「fal」の検索結果

Targeted deep research to fill a specific gap in an existing thesis. Use when user says "deepen", "flesh out", "expand on", "fill in", or specifies a thesis section to improve. Also supports --sync-metrics mode — detects stale financial metrics across every in-scope analytical section of a thesis (not just Key Metrics or Summary) and coherently updates every sentence that depends on them, using a Key-Metrics-table / FMP / web-search waterfall. Use when user says "sync metrics", "update the numbers throughout the note", or "fix stale figures across the whole thesis". The batch form `--sync-metrics --all-flagged` syncs every thesis flagged by the latest `$numbers --all-open` in one operation — detection fanned out to capped READ-ONLY agents, one consolidated confirmation gate, direct sequential writes (agents never write).

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Pull an earnings call (or investor-event) transcript from Quartr (FMP fallback), extract qualitative signal (management commentary deltas, hedging shifts, Q&A tone), and produce a thesis-delta-first Research note. Use when user says "transcript", "pull earnings call", "transcript diff", or "ingest [TICKER] earnings".

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Refresh the Key Metrics table in a thesis with current data from Financial Modeling Prep, with a Quartr standardized-statement tie-break for Revenue Growth / Gross Margin gaps (Step 4b-Q) and a scoped web-search fallback (Step 4b) when FMP has no data or resolved the wrong company. Use when user says "numbers", "refresh metrics", "update key metrics", or "refresh [TICKER]" with no other action implied. Surgical edit only — does NOT create research notes or propagate via /sync. Also flags (never auto-edits) stale price/valuation framing in the thesis Summary — see Step 10b.

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Refresh the Key Metrics table in a thesis with current data from Financial Modeling Prep, with a scoped web-search fallback (Step 4b) when FMP has no data or resolved the wrong company. Use when user says "numbers", "refresh metrics", "update key metrics", or "refresh [TICKER]" with no other action implied. Surgical edit only — does NOT create research notes or propagate via $sync. Also flags (never auto-edits) stale price/valuation framing in the thesis Summary — see Step 10b.

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Extract dominant-component soil profile variables for EcoSIM grid or template inputs from gSSURGO, with FAO HWSD v2.0 fallback when gSSURGO data are unavailable or incomplete. Use when deriving soil depth, bulk density, field capacity, wilting point, hydraulic conductivity, texture, rock fraction, pH, CEC, or soil organic carbon; or when converting EcoSIM grid NetCDF files to editable Excel workbooks and back.

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Execute an explicitly authorized exploratory charter and record notes, findings, evidence, and follow-up without claiming false coverage.

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Use when an existing skill must be refactored to cut context and ambiguity without losing behavior, safety or fallbacks — 'refatorar a skill', 'reduzir esta SKILL.md', 'revisar skill com métricas' — with before/after metrics, preserved invariants and three review rounds.

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Operação de aplicação Laravel em produção — Horizon, queue, scheduler, Octane, Redis, Supervisor, PHP-FPM, cache e deploy. Use quando o usuário disser "laravel", "horizon", "queue", "fila travada", "job falhando", "octane", "artisan", "php-fpm", "supervisor", "scheduler não roda".

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Pesquisa de Voz do Cliente (VOC) antes de escrever qualquer copy — coleta a linguagem literal do público em avaliações, fóruns, redes sociais, tickets de suporte e transcrições de vendas. Use quando o usuário disser "pesquisa de público", "voz do cliente", "VOC", "o que os clientes falam", "pesquisar concorrente", "analisar reviews", "levantar objeções", "não sei o que escrever", ou quando pedir copy sem que exista seção 6 preenchida em .claude/pwdev-copy-context.md. Produz frases verbatim, não paráfrases.

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Segurança de infraestrutura e pipeline — Trivy, Falco, CrowdSec, Fail2Ban, WAF, TLS, IAM, secrets, OWASP, Security Hub. Use quando o usuário disser "segurança", "vulnerabilidade", "CVE", "hardening", "WAF", "secrets", "exposto", "auditoria de segurança", "pentest".

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Confiabilidade da plataforma — SLO, error budget, capacidade, resiliência, ponto único de falha e revisão de prontidão. Use quando o usuário disser "SLA", "SLO", "disponibilidade", "resiliência", "aguenta?", "single point of failure", "production readiness", "quanto de folga temos".

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Read Haskell package documentation, Haddock HTML, Hackage pages, or dependency source for cabal nix-style projects. Prefer locally built/cached docs and source from the cabal store, dist-newstyle, plan.json, and repo-cache; fall back to Hackage only for packages outside the project dependency set or when local docs are unavailable.

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End-to-end Solana development playbook (Jan 2026). Prefer Solana Foundation framework-kit (@solana/client + @solana/react-hooks) for React/Next.js UI. Prefer @solana/kit for all new client/RPC/transaction code. When legacy dependencies require web3.js, isolate it behind @solana/web3-compat (or @solana/web3.js as a true legacy fallback). Covers wallet-standard-first connection (incl. ConnectorKit), Anchor/Pinocchio programs, Codama-based client generation, LiteSVM/Mollusk/Surfpool testing, and security checklists.

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Sanguo RAG unresolved mention resolution loop. Use for: 三國 RAG, unresolved mentions, alias review, observed mentions, MCQ triage, manual roster seeds, false-positive exclusion, running run_resolution_loop.py, applying unresolved-triage answers, delegating 三國名詞查證 to a web-capable agent, or Pilot ETL chunk experiments with LangChain text splitters / LangGraph / LangFlow around 張飛長坂橋等小樣本流程。

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Write a rigorous, decision-grade experiment spec — falsifiable hypothesis, primary metric, guardrails, randomisation unit, exposure definition, method (A/B, holdout, switchback, quasi-experiment, MAB), MDE/duration plan, peek policy, validity threats, and pre-committed decision rule. Platform-agnostic. Load when the user has a candidate experiment and needs to spec it before launch, or says "spec this experiment", "write the test plan", "design this A/B test", "what's the hypothesis", "how big a sample do we need", "how long should we run this", "define the metrics for this test", or when the experimentation orchestrator routes here.

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Build robust, production-grade backtesting systems that avoid common pitfalls and produce reliable strategy performance estimates.

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Evaluates genome assembly quality across the three orthogonal axes - contiguity (QUAST auN/NG50/NGx, not bare N50), completeness (BUSCO/compleasm gene-space plus Merqury k-mer completeness), and correctness (reference-free Merqury QV, Inspector/CRAQ structural errors, asmgene false-duplication/collapse). Covers why N50 is the most-gamed metric, why QV measured on the polishing reads is circular, distinguishing uncollapsed haplotigs from real WGD, and the EBP/VGP 6.C.Q40 standard. Use when judging whether an assembly is good enough to annotate or publish, comparing assemblers, diagnosing a fragmented or duplicated assembly, or assessing a phased diploid assembly.

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Orders and orients assembled contigs into chromosome-scale scaffolds from long-range linking data, inserting N-gap spacers (adds no sequence). Covers Hi-C/Omni-C scaffolding (YaHS, SALSA2, 3D-DNA/Juicer), Hi-C read-mapping prerequisites (map each end separately, no mate rescue, dedup, enzyme-aware), reading the contact map for misjoins/inversions/false-duplications, manual curation in Juicebox/PretextView (the VGP/DToL standard), reference-guided scaffolding (RagTag) and its karyotype-erasure hazard, genetic-map (ALLMAPS) and Bionano optical-map integration, chimera-breaking before scaffolding, gap-filling, and telomere/contig-vs-scaffold-N50 QC (tidk). Use when turning contigs into chromosomes with Hi-C, integrating a linkage map or optical map, choosing a scaffolder by available linking data, or judging whether a chromosome-scale assembly is trustworthy.

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Assembles genomes de novo from noisy long reads (Oxford Nanopore R9/R10/Dorado, PacBio CLR) with Flye (repeat graph), Canu (correct-trim-assemble OLC), NextDenovo, Shasta, Raven, wtdbg2, or miniasm, and reconciles bacterial assemblies into a consensus with Trycycler/Autocycler. Covers matching the input flag to the basecaller era (--nano-hq vs --nano-raw), why a raw long-read assembly is contiguous but low-QV and not finished until polished, haplotig false-duplication and purge_dups, coverage and read-N50 as non-substitutable inputs, and mid-read adapter de-chimerization. Use when assembling a bacterial or eukaryotic genome from ONT or PacBio noisy reads, choosing a long-read assembler, or diagnosing an over-collapsed or duplicated assembly. For PacBio HiFi use hifi-assembly instead.

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Creates DE-specific diagnostic and result visualizations using DESeq2/edgeR built-in functions and lightweight ggplot2 wrappers. Covers MA plot (with the shrunken-LFC compression effect), volcano (with the apeglm caveat that p-values are unchanged), PCA on VST/rlog (never raw counts), sample distance heatmaps, top-DE-gene heatmaps with the row-scaling trap, dispersion / BCV plot interpretation, p-value histogram diagnostics, plotCounts for individual genes, blind=TRUE vs FALSE rationale, and the n=3 visualization stake. Use when generating DE diagnostic plots, choosing VST vs rlog for visualization, troubleshooting suspicious plot patterns (shifted MA cloud, batch-dominated PCA, anti-conservative p-value histogram), or building a standard QC figure panel.

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Normalizes and transforms RNA-seq count matrices for DE, visualization, clustering, and ML. Covers between-sample (TMM, TMMwsp, RLE/median-of-ratios, upper quartile), within-sample (TPM, FPKM/RPKM), variance-stabilizing (VST, rlog, log-CPM), GC-content correction (cqn, EDASeq), and single-cell (scran deconvolution, scanpy normalize_total). Encodes the composition-bias rationale, the "most genes not DE" assumption and its catastrophic failure modes (MYC amplification, apoptosis, viral host shutoff, prokaryotic stress), the "lengthScaledTPM is not TPM" naming trap, the "TPM is not for DE" rule, the blind=TRUE vs FALSE decision, ERCC spike-in normalization (SBN), and the single-cell zero-inflation breakdown of TMM/RLE. Use when choosing or applying normalization, debugging shifted-MA-plot diagnostics, handling zero-heavy single-cell data, or correcting GC bias.

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Estimates time-scaled phylogenies, molecular clock rates, effective reproduction number R_e (or R_t), and population dynamics from dated pathogen genomes using TreeTime (maximum-likelihood) and BEAST2 (Bayesian; strict / uncorrelated lognormal / ORC clocks; constant / exponential / Bayesian Skyline / Skygrid / BICEPS / Birth-Death-Skyline / sampled-ancestor BDSKY priors; structured coalescent via MASCOT). Covers root-to-tip clock signal QC via TempEst, date-randomisation tests (Ramsden 2009; Duchêne 2015), recombination masking via Gubbins and ClonalFrameML before clock inference for recombining bacteria, BDSKY origin-vs-rootHeight pitfalls, sampling-bias correction (Volz & Frost 2014; preferential-sampling extensions), MASCOT structured coalescent for migration, BICEPS-vs-BSP skyline choice, multi-chain BEAST2 convergence diagnostics, and reconciliation between phylodynamic R_e and case-based R_t. Use when dating outbreak origins, estimating substitution rates, inferring R_e through time, building time-calibrated Nextstrain Augur trees, choosing between strict and relaxed clocks, fitting Birth-Death-Skyline (Stadler 2013) models, diagnosing temporal-signal failure, masking recombination before clock inference for *Streptococcus pneumoniae* / *Neisseria gonorrhoeae* / *Klebsiella* / *E. coli* phylodynamics, running MASCOT for structured-population analyses, or using UShER for pandemic-scale placement.

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Detect distant homologs using profile and structure-aware methods that go beyond standard BLAST. Use when sequence identity falls into the twilight zone (<35% pairwise), when BLAST fails to find homologs that should exist, when working at metagenomic scale (DIAMOND, MMseqs2), or when structure beats sequence (Foldseek). Covers PSI-BLAST (iterative PSSM), jackhmmer (iterative HMM), HHblits/HHsearch (profile-profile), DIAMOND, MMseqs2, and Foldseek (3Di structural alphabet, van Kempen 2024).

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Build local BLAST databases and run searches using NCBI BLAST+ command-line tools. Use when running >50 queries, building custom databases with -parse_seqids and -taxid, downloading prebuilt NCBI databases via update_blastdb.pl, choosing -task variants (megablast/dc-megablast/blastn/blastn-short), tuning soft/hard masking, scaling threads, or extracting hits with blastdbcmd. Encodes BLAST v5 vs v4 database format, taxonomy filtering, makeblastdb pitfalls.

日本語の概要は準備中です。原文の説明を表示しています。