「esi」の検索結果

Define or review a visual system, DESIGN.md, or redesign direction. Use for typography, layout, color, motion, and interaction design decisions.

日本語の概要は準備中です。原文の説明を表示しています。

Why expensive, wasteful, effortful, or self-deprecating actions build trust and desire — Rory Sutherland on signalling. Use when the problem is credibility or desirability rather than meaning: the user asks 'why don't people trust us', 'how do we look more credible/committed/premium', 'is our guarantee/warranty worth it', 'should we spend on brand advertising', 'how do we justify a higher price', or wonders why a cheaper-looking competitor wins. Covers costly signals (advertising spend, guarantees, over-delivery), price-as-quality-signal (Veblen goods), and the Pratfall Effect (admitting a real flaw to gain trust). Inspired by Rory Sutherland's *Alchemy*. Routed to from psycho-logic. 日本語の相談（「信頼されない」「安心してもらえない」「強気な価格で売りたい」「広告費に意味はある？」）にも使う。中文咨询（“不被信任”“想以高价出售”“广告费有意义吗？”）也适用。

Plan a resignation and the move to a new employer: check the intended notice date, last working day, and start date against the notice period the employer's own rules require, count the weekdays left against remaining paid leave, and work through the checklist of handover, documents to receive, items to return, and the insurance, pension, and residual tax steps that a gap between jobs creates. Use when a user has accepted an offer and needs to work out when and how to resign, or wants to know what to confirm before giving notice; do not use to rule on whether they can legally leave, to judge a non-compete clause, to promise the departure will go smoothly, or to notify anyone.

日本語の概要は準備中です。原文の説明を表示しています。

Designs donor/repair templates for precise CRISPR knock-ins -- choosing the format (ssODN, long-ssDNA/Easi-CRISPR, dsDNA/plasmid, AAV6), sizing homology arms, placing the cut within ~10 bp of the edit, and adding a mandatory codon-checked blocking (PAM/seed) mutation so the edited allele is not re-cut. Frames the HDR-vs-NHEJ-vs-MMEJ pathway competition, the MMEJ (PITCh) and homology-independent (HITI/HMEJ) alternatives for post-mitotic cells, ssODN strand/asymmetry choice, phosphorothioate end-protection, and ranked HDR enhancers. Use when designing a donor for a point mutation, epitope/fluorophore tag, allele replacement, or knock-in, or when HDR efficiency is low. Guide design and base/prime editing are separate skills.

日本語の概要は準備中です。原文の説明を表示しています。

Structures biological experiments so inference is valid by construction, covering Fisher's principles (randomization, replication, local control), the experimental-vs-observational unit distinction and pseudoreplication (Hurlbert 1984; Lazic 2018), randomization mechanics (complete, restricted, stratified, rerandomization, run-order), blocking layouts (randomized complete block, Latin square, incomplete block), factorial designs and interactions, and the split-plot/nested error strata hidden inside multi-batch genomics. Use when deciding the experimental unit and what counts as a replicate, planning randomization and run order, choosing a blocked/factorial/split-plot/nested layout, avoiding pseudoreplication in cell-culture or animal studies, or specifying the random-effects structure of the analysis model. For assigning samples to sequencing batches/lanes/plates and batch-effect correction see experimental-design/batch-design; for regulated clinical-trial randomization see clinical-biostatistics.

日本語の概要は準備中です。原文の説明を表示しています。

Aligns sample metadata with count matrices and constructs design matrices for downstream DE, handling the alphabetical-reference-level trap (relevel BEFORE DESeq), LRT reduced-model rules, the interaction-term resultsNames trap, continuous-covariate scaling and splines, repeated measures via duplicateCorrelation or dream, high-cardinality categorical pseudo-singular designs, sample swap detection via XIST/RPS4Y1 expression and somalier/NGSCheckMate genotypes, SABV (sex-as-biological-variable) mandate, Simpson's-paradox collapsing of technical replicates, and the `~ 0 + group` parameterization for clean contrasts. Use when building a design matrix, troubleshooting reversed fold-change direction, encoding paired or repeated-measures designs, detecting sample swaps, deciding sex-as-covariate, or aggregating technical replicates.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes CRISPR drug-modifier (chemogenomic) screens with drugZ (Li & Hart 2019 Genome Med), a bidirectional Z-score method that identifies synthetic-lethal sensitizing genes and resistance-conferring suppressor genes from vehicle vs drug comparisons. Covers vehicle-anchored design (not Day-0), the bidirectional Z math giving 2-3x sensitivity over MAGeCK / STARS / edgeR / RIGER on drug screens, per-gene sumZ and normZ, synth (sensitizer) vs supp (suppressor) FDR, multi-dose handling, integration with control sgRNAs, and comparison with MAGeCK MLE with dose covariate. Use when running a drug-modifier CRISPR screen, identifying sensitizing or resistance genes for a drug candidate, choosing drugZ vs MAGeCK MLE for chemogenomic analysis, troubleshooting low-effect drug screens where MAGeCK lacks sensitivity, or designing a drug-screen layout (vehicle vs drug arms).

日本語の概要は準備中です。原文の説明を表示しています。

Designs novel molecules using REINVENT 4 (de novo, scaffold decoration, linker design, R-group, molecular optimization), MolMIM, Diffusion-based generators (DiGress, DiffSMol), and JT-VAE with explicit handling of multi-parameter optimization (MPO), goal-directed scoring functions, transfer/reinforcement/curriculum learning, synthetic accessibility scoring, and chemical space exploration vs exploitation. Use when designing new chemical matter against a target, decorating a scaffold, linking fragments, or optimizing a hit for multiple ADMET / activity properties simultaneously.

日本語の概要は準備中です。原文の説明を表示しています。

Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Friede-Kieser, unblinded Cui-Hung-Wang, Mehta-Pocock promising zone), seamless Phase 2/3 with treatment-arm selection, population enrichment, and response-adaptive randomisation. Covers FDA 2019 Final Adaptive Designs Guidance, FDA 2022 Master Protocols, and ICH E20 Step 2b/3 draft (June 2025, NOT final). Use when planning interim analyses, sample-size re-estimation, or master/platform-trial designs.

日本語の概要は準備中です。原文の説明を表示しています。

Create a new investment thesis note with full analysis. Use when user says "create thesis", "new thesis", or "build a case for TICKER"

日本語の概要は準備中です。原文の説明を表示しています。

54 production-quality design systems extracted from real websites. Load a template to generate HTML/CSS that matches the visual identity of sites like Stripe, Linear, Vercel, Notion, Airbnb, and more. Each template includes colors, typography, components, layout rules, and ready-to-use CSS values.

日本語の概要は準備中です。原文の説明を表示しています。

Design clean, scalable, and maintainable REST and GraphQL APIs following industry best practices. Use when designing public or internal APIs, planning endpoint structures, defining request/response contracts, establishing versioning strategies, implementing authentication patterns, designing data models, creating API documentation, ensuring consistent error handling, optimizing for performance, or establishing service contracts between microservices.

日本語の概要は準備中です。原文の説明を表示しています。

Design scalable, normalized database schemas with proper relationships, indexes, constraints, and migration strategies for relational and NoSQL databases. Use when designing database schemas, planning table relationships and foreign keys, creating indexes for query optimization, defining constraints and validations, designing data models for scalability, planning database migrations, choosing between SQL and NoSQL, implementing sharding strategies, optimizing query performance, or establishing data integrity rules.

日本語の概要は準備中です。原文の説明を表示しています。

Render a proposed redesign of a page on the current website as a self-contained static HTML file, then iterate via the impeccable craft loop. Per-page, idempotent, stale-aware. Use when the user asks for a redesign prototype, a before/after comparison, a design preview, a page mockup, a visual diff of the redesign, or invokes /stardust:prototype.

日本語の概要は準備中です。原文の説明を表示しています。

Creates complete AEM components with dialog, HTL template, Sling Model, unit tests, and clientlibs. Supports extending Core Components and project components. When a Figma design URL is provided, fetches the design via Figma MCP (get_design_context) and translates it into pixel-perfect HTL, CSS, and JS. Follows Adobe Experience League best practices for AEM Cloud Service and 6.5. Use this skill whenever the user mentions creating, building, generating, or scaffolding an AEM component, or mentions component types like teaser, card, hero, banner, accordion, tabs, carousel, list, navigation, breadcrumb, or any custom AEM component. Also trigger when the user wants to extend a Core Component, create a component dialog, add a Sling Model, or convert a Figma design into an AEM component.

日本語の概要は準備中です。原文の説明を表示しています。

Resize, crop, or export any image or video into platform-ready social media assets using Adobe Creative Cloud tools. Use this skill when a user wants to prepare a photo, image, or video for one or more social platforms — Instagram, TikTok, LinkedIn, Facebook, YouTube, Snapchat, Pinterest, Threads, or X/Twitter. Triggers on: "prepare my image for Instagram", "resize for TikTok", "get this ready to post", "make versions for all platforms", "social media sizes", "crop for stories", "export for LinkedIn", "resize my video for social", "make social media assets", or any request to adapt a photo or video for specific platforms. Handles subject-aware cropping, AI canvas expansion, test previews before full runs, and same-ratio video resizing.

日本語の概要は準備中です。原文の説明を表示しています。

Route visual design, frontend art direction, motion, image generation, branding, and redesign work to focused design skills. Use when the task is primarily about how an interface or brand should look and feel.

日本語の概要は準備中です。原文の説明を表示しています。

Pick an icon strategy and produce a coherent icon set that doesn't look mass-produced. Solves the "Lucide everywhere" problem — every AI-generated UI uses the same 24px stroke-1.5 outline icons, which is the second-biggest vibecoded tell after Inter-on-purple-gradient. Generates custom SVG sets, tunes existing icon libraries to match archetype + typography, defines stroke weight, optical sizing, and corner-radius rules. Load when the user asks to pick icons, design an icon set, customize Lucide / Phosphor / Heroicons, generate SVG icons, make icons feel custom, says "the icons look generic", "design a custom icon system", "icons for this product", or when frontend-design routes here during icon craft. Sub-skill of frontend-design.

日本語の概要は準備中です。原文の説明を表示しています。

Run Mom Test–style customer-discovery interviews to validate or kill an unbuilt idea — generate a non-leading interview guide, conduct or coach the conversations, and synthesize signal vs compliments. Load when the user asks to do customer discovery, run problem interviews, validate an idea with users, run a Mom Test, design an interview guide, or says "talk to customers", "validate the problem", "interview users", "Mom Test this", "did real users want it", "synthesize my interviews", "I just talked to N people". Sub-skill of `venture-exploration`. Hard-bans "would you use this?", solution-pitching, friend/family-only ICP, and treating compliments as validation. Calls `secure-*` before synthesizing any pasted external transcripts.

日本語の概要は準備中です。原文の説明を表示しています。

Design state-of-the-art multi-agent systems, orchestration patterns, and wiring from scratch. Load when the user asks to build an agent system from scratch, design agent orchestration patterns, choose between sequential/parallel/hierarchical workflows, or define how multiple agents should collaborate. Also triggers on "agent architecture", "multi-agent wiring", "agent orchestration pattern", "how to connect these agents", "design the communication structure". Called by agent-builder for complex topologies (>4 agents or hierarchical). For process-driven agent design, use agent-builder instead.

日本語の概要は準備中です。原文の説明を表示しています。

Design structured evaluation rubrics for scoring LLM and agent outputs — defining quality dimensions, scoring scales, hard gates, score descriptions, and edge cases. Load when the user asks to create an eval rubric, define evaluation criteria, design scoring dimensions, write an eval spec, or says "what should I evaluate", "design a rubric", "create eval criteria", "define quality dimensions", "evaluation rubric for", "how do I measure quality of". Sub-skill of eval-output orchestrator.

日本語の概要は準備中です。原文の説明を表示しています。

Create beautiful visual art in .png and .pdf documents using design philosophy. You should use this skill when the user asks to create a poster, piece of art, design, or other static piece. Create original visual designs, never copying existing artists' work to avoid copyright violations.

日本語の概要は準備中です。原文の説明を表示しています。

Designs donor/repair templates for precise CRISPR knock-ins -- choosing the format (ssODN, long-ssDNA/Easi-CRISPR, dsDNA/plasmid, AAV6), sizing homology arms, placing the cut within ~10 bp of the edit, and adding a mandatory codon-checked blocking (PAM/seed) mutation so the edited allele is not re-cut. Frames the HDR-vs-NHEJ-vs-MMEJ pathway competition, the MMEJ (PITCh) and homology-independent (HITI/HMEJ) alternatives for post-mitotic cells, ssODN strand/asymmetry choice, phosphorothioate end-protection, and ranked HDR enhancers. Use when designing a donor for a point mutation, epitope/fluorophore tag, allele replacement, or knock-in, or when HDR efficiency is low. Guide design and base/prime editing are separate skills.

日本語の概要は準備中です。原文の説明を表示しています。

Structures biological experiments so inference is valid by construction, covering Fisher's principles (randomization, replication, local control), the experimental-vs-observational unit distinction and pseudoreplication (Hurlbert 1984; Lazic 2018), randomization mechanics (complete, restricted, stratified, rerandomization, run-order), blocking layouts (randomized complete block, Latin square, incomplete block), factorial designs and interactions, and the split-plot/nested error strata hidden inside multi-batch genomics. Use when deciding the experimental unit and what counts as a replicate, planning randomization and run order, choosing a blocked/factorial/split-plot/nested layout, avoiding pseudoreplication in cell-culture or animal studies, or specifying the random-effects structure of the analysis model. For assigning samples to sequencing batches/lanes/plates and batch-effect correction see experimental-design/batch-design; for regulated clinical-trial randomization see clinical-biostatistics.

日本語の概要は準備中です。原文の説明を表示しています。