「complex」の検索結果

Expert-level algorithms and complexity theory covering sorting, searching, graph algorithms, dynamic programming, greedy algorithms, NP-completeness, and algorithm design paradigms.

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Modelo de espaço de estados com complexidade O(n) versus O(n²) dos Transformers. Inferência 5× mais rápida, sequências de milhão de tokens, sem cache KV. SSM seletivo com design aware de hardware. Mamba-1 (d_state=16) e Mamba-2 (d_state=128, multi-head). Modelos 130M-2.8B no HuggingFace.

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Solves complex, open-ended problems using an evolutionary search mechanism inspired by genetic algorithms. Generates a diverse population of candidate answers, scores them against a rubric, then iteratively applies selection, crossover, and mutation to breed progressively better solutions. Use this skill whenever the user wants to explore a solution space deeply, asks for the "best" answer to a subjective or multi-dimensional problem, wants to evaluate competing approaches and distill the strongest, or uses any of these triggers: "evolutionary search", "genetic algorithm", "evolve an answer", "breed solutions", "population-based search", or phrases like "give me multiple approaches and refine the best one". Also trigger when the problem is complex, open-ended, or has no obvious single correct answer and the user wants a high-quality, well-explored result, not just a quick response.

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Mitigate incidental code complexity when control flow is tangled, nesting is deep, names are hard to parse, or reasoning requires cross-file hops. Use when a review stalls on readability, you need an analysis-first refactor plan before edits, or you want essential-vs-incidental verdicts, ranked simplification steps, a small structural sketch, and a TRACE assessment (analysis-only; no edits).

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Add or define specific fields in a collection's readSchema. Use when fields are missing from materialization field selection, pruned by complexity limit, need type refinement, need to be protected from future inference changes, or need to be required for downstream consumers. Use when user says "missing fields", "pruned fields", "field not showing up", "complexity limit", "define field in read schema", "restrict field type", or "protect field from inference".

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Expert-level guidance for Flutter production applications: architecture decisions (Clean/Layered/Hexagonal/Feature-First), advanced state management (BLoC/Riverpod/GetX), performance optimization (eliminating jank, memory profiling, reducing rebuild overhead), code review with design pattern enforcement, scalability assessments, native platform integration (MethodChannel/EventChannel/FFI), complex UI challenges (custom render objects, slivers), testing strategies (unit/widget/integration/golden), CI/CD pipeline architecture, build optimization, and accessibility compliance. Triggers: 'architecture decision', 'design pattern', 'performance issue', 'code review', 'production problem', 'scaling concerns', 'best practices', 'technical debt', 'refactoring strategy'. Essential for complex enterprise apps, critical production debugging, architectural refactors, or when choosing between competing technical approaches.

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Hive CE (Community Edition v2.19.x) NoSQL object database for Flutter providing blazing-fast key-value and object storage with TypeAdapters. Use this skill when implementing offline-first architecture, high-performance local data caching, NoSQL document-style object stores, custom TypeAdapter serialization for complex objects, lazy loading boxes for memory efficiency, encrypted boxes (HiveAES encryption), database compaction for size optimization, storing large datasets without SQL schema overhead, implementing local-first sync patterns, or migrating from SQLite to NoSQL. Supports primitive types, custom objects, lists, and maps. Ideal for apps requiring ultra-fast read/write operations (microsecond latency), object persistence without ORM complexity, or local-first data architecture.

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Validate protein designs using AlphaFold2 structure prediction. Use this skill when: (1) Validating designed sequences fold correctly, (2) Predicting binder-target complex structures, (3) Calculating confidence metrics (pLDDT, pTM, ipTM), (4) Self-consistency validation of designs, (5) Multi-chain complex prediction with AlphaFold-Multimer.

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Review code for readability, then simplify it to be easy to follow and understand. Use this skill when the user wants to simplify code, improve readability, clean up for handoff, make code skimmable, reduce complexity, refactor for clarity, strip boilerplate, prepare code for future maintainers, or make a codebase easier to pick up. Trigger liberally — any request touching readability, simplification, cleanup, or "make this easier to understand" should use this skill. Also trigger when the user says things like "review this", "clean this up", "tidy this", "make this simpler", "reduce complexity", "flatten this", "strip the noise", or "I want to understand this code quickly next time I open it".

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Implements Manus-style file-based planning for complex tasks. Creates task_plan.md, findings.md, and progress.md. Use when starting complex multi-step tasks, research projects, or any task requiring >5 tool calls.

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Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3 with constraints), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.

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MAGI System v2 — AoT 分解 + MELCHIOR/BALTHASAR/CASPAR 合議 + lam-harness:gabriel adversarial probe による 構造化意思決定フレームワーク。判断ポイント 2+ / 影響レイヤー 3+ / 選択肢 3+ で使用。 Use when facing complex decisions with multiple trade-offs or architectural choices.

MAGI System v2 — AoT 分解 + MELCHIOR/BALTHASAR/CASPAR 合議 + gabriel adversarial probe による 構造化意思決定フレームワーク。判断ポイント 2+ / 影響レイヤー 3+ / 選択肢 3+ で使用。 Use when facing complex decisions with multiple trade-offs or architectural choices.

Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3 with constraints), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.

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Assesses ChIP-seq quality across antibody specificity, fragmentation, enrichment, replicate concordance, and library complexity. Computes FRiP, NSC/RSC (phantompeakqualtools), library complexity (NRF/PBC1/PBC2), deepTools plotFingerprint (JS distance, AUC, synthetic JS), ChIPQC, IDR with ENCODE Nself/Nt rules, and detects hyper-ChIPable artifacts. Use when validating an antibody, diagnosing failed peak calls, deciding whether to proceed with downstream analysis, grading against ENCODE thresholds, or auditing replicate concordance.

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Analyzes alternative splicing from PacBio Iso-Seq (HiFi, Kinnex/MAS-Iso-seq) and Oxford Nanopore (direct cDNA, direct RNA, R10.4.1+) long-read RNA-seq with full-isoform resolution. Tools include FLAIR (correct/collapse/quantify/diffSplice for PacBio + ONT), IsoQuant (de-novo or annotation-guided isoform discovery 2024 SOTA), Bambu (annotation-aware Bayesian discovery + quantification with Novel Discovery Rate), SQANTI3/SQANTI-LR (isoform classification: FSM/ISM/NIC/NNC + artifact flags), rMATS-long (event calling on long-read isoforms), and minimap2 (-ax splice:hq for HiFi; -ax splice -k14 for ONT cDNA; add -uf only for direct RNA or stranded cDNA preps). Solves microexon detection, recursive splicing, complex multi-exon isoforms, and DTU without transcript-quantification uncertainty. Use when short-read AS limitations (anchor length, complex isoforms, microexons, recursive splicing, transcript ambiguity) demand full-isoform resolution.

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Design and coordinate multi-agent systems where specialized agents work together to solve complex problems. Covers agent communication, task delegation, workflow orchestration, and result aggregation. Use when building coordinated agent teams, complex workflows, or systems requiring specialized expertise across domains.

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Deep reasoning mode for complex problems requiring maximum cognitive depth. Use when facing difficult architectural decisions, complex debugging, multi-step problem solving, or situations requiring careful analysis before implementation.

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Break a stuck or complex problem into the smallest sub-question that, if answered, unlocks the next step — then answer it and repeat until the path forward is clear. Load when a problem feels genuinely stuck, when reasoning keeps circling, or when deep-thinking diagnoses a Socratic frame. Also triggers on "I keep going in circles", "what is the real question here", "help me reason through this step by step", "unstick my thinking", "recursive questioning", "what is the root question". Based on the recursive Socratic questioning method (EMNLP 2023) which outperforms CoT and Tree-of-Thought on complex reasoning tasks.

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Route user requests to the right skill, decompose complex work into parallel subagents, and manage project phase transitions. Load when the user asks "what should I do next", "which skill should I use", "orchestrate this", "run the full workflow", "split this into parallel tasks", or when a complex request spans multiple skills. Also triggers on "coordinate agents", "parallel execution", "task decomposition", "agent workflow", "what phase am I in", or when the user gives a broad instruction that requires multiple skills in sequence. This is the project's brain — it decides what runs, when, and whether to parallelise.

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Simplify application code for clarity without changing behavior — refactor after tests pass, reduce nesting and duplication, match project conventions. Load when refactoring for readability, cleaning up after a feature ships, or when code review flags complexity. Also triggers on "simplify this code", "code simplification", "make this easier to read", "reduce complexity", "refactor for clarity". Not for compress/split/prune-skill (skill-library files). Pairs with technical-debt-audit.

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Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3 with constraints), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.

日本語の概要は準備中です。原文の説明を表示しています。

Assesses ChIP-seq quality across antibody specificity, fragmentation, enrichment, replicate concordance, and library complexity. Computes FRiP, NSC/RSC (phantompeakqualtools), library complexity (NRF/PBC1/PBC2), deepTools plotFingerprint (JS distance, AUC, synthetic JS), ChIPQC, IDR with ENCODE Nself/Nt rules, and detects hyper-ChIPable artifacts. Use when validating an antibody, diagnosing failed peak calls, deciding whether to proceed with downstream analysis, grading against ENCODE thresholds, or auditing replicate concordance.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes alternative splicing from PacBio Iso-Seq (HiFi, Kinnex/MAS-Iso-seq) and Oxford Nanopore (direct cDNA, direct RNA, R10.4.1+) long-read RNA-seq with full-isoform resolution. Tools include FLAIR (correct/collapse/quantify/diffSplice for PacBio + ONT), IsoQuant (de-novo or annotation-guided isoform discovery 2024 SOTA), Bambu (annotation-aware Bayesian discovery + quantification with Novel Discovery Rate), SQANTI3/SQANTI-LR (isoform classification: FSM/ISM/NIC/NNC + artifact flags), rMATS-long (event calling on long-read isoforms), and minimap2 (-ax splice:hq for HiFi; -ax splice -k14 for ONT cDNA; add -uf only for direct RNA or stranded cDNA preps). Solves microexon detection, recursive splicing, complex multi-exon isoforms, and DTU without transcript-quantification uncertainty. Use when short-read AS limitations (anchor length, complex isoforms, microexons, recursive splicing, transcript ambiguity) demand full-isoform resolution.

日本語の概要は準備中です。原文の説明を表示しています。