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Test for regulatory compliance: GDPR/CMP consent verification, Google Consent Mode v2, Global Privacy Control (GPC), CCPA/US state opt-out, EU AI Act Article 50 transparency, Better Ads Standards, and cookie-inventory auditing. Covers automated consent-flow testing, third-party script blocking before consent, and cookie drift detection. Use when: "GDPR test," "compliance," "CMP test," "cookie consent," "consent mode," "CCPA," "GPC," "AI Act," "Better Ads," "privacy banner." Not for: WCAG/axe-core test authoring — use accessibility-testing. Not for: OWASP/vuln scanning — use security-testing. Not for: evaluating your LLM feature's quality or safety — use ai-system-testing. Related: accessibility-testing, security-testing, ai-system-testing, ci-cd-integration.

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Creates new Skills following Anthropic best practices. Use when discovering reusable workflows or repetitive patterns. Triggers on: create skill, new workflow, codify this process, standardize workflow.

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Systematically QA test any application — web apps, native macOS apps, Electron apps, CLI tools, interactive REPLs, or anything on screen. Three modes: browser (chromux/CDP, fast, DOM-level), computer (MCP computer-use, screenshot + pixel clicks, any app), and cli (tmux, send-keys + capture-pane for interactive terminals). Auto-selects mode or accepts --browser / --computer / --cli override. Use when asked to "qa", "QA", "test this site", "test this app", "find bugs", "test and fix", "fix what's broken", "dogfood", "exploratory test", "bug hunt", "QA this app", "사이트 테스트", "앱 테스트", "브라우저 QA", "화면 보고 테스트해줘", "네이티브 앱 테스트", "screen test". Three tiers: Quick (critical/high only), Standard (+ medium), Exhaustive (+ cosmetic). Produces before/after health scores, fix evidence, and a ship-readiness summary.

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Root cause based one-shot bug fix. debugger diagnosis → requirements.md generation → /execute. /bugfix "error description" Full investigation pipeline: debugger + gap-analyzer + standard verify. QA suggestion after successful fix.

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Layered technical-writing standard: Diátaxis structure, Google developer style sentences, STE instruction rules, Global English syntax. Use for /technical-writing or when writing or reviewing docs, RFCs, readmes, PR descriptions, or commit messages.

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Define reproducible development environments with Dev Containers. Use when a user asks to standardize dev environments, set up VS Code remote containers, create reproducible dev setups, or onboard developers faster.

日本語の概要は準備中です。原文の説明を表示しています。