「treatment」の検索結果

Identify differentially bound regions across CLIP-seq conditions (knockdown vs control, treatment vs vehicle, disease vs healthy) using DEWSeq (sliding-window DESeq2), Flipper (Skipper-downstream), ASpeak, edgeR, or limma-voom. Use when computing condition-level changes in RBP binding intensity, choosing peak-level vs window-level vs crosslink-level testing, designing replicate experiments, or distinguishing biological binding shifts from technical confounders.

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Reads, validates, and prepares CDISC SDTM and ADaM clinical trial data for analysis. Covers SDTM domain joins (DM, AE, EX, VS, LB, DS), ADaM architecture (ADSL, BDS, OCCDS, ADTTE) with traceability, treatment-emergent AE conventions, baseline derivation, SUPPQUAL/NSV handling, Define-XML 2.1, and Pinnacle 21 / CORE validation. Use when working with clinical trial datasets in CDISC SDTM/ADaM format, preparing analysis-ready data, or validating for regulatory submission.

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Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Friede-Kieser, unblinded Cui-Hung-Wang, Mehta-Pocock promising zone), seamless Phase 2/3 with treatment-arm selection, population enrichment, and response-adaptive randomisation. Covers FDA 2019 Final Adaptive Designs Guidance, FDA 2022 Master Protocols, and ICH E20 Step 2b/3 draft (June 2025, NOT final). Use when planning interim analyses, sample-size re-estimation, or master/platform-trial designs.

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Tests associations between categorical variables in clinical data using chi-square, Fisher's exact, Boschloo, Cochran-Mantel-Haenszel, and modern McNemar variants with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen). Use when analyzing categorical outcomes, paired binary endpoints, or testing treatment-outcome independence in confirmatory or exploratory clinical trials.

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Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.

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Identify differentially accessible chromatin regions across conditions using DiffBind, csaw, DESeq2, or edgeR. Use when comparing ATAC-seq accessibility between treatment groups, choosing between consensus-peak vs sliding-window approaches, picking the correct normalization (full library vs reads-in-peaks), correcting batch with SVA/RUVseq, or interpreting log2FC and FDR thresholds in a chromatin context.

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Decompose total effects into direct and indirect paths through mediators using mediation, CMAverse 4-way, HIMA/HIMA2 high-dimensional, BAMA, two-step / MVMR mediation, or double-ML medDML. Use when testing whether a molecular phenotype (expression, methylation, protein) mediates a treatment-outcome relationship, decomposing exposure-mediator interaction via VanderWeele 4-way, screening high-dimensional EWAS mediators, or running MR-based mediation when sequential ignorability is implausible.

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Exhaustively extract UX patterns from a reference web app. Walks every screen, captures screenshots of every state, records interaction patterns, copy verbatim, keyboard shortcuts, responsive treatments, motion, and empty/error/loading states. Produces a reusable pattern library that other audits can compare against. The inverse of ux-audit — asks 'what is the bar?' rather than 'does this match the bar?'. Trigger with 'learn from X', 'extract patterns from X', 'study X's UX', 'reverse engineer the UX of X', 'build a pattern library from X'.

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Expert ISO 27001 compliance assistant for security and compliance teams. Use this skill whenever a user asks about ISO 27001 or ISO/IEC 27001, including any of the following: gap analysis, auditing, compliance assessments, control checklists, policy writing, document generation, Statement of Applicability (SoA), risk assessment, risk registers, risk treatment plans, Annex A controls, ISMS implementation, clause requirements, certification readiness, transitioning from 2013 to 2022, control implementation guidance, incident response policies, access control policies, supplier security, or any information security management system (ISMS) topic. Trigger even if the user doesn't say "skill" — any ISO 27001 or ISMS question should use this skill.

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Direct visual and creative work for campaigns, photography, illustration, video, and branded experiences. Use this skill whenever the user wants to brief a photographer, direct illustrators, plan a creative campaign, develop visual concepts, or evaluate creative work for fit. Triggers on art direction, photo brief, photography brief, illustration brief, campaign concept, creative concept, visual direction, mood board, look and feel, visual treatment, video direction. Also triggers when the user has approved brand identity but needs to extend it into specific creative deliverables. Use `creative-direction` instead when the ask is the project-wide aesthetic brief that this skill consumes as input.

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Compliant, retrieval-grounded research over investor-State dispute settlement (ISDS) awards and decisions. Use when the user asks about ICSID / investment-treaty arbitration cases, awards, or doctrines (fair and equitable treatment, expropriation, jurisdiction, costs, annulment, etc.) and wants answers grounded in the actual document text with pinpoint citations. Identifies the correct document on the case page, confirms it against the PDF's own first pages, retrieves primary documents on demand from ICSID, PCA, etc., never scrapes or hosts a corpus in violation of applicable terms, and cites only retrieved text.

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Expert ISO 27001 compliance assistant for security and compliance teams. Use this skill whenever a user asks about ISO 27001 or ISO/IEC 27001, including any of the following: gap analysis, auditing, compliance assessments, control checklists, policy writing, document generation, Statement of Applicability (SoA), risk assessment, risk registers, risk treatment plans, Annex A controls, ISMS implementation, clause requirements, certification readiness, transitioning from 2013 to 2022, control implementation guidance, incident response policies, access control policies, supplier security, or any information security management system (ISMS) topic. Trigger even if the user doesn't say "skill" — any ISO 27001 or ISMS question should use this skill.

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Operational billing execution for legal matters. Monthly bill prep and billing instructions, LC invoice review and disbursement treatment, client billing query responses, cashflow modelling (LC payment obligations vs client receipts), and leverage and burn analysis (staffing mix, predicted total cost, margin trajectory). Trigger on: 'prepare the bill', 'billing instruction', 'end of month billing', 'LC invoice', 'local counsel invoice', 'pass through as disbursement', 'client querying the invoice', 'billing dispute', 'cashflow gap', 'when will we get paid', 'LC payment due', 'leverage analysis', 'staffing mix', 'predicted total cost', 'burn rate by grade', 'are we on track', 'what will this matter cost'.

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Tax-loss harvesting strategies for A-share portfolios. Adapts the original tax-loss-harvesting skill for Chinese tax rules, A-share market conventions, and domestic tax treatment. Triggers on "A股税务亏损抵扣", "亏损抵扣", "tax loss harvesting China", "税务优化", "亏损抵扣策略", or "harvest tax losses [portfolio]".

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Turns a brief, script, scene breakdown, treatment, or story idea into ONE connected director's shotlist for Seedance 2.0 — a single editable HTML artifact with a global Style Prefix, an @-asset glossary, and named per-scene prompts (1a, 1b, 2a…) each in Style → Characters → Scene → CUT 1..N form. Use whenever the user says 'make a shotlist', 'break this script into prompts', 'generate Seedance prompts for this ad/film', 'turn this brief into a shot list', 'director's shotlist', or wants many connected scene prompts rather than one. Also use to revise an existing shotlist (edit-once-propagates: 'change the style prefix everywhere', 'rewrite scene 4', 'split prompt 6'). Each prompt targets 15s; longer scenes split across 1a/1b/1c under one scene number.

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Use when the user asks about Mixed Media, wants to apply artistic preset styles to an image (Noir, Sketch, Paper, Canvas, Particles, Neon, etc.), combine multiple artistic treatments, or create stylized non-photorealistic outputs.

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Add captions or subtitles to an existing single-subject talking-head video without editing the footage. Use for plain verbatim captions, cinematic captions embedded behind the subject, VFX captions, “炸/特效/酷炫字幕,” or a named identity from the 35-style catalog. Route by visual identity, not by backend engine. The quiet `anchor` rail is the default; embed every word only when the user explicitly wants a fully cinematic treatment. The workflow runs locally end to end, including transcription and subject matting; split multi-shot footage before applying it.

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Evaluates observed product outcomes against a prior hypothesis; does not run experiments or change user treatment.

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Create cinematic movie poster concepts and final poster images from a user's brief, existing video plan, storyboard, character design, or project context. Use this skill whenever the user asks to generate a film poster, movie poster, key art, campaign poster, teaser poster, title poster, or promotional visual for a video project. This skill proposes several creative directions first when appropriate, defaults to a 3:4 poster ratio when no ratio is specified, and ensures typography, title treatment, imagery, genre, setting, and story tone are coherent and visually inventive.

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Use this skill whenever the user asks to create, improve, audit, or split prompts for AI video generators (Seedance, Kling, Veo, Runway, Luma, Pika, Sora, any image-to-video system). The skill also covers storyboards, shot lists, director treatments, dynamic montage, multi-clip story structure, camera direction, lighting, blocking, pacing, character continuity, dialogue, and sound design. Trigger even when the user says things like "придумай сцену для видео", "разбей на склейки", "сделай раскадровку", "улучши промпт для Kling", "переведи сценарий в промпты", "как снять X в AI-видео", or shares a prompt and asks to fix it — even if they never say the word "prompt". Do NOT use for still images (use the sibling image skill), for editing, colour-grading or assembling footage that already exists, or for writing feature-length screenplays with no generation step.

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Create distinctive Photo Relic editorial artworks from user-provided photographs: preserve the real photo and pair it with a recognizable, artful abstract relic shaped like memory, modern printmaking, quiet Eastern restraint, and source-derived light. Use when the user asks to turn a photo into minimal art, photographic relic posters, abstract editorial photography, gallery-like photo posters, Douyin-ready art series covers, graphic photo abstraction, afterimage compositions, or similar visual treatments while keeping the original photograph truthful.

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Generate luxury and premium aesthetic video prompts for Seedance 2.0 on Higgsfield. Use for luxury brand content, premium product showcases, high-end lifestyle, minimalist aesthetic, elegant brand videos, or any content requiring sophisticated visual treatment. Triggers on luxury, premium, high-end, elegant, minimalist, sophisticated, exclusive, refined, designer, couture, bespoke.

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Verify a claim with fresh local evidence: restate it falsifiably, capture baseline and treatment, compare artifacts, and return VERIFIED, NOT VERIFIED, or INCONCLUSIVE.

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Cancer genomics (TCGA et al.) via cBioPortal REST API. Retrieve somatic mutations, CNAs, expression, clinical data (survival/stage/treatment) across thousands of studies. Use for TMB, oncoprints, survival analysis. For population frequencies use gnomad-database; for drug-gene interactions use opentargets-database.

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