143 件 ・ 関連度順
概要と使いどころ
[Design System] Quantitative accessibility audit for UI - contrast ratios, font sizes, tap targets, heading hierarchy. Use when (1) checking WCAG color contrast compliance, (2) auditing text sizes for readability, (3) validating touch/click target sizes, (4) reviewing heading structure and landmarks, (5) user asks to 'check accessibility', 'audit contrast', 'WCAG compliance', or 'a11y check'.
日本語の概要は準備中です。原文の説明を表示しています。
ACGME regulatory compliance expertise for medical residency scheduling. Use when validating schedules, checking work hour limits, supervision ratios, or answering compliance questions. Integrates with MCP validation tools.
日本語の概要は準備中です。原文の説明を表示しています。
Official HeyGen plugin for OpenClaw — adds HeyGen as a first-class provider for the built-in video_generate tool. Identity-first avatar videos: pick an avatar_id, a voice, a script, and get an on-brand presenter video back. Use when: (1) generating a video where a specific avatar/person speaks specific lines, (2) "make a video of me / our brand presenter", (3) outreach, announcements, pitch decks, product walkthroughs, or any presenter-led video, (4) needing landscape or portrait output with deterministic aspect ratios, (5) integrating HeyGen into an OpenClaw agent through the standard provider interface (no bespoke REST glue required). Covers: HeyGen v3 Video Agent (api.heygen.com), avatar-presenter video, identity-preserving video, talking-head AI video, scripted avatar narration, brand spokesperson video. NOT for: cinematic b-roll (use Veo / Runway / Kling), video translation, TTS-only, streaming avatars, or photo-to-talking-head v2 pipelines.
日本語の概要は準備中です。原文の説明を表示しています。
Normalizes and transforms RNA-seq count matrices for DE, visualization, clustering, and ML. Covers between-sample (TMM, TMMwsp, RLE/median-of-ratios, upper quartile), within-sample (TPM, FPKM/RPKM), variance-stabilizing (VST, rlog, log-CPM), GC-content correction (cqn, EDASeq), and single-cell (scran deconvolution, scanpy normalize_total). Encodes the composition-bias rationale, the "most genes not DE" assumption and its catastrophic failure modes (MYC amplification, apoptosis, viral host shutoff, prokaryotic stress), the "lengthScaledTPM is not TPM" naming trap, the "TPM is not for DE" rule, the blind=TRUE vs FALSE decision, ERCC spike-in normalization (SBN), and the single-cell zero-inflation breakdown of TMM/RLE. Use when choosing or applying normalization, debugging shifted-MA-plot diagnostics, handling zero-heavy single-cell data, or correcting GC bias.
日本語の概要は準備中です。原文の説明を表示しています。
Identifies essential genes from CRISPR-Cas9 fitness screens using BAGEL2 (Kim & Hart 2021 Genome Med), a Bayesian classifier scoring per-gene Bayes Factors via log-likelihood ratios over per-sgRNA fold changes, calibrated against CEGv2 core-essentials (Hart 2017 G3, ~684 genes) and NEGv1 non-essentials (Hart 2014, ~927 genes). Covers the fc + bf + pr workflow, the linear-extrapolation improvement over BAGEL1 truncation, multi-target off-target correction, tumor-suppressor sensitivity (BAGEL2 detects enrichment), and BF-to-FDR calibration (BF >6 ≈ FDR 0.05 from Hart 2017). Use when classifying essential vs non-essential genes, calibrating BAGEL2 thresholds against PR curves, identifying tumor suppressors alongside essentials, comparing BAGEL2 hits to MAGeCK / drugZ, or generating publication-quality essentiality calls.
日本語の概要は準備中です。原文の説明を表示しています。
Comprehensive quality control for CLIP-seq libraries (eCLIP, iCLIP, iCLIP2, PAR-CLIP) covering library complexity (preseq), FRiP, IDR replicate reproducibility, read-distribution metagene, SMInput vs IgG control rationale, rRNA / snoRNA contamination, fragment-length distribution, and ENCODE-compliance thresholds. Use when assessing whether a CLIP library passed, deciding lenient vs stringent peak thresholds, comparing replicates with IDR rescue and self-consistency ratios, or distinguishing failed IP from over-amplified library.
日本語の概要は準備中です。原文の説明を表示しています。
Call copy number variants with the GATK best-practices workflows — the somatic CNV pipeline (CollectReadCounts, DenoiseReadCounts with tangent normalization, ModelSegments, CallCopyRatioSegments) and the germline GATK-gCNV pipeline (DetermineGermlineContigPloidy, GermlineCNVCaller cohort/case mode, PostprocessGermlineCNVCalls). Covers panel-of-normals construction, AnnotateIntervals/FilterIntervals, allelic-count integration, and QS-based filtering. Use when integrating CNV calling into a GATK variant pipeline, calling rare germline CNVs from an exome cohort, deciding between the somatic and germline GATK workflows, or diagnosing why tangent normalization removed a real event or why gCNV output has low precision.
日本語の概要は準備中です。原文の説明を表示しています。
Detect somatic and germline copy number variants from targeted, exome, and whole-genome sequencing with CNVkit, a read-depth caller that combines on-target and off-target (antitarget) coverage. Covers panel-of-normals construction, flat-reference tumor-only calling, hybrid/amplicon/WGS modes, CBS vs HMM segmentation selection, purity-aware integer calling, and reconciliation against GATK and allele-specific callers. Use when calling CNVs from hybrid-capture panels or exomes, deciding whether CNVkit (depth-only) is the right tool versus an allele-specific caller, building a panel of normals, diagnosing flat-reference false positives, or interpreting log2 ratios into copy-number states.
日本語の概要は準備中です。原文の説明を表示しています。
Quantifies alternative splicing as PSI (percent spliced in) from RNA-seq using rMATS-turbo (BAM-based event), SUPPA2 (TPM-based event), MAJIQ V3 (LSV-based Bayesian), leafcutter (annotation-free intron clusters), VAST-TOOLS (cross-species with microexon support), Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage), or IRFinder-S (intron retention coverage-aware). Distinguishes the five canonical event classes (SE, A5SS, A3SS, MXE, RI), special classes (microexons, exitrons, AFE/ALE), intron retention subtypes (canonical RI vs detained introns), and applies effective-length normalization. Use when measuring splice-site usage or isoform inclusion ratios from short-read RNA-seq.
日本語の概要は準備中です。原文の説明を表示しています。
Resize photos and videos to exact pixel dimensions or aspect ratios using Adobe tools. Use this skill whenever a user wants to resize, scale, or change the dimensions of an image or video file — including phrases like "resize this to 1920x1080", "make this 4K", "scale to 800x600", "change the aspect ratio to 16:9", "resize my video", "make the image smaller", "crop to square", "fit this to a specific size", "resize for print", "resize for web", "make it 300 DPI ready", "change canvas size", "resize a batch of photos", or any request specifying target dimensions (W×H, ratio, or named size like "4K", "HD", "A4"). Also triggers for: "make this fit a specific size", "resize to [any dimension]", "I need this at [WxH]", "scale my video down", "change resolution", "downscale", "upscale". NOT for social media platform sets (use adobe-create-social-variations for that). Uses image_crop_and_resize for photos, video_resize for videos.
日本語の概要は準備中です。原文の説明を表示しています。
Normalizes and transforms RNA-seq count matrices for DE, visualization, clustering, and ML. Covers between-sample (TMM, TMMwsp, RLE/median-of-ratios, upper quartile), within-sample (TPM, FPKM/RPKM), variance-stabilizing (VST, rlog, log-CPM), GC-content correction (cqn, EDASeq), and single-cell (scran deconvolution, scanpy normalize_total). Encodes the composition-bias rationale, the "most genes not DE" assumption and its catastrophic failure modes (MYC amplification, apoptosis, viral host shutoff, prokaryotic stress), the "lengthScaledTPM is not TPM" naming trap, the "TPM is not for DE" rule, the blind=TRUE vs FALSE decision, ERCC spike-in normalization (SBN), and the single-cell zero-inflation breakdown of TMM/RLE. Use when choosing or applying normalization, debugging shifted-MA-plot diagnostics, handling zero-heavy single-cell data, or correcting GC bias.
日本語の概要は準備中です。原文の説明を表示しています。
Identifies essential genes from CRISPR-Cas9 fitness screens using BAGEL2 (Kim & Hart 2021 Genome Med), a Bayesian classifier scoring per-gene Bayes Factors via log-likelihood ratios over per-sgRNA fold changes, calibrated against CEGv2 core-essentials (Hart 2017 G3, ~684 genes) and NEGv1 non-essentials (Hart 2014, ~927 genes). Covers the fc + bf + pr workflow, the linear-extrapolation improvement over BAGEL1 truncation, multi-target off-target correction, tumor-suppressor sensitivity (BAGEL2 detects enrichment), and BF-to-FDR calibration (BF >6 ≈ FDR 0.05 from Hart 2017). Use when classifying essential vs non-essential genes, calibrating BAGEL2 thresholds against PR curves, identifying tumor suppressors alongside essentials, comparing BAGEL2 hits to MAGeCK / drugZ, or generating publication-quality essentiality calls.
日本語の概要は準備中です。原文の説明を表示しています。
Comprehensive quality control for CLIP-seq libraries (eCLIP, iCLIP, iCLIP2, PAR-CLIP) covering library complexity (preseq), FRiP, IDR replicate reproducibility, read-distribution metagene, SMInput vs IgG control rationale, rRNA / snoRNA contamination, fragment-length distribution, and ENCODE-compliance thresholds. Use when assessing whether a CLIP library passed, deciding lenient vs stringent peak thresholds, comparing replicates with IDR rescue and self-consistency ratios, or distinguishing failed IP from over-amplified library.
日本語の概要は準備中です。原文の説明を表示しています。
Detect somatic and germline copy number variants from targeted, exome, and whole-genome sequencing with CNVkit, a read-depth caller that combines on-target and off-target (antitarget) coverage. Covers panel-of-normals construction, flat-reference tumor-only calling, hybrid/amplicon/WGS modes, CBS vs HMM segmentation selection, purity-aware integer calling, and reconciliation against GATK and allele-specific callers. Use when calling CNVs from hybrid-capture panels or exomes, deciding whether CNVkit (depth-only) is the right tool versus an allele-specific caller, building a panel of normals, diagnosing flat-reference false positives, or interpreting log2 ratios into copy-number states.
日本語の概要は準備中です。原文の説明を表示しています。
Call copy number variants with the GATK best-practices workflows — the somatic CNV pipeline (CollectReadCounts, DenoiseReadCounts with tangent normalization, ModelSegments, CallCopyRatioSegments) and the germline GATK-gCNV pipeline (DetermineGermlineContigPloidy, GermlineCNVCaller cohort/case mode, PostprocessGermlineCNVCalls). Covers panel-of-normals construction, AnnotateIntervals/FilterIntervals, allelic-count integration, and QS-based filtering. Use when integrating CNV calling into a GATK variant pipeline, calling rare germline CNVs from an exome cohort, deciding between the somatic and germline GATK workflows, or diagnosing why tangent normalization removed a real event or why gCNV output has low precision.
日本語の概要は準備中です。原文の説明を表示しています。
Quantifies alternative splicing as PSI (percent spliced in) from RNA-seq using rMATS-turbo (BAM-based event), SUPPA2 (TPM-based event), MAJIQ V3 (LSV-based Bayesian), leafcutter (annotation-free intron clusters), VAST-TOOLS (cross-species with microexon support), Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage), or IRFinder-S (intron retention coverage-aware). Distinguishes the five canonical event classes (SE, A5SS, A3SS, MXE, RI), special classes (microexons, exitrons, AFE/ALE), intron retention subtypes (canonical RI vs detained introns), and applies effective-length normalization. Use when measuring splice-site usage or isoform inclusion ratios from short-read RNA-seq.
日本語の概要は準備中です。原文の説明を表示しています。
Inspect and analyze codebases using pygount for LOC counting, language breakdown, and code-vs-comment ratios. Use when asked to check lines of code, repo size, language composition, or codebase stats.
日本語の概要は準備中です。原文の説明を表示しています。
AI image generation with OpenAI, Google, DashScope and Replicate APIs. Supports text-to-image, reference images, aspect ratios. Sequential by default; parallel generation available on request. Use when user asks to generate, create, or draw images.
日本語の概要は準備中です。原文の説明を表示しています。
Generate professional clinical decision support (CDS) documents for pharmaceutical and clinical research settings, including patient cohort analyses (biomarker-stratified with outcomes) and treatment recommendation reports (evidence-based guidelines with decision algorithms). Supports GRADE evidence grading, statistical analysis (hazard ratios, survival curves, waterfall plots), biomarker integration, and regulatory compliance. Outputs publication-ready LaTeX/PDF format optimized for drug development, clinical research, and evidence synthesis.
日本語の概要は準備中です。原文の説明を表示しています。
This skill calculates key financial ratios and metrics from financial statement data for investment analysis
日本語の概要は準備中です。原文の説明を表示しています。
Inspect codebases w/ pygount: LOC, languages, ratios.
日本語の概要は準備中です。原文の説明を表示しています。
Builds SOC performance metrics and KPI tracking dashboards measuring Mean Time to Detect (MTTD), Mean Time to Respond (MTTR), alert quality ratios, analyst productivity, and detection coverage using SIEM data. Use when SOC leadership needs operational visibility, continuous improvement tracking, or executive-level reporting on security operations effectiveness.
日本語の概要は準備中です。原文の説明を表示しています。
Resize photos and videos to exact pixel dimensions or aspect ratios using Adobe tools. Use this skill whenever a user wants to resize, scale, or change the dimensions of an image or video file — including phrases like "resize this to 1920x1080", "make this 4K", "scale to 800x600", "change the aspect ratio to 16:9", "resize my video", "make the image smaller", "crop to square", "fit this to a specific size", "resize for print", "resize for web", "make it 300 DPI ready", "change canvas size", "resize a batch of photos", or any request specifying target dimensions (W×H, ratio, or named size like "4K", "HD", "A4"). Also triggers for: "make this fit a specific size", "resize to [any dimension]", "I need this at [WxH]", "scale my video down", "change resolution", "downscale", "upscale". NOT for social media platform sets (use adobe-create-social-variations for that). Uses image_crop_and_resize for photos, video_resize for videos.
日本語の概要は準備中です。原文の説明を表示しています。