「diff」の検索結果

Performs structure-based virtual screening using AutoDock Vina, SMINA, GNINA (CNN scoring), and DiffDock-L hybrid workflows with explicit choice rules across rigid vs flexible docking, cross-docking vs self-docking, binding-site detection (P2Rank, fpocket), receptor preparation (PDB2PQR, PROPKA), ligand preparation (meeko, OpenBabel), and ultralarge-library screening (ZINC22, Enamine REAL). Use when screening chemical libraries against a protein target to find candidate binders, ranking docking poses, or selecting a docking workflow for a specific scenario.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes CUT&RUN (Skene Henikoff 2017) and CUT&Tag (Kaya-Okur 2019) chromatin profiling data. Handles SEACR vs MACS2 peak calling (with the btaf375 2025 benchmark guidance), pA-MNase vs pA-Tn5 vs pAG-Tn5 chimera differences, E. coli spike-in carryover normalization, IgG-only control logic (no input), characteristic fragment-size signatures (25-75 bp for CUT&Tag), and lower depth requirements (5M reads typical vs 25M for ChIP). Use when calling peaks from CUT&RUN/CUT&Tag, scaling by E. coli spike-in carryover, choosing SEACR norm mode, or comparing CUT&RUN/Tag results to traditional ChIP.

日本語の概要は準備中です。原文の説明を表示しています。

Computes sample size and power for clinical trials including continuous, binary, and time-to-event endpoints; superiority, non-inferiority, and equivalence designs; FDA 2016 non-inferiority margin selection with M1/M2 framework; Schoenfeld 1981 and Lakatos 1988 for survival; Schuirmann TOST and 80-125% bioequivalence; minimum clinically important difference (MCID) vs δ distinction. Use when justifying trial size in protocol or SAP per CONSORT 2025 item 16a.

日本語の概要は準備中です。原文の説明を表示しています。

Call accessible chromatin regions from ATAC-seq BAM files using MACS3, MACS2, Genrich, or HMMRATAC. Use when identifying open chromatin from aligned ATAC-seq, choosing between point-source vs HMM peak callers, applying ENCODE-style pseudoreplicate IDR, removing blacklist regions, or fixing 501bp consensus peaks for downstream differential analysis.

日本語の概要は準備中です。原文の説明を表示しています。

Detect transcription factor binding footprints in ATAC-seq using TOBIAS, HINT-ATAC, Wellington, or scprinter. Use when identifying bound TF sites within accessible regions, correcting Tn5 insertion bias before footprinting, choosing between cleavage-based and aggregate-based footprinters, or comparing differential TF activity between conditions.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes alternative splicing from PacBio Iso-Seq (HiFi, Kinnex/MAS-Iso-seq) and Oxford Nanopore (direct cDNA, direct RNA, R10.4.1+) long-read RNA-seq with full-isoform resolution. Tools include FLAIR (correct/collapse/quantify/diffSplice for PacBio + ONT), IsoQuant (de-novo or annotation-guided isoform discovery 2024 SOTA), Bambu (annotation-aware Bayesian discovery + quantification with Novel Discovery Rate), SQANTI3 (isoform classification: FSM/ISM/NIC/NNC + artifact flags), rMATS-long (event calling on long-read isoforms), and minimap2 (-ax splice:hq for HiFi; -ax splice -k14 for ONT cDNA; add -uf only for direct RNA or stranded cDNA preps). Solves microexon detection, recursive splicing, complex multi-exon isoforms, and DTU without transcript-quantification uncertainty. Use when short-read AS limitations (anchor length, complex isoforms, microexons, recursive splicing, transcript ambiguity) demand full-isoform resolution.

日本語の概要は準備中です。原文の説明を表示しています。

Process and analyze single-cell ATAC-seq data with Signac, ArchR, SnapATAC2, or Cell Ranger ATAC. Use when handling 10X scATAC or 10X Multiome (paired RNA+ATAC) data, performing per-cell QC, choosing between ArchR/Signac/SnapATAC2 ecosystems, building per-cluster consensus peaksets, integrating with paired scRNA-seq, doublet detection (AMULET vs ArchR vs scDblFinder), or running pseudobulk differential accessibility per cluster.

日本語の概要は準備中です。原文の説明を表示しています。

Implement, review, or improve localization and internationalization in iOS/macOS apps — String Catalogs (.xcstrings), generated localizable symbols, stable key naming, LocalizedStringKey, LocalizedStringResource, pluralization, FormatStyle for numbers/dates/measurements, right-to-left layout, Dynamic Type, and locale-aware formatting. Use when adding multi-language support, setting up String Catalogs, enabling generated symbols for compile-time-safe localization keys, handling plural forms, formatting dates/numbers/currencies for different locales, testing localizations, or making UI work correctly in RTL languages like Arabic and Hebrew.

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This skill should be used when the user asks to "simplify", "clean up the diff", "run simplify", "simplify the changes", "review changed code for cleanup", explicitly invokes "/simplify", or asks to "commit without simplify", "skip simplify for this commit", or "commit this but skip simplify". Reviews changed code across reuse, simplification, efficiency, and altitude, or grants an explicit one-commit bypass. Not for correctness bugs.

日本語の概要は準備中です。原文の説明を表示しています。

Deploys and operates a LiveKit agent in production: shipping a version to LiveKit Cloud and rolling it back, secrets and configuration, the worker process model and prewarming, safe async inside worker processes, provider timeouts and degradation, graceful shutdown, SDK upgrades, and observability. Use when the user says "deploy my agent", "roll back the deployment", "tail the agent logs", "the first call after a restart is slow", "attached to a different loop / event loop is closed", "prewarm the VAD", "shut down without dropping calls", "upgrade livekit-agents safely", "correlate logs by session", or is changing an agent codebase that is already live. Not for designing the agent (building-livekit-agents) or reproducing one bad conversation locally (debugging-livekit-agents).

日本語の概要は準備中です。原文の説明を表示しています。

Optimize RF PCB dimensions for bandwidth, return loss, or area via patternsearch and surrogateopt with constraints. TRIGGER: user asks to optimize an RF PCB component for performance (bandwidth, return loss, insertion loss, area) or apply constraints to a design. Invoke BEFORE writing optimization code — RF PCB Toolbox has a built-in optimize() function that differs from generic fmincon/ga approaches. SKIP: designing a component from scratch without an optimization objective (use the specific matlab-design-pcb-* skill), EM analysis without optimization (use matlab-analyze-em), material/stackup setup only (use matlab-manage-pcb-material).

日本語の概要は準備中です。原文の説明を表示しています。

Via modeling: pads, antipads, ground return vias, GRV placement, and signal integrity for high-speed layer transitions. TRIGGER: user asks to model a via, design a via transition, place ground return vias, analyze via performance, or check signal integrity through layer transitions. Invoke BEFORE writing code — only viaSingleEnded exists (no viaDifferential), and the location format is non-obvious. SKIP: general signal integrity without vias (use matlab-analyze-em), transmission line design (use matlab-design-pcb-transmission-line), PDN analysis (use matlab-analyze-pcb-pdn), material/stackup setup only (use matlab-manage-pcb-material).

日本語の概要は準備中です。原文の説明を表示しています。

Dielectric substrates, metal conductors, multi-layer stackups, and loss models (FR4, Rogers, Teflon) for RF PCB simulation. TRIGGER: user asks to set up a substrate, define dielectric properties, create a stackup, select a PCB material (FR4, Rogers, Teflon, etc.), or configure metal conductors. Invoke BEFORE writing dielectric() or metal() code — the API for named vs custom materials differs significantly. SKIP: PCB layout assembly (use matlab-assemble-pcb-layout), transmission line design (use matlab-design-pcb-transmission-line), EM analysis (use matlab-analyze-em), importing a PCB file (use matlab-read-pcb-layout).

日本語の概要は準備中です。原文の説明を表示しています。

Bandpass, lowpass, bandstop filter design — hairpin, coupled-line, combline, stub, SIW for frequency selection and harmonic rejection. TRIGGER: user asks to design, create, or analyze any RF filter (bandpass, lowpass, highpass, bandstop, hairpin, coupled-line, combline, stub, SIW). Invoke BEFORE writing code — filter class names differ from what you would guess. SKIP: EM simulation/S-parameter extraction of an existing filter (use matlab-analyze-em), general PCB layout assembly (use matlab-assemble-pcb-layout), material/stackup setup only (use matlab-manage-pcb-material), optimization sweeps (use matlab-optimize-pcb-design).

日本語の概要は準備中です。原文の説明を表示しています。

Competitor research — pricing comparison, bestseller analysis, differentiation strategy

日本語の概要は準備中です。原文の説明を表示しています。

Multi-shop management — category separation, brand differentiation, efficiency optimization

日本語の概要は準備中です。原文の説明を表示しています。

Read-only drift detector. Diffs SPEC.md against current code and reports violations grouped by severity. Writes nothing — suggests remedies via the spec or build skills but never invokes them. Triggers when the user asks to check drift, audit the spec, verify invariants, or ask whether code still matches the spec. Phrasings: "check drift", "audit the spec", "does the code still match §V", "check invariants", "spec vs code".

日本語の概要は準備中です。原文の説明を表示しています。

Pull latest agent harness improvements from the remote kit repository. Shows a dry-run diff summary, waits for confirmation, then applies updates.

日本語の概要は準備中です。原文の説明を表示しています。

Use when publishing harness improvements to the remote kit repo. Diffs managed files, shows what changed, bumps version, and pushes. Counterpart to vc-update (pull).

日本語の概要は準備中です。原文の説明を表示しています。

Rename a page safely: update the file, fix every inbound wikilink, add the old name as an alias, and log it. Use this skill whenever a page needs a different canonical title, the user says "rename X to Y", asks to fix an inconsistent title, or after a lint run flags naming problems. Do NOT use for merging two pages, for moving a page between folders without a name change, or for renaming files outside the wiki.

日本語の概要は準備中です。原文の説明を表示しています。

Trace where the user's recorded position on something has shifted: superseded claims, contradictions between sources of different dates, and what evidence moved them. Use this skill when the user asks what they have changed their mind about, how their thinking on a topic developed, what they used to believe, or wants a quarterly look back at their own positions. Do NOT use for finding contradictions between sources with no time dimension, or for a current-state answer.

日本語の概要は準備中です。原文の説明を表示しています。

Discover profitable business ideas from scratch. Analyzes market gaps, trending niches, user skills, and competitive landscapes with a competitive intelligence protocol including 4-filter benchmark stress test and Blue Ocean differentiation grid. Use when the user has no idea what to build, wants to explore opportunities, needs market research, competitive benchmarking, or says 'find me a business idea', 'what should I build', 'market research', 'find opportunities', or 'competitive analysis'.

日本語の概要は準備中です。原文の説明を表示しています。

Manage project learnings — small, atomic, validated patterns that the agent should remember across all skills and sessions. Different from /money-save (which captures full session state); learnings are individual insights that get auto-loaded into every other money-* skill's context. Use when the user has just discovered something worth remembering — a customer pattern, a pricing insight, a channel that works, a failure mode. Triggered by: 'remember this', 'log a learning', 'this is a pattern', 'show learnings', 'what have we learned', '记住这个', '存入经验', '查看经验库'.

日本語の概要は準備中です。原文の説明を表示しています。

Use for focused review of a Neva pull request, branch, diff, or patch.

日本語の概要は準備中です。原文の説明を表示しています。