「spr」の検索結果

Collage as a web design aesthetic — overlapping elements, mixed media, cut-out shapes, scrapbook layouts, and editorial magazine spreads adapted for the web. CSS techniques for layered compositions using z-index stacking, clip-path, mix-blend-mode, parallax layering, and grid-breaking layouts. Activate on 'collage web', 'editorial layout', 'magazine layout', 'overlapping elements', 'scrapbook', 'cut-out aesthetic', 'mixed media web', 'layered composition', 'grid-breaking', 'editorial web design', 'fashion website layout', 'David Carson'. NOT for photo collage/gallery grids (use collage-layout-expert), maximalist density (use maximalist-web-design), neobrutalism (use neobrutalist-web-designer).

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Corrects fluorophore spillover (conventional compensation) or spectral overlap (spectral unmixing) and applies variance-stabilizing transforms (logicle/biexponential, arcsinh, log) for flow and mass cytometry. Covers spillover-matrix estimation from single-stain controls, AutoSpill, the spillover spreading matrix and why panel design (not compensation) bounds resolution, compensate-then-transform ordering, and arcsinh cofactor choice (5 for CyTOF, ~150 for fluorescence, per-channel via flowVS). Use when correcting spectral overlap, preparing data for gating/clustering, choosing logicle vs arcsinh, deciding a cofactor, or distinguishing compensation from spectral unmixing.

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Build sequence logos from aligned DNA, RNA, or protein motifs using ggseqlogo (R), Logomaker (Python), or WebLogo with explicit bits vs probability encoding, background-frequency correction, custom alphabets, and multi-logo stacking. Use when visualizing motif PWMs (TF binding, splice sites, CRISPR spacers), aligned-position composition, or comparing two motif sets.

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Retrieve records from NCBI databases using Biopython Bio.Entrez (EFetch, ESummary). Use when downloading sequences, fetching GenBank/GenPept records, getting document summaries, parsing nested XML, navigating GI deprecation, choosing between rettype+retmode combinations, and parsing into Biopython SeqRecord/SwissProt objects. Covers nucleotide, protein, gene, pubmed, sra, gds, taxonomy, snp, clinvar.

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Detect introgression and admixture between species or populations using Dsuite (Malinsky 2021 fast D-statistics), Patterson's D / ABBA-BABA test (Green 2010; Durand 2011), f4-ratio and f-branch statistic (Malinsky 2018), TreeMix (Pickrell & Pritchard 2012), HyDe (Blischak 2018), QuIBL (Edelman 2019), sprime (Browning 2018), Twisst (Martin 2017), PhyloNet (Than 2008) for explicit phylogenetic networks, and qpAdm / qpGraph (Patterson 2012). Distinguish introgression from incomplete lineage sorting (ILS), ancestral structure, ghost-lineage admixture, and rate variation. Use when testing inter-species gene flow, dating admixture events, identifying introgressed segments, building phylogenetic networks for reticulate evolution, or applying the ABBAclustering (Koppetsch-Malinsky-Matschiner 2024) framework for divergent-species gene flow.

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Run remote BLAST searches against NCBI servers using Biopython Bio.Blast.NCBIWWW. Use when identifying unknown sequences, finding homologs, picking the correct BLAST program (blastn/blastp/blastx/tblastn/tblastx/psiblast/megablast/dc-megablast), interpreting Karlin-Altschul E-values, avoiding the max_target_seqs trap (Shah 2019), choosing composition-based statistics, or limiting searches by organism. Covers RID lifecycle, database choice (nt/nr/refseq_select/swissprot), word-size and CBS taxonomy.

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Predict enhancer-gene regulatory connections from ATAC-seq using ABC, ENCODE-rE2G, HiChIP, or Cicero. Use when linking distal enhancers to target genes, choosing between contact-aware (ABC, ENCODE-rE2G), accessibility-only (Cicero), and orthogonal (HiChIP H3K27ac, EpiMap) approaches, validating predictions against CRISPRi-FlowFISH gold-standard, or building cell-type-specific regulatory maps for fine-mapping or therapeutic target discovery.

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How to use the Adaptyv Bio Foundry API and Python SDK for protein experiment design, submission, and results retrieval. Use this skill whenever the user mentions Adaptyv, Foundry API, protein binding assays, protein screening experiments, BLI/SPR assays, thermostability assays, or wants to submit protein sequences for experimental characterization. Also trigger when code imports `adaptyv`, `adaptyv_sdk`, or `FoundryClient`, or references `foundry-api-public.adaptyvbio.com`.

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Recommends spironolactone as first-line mineralocorticoid receptor antagonist for initial medical therapy of primary aldosteronism due to low cost and widespread availability. Use when a clinician queries which MRA to start for a patient with PA requiring medical therapy.

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Run an org-team workflow — a flat pod of up to four peer Claude Code sessions claims lane-tagged slices of an approved spec over the baseline MCP channel and implements them concurrently, each in its own git worktree. Each peer DECIDES its own in-lane implementation choices in its own main context (Article X); only un-decidable or cross-lane forks escalate peer→lead→human (yield_fork for task-bound forks, ask_lead for free-form queries). Opt-in and OFF by default (velocity.org_mode.enabled). Graduates the retired sprint-dispatch prototype into the constitutionally-sanctioned org-team model (Article X — Multi-session coordinated workflows). Requires git.

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Power batch-sprint helper — hosts the two behaviours that distinguish the `power` workflow track from spec-entry. (1) Per-ticket iteration: security runs once PER TICKET over workflow.json.tickets[] while the mechanical phases run once for the batch. (2) Commit split: at the commit phase, group the batch's working tree into ordered Conventional Commits via commit-split.mjs, closure last. Invoked within a `power`-track workflow; not a standalone feature. Opt-in via velocity.power_mode.enabled; requires git.

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Claude Code（.claude）と Codex（.codex / .agents / AGENTS.md）に分裂したエージェント設定を、 実ファイル1つ + symlink と双方向変換で単一化・同期するスキル。 実ファイルをどちら側に置くか（symlink の向き）は共通設定 source で選べる。 プロジェクト単位の導入ウィザード、既に分裂しているリポジトリを危険度の低い順に解決する手順、 片方しか無いリポジトリへもう片方を生成する scaffold、書き換え前のバックアップと復元、常駐の管理を含む。 「エージェント設定を同期して」「.codex と .claude がずれている」「Codex でも同じスキルを使いたい」 「AGENTS.md と CLAUDE.md を一本化したい」「MCP を Codex でも使えるようにして」 「サブエージェントを Codex 側にも作って」「設定の分裂を解消して」「元に戻して」 「agents-sync」「同期デーモン」などと言われたら使う。 Keywords: agents-sync, エージェント設定同期, .claude, .codex, .agents, AGENTS.md, symlink 統合, symlink の向き, 実ファイルを置く側, 双方向同期, scaffold, 分裂解消, MCP 同期, hooks 同期, サブエージェント同期, バックアップ, 復元, fswatch, launchd, 常駐デーモン

2D game development principles. Sprites, tilemaps, physics, camera.

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Use for design thinking, or when a product or service problem needs user understanding before solutions: "what do users really need?", "how might we...", "plan a discovery sprint", "validate this concept". Skip when the spec is frozen or the task is code maintenance.

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Generate production-ready manga pages, chapter pages, covers, and panel sequences with strict recurring-character consistency. Use this when the user asks for a manga page, manga scene, chapter page, comic page, storyboard page, or character-consistent page generation. Before generating any page, inspect `img-memory`, create missing character sprites/reference sheets, make those images visible to image generation, then generate the final manga page.

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Expert-level genetics covering Mendelian inheritance, molecular genetics, mutations, linkage analysis, population genetics, epigenetics, and GWAS. Covers classical and modern approaches from Mendel to CRISPR.

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Retrieve current documentation, API references, and code examples for any library, framework, SDK, CLI tool, or cloud service — including well-known ones like React, Next.js, Prisma, Django, or Spring Boot. Use for API syntax, configuration options, version migrations, setup instructions, and library-specific debugging, even when you already think you know the answer: training data on API details and signatures is frequently outdated. Prefer this over web search for library documentation.

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Pushes interfaces past conventional limits with technically ambitious implementations — shaders, spring physics, scroll-driven reveals, 60fps animations. Use when the user wants to wow, impress, go all-out, or make something that feels extraordinary.

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Execute story implementation following a context filled story spec file. Use when the user says "dev this story [story file]" or "implement the next story in the sprint plan"

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Scrum master for sprint planning and story preparation. Use when the user asks to talk to Bob or requests the scrum master.

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Build React animations with Motion (Framer Motion) - gestures (drag, hover, tap), scroll effects, spring physics, layout animations, SVG. Bundle: 2.3 KB (mini) to 34 KB (full). Use when: drag-and-drop, scroll animations, modals, carousels, parallax. Troubleshoot: AnimatePresence exit, list performance, Tailwind conflicts, Next.js "use client".

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Generate or edit raster images when the task benefits from AI-created bitmap visuals such as photos, illustrations, textures, sprites, mockups, or transparent-background cutouts. Use when Codex should create a brand-new image, transform an existing image, or derive visual variants from references, and the output should be a bitmap asset rather than repo-native code or vector. Do not use when the task is better handled by editing existing SVG/vector/code-native assets, extending an established icon or logo system, or building the visual directly in HTML/CSS/canvas.

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Generate architecture and design documents for implemented code changes with risk-based depth selection. Automatically evaluates risk signals, layer spread, and change magnitude to choose documentation level (A/B/C). Use after completing a feature, before merging a PR that touches multiple layers or sensitive areas (auth, infra, migrations, payments), or when an implemented change needs a design record or ADR.

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Use when picking a mobile E2E framework — Detox / Appium / Maestro / XCUITest / Espresso — or planning iOS Simulator / Android Emulator coverage in CI for RN, Expo, or native apps.

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