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Designs novel molecules using REINVENT 4 (de novo, scaffold decoration, linker design, R-group, molecular optimization), MolMIM, Diffusion-based generators (DiGress, DiffSMol), and JT-VAE with explicit handling of multi-parameter optimization (MPO), goal-directed scoring functions, transfer/reinforcement/curriculum learning, synthetic accessibility scoring, and chemical space exploration vs exploitation. Use when designing new chemical matter against a target, decorating a scaffold, linking fragments, or optimizing a hit for multiple ADMET / activity properties simultaneously.

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Guides Stripe integration decisions across development and test environment planning (separate sandboxes vs the shared test mode sandbox), API selection (Checkout Sessions vs PaymentIntents), Connect platform setup (Accounts v2, controller properties), billing/subscriptions, tax and registrations (Stripe Tax, automatic_tax, product tax codes), Treasury financial accounts, integration options (Checkout, Payment Element), migrating from deprecated Stripe APIs, and security best practices (API key management, API key permissions, webhooks, OAuth). Use when planning, building, modifying, testing, or reviewing any Stripe integration, including choosing a development environment, accepting payments, building marketplaces, integrating Stripe, processing payments, setting up subscriptions, collecting sales tax, VAT, or GST, creating connected accounts, or implementing secure key handling.

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Prevents crashes due to problematic scope-related API misuse caused by agent escalation into internal scope framework objects. Use when configuring properties of scope-related Simulink blocks or MATLAB objects — constrains the agent to documented APIs and directs users to the scope UI when a property is not programmatically accessible.

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Dielectric substrates, metal conductors, multi-layer stackups, and loss models (FR4, Rogers, Teflon) for RF PCB simulation. TRIGGER: user asks to set up a substrate, define dielectric properties, create a stackup, select a PCB material (FR4, Rogers, Teflon, etc.), or configure metal conductors. Invoke BEFORE writing dielectric() or metal() code — the API for named vs custom materials differs significantly. SKIP: PCB layout assembly (use matlab-assemble-pcb-layout), transmission line design (use matlab-design-pcb-transmission-line), EM analysis (use matlab-analyze-em), importing a PCB file (use matlab-read-pcb-layout).

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Connect to and acquire images from cameras in MATLAB using Image Acquisition Toolbox. Use this skill when the user wants to: use a webcam, acquire images, capture video, stream from a camera, connect to a GigE Vision camera, preview live video, list available cameras, configure camera properties, use a CoaXPress frame grabber, or use a Camera Link frame grabber. Covers USB webcams, GigE Vision, USB3 Vision, CoaXPress, Camera Link, and GenICam-compliant cameras. Always prefer videoinput from Image Acquisition Toolbox over webcam support package or gigecam.

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End-to-end finite element analysis in MATLAB PDE Toolbox — geometry creation, model setup, solve, and post-processing in one skill. Use when building geometry from primitives or file import, setting up femodel with BCs/loads/materials, solving thermal/structural/EM problems, and extracting or visualizing results. Covers fegeometry, multicuboid, multicylinder, multisphere, decsg, boolean ops, mesh generation, femodel, all AnalysisTypes (thermalSteady, thermalTransient, structuralStatic, structuralTransient, structuralModal, structuralFrequency, electrostatic, magnetostatic, dcConduction, harmonic EM), materialProperties, faceBC, faceLoad, cellLoad, vertexLoad, solve, interpolation, von Mises stress, principal stress, reaction forces, heat flux, pdeplot3D visualization. Triggers on: PDE Toolbox, finite element, FEA, thermal analysis, structural analysis, electromagnetic analysis, femodel, mesh, boundary conditions, stress, displacement, heat transfer, post-processing.

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Compute aerospace environment properties including atmosphere (ISA, COESA, NRLMSISE-00, non-standard, CIRA), gravity (spherical harmonic, WGS84, zonal, centrifugal), horizontal wind (HWM), magnetic field (WMM, IGRF), geoid height, geocentric radius, space weather data, planetary ephemeris, Earth orientation (polar motion, nutation, delta-UT1, CIP). Use when computing atmospheric density, temperature, pressure, gravity vectors, wind profiles, magnetic field components, geoid undulation, solar flux indices, planet positions, or Earth orientation parameters for aerospace vehicle analysis, spacecraft environment modeling, or navigation corrections.

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Format reference for Power BI Enhanced Report (PBIR) JSON schemas and patterns. Automatically invoke when the user asks about PBIR JSON structure, visual.json properties, PBIR expressions, objects vs visualContainerObjects, theme inheritance, conditional formatting patterns, extension measures, bookmarks, field references, filter formatting, query roles, PBIR page structure, report wallpaper, or any PBIR metadata format question.

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Use when rigging a character, creature or prop in Blender through Python: "rig this character", Rigify metarig fitting or generation errors, automatic weights or "Bone Heat Weighting failed", weight painting fixes, clothes that do not follow, IK/FK switch, foot roll, twist bones, drivers and custom properties, corrective shape keys, a stylized face rig, a mechanical or hard-surface rig, or testing how a rig deforms.

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Gary Vaynerchuk's jab-jab-jab-right-hook framework applied to a personal portfolio rotation on X and LinkedIn. Jabs = build-in-public + educational (value). Hooks = promo (the ask). Each property in the user's configured portfolio (see `~/.config/makerskills/jab-hook/properties.yaml`) gets a hook at least once every ~3 weeks; jabs fill the rest. Drafts go into the user's Typefully workspace via MCP. Modes — plan (7-day plan), pick-next (single post), audit (coverage report), draft (specific post). Triggers on "/jab-hook," "what should I post," "plan my socials," "next promo," "next jab," "next hook," "social rotation," "promote [property]," "BIP post," "audit my socials," "what haven't I posted about."

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Configure and author rgthree-comfy nodes — Fast Groups Bypasser/Muter (group toggles), Power Lora Loader, Context/Context Big, Seed, Any Switch. Use when a workflow contains rgthree nodes, when asked to add stage/section toggles or an A/B switch, when stacking LoRAs, or when an rgthree node needs configuring. Covers the frontend-only nodes that are absent from /object_info and the properties-not-widgets configuration model.

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Multivariate methods are well suited to large omics data sets where the number of variables (e.g. genes, proteins, metabolites) is much larger than the number of samples (patients, cells, mice). They have the appealing properties of reducin

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cogeqc aims to facilitate systematic quality checks on standard comparative genomics analyses to help researchers detect issues and select the most suitable parameters for each data set. cogeqc can be used to asses: i. genome assembly and annotation quality with BUSCOs and comparisons of statistics with publicly available genomes on the NCBI; ii. orthogroup inference using a protein domain-based approach and; iii. synteny detection using synteny network properties. There are also data visualizat

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Force unrelated concepts together to discover emergent properties - "What if we treated X like Y?"

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Search Bilt Rewards travel portal for cash and Bilt Points pricing on hotels and flights. Public REST API, no auth required. Includes Home Away From Home (HaFH) properties with $300+ benefits.

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Maps hotel brand names (Westin, Sheraton, Holiday Inn, etc.) to chain families and loyalty programs. Use when hotel results contain branded properties or deciding whether to check award rates.

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Use when logging analytics events, setting user properties, configuring default event parameters, building funnels, or adding screen-view tracking.

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Monthly, browser conditional. On its first run it discovers the member's properties from the sites they name, writes the three strategy files, creates every ledger and folder the kit reads, files the opening cards, and registers the eight scheduled jobs. Every month after that it re-reads the evidence rather than its own previous conclusions, rebuilds the topic map and the internal link map, corrects any property fact it can prove wrong, and records every change with the path of the evidence that forced it. It holds publishing and spending unless you released the channel, and it never touches a credential.

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Apply core PHP language standards and modern 8.x features. Use when working with PHP 8.x features like enums, fibers, readonly properties, or named arguments.

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Core Kotlin patterns for scope functions, backing properties, and read-only collection interfaces. Use for let/apply/run/also/with choices or encapsulating mutable state; defer general language constructs, extension functions, coroutines/runCatching, Android/Room recipes, and testing/tooling setup.

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Write idiomatic Kotlin 1.9+ with null safety, sealed classes, data classes, extension functions, delegates, collections, inline/reified generics, and expression syntax. Use for Kotlin language constructs, Java-to-Kotlin migration, lazy delegates, data classes, backing properties, or inline/reified generics; keep language constructs in scope even inside response models, and defer coroutine configuration, Android Context/framework, Retrofit/OkHttp client setup, and other library-specific recipes.

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Operational rubric that turns "don't make AI slop" into observable properties, severity levels, evidence requirements, and repair actions for interface design. Use as the reference rubric when building or reviewing marketing sites, product interfaces, dashboards, portfolios, or e-commerce pages, especially alongside frontend-design.

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Guide for optimizing MSBuild incremental builds. USE FOR: builds slower than expected on subsequent runs, 'nothing changed but it rebuilds anyway', diagnosing why targets re-execute unnecessarily, fixing broken no-op builds. Covers 8 common causes: missing Inputs/Outputs on custom targets, volatile properties in output paths (timestamps/GUIDs), file writes outside tracked Outputs, missing FileWrites registration, glob changes, Visual Studio Fast Up-to-Date Check (FUTDC) issues. Key diagnostic: look for 'Building target completely' vs 'Skipping target' in binlog. DO NOT USE FOR: first-time build slowness (use build-perf-baseline), parallelism issues (use build-parallelism), evaluation-phase slowness (use eval-performance), non-MSBuild build systems.

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Convert .NET projects and solutions (.sln, .slnx) to NuGet Central Package Management (CPM) using Directory.Packages.props. USE FOR: converting to CPM, centralizing or aligning NuGet package versions across multiple projects, inlining MSBuild version properties from Directory.Build.props into Directory.Packages.props, resolving version conflicts or mismatches across a solution or repository, updating or bumping or syncing package versions across projects. Also activate when packages are out of sync, drifting, or inconsistent -- even without the user mentioning CPM. Provides baseline build capture, version conflict resolution, build validation with binlog comparison, and a structured post-conversion report. DO NOT USE FOR: packages.config projects (must migrate to PackageReference first) or repositories that already have CPM fully enabled.

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