「are」の検索結果

Analyzes chemical libraries by scaffold using Bemis-Murcko scaffolds, generic frameworks, cyclic skeletons, matched molecular pair (MMP) analysis via mmpdb, R-group decomposition, Free-Wilson analysis, scaffold hopping, and chemotype-aware ML train/test splits. Use when identifying chemotype clusters in a library, deriving SAR transformation rules, decomposing series into R-groups, performing scaffold-balanced QSAR splits, or planning analog campaigns.

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Calculates molecular fingerprints (ECFP/Morgan, FCFP, MACCS, RDKit, AtomPair, TopologicalTorsion, Avalon, MAP4, MHFP6) and physicochemical descriptors (Lipinski, QED, TPSA, Crippen LogP, 3D shape) with explicit choice tables, bit vs count semantics, and partial-charge model selection. Use when featurizing molecules for similarity, QSAR, virtual screening, or ML, or selecting the correct fingerprint for a chemotype-aware task.

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Designs and validates quantitative targeted metabolomics assays (MRM/SRM on triple-quadrupole, PRM on high-resolution instruments) to report absolute concentrations. Covers the internal-standard strategy (external cal -> global IS -> standard addition -> stable-isotope-labeled IS), weighted calibration judged by back-calculated %RE not R-squared, ion-ratio quantifier/qualifier confirmation, matrix-effect/recovery characterization, and ICH M10 method validation. Use when quantifying a closed panel of known metabolites with units, building or validating an LC-MS/MS assay, choosing an IS or calibration weighting, or judging whether a reported concentration is trustworthy. For untargeted feature detection see metabolomics/xcms-preprocessing; for group statistics see metabolomics/statistical-analysis; for flux/MID/tracing see metabolomics/isotope-tracing.

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Assigns honest lipid annotation levels, designs class-based internal-standard quantification, and runs lipid-aware differential and enrichment analysis with lipidr, guarding against in-source-fragment phantoms, sn-position over-claims, and invalid cross-class quantification. Use when naming or canonicalizing lipid species (shorthand separators, Goslin), deciding shotgun vs RP vs HILIC LC-MS, picking internal standards (SPLASH/EquiSPLASH), interpreting MS-DIAL/LipidSearch output, or comparing lipid classes. For general feature detection see metabolomics/xcms-preprocessing and metabolomics/msdial-preprocessing; for non-lipid annotation confidence see metabolomics/metabolite-annotation; for normalization/QC see metabolomics/normalization-qc; for multivariate stats see metabolomics/statistical-analysis.

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Performs molecular similarity searching using Tanimoto, Tversky, Dice, and cosine coefficients on bit/count fingerprints with explicit choice rules for symmetric vs asymmetric measures, scaffold-hopping vs lead-optimization regimes, activity-cliff diagnosis, and large-library nearest-neighbor methods (BulkTanimoto, Annoy MHFP6, USRCAT). Use when ranking compounds by structural resemblance to a query, clustering libraries, finding analogs, or diagnosing activity cliffs.

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Generates 3D conformer ensembles using RDKit ETKDGv3 with knowledge-enhanced distance geometry, MMFF94/UFF force-field optimization, CREST + GFN2-xTB semi-empirical refinement, and macrocycle-aware torsion preferences. Provides explicit decision rules for single vs ensemble conformer use, RMSD pruning, energy windows, conformer count, and force-field choice. Use when preparing 3D ligands for docking, generating descriptor input for 3D QSAR, or sampling macrocycle/peptide conformational ensembles.

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Add a standard AdwAboutDialog wired to app metadata, plus the AppStream metainfo file it should share data with. Use when adding an About entry, release notes, credits, or preparing app metadata.

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Query aggregate Langfuse cost, volume, latency, and model telemetry efficiently with Metrics API v2. Use for dashboards, rollout checks, usage summaries, and cost or latency comparisons; use Observations API v2 instead when individual rows are actually required.

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Cross-chain interoperability for Stellar. Entry point with a rail-selection decision table and shared pitfalls, routing to two companion files — cctp.md (Circle CCTP V2, native USDC burn-and-mint between Stellar and EVM/Solana chains, domain 27, the CctpForwarder requirement for Stellar recipients) and axelar.md (Axelar GMP for Soroban contracts calling contracts on other chains, and the Interchain Token Service for multichain tokens). Also covers NEAR Intents (intent-based cross-chain swaps into XLM or Stellar USDC) at the routing level. Use when bridging USDC to or from Stellar, sending messages between a Stellar contract and another blockchain, making a token exist on multiple chains, or adding cross-chain swaps to an app.

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Forensic case investigation with evidence-graded findings, calibrated to the input. Use when the user asks to investigate a bug, trace what caused an incident, walk through unfamiliar code, or build a mental model of a code area before working on it.

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Senior software engineer for story execution and code implementation. Use when the user asks to talk to Elliot or requests the developer agent.

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Map the competitive landscape for a Stellar project idea. Use when a user says "who are my competitors on Stellar", "competitive analysis Stellar", "what already exists in this space on Stellar", "show me similar Stellar projects", "is anyone else building this on Stellar", or "map the Stellar landscape for X". Queries the 728-project LumenLoop ecosystem database and Electric Capital developer activity to rank competitors by SCF funding history and repo activity.

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Daily per-section review cycle driving a section toward the smallest, clearest form that still does everything it does today. Selects its section live each run (scripted), inventories every file, derives the target shape before any scan, works parallel reading threads into one ranked list and strikes it on a 2-3h budget. One PR per run; each run's report and Needs-Peter queue live in its own docs/health/runs/ file; 'resume' applies Peter's answers later. Use for the morning section-improvement run, 'doctor <section>', or 'run section doctor'.

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Scrap and regenerate the in-flight EF migrations on the current branch as one consolidated migration. Use when migrations have accumulated mid-development cruft (added/removed columns, stacked add-column-to-existing-table fixes, hand-edited SQL that needs to come out, schema changes that should have been one migration but ended up as five), or when the branch has merged main and its migrations are now stuck mid-chain so `dotnet ef migrations remove` is unsafe. Triggers on phrases like 'regen the migrations', 'redo these migrations', 'scrap and regen migrations', 'consolidate the in-flight migrations', 'redo the migration stack', or any time an agent hits the mid-chain situation in `memory/architecture/migration-regen-after-rebase.md`.

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Guide for implementing smooth, native-feeling animations using React's View Transition API (`<ViewTransition>` component, `addTransitionType`, and CSS view transition pseudo-elements). Use this skill whenever the user wants to add page transitions, animate route changes, create shared element animations, animate enter/exit of components, animate list reorder, implement directional (forward/back) navigation animations, or integrate view transitions in Next.js. Also use when the user mentions view transitions, `startViewTransition`, `ViewTransition`, transition types, or asks about animating between UI states in React without third-party animation libraries.

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Keep responsive shared interactions deterministic and free of duplicated side effects while server authority wins.

日本語の概要は準備中です。原文の説明を表示しています。

Implement EUI sessions, shared state and messages, server lifecycle, and client presentation.

日本語の概要は準備中です。原文の説明を表示しています。

Place contracts and behavior across authority, prediction, presentation, localization, and assembly boundaries.

日本語の概要は準備中です。原文の説明を表示しています。

Search academic literature and generate, validate, or compare Knows paper sidecars. Use for claim/evidence analysis and literature synthesis.

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When the user needs marketing ideas, inspiration, or strategies for their SaaS or software product. Also use when the user asks for 'marketing ideas,' 'growth ideas,' 'how to market,' 'marketing strategies,' 'marketing tactics,' 'ways to promote,' or 'ideas to grow.' This skill provides 139 proven marketing approaches organized by category.

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When the user wants to plan, evaluate, or build a free tool for marketing purposes — lead generation, SEO value, or brand awareness. Also use when the user mentions "engineering as marketing," "free tool," "marketing tool," "calculator," "generator," "interactive tool," "lead gen tool," "build a tool for leads," or "free resource." This skill bridges engineering and marketing — useful for founders and technical marketers.

日本語の概要は準備中です。原文の説明を表示しています。

Write AI disclosure policies for transparency with customers and stakeholders. TRIGGERS - Use when user needs help with ai-disclosure-policy related tasks.

日本語の概要は準備中です。原文の説明を表示しています。

Curate and prepare datasets for AI training. TRIGGERS - Use when user needs help with ai-dataset-curator related tasks.

日本語の概要は準備中です。原文の説明を表示しています。

Prepare for educational accreditation. TRIGGERS - Use when user needs help with accreditation-preparation related tasks.

日本語の概要は準備中です。原文の説明を表示しています。