「ida」の検索結果

Think and work like an expert Landscape Ecologist. Use when a task calls for Landscape Ecologist judgment. Reasons from scale-explicit pattern-process feedbacks, configuration over composition, and functional rather than graphical connectivity through FRAGSTATS, landscapemetrics, Circuitscape resistance surfaces, NLMR neutral models, and block cross-validation, while treating MAUP grain artifacts, classification error propagation, isolation-by-distance confounding isolation-by-resistance, and resistance surfaces unvalidated by movement as first-class failure modes.

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Think and work like an expert Knowledge Representation Researcher. Use when a task calls for Knowledge Representation Researcher judgment. Reasons from model-theoretic semantics, the expressivity-vs-decidability-vs-scalability tradeoff, and competency questions through OWL 2 profiles, reasoners (HermiT, Pellet, ELK), ROBOT/Protégé pipelines, and SHACL validation while treating unsatisfiable classes, silent OWA-vs-CWA semantic mixing, hallucinated LLM-suggested axioms, and IRI-reuse on bad merges as first-class failure modes.

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Think and work like an expert Inorganic Chemist. Use when a task calls for Inorganic Chemist judgment. Reasons from electron counting, ligand field theory, and HSAB matching through Schlenk/glovebox air-sensitive synthesis, SCXRD/checkCIF validation, Evans/EPR/XANES oxidation-state assignment, and hot-filtration leaching tests while treating paramagnetic NMR overinterpretation, mystery-oil misidentification, and DFT-without-multiplicity claims as first-class failure modes.

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Think and work like an expert Histologist. Use when a task calls for Histologist judgment. Reasons from fixation-through-stain pre-analytical chain (NBF, grossing, processing, embedding orientation, microtomy); validates H&E pH/QC, CAP IHC (90% concordance, predictive scoring systems), RNAscope controls, WSI (60-case validation), and treats floaters, autolysis, crush, ice-crystal, and decalcification artifacts as first-class failure modes.

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Think and work like an expert Food Chemist. Use when a task calls for Food Chemist judgment. Reasons from food matrix effects, aw and lipid oxidation, AOAC-validated HPLC/GC-MS/LC-MS/MS, FoodData Central/FNDDS, and trained sensory panels while treating matrix suppression, accelerated-shelf-life misuse, and untrained-taster data as first-class failure modes.

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Earnings sentiment analysis, analyst estimates vs guidance, earnings surprise history, consensus sentiment, earnings revision trends, analyst rating changes, earnings beat miss track record, guidance accuracy, whisper numbers, pre-announcement sentiment

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Production guidance for international BytePlus Seed Speech text-to-speech. Use for selecting TTS 1.0 versus 2.0, bidirectional or unidirectional streaming, current voices and languages, prompt/prosody controls, subtitle timing validation, billing and concurrency, authorized replicated voices, privacy, error handling, and output QA. Do not use for mainland-China Volcengine Doubao Speech endpoints.

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Produce and review production image-generation and image-editing workflows with Amazon Nova Canvas on Amazon Bedrock, including native InvokeModel payloads, safe authentication, validation, retries, cost controls, provenance, and lifecycle migration checks. Use when a task names Nova Canvas, amazon.nova-canvas-v1:0, Bedrock image generation, Canvas inpainting/outpainting/background removal, image conditioning, color guidance, image variation, virtual try-on, or Canvas fine-tuning.

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Production guidance for assessing, exporting, packaging, integrating, capturing, validating, and handing off Lottie vector animations. Use for Bodymovin/Lottie JSON, dotLottie archives, renderer and player compatibility, fonts and glyphs, image assets, markers and segments, deterministic video capture, responsive sizing, optimization, accessibility, and cross-platform QA; not for general After Effects animation craft or live-action/video delivery.

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Deep behavioral audit of a Lattice skill — proposes 3 review personas relevant to the skill, runs independent scenario analysis from each persona's perspective, then merges only the high-confidence, practical findings into a severity-ordered gap report with proposed fixes. Structural validation (conventions, cross-references) is skill-validate's job — this skill finds gaps that would realistically surface when someone actually uses the skill: missing scenario handling, ambiguous instructions, silent failure cases, and behavioral inconsistencies. Filters out theoretical edge cases, low-likelihood speculation, and findings owned by other skills. Use after writing or significantly changing any skill, or when the user says 'review this skill', 'deep review', 'does this skill work', 'find gaps in this skill', 'stress test this skill', 'review from different angles', or 'skill review'. Standalone — does not call other skills.

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Full enhancement pipeline for an existing Lattice skill — rewrites a molecule or atom to modern-capable-model grade: restores degraded grammar, deduplicates, hardens gates and branching to one-unambiguous-action precision, verifies zero behavioral loss against a pre-capture diff, then runs the combined QA gate (skill-review, skill-tighten, skill-validate) and an independent fresh-context verifier, fixing everything found. Consumer-first: optimized for first-time open-source users on fresh repos with minimal .lattice/ setup, running capable models. Use when the user says 'enhance this skill', 'upgrade this molecule', 'modernize this skill', 'optimize this skill', 'make this skill production grade', 'full enhancement', 'polish this molecule like design-blueprint', or names a molecule/atom to overhaul. For gap-finding only use skill-review; for conventions only use skill-validate — this skill runs the whole loop end to end.

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Apply security-conscious thinking when generating or modifying code. Enforces trust boundary awareness, input validation, injection prevention, secrets management, and defense-in-depth authorization. Use when generating code that handles user input, authentication, authorization, database queries, external APIs, or file operations, or when the user mentions 'security review', 'secure this', 'check for vulnerabilities', 'trust boundary', 'input validation', or 'OWASP'. Loaded automatically by the code-generating molecules (code-forge, refactor-safely, bug-fix). This skill governs the security posture of generated code -- not architecture (see architecture) and not code craft (see clean-code).

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Enforce architectural rules when generating or modifying code, and validate proposed designs before approval (design mode). Defaults to clean architecture; supports any architecture style via the architecture-refiner. Validates layer responsibilities, dependency direction, and structural constraints using the loaded architecture rules. Use when generating code, reviewing architecture, creating new files, or when the user mentions 'architecture', 'layers', 'structure', 'dependency rules', 'hexagonal architecture', 'ports and adapters', 'modular monolith', or 'onion architecture'. Also use when reviewing generated code for structural compliance.

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Perform a structured code review by composing validation checklists from relevant atoms based on what code changed. Loads atoms conditionally -- clean-code always, architecture/DDD/security/tests only when the delta touches their domain. Produces a severity-ordered report with specific locations and fixes. Use when the user asks to 'review this', 'code review', 'quality check', 'validate the code', 'check my code', 'review the delta', or 'review this PR'.

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Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda window scheduling, soft-core potentials, REST2 enhanced sampling, MBAR/BAR analysis, and cycle closure validation. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.

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Maps GWAS-implicated loci to candidate effector (causal) genes by integrating variant-to-gene (V2G) features via Open Targets L2G (Mountjoy 2021), MAGMA gene-based association (de Leeuw 2015), FUMA SNP2GENE, cS2G combined SNP-to-gene scores (Gazal 2022), Polygenic Priority Scores (PoPS, Weeks 2023), FLAMES, INQUISIT, DEPICT, and enhancer-gene predictors (ABC, ENCODE-rE2G). Use when narrowing a GWAS lead locus to a candidate causal gene, picking between proximity, eQTL-based, and similarity-based prioritizers, integrating multi-evidence streams (fine-mapping, colocalization, ABC enhancer-gene, distance, chromatin), reconciling discordant L2G vs PoPS calls, prioritizing tissue-specific eQTL evidence, or triangulating across at least three independent lines of evidence for a publication-grade effector-gene nomination.

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Discover RBP binding motifs from CLIP-seq peaks or single-nucleotide crosslink sites using HOMER, MEME/STREME, kpLogo, mCross (CL-position-registered motifs), PEKA (positional k-mer enrichment), RBPamp (affinity), and RNA Bind-n-Seq (RBNS) cross-validation. Use when characterizing RBP sequence specificity, registering motifs to crosslink positions, validating in vivo CLIP motifs against in vitro RBNS Kd, reconciling motif disagreements across tools, or correcting for the uracil crosslinking bias that contaminates raw CLIP motif logos.

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End-to-end biomarker discovery workflow from expression data to validated biomarker panels. Covers feature selection with Boruta/LASSO, classifier training with nested CV, and SHAP interpretation. Use when building and validating diagnostic or prognostic biomarker signatures from omics data.

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Validate alignment quality with insert size distribution, proper pairing rates, GC bias, strand balance, and other post-alignment metrics. Use when verifying alignment data quality before variant calling or quantification.

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Protein design quality control, filtering thresholds, and ranking guidance. Use this skill when: (1) Evaluating design quality for binding, expression, or structure, (2) Setting filtering thresholds for pLDDT, ipTM, PAE, (3) Checking sequence liabilities (cysteines, deamidation, polybasic clusters), (4) Creating multi-stage filtering pipelines, (5) Computing PyRosetta interface metrics (dG, SC, dSASA), (6) Checking biophysical properties (instability, GRAVY, pI), (7) Ranking designs with composite scoring. This skill provides research-backed thresholds from binder design competitions and published benchmarks.

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Query OpenTargets for drug targets, disease associations, and therapeutic evidence. Use when user asks about drug targets, disease mechanisms, target validation, or drug-disease associations. Triggers on "opentarget", "drug target", "target validation", "disease association", "therapeutic target", "drug for disease".

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SPR and BLI assay planning, kinetic interpretation, and troubleshooting guidance. Use when: (1) Planning binding kinetics experiments, (2) Troubleshooting poor/no binding signal, (3) Interpreting kinetic data artifacts, (4) Choosing between SPR vs BLI platforms.

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End-to-end binder design using BindCraft hallucination. Use this skill when: (1) Designing protein binders with built-in AF2 validation, (2) Running production-quality binder campaigns, (3) Using different design protocols (fast, default, slow), (4) Need joint backbone and sequence optimization, (5) Want high experimental success rate. For backbone-only generation, use rfdiffusion. For QC thresholds, use protein-qc. For tool selection guidance, use binder-design.

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Guidance for choosing the right protein binder design tool. Use this skill when: (1) Deciding between BoltzGen, BindCraft, or RFdiffusion, (2) Planning a binder design campaign, (3) Understanding trade-offs between different approaches, (4) Selecting tools for specific target types. For specific tool parameters, use the individual tool skills (boltzgen, bindcraft, rfdiffusion, etc.).

日本語の概要は準備中です。原文の説明を表示しています。