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概要と使いどころ
Think and work like an expert Cell Signaling Biologist. Use when a task calls for Cell Signaling Biologist judgment. Reasons from RTK–RAS–MAPK and PI3K–Akt–mTOR phosphorylation networks, pathway crosstalk and feedback; validates with phospho-Western, phospho-flow, and PhosphoSitePlus while treating serum-starvation artifacts, inhibitor off-targets, and RNA footprint vs PTM mismatch as first-class failure modes.
日本語の概要は準備中です。原文の説明を表示しています。
Think and work like an expert Automotive Engineer. Use when a task calls for Automotive Engineer judgment. Reasons from vehicle-level requirements, regulatory limits, energy/exergy budgets, and distribution-based durability through DFMEA/DVP&R, DoE calibration (INCA, CANape, HIL), Pacejka tire and multibody models, rainflow fatigue, and source-path NVH analysis while treating undocumented build-level and cal-ID deltas, unmet emissions preconditioning and OBD readiness, ADAS sensor misalignment, and cross-domain torque-arbitration conflicts as first-class failure modes.
日本語の概要は準備中です。原文の説明を表示しています。
Think and work like an expert Bacteriologist. Use when a task calls for Bacteriologist judgment. Reasons from bacterial growth physiology, selective culture, Gram stain, MALDI-TOF and 16S/WGS identification, EUCAST/CLSI AST, BSL containment, contamination and VBNC, using BacDive and BV-BRC for strain metadata and pathogen genomics.
日本語の概要は準備中です。原文の説明を表示しています。
The order of operations for an Active Directory penetration test: setup, collection, exploitation, post-processing. Use this whenever you are planning or driving an AD assessment and need to know what to run before what and why (map before you exploit; harvest easy credentials before spraying to avoid lockouts; collect the graph before you reason about paths). Covers phase sequencing with standard tooling: netexec/nxc, impacket, certipy, bloodyAD, kerbrute, BloodHound CE. Invoke it at the start of an engagement, when deciding the next phase, or when a step feels out of order.
日本語の概要は準備中です。原文の説明を表示しています。
Abusing Active Directory object ACLs (DACL/ownership) for privilege escalation and lateral movement (GenericAll, GenericWrite, WriteDACL, WriteOwner, AddMember, ForceChangePassword, and replication rights via DS-Replication-Get-Changes-All). Use when BloodHound CE shows an outbound control edge from a principal you own toward a higher-value object, and you want the exact bloodyAD/impacket command to weaponize that ACE, plus detection and remediation. DCSync is covered here strictly as a post-compromise technique, not a user entry path.
日本語の概要は準備中です。原文の説明を表示しています。
Adversarial verification of research theses — cross-run/cross-thesis contradiction via the entity index, pre-mortem (Klarman/Kahneman: assume the loss already happened, reverse the path), inversion (Munger: invert, always invert), and wrong_if falsifiability review. ≈50-finding cap sorted by severity; content-derived finding IDs; incremental scoping with three backstops; lifecycle hooks at pillar-complete / thesis-complete / pre-reduction.
日本語の概要は準備中です。原文の説明を表示しています。
Vaccine pipeline analysis: immunogenicity and seroconversion studies, lot-consistency trials, healthy-population efficacy designs, and age-cohort bridging, with the ACIP gate built into the value path across the med universe.
日本語の概要は準備中です。原文の説明を表示しています。
Vaccine catalyst analysis across the two-gate path: CBER BLA review and the ACIP recommendation gate that turns FDA approval into commercial availability. Lot release, procurement milestones, pediatric bridging, and healthy-population efficacy context — dated, verified, and sized per event.
日本語の概要は準備中です。原文の説明を表示しています。
Production guidance for authoring, integrating, and reviewing GSAP animation in browser-rendered media. Use for deterministic kinetic typography, SVG drawing and morphing, motion paths, FLIP transitions, responsive motion systems, or frame-seekable GSAP timelines inside HTML video composition and React-based renderers; not for ordinary CSS transitions or generic frontend development.
日本語の概要は準備中です。原文の説明を表示しています。
Visualize enrichment results using enrichplot package functions. Use when creating publication-quality figures from clusterProfiler results. Covers dotplot, barplot, cnetplot, emapplot, gseaplot2, ridgeplot, and treeplot.
日本語の概要は準備中です。原文の説明を表示しています。
Designs and analyzes combinatorial CRISPR screens covering paired-Cas9 (Big Papi, Najm 2018), enhanced AsCas12a multiplex (enCas12a, DeWeirdt 2021), in4mer 4-guide-array Cas12a (Esmaeili Anvar N et al 2024 Nat Commun 15:3577) and the Inzolia paralog-pair library, paralog-buffering detection (Dede 2020 Genome Biol; Thompson 2021 Cell Reports 36:109597), genetic-interaction (GI) scoring as observed_double_LFC minus expected_additive_double_LFC, synthetic-lethal and synthetic-rescue interaction interpretation, the half-of-essentiality buffered by paralogs phenomenon, multiplex screen statistical analysis with MAGeCK MLE interaction terms, and the relationship to single-cell combinatorial Perturb-seq. Use when designing a paralog or pathway-pair screen, choosing between paired-Cas9 (Big Papi) and Cas12a multiplex (Inzolia), interpreting genetic interaction scores, identifying synthetic-lethal targets for drug development, or scaling beyond single-gene CRISPR screens.
日本語の概要は準備中です。原文の説明を表示しています。
Queries ClinVar for variant pathogenicity classifications, ClinGen VCEP curations, and somatic-vs-germline interpretations via REST API, weekly VCF, or bulk XML. Use when determining clinical significance, triangulating conflicting interpretations, or aggregating evidence against the ACMG/AMP framework with ClinGen SVI specifications.
日本語の概要は準備中です。原文の説明を表示しています。
Clinical variant interpretation using ClinVar, ACMG guidelines, and pathogenicity predictors. Prioritize variants for diagnostic and research applications. Use when interpreting clinical significance of variants.
日本語の概要は準備中です。原文の説明を表示しています。
Applies ACMG/AMP 2015 framework with ClinGen SVI specifications, Tavtigian 2018/2020 Bayesian point system, Abou Tayoun 2018 PVS1 decision tree, Pejaver 2022 calibrated PP3/BP4 thresholds for REVEL/BayesDel/AlphaMissense, Brnich 2020 PS3/BS3 OddsPath, Walker 2023 SpliceAI splicing framework, and AMP/ASCO/CAP 2017 tumor tiers. Use when classifying germline variants P / LP / VUS / LB / B, applying VCEP-specific CSpec rules, computing Whiffin BS1, or assigning cancer Tier I-IV per Li 2017.
日本語の概要は準備中です。原文の説明を表示しています。
Workflow for untargeted or targeted metabolomics including preprocessing, normalization, annotation, statistics, and pathway mapping.
日本語の概要は準備中です。原文の説明を表示しています。
Guide human-centered design processes using empathy-driven methodologies. Use when the user says "lets run design thinking" or "I want to apply design thinking"
日本語の概要は準備中です。原文の説明を表示しています。
Apply the bundled self-contained Godot WeChat Mini Game adapter kit to an official Godot checkout. Use when the user wants to port official Godot to WeChat Mini Game, refresh a nearby 4.6-based port, or inspect the shipped patch/source bundle for WXMEMFS, `wx.request`, audio cleanup, display/input, WXGLX dual-path rendering, `.wasm.br`, and `wx.exitMiniProgram`. This skill is version-locked to the bundled upstream base and must not be described as a generic “Godot 4.x” patch dump.
日本語の概要は準備中です。原文の説明を表示しています。
Use when adding or modifying generator scripts that write files; keeps generated artifacts out of docs/ and aligns script defaults with ownership paths plus CI gate updates.
日本語の概要は準備中です。原文の説明を表示しています。
Use when changing REPL clear/reset/resume/surface behavior (onClearTerminal, transcriptSeq remount, Ink Static paths, Ctrl+O/Ctrl+E transitions). Enforces single-owner reset transaction and prevents black-screen/flicker/duplicate-row regressions.
日本語の概要は準備中です。原文の説明を表示しています。
Read incoming retalk messages from this session's user's DESIGNATED sender(s) — one-shot, or as a background --follow reader that surfaces new messages in the session as they arrive (on your next turn). agent-talk only ever receives from specific saved peers, never the whole mailbox (safety). `<user>` is this session's user directory (absolute path; from init). Always renders the conversation (sent + received) as a beautiful chat transcript so the user can track it. Use to check mail or stay reachable.
日本語の概要は準備中です。原文の説明を表示しています。
Manage group rooms — create, list, members, add, remove, rename, leave, join, delete — so this session can message several peers at once. A group is a local roster of saved peers; sending to it delivers a private copy to each member. Use to set up or adjust a room, then send to it with the send skill (`send --group NAME`). `<user>` is this session's user directory (absolute path; from init).
日本語の概要は準備中です。原文の説明を表示しています。
Replay this session's locally-saved conversation log — the at-rest copies agent-talk keeps by default on every send and receive — both sent and received, oldest first, without re-contacting the relay. Use to review the conversation with a peer. `<user>` is this session's user directory (absolute path; from init).
日本語の概要は準備中です。原文の説明を表示しています。
Save a contact someone shared with you (a Contact card) as a local peer. agent-talk does NOT auto-import — review staged cards and import only ones from a peer you trust. `<user>` is this session's user directory (absolute path; from init).
日本語の概要は準備中です。原文の説明を表示しています。
Send a saved contact (as a Contact card) to a recipient over the relay — introduce one peer to another, nickname and all, instead of making them retype a 32-hex fingerprint. `<user>` is this session's user directory (absolute path; from init).
日本語の概要は準備中です。原文の説明を表示しています。