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Patterns for computer-aided drug discovery including virtual screening, molecular docking, ADMET prediction, lead optimization, and integration with AI/ML methods. Covers both structure-based and ligand-based approaches. Use when ", " mentioned.
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Expert in designing and structuring online courses - curriculum architecture, learning outcomes, module design, and assessment strategies. Covers backward design methodology, scaffolding content, and creating courses that actually deliver transformation. Use when "create a course, course curriculum, course outline, learning outcomes, course structure, design a course, online course, " mentioned.
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Expert in entertainment industry concept art workflows, from initial ideation through final production-ready deliverables. Combines traditional art fundamentals with modern digital workflows used at AAA studios and film production houses. Draws from methodologies of industry masters: Feng Zhu's efficient design process, Scott Robertson's perspective and vehicle design systems, Sparth's graphic shape language, and Syd Mead's industrial design thinking. Use when "concept art, visual development, vis dev, keyframe, color script, production design, mood board, thumbnail sketch, environment concept, character concept, prop design, callout sheet, orthographic views, design exploration, photobash, speedpaint, concept-art, visual-development, game-art, film-art, pre-production, ideation, design" mentioned.
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健身私教 — 为客户设计、指导和推进个性化训练方案的专业工艺, 有别于团课教练、物理治疗师或运动队教练: (a) 训练方案设计与周期化 (线性 / 波动 / 板块周期化 Bompa & Haff; NSCA《力量训练与体能训练精要》行业圣经; Schoenfeld 肌肥大机制; Helms/Valdez/Morgan 肌肉与力量金字塔; 共轭训练法 Simmons/Westside; Starting Strength 线性渐进 Rippetoe; Renaissance Periodization 训练量地标 Israetel); (b) 动作评估与筛查 (FMS 功能性动作筛查 Gray Cook; NASM CEx 纠正性训练连续体 抑制-拉伸-激活-整合; 关节逐级方法 Cook/Boyle; 姿势与代偿模式识别; PAR-Q+ 与 ACSM 运动前筛查指南); (c) 教学与指令 (外部 vs 内部注意焦点 Wulf; 差异化学习 Schöllhorn; 约束导向方法 Davids/Renshaw; RIR/RPE 自动调节 Zourdos/Helms; 动机访谈在健身中的应用 Rollnick/Miller); (d) 营养指导的执业边界 (宏量营养素周期化; Precision Nutrition / ISSN 立场声明的循证建议; 边界: 私教提供一般性指导, 医学营养治疗需 RD/RDN 资质; 能量可用性与 RED-S Mountjoy IOC 共识); (e) 商业与客户管理 (客户留存与方案依从; 咨询与销售伦理; 线上教练平台与规模化 Goodman PTDC; 方案交付工具 TrueCoach/Trainerize/TrainHeroic; 课时定价模型; 独立教练 vs 健身房雇员); (f) 专项方向 (运动表现 CSCS; 纠正性训练 CES; 老年健身 SFN; 产前产后; 青少年 YSCA; 适应性 / 无障碍健身; 健美 / 形体; 力量举; 耐力运动 S&C)。诚实处理: 兄弟科学 vs 循证之争, 补剂行业利益冲突, 合成代谢激素使用现状 (诚实但不推广: 匿名调查约 30% 有经验男性健身者使用过 — 业内估, Kanayama/Pope/Hudson 记录健康风险, WADA 禁用清单用于竞技语境), 体型焦虑与进食障碍风险 (男性私教肌肉变形症, 正食症倾向, NEDA 负责任语言指南), 健身房掠夺性销售 (高压推销、误导性对比照、长约锁定), 执业边界违规 (私教诊断伤病或超范围开饮食处方), 线上教练认证造假 (周末速成、未经认可的认证)。不含: 物理治疗 / 康复治疗 (持照医疗职业), 不含: 团课教练 (Les Mills/Zumba/CrossFit 分馆教练 — 相邻但不同), 不含: 精英竞技运动教练 (团队项目周期化, 不同职业路径), 不含: 营养作为主业 (临床营养学需单独资质)。 (Personal Trainer — the craft of designing, coaching, and progressing individualized exercise programs for clients, distinct from group fitness instruction, physiotherapy, or sports coaching: (a) exercise programming and periodization (linear / undulating / block periodization per Bompa & Haff; NSCA Essentials of Strength Training and Conditioning as industry bible; Schoenfeld on hypertrophy mechanisms; Helms/Valdez/Morgan Muscle & Strength Pyramids; conjugate method Simmons/Westside; Starting Strength linear progression Rippetoe; Renaissance Periodization volume landmarks Israetel); (b) movement assessment and screening (FMS Gray Cook; NASM CEx corrective exercise continuum inhibit-lengthen-activate-integrate; joint-by-joint approach Cook/Boyle; posture and compensation pattern identification; PAR-Q+ and pre-exercise screening ACSM guidelines); (c) coaching and cueing (external vs internal cueing Wulf attentional focus research; differential learning Schöllhorn; constraints-led approach Davids/Renshaw; RIR/RPE autoregulation Zourdos/Helms; motivational interviewing for adherence Rollnick/Miller adapted to fitness); (d) nutrition guidance within scope of practice (macronutrient periodization; evidence-based recommendations per Precision Nutrition / ISSN position stands; scope boundary: PT gives general guidance NOT medical nutrition therapy which requires RD/RDN credential; energy availability and RED-S awareness Mountjoy IOC consensus); (e) business and client management (client retention and programming adherence; consultation and sales ethics; online coaching platforms and scaling Goodman PTDC; programming delivery tools like TrueCoach/Trainerize/TrainHeroic; session pricing models; independent contractor vs gym employee dynamics); (f) specialization tracks (sports performance CSCS; corrective exercise CES; senior fitness SFN; pre/postnatal; youth YSCA; adaptive/inclusive fitness; bodybuilding/physique coaching; powerlifting/strength sports; endurance athlete S&C). Evidence-based practice as the core ethos: Schoenfeld/Krieger meta-analyses on volume-response, Helms systematic reviews on protein/resistance training, Brad Schoenfeld's MASS journal bridging research to practice, Menno Henselmans and Eric Helms as practitioner-researchers, Greg Nuckols Stronger By Science as translation layer. Chinese fitness industry context: rapid growth of personal training in commercial gyms (Keep/Lefit/Megafit chains), NSCA-CPT and ACE-CPT as dominant certifications alongside local CSFA (China Sport and Fitness Association) credential, '体适能' (physical fitness) as formal term, online coaching boom post-COVID, PT business models in tier 1-3 cities diverge sharply. Honest treatment of: bro science vs evidence-based d
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DevOps 与站点可靠性工程 (SRE) — 平台 / 基础设施 / 可靠性工程师的认知操作系统, 覆盖软件交付 + 运维全生命周期 (CI/CD 与发布工程 trunk-based + 渐进式发布 canary/blue-green/feature flag + GitOps Argo CD/Flux / 基础设施即代码 Terraform/OpenTofu/Pulumi/Ansible + policy-as-code OPA / 容器与编排 Docker/Kubernetes + Helm/Kustomize + service mesh Istio/Linkerd / 可观测性 Prometheus + Loki + OpenTelemetry + Honeycomb + eBPF + RED/USE / SLO-SLI-error budget 与可靠性工程 Google SRE 学科 + 容量规划 + 优雅降级 / 事件管理与 on-call 事件指挥 + PagerDuty + runbook + 无指责复盘 + MTTR / 云平台与 FinOps AWS/GCP/Azure + 成本优化 + 弹性伸缩 / 平台工程与开发者体验 IDP + Backstage + golden path + Team Topologies / DevSecOps 与供应链安全 shift-left + SBOM + SLSA + sigstore + Vault / 韧性与混沌工程 fault injection + game day + 安全科学 / DORA 指标与工程效能 部署频率 + 变更前置时间 + 变更失败率 + Accelerate 研究 / 数据库与有状态运维 schema 迁移 + 备份容灾) — 不含 通用应用开发 / 纯云销售认证速成 / 'DevOps = 跑 Jenkins 的岗位' 窄化误解 / ITIL 工单文化传统运维 (旧范式仅做边界) / 把手工运维 ClickOps 当稳态 (是 toil, 本 skill 核心反模式) (DevOps & Site Reliability Engineering — the cognitive operating system of platform / infrastructure / reliability practitioners who own the full software delivery + operational lifecycle, covering (a) CI/CD & release engineering (build pipelines, trunk-based development, progressive delivery — canary / blue-green / feature flags, GitOps with Argo CD / Flux), (b) Infrastructure as Code (Terraform / OpenTofu, Pulumi, CloudFormation, Ansible, Crossplane — module design, state management, drift, policy-as-code OPA / Sentinel / Checkov), (c) containers & orchestration (Docker / OCI, Kubernetes — scheduling, networking CNI, storage CSI, operators / CRDs, Helm / Kustomize, service mesh Istio / Linkerd), (d) observability (the three pillars + beyond — metrics Prometheus / VictoriaMetrics, logs Loki / ELK, traces OpenTelemetry / Jaeger / Tempo, high-cardinality observability Honeycomb, eBPF, RED / USE methods, SLO-based alerting), (e) SLO / SLI / error budgets & reliability engineering (Google SRE discipline — service level objectives, error budget policy, toil budgets, capacity planning, load shedding, graceful degradation), (f) incident management & on-call (incident command, PagerDuty / Opsgenie, runbooks, blameless postmortems, MTTR / MTTD, error budget burn), (g) cloud platforms & FinOps (AWS / GCP / Azure well-architected, multi-region, cost optimization, autoscaling), (h) platform engineering & developer experience (internal developer platforms, Backstage, golden paths, self-service, Team Topologies), (i) DevSecOps & supply-chain security (shift-left, SAST / DAST, SBOM, SLSA, sigstore / cosign, secrets management Vault), (j) resilience & chaos engineering (chaos experiments, fault injection, game days, resilience engineering / safety science), (k) DORA metrics & engineering effectiveness (deployment frequency, lead time, change failure rate, MTTR, the Accelerate research), (l) databases & stateful operations (schema migrations, backups / DR, replication); NOT generic software development / app feature coding (是 平行学科, DevOps/SRE 关注 delivery + operability 不是 product feature), NOT pure cloud sales / certification cram without operational depth, NOT 'DevOps = a job title that runs Jenkins' 的窄化误解 (DevOps 是 文化 + 实践, SRE 是 Google 对 reliability 的工程化具体实现), NOT ITIL-heavy 传统运维 工单文化 (是 被 DevOps 取代的旧范式, 仅做边界标注), NOT manual ops / ClickOps as a steady state (是 toil, 本 skill 的核心反模式).) Master OS — automated mastery of DevOps & Site Reliability Engineering — the cognitive operating system of platform / infrastructure / reliability practitioners who own the full software delivery + operational lifecycle, covering (a) CI/CD & release engineering (build pipelines, trunk-based development, progressive delivery — canary / blue-green / feature flags, GitOps with Argo CD / Flux), (b) Infrastructure as Code (Terraform / OpenTofu, Pulumi, CloudFormation, Ansible, Crossplane — module design, state management, drift, policy-as-code OPA / Sentinel / Checkov), (c) containers & orchestration (Docker / OCI, Kubernetes — scheduling, networking CNI, storage CSI, operators / CRDs, He
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红队渗透 / 攻防 — 受授权的红队作业者 + 渗透测试工程师 + 攻击型安全顾问的认知操作系统 (侦察 OSINT / 外网渗透 / 内网 AD 渗透 BloodHound + Kerberoasting + ADCS 利用 + 横向移动 / Web 应用渗透 OWASP WSTG / 移动 OWASP MASTG / 云渗透 AWS Azure GCP IAM 路径 + 容器逃逸 + K8s / C2 操作 Cobalt Strike Sliver Mythic Havoc + OPSEC / 初始访问 + AV EDR 绕过 (仅授权场景) / 无线 RF / 物理社工 / 报告与整改 / 框架 MITRE ATT&CK + D3FEND + PTES + OSSTMM + NIST 800-115 + Kill Chain / 法律伦理 CFAA + 网络安全法 + 刑法 285 286 + 数据安全法 + GDPR + 授权书 + 范围 + 交战规则 — 不含 黑产 / 未授权攻击 / 大规模 exploitation / 供应链投毒 / 未授权 DoS — 这是 重罪 + 行业封杀 + 律师吊销, 本 skill 严守 authorized-only 边界 — 也不含 蓝队 SOC + 恶意软件 即服务 / 僵尸网络 / 勒索软件作者 — 这是 cybercrime 不是 红队) (Cybersecurity Red Team / Offensive Security Operations — the cognitive operating system of authorized red team operators, penetration testers, and offensive security consultants covering (a) reconnaissance & OSINT (passive + active discovery, asset surface mapping), (b) external network pentest (perimeter, exposed services, web), (c) internal network / Active Directory pentest (AD enumeration via BloodHound, Kerberos abuse — Kerberoasting / AS-REP-roasting / Unconstrained delegation / S4U2self, NTLM relay, ADCS abuse, GPO abuse, lateral movement, privilege escalation), (d) web application pentest (OWASP WSTG, authentication, authorization, SSRF, XXE, deserialization, SSTI, prototype pollution, GraphQL, JWT, API), (e) mobile pentest (OWASP MASTG, iOS / Android, instrumentation Frida / Objection, MASVS), (f) cloud pentest (AWS / Azure / GCP — IAM enumeration, privilege escalation paths, container escape, K8s RBAC, serverless), (g) C2 operations & post-exploitation (Cobalt Strike / Sliver / Mythic / Havoc, beacon ops, malleable profiles, OPSEC), (h) initial access & evasion (phishing infrastructure, payload development, AV / EDR evasion, BYOVD, AMSI / ETW bypass — strictly for authorized engagements), (i) wireless / RF (WPA2/3, evil twin, Wi-Fi pivots), (j) physical / social engineering (badge cloning, pretexting, vishing — under engagement letter), (k) reporting & remediation (executive summary, technical findings, CVSS, MITRE ATT&CK mapping, retest), (l) frameworks & methodology (MITRE ATT&CK, MITRE D3FEND, PTES, OSSTMM, NIST SP 800-115, OWASP WSTG / MASTG, Cyber Kill Chain, Unified Kill Chain, Diamond Model), (m) law & ethics (CFAA US, Computer Misuse Act UK, 中国 刑法 285/286 + 网络安全法 + 数据安全法, GDPR for tested EU systems, engagement letter, scope, rules of engagement, safe harbor for bug bounty); NOT criminal hacking / 黑产 / unauthorized targeting / mass exploitation / supply-chain compromise / DoS against unconsented systems (这是 重罪 + 业内开除 + 律师执照吊销, 本 skill 严守 authorized-only 边界), NOT pure defensive blue team / SOC analyst tradecraft (是 平行学科, 仅做 边界标注 + ATT&CK 反推方向), NOT malware-as-a-service development / botnet ops / ransomware authoring (是 cybercrime 不是 红队), NOT 'ethical hacking' 在 'just curious 看看' 自我合理化的灰色操作 (违反 authorization 原则即不是 红队).) Master OS — automated mastery of Cybersecurity Red Team / Offensive Security Operations — the cognitive operating system of authorized red team operators, penetration testers, and offensive security consultants covering (a) reconnaissance & OSINT (passive + active discovery, asset surface mapping), (b) external network pentest (perimeter, exposed services, web), (c) internal network / Active Directory pentest (AD enumeration via BloodHound, Kerberos abuse — Kerberoasting / AS-REP-roasting / Unconstrained delegation / S4U2self, NTLM relay, ADCS abuse, GPO abuse, lateral movement, privilege escalation), (d) web application pentest (OWASP WSTG, authentication, authorization, SSRF, XXE, deserialization, SSTI, prototype pollution, GraphQL, JWT, API), (e) mobile pentest (OWASP MASTG, iOS / Android, instrumentation Frida / Objection, MASVS), (f) cloud pentest (AWS / Azure / GCP — IAM enumeration, privilege escalation paths, container escape, K8s RBAC, serverless), (g) C2 operations & post-exploitation (Cobalt Strike / Sliver / Mythic / Havoc, beacon ops, malleable profiles, OPSEC), (h) initial access & evasi
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Systematic research methodology for building comprehensive, current knowledge on any topic. Requires web_search tool. Use when questions require thorough investigation, recent developments post-cutoff, synthesis across multiple sources, or when Claude's knowledge may be outdated or incomplete. Triggered by "Research", "Investigate", "What's current on", "Latest info on", complex queries needing validation, or technical topics with recent changes.
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Multi-conversation methodology for iterative stateful work with context accumulation. Use when users request work that spans multiple sessions (research, debugging, refactoring, feature development), need to build on past progress, explicitly mention iterative work, work logs, project knowledge, or cross-conversation learning.
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Analyzes an AI/ML publication — paper, preprint, article, technical blog post — and extracts what an enterprise AI engineer should do about it. Use when someone supplies a URL or document on RAG, embeddings, fine-tuning, prompt engineering, agents, or LLM deployment and asks "review this paper", "what do you make of this", "is this worth adopting", or "summarise the method and its limits". The subject matter must itself be machine learning.
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Exhaustive problem space exploration using the MIT Synthetic Neurobiology "tiling tree" method. Partitions a problem into MECE (Mutually Exclusive, Collectively Exhaustive) subsets recursively via parallel subagents, then evaluates leaf ideas against specified criteria. Use when users say "tiling tree", "tile the solution space", "exhaustively explore approaches to", "what are all the ways to", or request a MECE breakdown of a problem. Requires orchestrating-chat-agents skill.
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Convenes expert panels for problem-solving. Use when user mentions panel, experts, multiple perspectives, MECE, DMAIC, RAPID, Six Sigma, root cause analysis, strategic decisions, process improvement, or asks for philosophers/ancients (Socratic, Aristotelian, Stoic method experts).
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Odoo 19 development knowledge base with 18 specialized guides covering Actions (ir.actions.*, cron jobs, server actions), Controllers (HTTP routing, endpoints, auth types), Data files (XML/CSV records, shortcuts, noupdate), API Decorators (@api.depends, @api.constrains, @api.ondelete, @api.onchange, @api.model, @api.private), SQL Constraints (models.Constraint replacing _sql_constraints), Database Indexes (models.Index), Module development (manifest, wizards, reports), Field types (Char, Text, Monetary, relational fields), Manifest configuration (__manifest__.py, dependencies, asset bundles), Mixins (mail.thread, mail.activity.mixin, mail.alias.mixin, utm.mixin), ORM Model methods (search, CRUD, domain filters, recordsets, CamelCase model naming), Migration scripts (pre/post/end hooks, data migration), OWL frontend components (hooks, services, lifecycle), Performance optimization (N+1 prevention, batch ops, _read_group), QWeb Reports (PDF/HTML, paper formats, barcodes, t-out), Security/ACL (record rules, field permissions, privilege-based groups, @api.private), Testing (TransactionCase, HttpCase, mocking, query count assertions), Transactions (savepoints, UniqueViolation, serialization failures), Translations (i18n, PO files, translatable fields), XML Views (list/form/search, kanban card templates, xpath inheritance, QWeb templates). Use when writing, reviewing, or debugging any Odoo 19 Python or XML code, creating or modifying modules, fixing performance issues, or looking up Odoo 19 API patterns and best practices. Includes CSS/SCSS asset authoring and review for Odoo addons.
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Complete reference for DTG Base module utilities and helpers. DTGBase is an abstract model providing common utility methods for date/time handling, barcode generation, timezone conversion, file operations, and more.
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Design adaptive layouts and interactions that work across all screen sizes and input methods.
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Choose the right prototyping fidelity and method for the design question.
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Runs a full dead-end page audit for any website. Discovers all blog/content pages, detects which ones have zero outgoing links to any URL on the same domain, fetches keywords, clusters pages by topic, and generates 3 outgoing link suggestions per dead-end page with anchor text, placement guidance, and ready-to-paste context copy. Outputs a styled HTML report matching report-style-reference.html. Automatically detects site framework (Next.js, static, WordPress) and uses the correct detection method: RSC header for Next.js/Vercel sites, standard curl for static and traditional CMS sites. Trigger when a user provides a domain or URL and asks for a dead-end page audit, outgoing internal links audit, "which pages don't link out", "find pages with no internal links in the content", "pages that are link dead-ends", or any variation of finding pages that have zero outgoing links to the same domain. Always use this skill for dead-end page audits — never attempt the workflow without following every step here.
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Builds end-to-end predictive modeling pipelines on tabular datasets—data exploration, preprocessing, baseline modeling, and mandatory optimization—producing valid saved predictions in the required output format. Use for any supervised machine learning or data modeling task, including classification and regression on tabular data, Kaggle-style competitions or submission-file challenges, training a model to predict a target from features, or requests to fit/tune/evaluate models with scikit-learn, XGBoost, Random Forest, Logistic Regression, and similar non-deep-learning methods. Runs fully automated end-to-end without asking the user for intermediate decisions.
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Default Looper review method for implementation and spec PRs. Read before reviewing. Covers correctness, tests, concurrency, contracts, and comment quality.
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Applies the foundationalist reasoning and methodological doubt of René Descartes (17th-century French rationalist philosopher). Use this skill whenever the user is questioning fundamental assumptions, seeking absolute certainty in a decision, dismantling flawed systems, or trying to rebuild a project from first principles. Trigger this skill for topics involving epistemology, rationalism, radical doubt, systemic reconstruction, or separating objective truth from sensory illusion. Reach for this whenever a user needs to cut through probabilities and consensus to find an indubitable 'Archimedean point' to build upon.
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This skill channels the reasoning of Walter C. Willett, nutrition epidemiologist at Harvard University. Use this skill whenever you are asked to evaluate diets, give nutritional advice, critique food policy, or discuss the environmental impact of food systems. Trigger this skill for topics like macronutrient quality (fats vs. carbs), plant-based diets, the health impacts of red meat or dairy, seed oils, epidemiological methodology, and planetary health. Apply his frameworks to shift focus from macronutrient quantity to quality, evaluate foods using the 'Compared to what?' rule, and prioritize public health over personalized nutrition fads.
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Use this skill to reason like JoAnn E. Manson, epidemiologist at Harvard Medical School and women's health expert. Trigger this skill whenever you are evaluating hormone replacement therapy (HRT), menopause management, nutritional epidemiology, dietary supplements, or clinical trial methodology. Apply her frameworks when users ask about the risks and benefits of HRT, bioidentical hormones, or targeted supplementation. Reach for this skill to differentiate between symptom management and chronic disease prevention, or when assessing observational data versus randomized clinical trials (RCTs) in public health contexts.
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This skill channels the strategic and scientific reasoning of Demis Hassabis, CEO and co-founder of Google DeepMind, AlphaGo and AlphaFold, and 2024 Nobel Prize in Chemistry. Use this skill whenever you are evaluating AI for scientific discovery, tackling "root node" problems, designing reinforcement learning systems, or discussing AGI timelines, safety, and global governance. Reach for it when the user faces massive combinatorial search spaces, wants to apply AI to physical/biological sciences (like digital biology), or needs to balance rapid AI scaling with the rigorous scientific method. Apply these mental models to shift the focus from building consumer apps to using AI as the ultimate meta-solution for understanding reality.
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Applies the behavioral genetics and twin-study methodologies of Dorret I. Boomsma (behavior geneticist, Vrije Universiteit Amsterdam). Use this skill when reasoning about heritability, genetic epidemiology, nature vs. nurture debates, psychiatric genetics, or longitudinal phenotyping. Trigger this whenever the user asks about the genetic basis of intelligence, lifestyle factors, educational attainment, or psychopathology, or when designing epidemiological studies. It helps deconfound environmental and genetic variables using extended family designs and discordant twin models.
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Create and refine sales playbooks, deal strategies, MEDDPICC analyses, customer decks, and outreach sequences. Use for any sales methodology work, pipeline review, or go-to-market planning.
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