「coo」の検索結果

Designs and orchestrates a realistic interview simulation platform with voice AI, whiteboard evaluation, gaze-tracking proctoring, and mobile spaced repetition. Use for building mock interview infrastructure, configuring sessions, and adaptive difficulty. Activate on "interview simulator", "mock interview", "practice session", "voice mock". NOT for individual round-type coaching, resume writing, or prep timeline coordination.

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Patterns for vibe coding that produce production-quality output instead of garbage. Covers prompt engineering for AI coding, verification without reading every line, accept/reject/refine decision framework, architectural guardrails, context management (CLAUDE.md, .cursor/rules), TDD-driven vibe coding, screenshot-driven development, diff review discipline, and the anti-patterns that destroy quality. Activate on: "vibe coding", "AI coding quality", "Claude Code workflow", "AI-assisted development", "how to use AI for coding", "coding with AI", "agentic engineering workflow", "AI code quality", "vibe code without garbage", "production quality AI code", "CLAUDE.md setup", "cursorrules setup", "pre-commit hooks for AI", "TDD with AI", "test-driven vibe coding". NOT for: multi-person collaborative coding sessions (use cooperative-vibe-coding), building AI/LLM applications (use ai-engineer), prompt engineering for non-coding LLM use cases (use prompt-engineer).

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Use when building APIs on Hono (Cloudflare Workers, Bun, Deno, Node), debugging route ordering, wiring middleware, validating with @hono/zod-validator, returning streaming responses, configuring CORS with credentials, handling errors via app.onError, or composing typed RPC clients. Triggers: c.env binding types, c.header + c.redirect interaction, missing await next() bugs, Set-Cookie not attaching to redirect, route-precedence surprises, JWT middleware setup, hono/client typed RPC end-to-end. NOT for Express/Fastify/Koa idioms, tRPC/GraphQL paradigms, or Next.js Route Handlers.

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Expert in Git workflows, conventions, and patterns for modern development teams and AI agents. Activate on: branching strategy, commit conventions, git hooks, pre-commit, husky, lint-staged, trunk-based development, git worktree, monorepo git, PR review workflow, conventional commits, git workflow. NOT for: CI/CD pipelines (use github-actions-pipeline-builder), repository hosting (use devops-automator), multi-agent orchestration (use multi-agent-coordination).

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Framework for coordinating meaning across autonomous agents that use different conceptual models, vocabularies, and knowledge representations. Treats ontologies as first-class negotiable resources rather than hardcoded implementation details.

日本語の概要は準備中です。原文の説明を表示しています。

Meta-skill that orchestrates the discourse skill suite: routes between steel-man-argument, socratic-questioning, toulmin-argument-analysis, logical-fallacy-detector, bad-faith-rhetoric-detector, discourse-elision-analyzer, forensic-speech-structure, and productive-discourse-facilitator. Use when analyzing conversations, facilitating discourse, or operating as a dialogue copilot. Maintains mode (silent analysis, coaching overlay, active facilitator) and decides which skills to invoke based on conversation dynamics.

日本語の概要は準備中です。原文の説明を表示しています。

Apply Conway's homomorphism principle to multi-agent system design, recognizing that agent coordination structure predetermines system architecture and capability.

日本語の概要は準備中です。原文の説明を表示しています。

The intelligence layer of WinDAGs. Decomposes natural language tasks into Hierarchical Task DAGs (HTDAGs), matches subtasks to skills, executes waves in parallel, and dynamically expands nodes when complexity exceeds executor capability. Use for 'orchestrate', 'execute DAG', 'parallel agents', 'decompose task', 'coordinate skills'. NOT for single-skill tasks or simple linear workflows.

日本語の概要は準備中です。原文の説明を表示しています。

Executes DAG waves with controlled parallelism using the Task tool. Manages concurrent agent spawning, resource limits, and execution coordination. Activate on 'execute dag', 'parallel execution', 'concurrent tasks', 'run workflow', 'spawn agents'. NOT for scheduling (use dag-task-scheduler) or building DAGs (use dag-graph-builder).

日本語の概要は準備中です。原文の説明を表示しています。

Use when designing or fixing a Content Security Policy on a real site, choosing between nonce-based and hash-based CSP, adding strict-dynamic, debugging "Refused to execute inline script" errors, deploying CSP in report-only mode first, configuring report-to / report-uri, or auditing an existing policy for unsafe-inline / unsafe-eval / wildcards. Triggers: "CSP blocks legitimate inline script", strict-dynamic, nonce-{RANDOM}, sha256-{HASH}, object-src none, base-uri none, frame-ancestors, Trusted Types, X-Content-Security-Policy obsolete, report-only vs enforced. NOT for general HTTP security headers (HSTS, COOP/COEP), Trusted Types deep dive, CORS configuration, or building a WAF.

日本語の概要は準備中です。原文の説明を表示しています。

Use when wrangler deploys silently fail or produce wrong artifacts, secrets upload as empty strings, custom domain DNS is not resolving, route assignment broke after rename, observability/tail logs are needed, D1/KV/R2 bindings are missing, OAuth scope errors block a command, cookies on a redirect are not attaching, or the worker exceeds CPU time. Triggers: "Tenant or user not found", "Authentication error" on wrangler d1 push, secret length is 0 after upload, route returns origin not worker, "compatibility_date too old", 1101 errors, custom_domain assignment lost on script rename. NOT for AWS Lambda / Vercel Edge / Deno Deploy (different runtimes), Cloudflare Zero Trust, or R2-specific tuning.

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Use for bounded reasoning, partial planning, commitment policy, deliberation cost, and reconsideration-threshold design instead of assuming free deliberation. NOT for exhaustive planning, static optimization, or domains where reconsideration cost is irrelevant.

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Data structures and serialization formats for agent-to-agent communication. Covers message envelopes, structured output schemas, capability declarations, task handoff payloads, error/retry signaling, and context windows as data structures. Deep comparison of A2A protocol, MCP, OpenAI function calling, and LangChain message types. Teaches when to use rigid schemas vs free-form with validation, typed vs untyped, streaming vs batch. Activate on: "agent message format", "agent communication schema", "agent-to-agent protocol", "A2A protocol", "MCP message format", "structured output for agents", "agent interop", "interchange format", "agent serialization", "task handoff format", "capability declaration". NOT for: what agents say to each other (use agent-conversation-protocols), orchestration topology (use multi-agent-coordination), building agent infrastructure (use agentic-infrastructure-2026).

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Extracts, filters, annotates, and exports differential expression results from DESeq2 or edgeR with proper handling of padj=NA (independent filtering, Cook's outliers, all-zero), multiple-testing correction choice (BH vs Storey q-value vs IHW vs lfsr), TREAT vs post-hoc fold-change filtering, p-value histogram diagnostics, gene annotation via org.db/biomaRt/mygene, GSEA preranked input, ORA background construction, replication reality (Schurch 2016 small-n result), and SABV/sex-stratified reporting. Use when extracting and interpreting DE results, troubleshooting padj=NA, choosing FDR method, preparing ranked lists for pathway analysis, annotating gene IDs, or comparing DESeq2 vs edgeR outputs.

日本語の概要は準備中です。原文の説明を表示しています。

Performs differential expression on bulk RNA-seq count data with DESeq2's negative-binomial GLM, Wald and LRT testing, apeglm/ashr/normal LFC shrinkage, independent filtering, Cook's outlier handling, VST/rlog transforms, and design formulas including paired, batch, and interaction terms. Use when running bulk DE, choosing DESeq2 over edgeR or limma-voom, building a paired or interaction design, applying LFC shrinkage for ranking or GSEA, choosing Wald vs LRT, troubleshooting padj=NA, picking VST vs rlog, importing salmon/kallisto via tximport, or analyzing prokaryotic RNA-seq.

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Trains and applies base-resolution deep learning models on ChIP-seq / ChIP-nexus / CUT&RUN data. Uses BPNet (Avsec 2021 Nat Genet 53:354; soft motif syntax from ChIP-nexus), chromBPNet (Pampari A et al 2024 bioRxiv; bias-factorized base-resolution profiles), EnFormer (Avsec 2021 Nat Methods 18:1196; 196 kb input, ~100 kb effective receptive field), DeepSEA (Zhou 2015; multi-task CNN), and JASPAR 2026 deep-learning collection (1259 BPNet ChIP models). Performs in silico mutagenesis for variant-effect prediction, DeepLIFT/Grad attribution, and TF-MoDISco motif discovery from attribution scores. Use when predicting variant effects on TF binding, discovering soft motif syntax / cooperativity, integrating ChIP-seq with sequence-only predictions, or applying precomputed JASPAR Deep Learning models to new variants.

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Decides how to preprocess plasma cfDNA sequencing data so the recoverable signal survives - library-prep-aware fragment expectations (dsDNA vs ssDNA/adaptase prep), UMI/duplex consensus with fgbio (ExtractUmisFromBam, GroupReadsByUmi --strategy paired for duplex, CallMolecularConsensusReads vs CallDuplexConsensusReads, FilterConsensusReads min-reads "total s1 s2"), the align->group->consensus->RE-align ordering, and the cfDNA dedup trap where naive coordinate dedup collapses nucleosome-coincident independent molecules. Covers when single-strand consensus suffices vs when duplex is mandatory, the singleton/sensitivity tax at low input, and reading the insert-size histogram as a pre-analytical QC instrument. Use when processing plasma cfDNA reads before fragmentomics, ctDNA mutation calling, or tumor-fraction estimation.

日本語の概要は準備中です。原文の説明を表示しています。

Build a differential-ready consensus peakset from per-replicate ATAC-seq peaks using iterative overlap removal, fixed-width re-centering, and majority-rule overlap. Use when generating a stable peak coordinate system for downstream differential accessibility, ML feature engineering, cross-sample comparison, or fixed-width peak counts; covers Corces 2018 iterative overlap (501 bp), DiffBind summit re-centering, and ENCODE consistency rules.

日本語の概要は準備中です。原文の説明を表示しています。

Align protein structures using Foldseek 3Di, TM-align, US-align, DALI, or Foldmason for structural MSA. Predict, score, and superpose backbone coordinates when sequence identity is below the twilight zone or remote-homology detection is required. Use when sequence MSA fails (<25% identity), when the dark proteome is the target, when AlphaFoldDB / ESM Atlas search is needed, or when structural superposition is the goal.

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Sort alignment files by coordinate or read name using samtools and pysam. Use when preparing BAM files for indexing, variant calling, or paired-end analysis.

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Autonomously improve a real artifact (code, training recipe, agent harness, data pipeline, prompt) against an objective and an evaluator, using Hypothesis Tree Refinement (HTR) from the Arbor paper. Use this whenever someone wants to iteratively optimize something over many experiments without overfitting — e.g. "get my model's eval score up", "improve this agent/harness", "tune this pipeline", "beat the baseline on this benchmark", "run a search over approaches and keep the best", "do an MLE-bench / Kaggle-style optimization", or any long-horizon "make this artifact better and don't just memorize the dev set" task. Trigger it even when the user doesn't say "Arbor" or "hypothesis tree" but describes repeated experiment-and-evaluate loops, branching exploration of competing ideas, or worries about a dev/test gap. Runs Claude itself as the coordinator with subagent executors in isolated git worktrees; for the standalone `arbor` CLI tool see references/arbor-upstream.md.

日本語の概要は準備中です。原文の説明を表示しています。

Master advanced AgentDB features including QUIC synchronization, multi-database management, custom distance metrics, hybrid search, and distributed systems integration. Use when building distributed AI systems, multi-agent coordination, or advanced vector search applications.

日本語の概要は準備中です。原文の説明を表示しています。

Core Python library for astronomy and astrophysics workflows that need Astropy APIs, including units/quantities, coordinates, FITS I/O, tables, time systems, WCS, and cosmology. Use when implementing or debugging astronomical data analysis code with Astropy.

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This skill recommends obtaining an oncology consultation to direct treatment of the underlying malignancy causing hypercalcemia of malignancy. It is triggered when a clinician diagnoses HCM and seeks guidance on coordinating cancer‑directed therapy.

日本語の概要は準備中です。原文の説明を表示しています。