「eth」の検索結果

Manage software complexity through deep modules, information hiding, and strategic programming. Use when the user mentions "module design", "API too complex", "shallow class", "complexity budget", "strategic vs tactical", "deep module", "information leakage", "pass-through method", "this code is over-engineered", or "simplify this design". Also trigger when reviewing an interface for simplicity, evaluating whether an abstraction is pulling its weight, deciding whether a comment is worth writing, or choosing between general-purpose and special-purpose approaches. Covers deep vs shallow modules, red flags for complexity, and comments as design documentation. For code quality, see clean-code. For architecture boundaries, see clean-architecture.

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Apply the seven principles of ethical persuasion (reciprocity, commitment, social proof, authority, liking, scarcity, unity) to product design, copy, and sales. Use when the user mentions "social proof", "persuasive copy", "why users dont convert", "ethical persuasion", "reciprocity", "scarcity tactics", "commitment and consistency", "shared identity", "in-group", "make my copy more persuasive", "increase trust", or "get more people to say yes". Also trigger when designing testimonial sections, crafting urgency messaging, or improving trust signals on landing pages. Covers the principles, when each applies, and ethical limits. For deal negotiation tactics, see negotiation. For viral word-of-mouth, see contagious.

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Finds out whether a problem is real and a solution would work, before building it — recruiting the right people, interviewing without leading them, separating what users say from what they do, naming the riskiest assumption and testing that one first, and reaching a decision rather than a summary. Use this to validate a problem, test an idea cheaply, decide whether to build something, or fix a discovery process that keeps confirming what the team already believed.

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Establishes what something actually costs — fixed, variable and mixed cost behavior, absorption versus variable costing, job-order, process and activity-based methods, breakeven and operating leverage, and price/volume/mix decomposition. Use this to set a price floor, explain why revenue or margin moved, decide make versus buy, judge whether a product line earns its place, or work out how an allocation basis is distorting a reported margin.

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Decompose genetic effects into direct and indirect paths through mediating variables using the mediation R package. Tests whether gene expression, methylation, or other molecular phenotypes mediate the effect of genetic variants on disease. Use when testing whether a molecular...

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Verifies whether a scientific or biomedical claim is actually supported by the cited original papers rather than by citation drift, overstatement, selective citation, or correlation-to-causation inflation. Use this skill whenever a user wants to check whether a repeated statement, slide claim, manuscript sentence, review assertion, or “people often say” scientific conclusion is truly supported by the underlying primary literature. Always separate the claim itself, the cited paper(s), what the paper actually showed, what it did not show, and whether later retellings drifted beyond the original evidence. Never fabricate references, findings, study features, or citation chains.

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Applies the scientific method to debugging by helping users form specific, testable hypotheses, design targeted experiments, and systematically confirm or reject theories to find root causes. Use when a user says their code isn't working, they're getting an error, something broke, they want to troubleshoot a bug, or they're trying to figure out what's causing an issue. Concrete actions include isolating failing components, forming and testing hypotheses, analyzing error messages, tracing execution paths, and interpreting test results to narrow down root causes.

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Think clearly about whether bankruptcy is the right move, or whether another path fits better — without shame and without a sales pitch. Use when asked should I file for bankruptcy, is bankruptcy my best option, alternatives to bankruptcy, or what happens if I file. Produces an honest read on whether your situation is the kind bankruptcy actually helps, the main types and what each does (and doesn't) discharge, the real trade-offs (what you keep, the credit impact and its recovery, what's not dischargeable), the alternatives to weigh first (negotiation, debt management, doing nothing on time-barred debt), and a strong push to consult a bankruptcy attorney. Not legal advice.

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Conduct a structured ethical review of an AI or ML feature, model, or product. Use when preparing to deploy an AI system, assessing algorithmic risk, auditing a model for bias, or producing a responsible AI impact assessment. Produces a structured ethics review covering fairness, transparency, privacy, safety, accountability, and societal impact with a risk tier score, pre-deployment checklist, and prioritised mitigations.

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Generate a bounded task plan (and the agent prompt for it) that runs the 5-layer profiling methodology in .claude/skills/model-profiling/METHODOLOGY.md against one model, stops for human confirmation before any GPU work starts, then delegates the actual run to a background agent, verifies its completion claim, and routes findings into a gitignored .profiling-runs/<model>/ directory — durably tracked as a sub-issue under the tracking issue named in SKILL.md's "Result tracking" section — plus the methodology doc.

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Use when choosing and applying a theory-construction method for an Academy of Management Review (AMR) manuscript — building constructs, defining their domain, specifying relationships, articulating the underlying logic/mechanisms, and setting boundary conditions. This is the THEORY-CONSTRUCTION craft, NOT empirical method; AMR publishes no datasets, no measures, and no statistical tests.

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Use when the research design and method are the bottleneck for an Academy of Management Journal (AMJ) manuscript — matching design (archival, survey, experiment, multi-method, field) and level of analysis to the theoretical question. Designs the study; it does not run the estimation or validity checks (amj-data-analysis).

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Differential abundance (DA) and differential state (DS) analysis for flow and mass cytometry - tests which cell populations change in frequency or marker expression between conditions using diffcyt (edgeR/voom/GLMM for DA, limma/LMM for DS), with cydar, CITRUS, and compositional methods (sccomp, scCODA, DCATS) as alternatives. Covers the sample-is-the-experimental-unit principle, design/contrast and mixed-model formulas, compositionality of cluster proportions, and FDR across clusters. Use when comparing populations between groups, choosing a DA method, handling paired/batch designs, or deciding whether compositional correction is needed.

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Detect horizontal gene transfer (HGT / LGT) using compositional methods (GC%, codon usage, tetranucleotide z-scores via SIGI-HMM, AlienHunter, IslandViewer 4, IslandPath-DIMOB), phylogenetic-incongruence methods (AvP, HGTphyloDetect, ALE / GeneRax / AleRax reconciliation, RANGER-DTL), and BLAST-distribution methods (HGTector v2, DarkHorse, Alien Index). Use when screening prokaryote genomes for genomic islands and HGT events, distinguishing HGT from incomplete lineage sorting / differential gene loss / hybridization, mapping donor lineages via phylogenetic placement, separating eukaryotic HGT from contamination, ruling out gBGC as a false signal, or quantifying DTL rates with ALE/GeneRax on bacterial trees.

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Map N6-methyladenosine (m6A) RNA modifications at single-nucleotide resolution using miCLIP (Linder 2015), miCLIP2 + m6Aboost machine learning (Kortel 2021), GLORI (Liu 2023, antibody-free chemical conversion), DART-seq (Meyer 2019, APOBEC1-YTH fusion), m6Anet (nanopore direct RNA), or MeRIP-seq with calibration. Use when distinguishing antibody-based from antibody-free m6A detection methods, applying the DRACH motif constraint, reconciling cross-method disagreements (DART 44% in DRACH vs GLORI), or detecting m6Am at the cap.

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Plan manipulator motion and generate trajectories in MATLAB. Use when the task involves moving a robot arm between configurations or poses — whether the user says "trajectory," "motion," "path," "move from A to B," or "plan." This skill applies regardless of whether the user explicitly mentions collisions or obstacles; if geometry exists in the workspace, collision safety is implicit. Triggers on: manipulatorRRT, manipulatorCHOMP, dlCHOMP, contopptraj, trapveltraj, collision-free path, motion planner, RRT, CHOMP, TOPPRA, path shortening, obstacle avoidance for manipulators, time-optimal trajectory, velocity limits, acceleration limits, occupancyMap3D, meshtsdf, collision objects as environment, trajectory between waypoints, joint interpolation, move between poses, constant velocity, trapezoidal profile, feed rate. Also triggers when a user has IK solutions or waypoints and needs to connect them — whether for time-optimal motion, constant-speed welding/cutting, or any other trajectory parameterization.

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Price financial instruments in MATLAB using the Financial Instruments Toolbox. Route to the appropriate numerical method reference based on the user's request: Monte Carlo simulation (AssetMonteCarlo, IRMonteCarlo, RoughVolMonteCarlo), FFT / Numerical Integration (Vanilla European options), or Interest-Rate Trees (option-embedded bonds with IRTree). Use when the user asks to price financial instruments or compute Greeks using any of these methods. Use one of the following models depending on the pricing method and instrument: Black-Scholes, Bachelier, Heston, Bates, Merton, Hull-White, Black-Karasinski, Black-Derman-Toy, Cox-Ingersoll-Ross, Linear Gaussian 2 Factor (G2PP), Brace-Gatarek-Musiela (BGM), SABR-BGM, RoughBergomi, RoughHeston.

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Build the authoritative final method explanation for a submission-ready subquestion from the method card, human decision ledger, code plan, final results, and robustness evidence.

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Validate a third-party control repo across four automated layers plus one printed manual recipe. Layer 1 asserts native-source structure (Android getName() and iOS +moduleName to manifest nativeModule; @ReactMethod / RCT_EXPORT_METHOD to methods; no @ReactModule) plus load/init readiness (ReactPackage public no-arg constructor, iOS [cls new] no-arg init, requiresMainQueueSetup NO, non-throwing eager construction), so launch-time crashes surface before any build. Layer 2 validates the committed `./manifest.json` against the ppmplugin-format rules. Layer 3 asserts request/response/error-code agreement across native and PCF. Layer 4 compiles the PCF (auto-skipped if absent). Layer 5 prints a device end-to-end recipe. Native compile belongs to /build-android-binary and /build-ios-binary — this is the cheap structural pre-flight before those slow builds. Reports pass/fail per layer with a fix hint and updates .extension-state.md.

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Produce honest product reviews and buying guides without fabricated first-hand experience, using disclosed evidence tiers: verified specs, owner-experience synthesis at scale, expert triangulation, and hands-on only when true. Use this skill whenever the user wants to write product reviews or buying guides without hands-on access, set up a review methodology, add evidence disclosure to review content, align reviews with Google's reviews system or FTC affiliate disclosure expectations, or decide when Review and Product schema are honest to use. Triggers on product review, buying guide, best-of list, review methodology, evidence basis, hands-on testing, we tested, affiliate review site, review disclosure, methodology block, original research, reviews system. Also triggers when review content claims testing that did not happen, or when an affiliate site needs a trust mechanism that survives scrutiny.

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SPARC (Specification, Pseudocode, Architecture, Refinement, Completion) comprehensive development methodology with multi-agent orchestration

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Methods to infer clonal tree configuration for a population of cells using single-cell RNA-seq data (scRNA-seq), and possibly other data modalities. Methods are also provided to assign cells to inferred clones and explore differences in gene expression between clones. These methods can flexibly integrate information from imperfect clonal trees inferred based on bulk exome-seq data, and sparse variant alleles expressed in scRNA-seq data. A flexible beta-binomial error model that accounts for stoc

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Intuitive framework for identifying spatially variable genes (SVGs) via edgeR, a popular method for performing differential expression analyses. Based on pre-annotated spatial clusters as summarized spatial information, DESpace models gene expression using a negative binomial (NB), via edgeR, with spatial clusters as covariates. SVGs are then identified by testing the significance of spatial clusters. The method is flexible and robust, and is faster than the most SV methods. Furthermore, to the

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Provides R wrappers of several on-target and off-target scoring methods for CRISPR guide RNAs (gRNAs). The following nucleases are supported: SpCas9, AsCas12a, enAsCas12a, and RfxCas13d (CasRx). The available on-target cutting efficiency scoring methods are RuleSet1, Azimuth, DeepHF, DeepCpf1, enPAM+GB, and CRISPRscan. Both the CFD and MIT scoring methods are available for off-target specificity prediction. The package also provides a Lindel-derived score to predict the probability of a gRNA to

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