「scaffolds」の検索結果

Performs 3D shape-based similarity searching using ROCS (OpenEye), USRCAT (ultra-fast), Open3DAlign (RDKit), ESPSim (electrostatic), and ShaEP with explicit handling of Tanimoto-Combo (shape + color), shape vs ECFP4 complementarity, conformer-ensemble searching, alignment optimization, and scaffold hopping. Use when searching for shape-mimicking compounds with different scaffolds, identifying bioisosteric replacements, prospective scaffold hopping, or expanding hit series beyond 2D similarity.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes chemical libraries by scaffold using Bemis-Murcko scaffolds, generic frameworks, cyclic skeletons, matched molecular pair (MMP) analysis via mmpdb, R-group decomposition, Free-Wilson analysis, scaffold hopping, and chemotype-aware ML train/test splits. Use when identifying chemotype clusters in a library, deriving SAR transformation rules, decomposing series into R-groups, performing scaffold-balanced QSAR splits, or planning analog campaigns.

日本語の概要は準備中です。原文の説明を表示しています。

Use when building PHP applications with modern PHP 8.3+ features, Laravel, or Symfony frameworks. Invokes strict typing, PHPStan level 9, async patterns with Swoole, and PSR standards. Creates controllers, configures middleware, generates migrations, writes PHPUnit/Pest tests, defines typed DTOs and value objects, sets up dependency injection, and scaffolds REST/GraphQL APIs. Use when working with Eloquent, Doctrine, Composer, Psalm, ReactPHP, or any PHP API development.

日本語の概要は準備中です。原文の説明を表示しています。

Generate and run tests for Adobe App Builder actions and UI components. Scaffolds Jest unit tests, integration tests against deployed actions, contract tests for Adobe API interactions, and React component tests using Testing Library. Provides mock helpers for State, Files, Events SDKs, @adobe/aio-lib-* clients, ExC Shell context (@adobe/exc-app), and UIX Guest SDK (@adobe/uix-guest). Use this skill whenever the user mentions testing App Builder actions, writing unit tests for Runtime actions, creating integration tests, mocking Adobe SDKs, setting up test fixtures, running aio app test, or wants to verify action behavior before deployment. Also trigger when users mention Jest configuration for App Builder, test coverage, CI test setup, React component test, Testing Library, UI test, Provider wrapper, test my page, test my form, test my table, test my component, mock shell context, mock extension context, debug test failures, or fix Jest errors.

日本語の概要は準備中です。原文の説明を表示しています。

Orders and orients assembled contigs into chromosome-scale scaffolds from long-range linking data, inserting N-gap spacers (adds no sequence). Covers Hi-C/Omni-C scaffolding (YaHS, SALSA2, 3D-DNA/Juicer), Hi-C read-mapping prerequisites (map each end separately, no mate rescue, dedup, enzyme-aware), reading the contact map for misjoins/inversions/false-duplications, manual curation in Juicebox/PretextView (the VGP/DToL standard), reference-guided scaffolding (RagTag) and its karyotype-erasure hazard, genetic-map (ALLMAPS) and Bionano optical-map integration, chimera-breaking before scaffolding, gap-filling, and telomere/contig-vs-scaffold-N50 QC (tidk). Use when turning contigs into chromosomes with Hi-C, integrating a linkage map or optical map, choosing a scaffolder by available linking data, or judging whether a chromosome-scale assembly is trustworthy.

日本語の概要は準備中です。原文の説明を表示しています。

Performs 3D shape-based similarity searching using ROCS (OpenEye), USRCAT (ultra-fast), Open3DAlign (RDKit), ESPSim (electrostatic), and ShaEP with explicit handling of Tanimoto-Combo (shape + color), shape vs ECFP4 complementarity, conformer-ensemble searching, alignment optimization, and scaffold hopping. Use when searching for shape-mimicking compounds with different scaffolds, identifying bioisosteric replacements, prospective scaffold hopping, or expanding hit series beyond 2D similarity.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes chemical libraries by scaffold using Bemis-Murcko scaffolds, generic frameworks, cyclic skeletons, matched molecular pair (MMP) analysis via mmpdb, R-group decomposition, Free-Wilson analysis, scaffold hopping, and chemotype-aware ML train/test splits. Use when identifying chemotype clusters in a library, deriving SAR transformation rules, decomposing series into R-groups, performing scaffold-balanced QSAR splits, or planning analog campaigns.

日本語の概要は準備中です。原文の説明を表示しています。

Meta-skill for creating Agent Forge skills under .claude/skills/ with SKILL.md, optional references/ and scripts/, and Bun scaffolds. Use when the user wants to add or author a skill, scaffold a new skill folder, or align skill docs with harness conventions (JSON script output, Beads for tasks).

日本語の概要は準備中です。原文の説明を表示しています。

Adds test infrastructure to a .NET project. Scaffolds xUnit project, coverlet, layout.

日本語の概要は準備中です。原文の説明を表示しています。

Generate and run tests for Adobe App Builder actions and UI components. Scaffolds Jest unit tests, integration tests against deployed actions, contract tests for Adobe API interactions, and React component tests using Testing Library. Provides mock helpers for State, Files, Events SDKs, @adobe/aio-lib-* clients, ExC Shell context (@adobe/exc-app), and UIX Guest SDK (@adobe/uix-guest). Use this skill whenever the user mentions testing App Builder actions, writing unit tests for Runtime actions, creating integration tests, mocking Adobe SDKs, setting up test fixtures, running aio app test, or wants to verify action behavior before deployment. Also trigger when users mention Jest configuration for App Builder, test coverage, CI test setup, React component test, Testing Library, UI test, Provider wrapper, test my page, test my form, test my table, test my component, mock shell context, mock extension context, debug test failures, or fix Jest errors.

日本語の概要は準備中です。原文の説明を表示しています。