1.4万 件 ・ 関連度順
End-to-end neoantigen discovery from somatic variants to ranked vaccine candidates. Integrates HLA typing, MHC binding prediction, pVACtools neoantigen calling, and immunogenicity scoring. Use when identifying tumor neoantigens for personalized vaccine design or checkpoint biomarkers.
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Authors bioinformatics pipelines in WDL (Workflow Description Language) run by Cromwell or miniwdl, targeting the GATK/Broad and Terra/AnVIL/BioData Catalyst cloud ecosystem, with tasks, workflows, scatter-gather parallelism, structs, and a runtime block that sizes the cloud VM. Use when deciding to target Terra/AnVIL/GATK/WARP (chosen for the ecosystem, not the language); sizing runtime disks dynamically for a fresh-per-task cloud VM (ceil(size(f)*factor)+buffer); choosing preemptible vs on-demand VMs by task length and idempotency; picking Cromwell (production, cloud, call-caching) vs miniwdl (local dev, miniwdl check linting, readable errors); enabling and debugging call-caching silent-miss modes; pinning Docker by digest for reproducibility and cache stability; or scattering an array for parallel fan-out.
日本語の概要は準備中です。原文の説明を表示しています。
End-to-end eDNA metabarcoding from raw amplicons to community ecology. Covers QC, primer removal (mandatory before DADA2 filterAndTrim), denoising with OBITools3 v3 (obi stats plural; DMS-based) or DADA2 ASVs (Callahan 2017), decontam combined method as screening-not-classifier (Davis 2018), tag-jumping with NovaSeq 10x MiSeq caveat (Schnell 2015), Hill-number effective species counts with coverage-based rarefaction (Jost 2006; Chao & Jost 2012; doubling rule), beta-diversity decomposition with MANDATORY PERMANOVA + PERMDISP pair (Anderson & Walsh 2013), constrained ordination, and the read-counts-not-abundance critique (Lamb 2019). Use when processing eDNA samples for biodiversity assessment, deciding ASV vs OTU, configuring OBITools3 v3, interpreting decontam screening, or reporting community comparisons with the dispersion confound check.
日本語の概要は準備中です。原文の説明を表示しています。
Detect and auto-install missing ToolUniverse research skills. Checks common Claude Code/Cursor/Codex skill directories for the canary file, and installs any missing skills if none found. Use when the plugin's research skills aren't loading, when migrating between clients, or when verifying a skill installation.
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Guided statistical analysis with test selection and reporting. Use when you need help choosing appropriate tests for your data, assumption checking, power analysis, and APA-formatted results. Best for academic research reporting, test selection guidance. For implementing specific models programmatically use statsmodels.
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Orchestrates an end-to-end CRISPR editing experiment design from target gene to delivery-ready, validatable constructs. Sequences guide design, off-target assessment, edit-modality selection (knockout, base editing, prime editing, HDR knock-in), and template/donor design, with a QC checkpoint at each handoff. Use when designing a complete CRISPR experiment for knockout, point correction, or tagging and the order of operations, the modality decision, and the cross-cutting traps are needed rather than a single step. Defers each step's mechanics to the genome-engineering skills.
日本語の概要は準備中です。原文の説明を表示しています。
Code quality patterns and guidelines for ToolUniverse tool development. Apply when writing, fixing, or refactoring tool Python code in the ToolUniverse project. Encodes lessons from 80+ debug rounds. Use alongside devtu-fix-tool and devtu-self-evolve. Triggers: implementing tool fixes, writing new tool classes, reviewing tool code quality, checking schema correctness, looking up API-specific bug fixes.
日本語の概要は準備中です。原文の説明を表示しています。
Continuous improvement system for ToolUniverse tools, skills, and plugin. Run benchmarks, diagnose failures, route fixes to devtu skills, retest. Use after skill optimization, tool additions, or as regression check.
日本語の概要は準備中です。原文の説明を表示しています。
Bayesian modeling with PyMC. Build hierarchical models, MCMC (NUTS), variational inference, LOO/WAIC comparison, posterior checks, for probabilistic programming and inference.
日本語の概要は準備中です。原文の説明を表示しています。
Optimize tool descriptions in ToolUniverse JSON configs for clarity and usability. Reviews descriptions for missing prerequisites, unexpanded abbreviations, unclear parameters, and missing usage guidance. Use when reviewing tool descriptions, improving API documentation, or when user asks to check if tools are easy to understand.
日本語の概要は準備中です。原文の説明を表示しています。
Validates docked / generated protein-ligand poses using PoseBusters physical-validity tests, strain energy quantification, geometric checks (planarity, vdW overlap, bond/angle distortion), and pose-energy reasonableness. Filters AI-docking outputs (DiffDock, EquiBind, NeuralPLexer) where ~50% of poses fail physical-validity tests. Use when QC-ing docking results, comparing classical vs ML docking outputs, or filtering pose lists before SAR analysis.
日本語の概要は準備中です。原文の説明を表示しています。
Exclusive-choice UI: CheckButton radio groups in list rows, when to use them vs ComboRow vs ToggleGroup. Use when presenting mutually exclusive options in GNOME preferences or dialogs.
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Package a GNOME app as a Flatpak — manifest for the GNOME runtime, sandbox permissions, build/run/test loop, and Flathub submission checklist. Use when packaging, distributing, or preparing a GNOME app for Flathub.
日本語の概要は準備中です。原文の説明を表示しています。
Run technical quality checks across accessibility, performance, theming, responsive design, and anti-patterns. Generates a scored report with P0-P3 severity ratings and actionable plan. Use when the user wants measurable accessibility, performance, responsive, theming, or anti-pattern findings—not when they mainly want an overall UX critique or final visual/detail polish.
日本語の概要は準備中です。原文の説明を表示しています。
Use to process automated PR review feedback (Copilot, Greptile, Codex) and iterate until all AI threads are addressed, checks are green, and the PR is merge-ready. Trigger when the user says "address review feedback", "recycle reviews", or references an automated reviewer.
日本語の概要は準備中です。原文の説明を表示しています。
Query aggregate Langfuse cost, volume, latency, and model telemetry efficiently with Metrics API v2. Use for dashboards, rollout checks, usage summaries, and cost or latency comparisons; use Observations API v2 instead when individual rows are actually required.
日本語の概要は準備中です。原文の説明を表示しています。
Configure and debug MCP servers for Claude Code, OpenCode, and Codex CLI, including auth headers, scope, and validation checks. Use when MCP tools fail to connect, when an MCP server returns 401/404/HTML, or when adding a new MCP server to this repo.
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Configure and debug MCP servers for OpenCode, Codex CLI, and Claude Code, including auth headers, scope, and validation checks. Use when MCP tools fail to connect or when adding a new MCP server.
日本語の概要は準備中です。原文の説明を表示しています。
Stellar smart contract development (Rust, soroban-sdk). Entry point with project setup, contract anatomy, and build/deploy workflow, routing to three companion files in this directory — development.md (storage/TTL, authorization, cross-contract calls, tokens, events, errors, upgrades, fees, troubleshooting), testing.md (unit, fuzz, property, fork, mutation, integration), and security.md (vulnerability classes, checklists, tooling, audits). Use when writing, testing, reviewing, securing, debugging, or shipping Stellar smart contracts, including anything the user calls "Soroban" — Soroban contracts, soroban-sdk, Soroban auth/storage/TTL errors, SEP-41 tokens, or SAC integration from contract code.
日本語の概要は準備中です。原文の説明を表示しています。
Review code changes against linked GitHub issue specs to catch implementation drift — building something plausible but wrong. Checks each acceptance criterion against actual code.
日本語の概要は準備中です。原文の説明を表示しています。
Triage application logs, open GitHub issues, pending feedback, in-app Issues, and agent conversations. Runs five phases: logs → close shipped issues → feedback → in-app issues → agent FAQ gaps. Use when /whats shows pending feedback, checking app logs, cleaning up shipped issues, or working the in-app Issues backlog.
日本語の概要は準備中です。原文の説明を表示しています。
Pre-PR verification for VenTu — tests, data validation, static build, and e2e for the touched surface. Use before opening any PR. For visual UI checks also load ventu-verify-ui.
日本語の概要は準備中です。原文の説明を表示しています。
Progressively activates todo tests one at a time, updates implementation code until each passes (verified via Wallaby), checks off matching design doc progress, then moves to the next—following the design doc as the single source of truth.
日本語の概要は準備中です。原文の説明を表示しています。
Design workflow — create design systems, DESIGN.md, and design tokens with anti-pattern enforcement and accessibility checks
日本語の概要は準備中です。原文の説明を表示しています。