3,718 件 ・ 関連度順
概要と使いどころ
Predicts ADMET properties using ADMETlab 3.0 API or DeepChem models. Estimates bioavailability, CYP inhibition, hERG liability, and 119 toxicity endpoints with uncertainty quantification. Filters for PAINS and other structural alerts. Use when filtering compounds for drug-likeness or prioritizing leads by predicted safety.
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Detect and correct for horizontal pleiotropy in Mendelian randomization analyses using MR-PRESSO for outlier removal, MR-Egger regression for directional pleiotropy, and Steiger filtering for variant directionality. Use when validating MR results, detecting pleiotropic instruments, or running sensitivity analyses for causal inference.
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Estimate causal effects between exposures and outcomes using genetic variants as instrumental variables with TwoSampleMR. Implements IVW, MR-Egger, weighted median, and MR-PRESSO methods for robust causal inference from GWAS summary statistics. Use when testing whether an exposure causally affects an outcome using genetic instruments.
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Apply Michael T. Nygard-inspired production reliability rules when designing failure handling, timeouts, retries, circuit breakers, observability, or deployment behavior.
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Apply Martin Kleppmann-inspired data-system rules when designing reliability, scalability, consistency, replication, transactions, streams, or schema evolution.
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Detects Follow-Through Day (FTD) signals for market bottom confirmation using William O'Neil's methodology. Dual-index tracking (S&P 500 + NASDAQ) with state machine for rally attempt, FTD qualification, and post-FTD health monitoring. Use when user asks about market bottom signals, follow-through days, rally attempts, re-entry timing after corrections, or whether it's safe to increase equity exposure. Complementary to market-top-detector (defensive) - this skill is offensive (bottom confirmation).
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Screen US stocks using William O'Neil's CANSLIM growth stock methodology. Use when user requests CANSLIM stock screening, growth stock analysis, momentum stock identification, or wants to find stocks with strong earnings and price momentum following O'Neil's investment system.
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Use when the user asks to "figure out where our direct traffic really comes from", "measure dark social", "add a how-did-you-hear-about-us field", or "show social drives signups without click data"; produces a share-link/UTM hygiene spec for owned share surfaces, a self-reported attribution field design that replaces an existing form field (free-text first, coded later), a GA4 direct-traffic decomposition read (deep-URL directs, mobile-app skew, private-push correlation) with every derived number hard-labeled Estimated/proxy, and a branded-search-lift proxy from GSC plus Wikipedia pageviews — the declared dark-social method behind ECHO O2. Not for paid-channel attribution reconciliation (platform-claimed vs analytics conversions) — use attribution-reconciler. 暗社交归因/直接流量分解/自报来源字段/分享链路UTM
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Use when the user asks to "monitor brand mentions", "set up social listening", "did anything spike about us this week", or "watch these accounts for buying triggers"; runs always-on keyless listening — a versioned listening-query architecture (brand variants incl. misspellings and 中文 names, exclusion terms, per-source syntax for HN Algolia / Bluesky / GDELT / Tavily), a mention sweep with six-class triage (crisis / bug / lead / praise / question / spam) each routed with an SLA, a 7-day rolling baseline with spike flags (the crisis trigger input), a B2B trigger watchlist (funding / hiring / launch signals), and an explicit coverage disclosure where X/IG/TikTok/LinkedIn/小红书 numbers are proxy-labeled, never Measured. Not for launch-window telemetry (T-0→T+30 rank and review polling) — use launch-monitor. 舆情监听/品牌提及监测/基线突刺/触发信号
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Use when the user asks to "triage launch feedback", "cluster reviews, comments, and board posts into themes", or "set up a you asked, we shipped loop"; produces a feedback theme digest (frequency, severity, representative quotes per theme), an open→planned→started→completed/declined status loop with duplicate-merge and notification rules, shipped-change announcement material, and a compliant social-proof harvest protocol (never incentivized store reviews). Not for repurposing or amplifying the harvested proof — use content-amplifier; not for executing testimonial outreach threads — use outreach-manager. 反馈分诊/状态环/社证收割/评测合规
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Use when the user asks to "plan an influencer campaign", "build a campaign blueprint", "track or close a creator campaign", or "record a late campaign correction"; produces the plan and, when requested, a non-canonical evidence tracker with scoped identity, publication, reconciliation, close, and reopen receipts. Not for individual creator briefs — use brief-generator; not for overall product launches without creators — use launch-tier-planner; not for sending, publishing, amplifying, or paying — use the owning execution workflow. 达人营销策划/种草方案/活动追踪与关账
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Use when the user asks to "build a B2B cold-outbound sequence", "design reply-triage branching", "plan a domain warmup / sending throttle", or "make my outbound CAN-SPAM / opt-in compliant"; produces a multi-step outbound sequence with reply-triage branches (positive / objection / referral / not-now / opt-out), a warmup + send-throttle ramp schedule, jurisdiction opt-in/CAN-SPAM guardrails (guidance, not legal advice), and a SEND S-dimension read. Not for B2C lifecycle flows — use email-sequence-designer; not for the consent record — use consent-registry; not for computing EQS — use email-quality-auditor. B2B冷启动外联序列/回复分流/域名预热
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Use when the user asks "what did we pay this creator last time" or to "update the creator roster"; curates creator identity, rate, rights, exclusivity, compliance-event, and performance facts through the append-only creators event stream. Not for scoring fit — use fit-scorer; not for reviewing content — use creator-content-auditor. 创作者档案/达人名册
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Use when the user asks to "amplify influencer content with paid media", "set up whitelisting or Spark Ads", "decide which posts to boost", "repurpose influencer content", "turn one video into multiple ads", or "build a UGC asset library"; produces (paid mode) a content-selection scorecard, a paid amplification strategy (whitelisting/boosting/dark posts), audience targeting, and a budget+optimization plan, or (repurpose mode) a rights-tracked content inventory, a 1-video-to-10+-asset repurposing map, per-format transformation specs, and a 30-day distribution plan. Not for gating whether a deliverable is publishable or FTC-compliant — use creator-content-auditor; not for the always-on brand posting calendar — use social-calendar-builder; not for drafting a net-new idea into platform-native packages — use social-creative-builder. 复用达人内容 / 内容放量.
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Use when the user asks to "grow my email list", "design a lead magnet / signup incentive", "set up double opt-in", or "plan a referral / recommendation loop"; produces a list-growth plan — acquisition channels, lead-magnet / incentive concepts, a compliant double-opt-in capture-flow spec, referral-loop mechanics, and subscriber-growth / cost-per-opt-in targets (labeled Estimated) — that feeds SEND-S (consent quality captured at acquisition) and SEND-N (lifecycle entry). Not for the signup page/popup UX itself — use landing-optimizer; not for recording the opt-in — use consent-registry; not for the confirmation-email copy — use email-creative-builder. 邮件列表增长/lead magnet/双重确认/推荐环
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Use when platform-reported conversions disagree with GA4/ecommerce, when you suspect Meta and Google are double-counting the same sales, or for a standing (monthly) reconciliation workbook that de-dups stacked credit against an order-ID truth set, normalizes attribution windows and currency, compares attribution models, and reads incrementality from a geo/holdout test. Not for the point-in-time R2 veto or RQS gate — use ad-account-auditor; not for the ROI/ROAS ratio math itself — use roi-calculator; not for organic dark-social share attribution or GA4 direct-traffic decomposition — use dark-social-attributor. 付费广告归因对账/去重/增量
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Audit and improve web accessibility following WCAG 2.2 guidelines. Use when asked to "improve accessibility", "a11y audit", "WCAG compliance", "screen reader support", "keyboard navigation", or "make accessible".
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Critique a rendered screen's typography — scale usage, readability, consistency, and token compliance. Use when reviewing type on a screen. For defining the scale itself, use `typography-scale` (ui-design).
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Critique a rendered screen against mood.md, voice.md, and tokens.md. Use when those brand files exist and you are checking compliance. For defining the visual language itself, use `illustration-style` (ui-design).
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Build a product colour system — tonal scales, semantic roles, and contrast compliance. Use when defining or rebuilding colour from scratch. For dark-mode adaptation use `dark-mode-design`; for chart palettes use `data-visualization`; for multi-brand token architecture use `theming-system` (design-systems).
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Apply Jakob's Law — users expect your product to work like the others they already use. Use when deciding whether to innovate on a familiar pattern. For OS-mandated conventions specifically, use `platform-conventions` (ui-design).
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Produce a one-screen map of an unfamiliar area of the codebase: entry points, modules, data flow, callers. Designed to be read in fifteen seconds. Use when the user says "I do not know this area", "give me the map", "zoom out", "orient me".
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Configures Amazon Route 53 to route traffic to a CloudFront distribution using a custom domain. Use when setting up DNS alias records, alternate domain names (CNAMEs), ACM certificates for HTTPS, and IPv6 support for CloudFront.
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Configures AWS Transit Gateway: creating a hub and attaching VPCs, segmenting traffic with route tables, centralizing egress and inspection through a hub (appliances or a Gateway Load Balancer endpoint), forcing east-west traffic between VPCs through AWS Network Firewall, connecting on-premises networks over the transit-gateway side of a Site-to-Site VPN or Direct Connect attachment (including ECMP to aggregate bandwidth across multiple VPN tunnels), peering transit gateways across Regions, migrating from a VPC peering mesh, and routing IP multicast. Applicable when connecting many VPCs through one router, isolating environments, forcing VPC-to-VPC traffic through a central Network Firewall, reaching on-premises over the hub, linking Regions, or moving off a peering mesh. Not applicable for single-VPC routing, VPC peering between two VPCs (vpcpeering skill), Direct Connect gateway or virtual interface setup (directconnect skill), or Route 53 DNS work.
日本語の概要は準備中です。原文の説明を表示しています。