「stability」の検索結果

Designs covalent inhibitors and warheads targeting cysteine (most common, 98% of covalent drugs), lysine, serine, threonine, tyrosine, and aspartate residues, with explicit handling of warhead reactivity (acrylamide, chloroacetamide, vinyl sulfone, sulfonyl fluoride, fluorosulfate, aldehyde, boronate, nitrile), reversibility (kinact/Ki, t_residence), glutathione (GSH) stability, intrinsic reactivity assays, and covalent docking (DOCKovalent, GOLD, HCovDock). Use when designing covalent inhibitors for targeted covalent inhibition (TCI), KRAS G12C-style approaches, or rationalizing covalent SAR.

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Comprehensive quality control for flow cytometry and CyTOF data. Covers flow rate stability, signal drift, margin events, dead cell exclusion, and batch QC. Use when assessing acquisition quality or identifying problematic samples before analysis.

日本語の概要は準備中です。原文の説明を表示しています。

Protein design quality control, filtering thresholds, and ranking guidance. Use this skill when: (1) Evaluating design quality for binding, expression, or structure, (2) Setting filtering thresholds for pLDDT, ipTM, PAE, (3) Checking sequence liabilities (cysteines, deamidation, polybasic clusters), (4) Creating multi-stage filtering pipelines, (5) Computing PyRosetta interface metrics (dG, SC, dSASA), (6) Checking biophysical properties (instability, GRAVY, pI), (7) Ranking designs with composite scoring. This skill provides research-backed thresholds from binder design competitions and published benchmarks.

日本語の概要は準備中です。原文の説明を表示しています。

Quality control metrics and filtering thresholds for protein design. Use this skill when: (1) Evaluating design quality for binding, expression, or structure, (2) Setting filtering thresholds for pLDDT, ipTM, PAE, (3) Checking sequence liabilities (cysteines, deamidation, polybasic clusters), (4) Creating multi-stage filtering pipelines, (5) Computing PyRosetta interface metrics (dG, SC, dSASA), (6) Checking biophysical properties (instability, GRAVY, pI), (7) Ranking designs with composite scoring. This skill provides research-backed thresholds from binder design competitions and published benchmarks.

日本語の概要は準備中です。原文の説明を表示しています。

Design protein sequences using ProteinMPNN inverse folding. Use this skill when: (1) Designing sequences for RFdiffusion backbones, (2) Redesigning existing protein sequences, (3) Fixing specific residues while designing others, (4) Optimizing sequences for expression or stability, (5) Multi-state or negative design. For backbone generation, use rfdiffusion or bindcraft. For ligand-aware design, use ligandmpnn. For solubility optimization, use solublempnn.

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Use when adding or fixing Formax tests (especially Ink UI tests) and you need deterministic synchronization in test interactions.

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Runtime per-test healing with evidence: multi-attribute selector healing, environment-aware diagnosis, flake classification, quarantine management, and confidence-scored auto-repair. Goes beyond simple locator fallbacks to cover action-level healing, data healing, and observable repair workflows. Use when: "flaky test," "test stability," "self-healing locator," "broken locator recovery," "unreliable test," "quarantine flaky test." Not for: bulk regenerating selectors after a planned UI refactor — use selector-drift-recovery (this skill heals ONE test at runtime; that one rewrites many tests offline). Not for: classifying/clustering CI failures into bug reports — use ai-bug-triage. Related: playwright-automation, selector-drift-recovery, ci-cd-integration, qa-metrics, ai-bug-triage.

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Power systems engineering covering grid modeling, power flow analysis, energy storage dispatch, demand response, and electricity market economics. Spans transmission/distribution planning to real-time operations. Use when "power flow|load flow|grid model, energy storage|battery dispatch|ESS, demand response|load management|peak shaving, electricity market|LMP|locational marginal price, grid stability|frequency|voltage, capacity planning|resource adequacy, unit commitment|economic dispatch, transmission|distribution|power system, " mentioned.

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Patterns for feedback control systems including PID tuning, state-space control, Model Predictive Control (MPC), trajectory tracking, and stability analysis. Covers both classical and modern control approaches for robotics and automation. Use when ", " mentioned.

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Translate technical decisions into human language. Explain in cost, speed, stability.

日本語の概要は準備中です。原文の説明を表示しています。

Full repository maintenance pipeline that orchestrates all project agents in sequence - code review, accessibility, bundle size, security, API stability, test coverage, ecosystem, and release preparation. Acts as a quality gate before publishing or merging major changes. Use when: maintenance, health check, pre-release audit, quality gate, full pipeline, repo health, pre-merge check, release readiness, audit all.

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Reviews an existing codebase for structural friction, unclear ownership, leaky or shallow interfaces, excessive coupling, misplaced state, poor testability, and risky dependency direction, then prioritizes evidence-backed improvement candidates. Use for architecture audits, modularization, modernization, or recurring cross-cutting change pain. Not for designing one new interface, simplifying a local function, or fixing a reproduced bug.

日本語の概要は準備中です。原文の説明を表示しています。

Claude adapter for reviewing PlainTab architecture, coupling, testability, and refactoring opportunities.

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Use when reviewing PlainTab architecture, looking for refactoring opportunities, reducing coupling, improving testability, or making modules easier for agents to understand without redesigning stable behavior.

日本語の概要は準備中です。原文の説明を表示しています。

Performs an architectural and quality code review on a specified file or set of files. Checks for coding standard compliance, architectural pattern adherence, SOLID principles, testability, and performance concerns.

日本語の概要は準備中です。原文の説明を表示しています。

Validate Blender animation attempts before accepting them by rendering contact sheets, checking silhouette stability, flicker, framing, subject dominance, layer separation, export compatibility, and motion-design coherence. Use after animation renders or when the user says motion/morph/outside elements look bad.

日本語の概要は準備中です。原文の説明を表示しています。

Comprehensive Go web development persona enforcing zero global state, explicit error handling, input validation, testability, and documentation conventions. Use when building Go web applications to ensure production-quality code from the start.

日本語の概要は準備中です。原文の説明を表示しています。

Emergency fund analyzer. Calculates the right emergency fund size based on job stability, family structure, fixed expenses, dependents, and employee vs. business-owner status. Recommends where to keep it (HYSA, money market, T-bills, I-Bonds), how fast to build it, what counts as a true emergency, and how to replenish after use. Produces FINANCE-EMERGENCY.md.

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Calculus, series, numerical methods, and optimization for computational mathematics. Covers limits (epsilon-delta, L'Hopital, squeeze theorem), derivatives (rules, optimization, related rates), integrals (Riemann sums, Fundamental Theorem of Calculus, integration techniques), series (convergence tests, Taylor and Maclaurin expansions), differential equations (separable, linear, exact), numerical methods (Newton-Raphson, Euler method, Simpson's rule), and computational pitfalls (floating-point arithmetic, catastrophic cancellation, numerical stability). Use when computing derivatives, integrals, limits, series, solving differential equations, or analyzing numerical accuracy.

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Design and analysis of combinational and sequential digital circuits using Boolean algebra, truth tables, K-maps, CMOS gate implementation, flip-flops, registers, counters, and finite state machines. Covers De Morgan's theorems, canonical sum-of-products and product-of-sums forms, minimization techniques, propagation delay, setup and hold times, metastability, synchronous design discipline, and FSM encoding. Use when designing, minimizing, verifying, or debugging any circuit whose signals take only discrete logic values.

日本語の概要は準備中です。原文の説明を表示しています。

Atomic theory, periodic table organization, electron configuration, periodic trends, and isotopes/radioactivity. Covers Dalton through quantum mechanical models, electron shell filling (Aufbau, Hund, Pauli), periodic law and block structure, trend prediction (electronegativity, ionization energy, atomic radius, electron affinity), isotope notation, nuclear stability, and radioactive decay modes. Use when teaching, problem-solving, or reasoning about atomic-level chemistry.

日本語の概要は準備中です。原文の説明を表示しています。

Cloud laboratory platform for automated protein testing and validation. Use when designing proteins and needing experimental validation including binding assays, expression testing, thermostability measurements, enzyme activity assays, or protein sequence optimization. Also use for submitting experiments via API, tracking experiment status, downloading results, optimizing protein sequences for better expression using computational tools (NetSolP, SoluProt, SolubleMPNN, ESM), or managing protein design workflows with wet-lab validation.

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Validate whether an implementation plan can achieve its stated outcome before execution. Use to check requirement coverage, task contracts, dependencies, data/artifact flow, testability, ownership, impact coverage, and executable ordering without checking whether implementation already exists.

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Critical Akka.NET best practices including EventStream vs DistributedPubSub, supervision strategies, error handling, Props vs DependencyResolver, work distribution patterns, and cluster/local mode abstractions for testability.

日本語の概要は準備中です。原文の説明を表示しています。