2,602 件 ・ 関連度順
概要と使いどころ
Guidance for choosing the right protein binder design tool. Use this skill when: (1) Deciding between BoltzGen, BindCraft, or RFdiffusion, (2) Planning a binder design campaign, (3) Understanding trade-offs between different approaches, (4) Selecting tools for specific target types. For specific tool parameters, use the individual tool skills (boltzgen, bindcraft, rfdiffusion, etc.).
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Use when the user asks to "check our positioning against what we can actually ship", "trace which differentiators we can defend", or "reconcile the positioning canvas with the claims ledger"; reconciles the reused positioning canvas against the shippable stage and the claims ledger to produce a differentiation truth set — every differentiating claim verifiable or marked '[needs source]' — that TALE-T1 is judged against. Not for building the canvas — use positioning-mapper; not for adjudicating claims — use offer-claims-registry; not for authoring the message house — use message-system-architect. 定位真相/差异化校准/可交付现实/主张核对
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Run a fast AWS Security Agent diff scan on only the changed code since a git ref. Use when the user asks to scan changes, run a diff scan, check what changed for security issues, scan before committing, scan before PR, or any pre-commit/pre-push security check.
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Compares an app clone against the original: a feature parity score from the feature matrix (weighted by must, should, could) with the missing list in build order, plus a screenshot layout diff that ignores colour so a rebrand does not count against you. Two standard-library Python tools. Use when the user says "how close is my clone", "compare it to the original", "what's missing", "parity check", "diff the screens", "is it ready", or after /replica-test.
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When the user wants to design, deploy, or measure Apple Custom Product Pages (CPP) — the alternate App Store product pages with different screenshots, preview videos, and promo text shown to users coming from specific URLs (typically ad campaigns or social posts). Use when the user mentions "Custom Product Page", "CPP", "alternate product page", "App Store URL variant", "ASA CPP", "campaign-specific landing page", "product page per audience", "App Store Connect CPP", "ppoUrl", "?cpp=" parameter, or "show different screenshots to different ad audiences". For App Store A/B tests on the default page, see ab-test-store-listing. For paid ad campaigns that route to CPPs, see apple-search-ads or ua-campaign.
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Generates PR reference XML with commit history and unified diffs between branches, with extension and path filtering. Use when creating pull request descriptions, preparing code reviews, analyzing branch changes, discovering work items from diffs, or generating structured diff summaries.
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Mandatory pre-publish review gate for a UGC video render. Transcribes the finished render's AUDIO with Whisper and word-diffs it against the approved spoken script, then gates pinning the final render (video_project_upsert patch.final_render_id) — blocking a render whose generated audio mis-voices a word (e.g. the approved "human-vetted" spoken as "human witted"), says a different number or brand name, flips a negation, drops an approved phrase, or comes back silent. Correct speech written differently ("5mg" said "five milligrams", "30%" said "thirty percent", a spoken URL, "don't" said "do not", "braxleybands" said "braxley bands", a confirmed pronunciation like "AG1" said "A G one") passes. Runnable, gating counterpart to content-goose's review-transcript-integrity atom. Every ugc-video-formats recipe runs this after render and BEFORE pinning the final render.
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Performs ML-based protein-ligand pose prediction and scoring using DiffDock-L (diffusion-based), Boltz-1 / Boltz-2 (foundation model with affinity), Chai-1, AlphaFold3 ligand, EquiBind, TANKBind, NeuralPLexer, and hybrid workflows (DiffDock pose + GNINA rescore + PoseBusters QC). Explicit handling of when ML beats classical docking, when classical beats ML, the PB-invalid pose problem, and rescoring as the standard production hybrid. Use when modern docking is needed: foundation-model ligand-pose prediction, AI rescoring of classical poses, or scaffold-hopping in cross-docking scenarios.
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Identify differentially accessible chromatin regions across conditions using DiffBind, csaw, DESeq2, or edgeR. Use when comparing ATAC-seq accessibility between treatment groups, choosing between consensus-peak vs sliding-window approaches, picking the correct normalization (full library vs reads-in-peaks), correcting batch with SVA/RUVseq, or interpreting log2FC and FDR thresholds in a chromatin context.
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Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.
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Build a differential-ready consensus peakset from per-replicate ATAC-seq peaks using iterative overlap removal, fixed-width re-centering, and majority-rule overlap. Use when generating a stable peak coordinate system for downstream differential accessibility, ML feature engineering, cross-sample comparison, or fixed-width peak counts; covers Corces 2018 iterative overlap (501 bp), DiffBind summit re-centering, and ENCODE consistency rules.
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Market positioning strategy using the April Dunford framework, enriched with JTBD discovery, Moore positioning statement, and Neumeier's Onliness Test. Produces a complete positioning document, positioning statement, competitive alternatives map, and market category analysis. Use when the user wants to define or refine their market positioning, find their unique position, differentiate from competitors, craft a positioning statement, choose a market category, or figure out "how should we position this product." Triggers for "positioning", "how to position", "market position", "differentiation strategy", "positioning statement", "competitive positioning", "category strategy", "where do we fit in the market", "how are we different", "unique value proposition", or any request to define, sharpen, or rethink positioning. Works standalone — no prior startup-design or startup-competitors session needed, but leverages their output if available.
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Amazon product differentiation strategy tool. Analyze competitor weaknesses, extract pain points from negative reviews, identify unique selling points from positive reviews, and generate actionable differentiation strategies. Progressive L1-L4 analysis depth. No API key required.
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Shopify/DTC product differentiation strategy tool. Analyze competitor stores, extract pain points from reviews, identify brand positioning opportunities, and generate actionable differentiation strategies. Includes DTC-specific metrics like CAC, LTV, and brand story analysis. No API key required.
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TikTok Shop product differentiation strategy tool. Analyze viral product trends, competitor affiliate strategies, content performance, and identify differentiation opportunities. Includes TikTok-specific metrics like engagement rate, viral potential, and creator collaboration insights. No API key required.
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eBay product differentiation strategy tool. Analyze competitor weaknesses, extract pain points from negative feedback, identify unique selling points, and generate actionable differentiation strategies. Includes eBay-specific seller feedback analysis. No API key required.
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Molecular docking prediction using DiffDock diffusion model
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Coordinates UDL and differentiation tools through a universal-first hierarchy: barrier removal before targeted differentiation before individualised accommodation. Use when planning accessible learning.
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Adapt a classroom task for specific learner needs while preserving the core learning objective intact. Use when differentiating for SEND, EAL, gifted, ADHD, dyslexia, or anxiety.
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This package performs differential pattern analysis for Ribo-seq data. It identifies genes with significantly different patterns in the ribosome footprint between two conditions. RiboDiPA contains five major components including bam file processing, P-site mapping, data binning, differential pattern analysis and footprint visualization.
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Define and sharpen a brand's market positioning — where it sits relative to competitors, what it owns, and how it differentiates. Use when the user says "brand positioning", "positioning statement", "where do we sit in the market", "how are we different", "differentiation strategy", "positioning map", "competitive positioning", "what space do we own", "brand territory", "we're too similar to competitors", "help me position this brand", or wants to find a defensible place in a crowded category.
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Kernel-version skew check (ADR-027). Reports manifest surface + manifest kernel + installed kernel + verdict (match/patch-diff/minor-diff/major-diff). Exits 1 on minor/major skew with a copy-pasteable `npm install @metaharness/kernel@X.Y.Z` next step. Exits 2 if no .harness/manifest.json at path.
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跨版本符号迁移与二进制差分。当你有旧版本的符号/逆向结果，需要快速迁移到新版本时使用。 适用场景：内核缺 PDB 用旧版符号推导、程序更新后批量迁移函数名、应用更新后快速定位新偏移。 核心方法：用 LLM 做结构化差异比对，程序化输入输出，成本极低（200 函数 ~1 元）。 触发关键词：符号迁移、bindiff、跨版本、PDB 缺失、函数偏移迁移、symbol migration、binary diff、版本对比。
日本語の概要は準備中です。原文の説明を表示しています。
Performs security-focused differential review of code changes (PRs, commits, diffs). Adapts analysis depth to codebase size, uses git history for context, calculates blast radius, checks test coverage, and generates comprehensive markdown reports. Automatically detects and prevents security regressions.
日本語の概要は準備中です。原文の説明を表示しています。