「cer」の検索結果

Use when a task needs the judgment of an Administrative Law Judge, Adjudicator, or Hearing Officer — applying a mandatory sequential/structured evaluation framework in required order, weighing conflicting medical or vocational opinion evidence using specific regulatory factors, writing findings that explicitly address significant contrary evidence in the record, drafting a credibility/consistency finding tied to specific record citations, or checking whether a draft decision would survive substantial-evidence review.

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Use when a task needs the judgment of a board-certified anesthesiologist — building a preoperative anesthesia plan and risk stratification, choosing general vs. regional technique and airway strategy, managing an intraoperative crisis (difficult airway, malignant hyperthermia, local anesthetic systemic toxicity), or writing a PACU handoff and postoperative pain-management order set.

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Use when a task needs the judgment of an Adhesive Bonding Machine Operator — distinguishing an open-time violation from a pot-life check, controlling bond line thickness with calibrated spacers rather than clamping pressure alone, verifying surface prep with a test rather than visual cleanliness, or confirming actual part temperature reached full cure rather than trusting chamber setpoint and elapsed time.

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Use when a task needs the judgment of a Certified Anesthesiologist Assistant (CAA) working inside an Anesthesia Care Team — building and executing an intraoperative anesthetic plan under a directing anesthesiologist, reading a vital-sign trend for anesthesia-specific emergencies (malignant hyperthermia, local anesthetic systemic toxicity, awareness), deciding when a deviation is an immediate-escalation trigger versus an independently correctable event, or navigating the jurisdiction/concurrency limits of CAA practice.

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Use when a task needs the judgment of a certificated aircraft mechanic — triaging a maintenance discrepancy, deciding whether an item can be MEL-deferred or grounds the aircraft, working out an Airworthiness Directive's compliance deadline, reviewing a torque/safety-wire job before sign-off, or writing a return-to-service log entry.

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Use when a task needs the judgment of an Aircraft Cargo Handling Supervisor — verifying a built ULD against its type's certified max gross weight before it's spotted for loading, running a hazmat item through the segregation table against its actual compartment neighbors, reconciling an actual cargo build against the dispatcher's load plan and deciding whether it clears a last-minute-change threshold or needs a reissued loadsheet, calling a ULD's lock/net restraint good or rejecting it, or running ramp FOD and ground-equipment clearance discipline around an aircraft during turn.

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Use when a task needs the judgment of an Aerospace Engineering and Operations Technologist/Technician — verifying an installed fastener's preload against a drawing's torque callout via the T=K·D·F relationship, reducing strain-gauge data from a structural proof-load test into stress and checking it against an FEA-predicted margin, selecting and executing an NDI method against a defect type and material, reducing a wind-tunnel test point's dynamic-pressure and Reynolds-number data, or ballooning and dispositioning an AS9102 first article inspection. Distinct from an aerospace-engineer (owns the design, structural analysis, and certification basis) — this role builds, instruments, tests, and inspects the hardware the engineer specified, closing the loop with measurement rather than deriving a new analysis.

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Annotate genetic variants (GWAS hits, eQTLs, rare variants) with ENCODE functional data to interpret non-coding variation. Use when the user has variants of interest and wants to understand their regulatory context, identify causal variants from GWAS loci, assess variant impact on regulatory elements, perform enrichment testing of variant sets in tissue-specific annotations, or link variants to target genes through enhancer-gene maps. Handles the full post-GWAS workflow from variant set → tissue mapping → functional annotation → fine-mapping awareness → enrichment → variant-to-gene → prioritization. Use this skill for ANY variant interpretation task involving ENCODE chromatin, accessibility, TF binding, or 3D genome data.

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Use ENCODE functional genomics data for disease mechanism research. Use when the user wants to connect GWAS variants to regulatory elements, annotate disease-associated loci with functional data, identify therapeutic targets from epigenomic data, build disease regulatory models, cross-reference with clinical trials and drug databases, or conduct any disease-focused, pathology-driven, or clinical variant interpretation workflow. Covers the full pipeline from disease-tissue mapping through GWAS variant annotation, heritability enrichment, cancer epigenomics, drug target identification, and clinical trial cross-referencing. Integrates ENCODE with Open Targets, PubMed, ClinicalTrials.gov, and bioRxiv.

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Plan and execute integrative analysis combining multiple ENCODE experiments for cross-dataset or multi-omic workflows. Use when the user wants to combine experiments, perform cross-dataset comparison, multi-omic integration, peak overlap analysis, differential binding, signal correlation, chromatin state segmentation, enhancer-gene linkage, or any analysis that requires merging or comparing data from two or more ENCODE experiments. Covers same-assay cross-sample, multi-omic same-sample, cross-organism, and perturbation integration designs. Guides compatibility checks, batch effect detection, normalization, integration strategy selection, and provenance documentation.

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Execute ENCODE Hi-C pipeline from FASTQ to contact matrices and loop calls. Child of pipeline-guide. Provides Nextflow execution with Docker and cloud deployment. Use when processing Hi-C data, generating contact matrices, or calling loops. Trigger on: Hi-C pipeline, chromatin conformation, contact matrix, loop calling, TAD detection, Juicer, HiCCUPS, 3D genome.

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Assess the scientific integrity and trustworthiness of publications before relying on their findings. Use this skill whenever evaluating a paper for a workflow, citing a study, building an analysis on published methods, or when a user asks about the reliability of a study. Checks for formal retractions, corrections, expressions of concern, and — critically — informal contradictions where subsequent studies failed to reproduce key findings. Integrates with PubMed, bioRxiv, and Consensus to provide a trust assessment. Use this skill for ANY publication evaluation, retraction checking, author reliability assessment, or when a user says "can I trust this paper", "is this study reliable", "has this been refuted", or "check this publication".

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Find and work with ENCODE single-cell genomics data including scRNA-seq and scATAC-seq. Use when the user asks about single-cell experiments, cell type resolution, clustering from ENCODE data, deconvolution of bulk signals using single-cell references, or comparing single-cell vs bulk profiles. Covers platform differences (10X Chromium, Smart-seq2, Drop-seq), quality limitations of single-cell data, multimodal integration (RNA+ATAC), and cross-study reproducibility concerns. Also use for cell type annotation, gene detection limits, dropout artifacts, and single-cell data structure in ENCODE.

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Build comprehensive epigenomic profiles for tissues or cell types using ENCODE data. Use when the user wants to characterize chromatin states, assemble histone modification panels, create epigenomic landscapes, run ChromHMM segmentation, identify super-enhancers or bivalent domains, profile regulatory elements across a biosample, or understand epigenetic regulation in a specific biological context. Covers histone marks, chromatin accessibility, TF binding, transcription, DNA methylation, and 3D genome structure.

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Analyze server log files for crawl budget insights. Reads Apache Combined/Common or Nginx access logs locally (no external calls). Classifies bot vs user traffic, identifies top crawled URLs, crawl frequency by path, and crawl budget concerns. Use when user says "log analysis", "crawl budget", "server logs", "bot traffic", "crawl frequency", "access log", "analyze logs".

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Audit an existing Lamport-style hierarchical mathematical proof forward for validity and whether its hierarchy, scope, dependencies, side conditions, and proof constructs discharge the stated theorem. Use when the central question concerns a top-down proof with numbered levels, subproofs, ASSUME/PROVE, SUFFICES, PICK, CASE, DEFINE, Q.E.D., or prose equivalents. For an ordinary proof that first needs source-preserving hierarchy, use convert-lamport; for conclusion-first AND/OR obligation reconstruction, use reverse-lamport. Do not use to generate or replace a proof, or to audit Lean, Coq, Isabelle, or other proof-assistant source.

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Convert an existing prose, flat, or loosely organized mathematical proof into a source-mapped Lamport-style hierarchy without repairing or completing its mathematics. Use when a submitted proof needs a traceable hierarchical rendering before a forward Lamport audit or for clearer presentation. Do not use to invent a proof, certify validity, or restructure an already hierarchical proof merely to audit it.

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Guideline for designing, implementing, and verifying secure APIs following OWASP API Security Top 10 (2023) best practices. Use when the user wants to: (1) review API code or design for security vulnerabilities, (2) design a secure REST, GraphQL, or gRPC API architecture, (3) implement API authentication and authorization (OAuth2, JWT, API keys, mTLS), (4) configure rate limiting, input validation, or CORS, (5) audit API endpoints for BOLA, BFLA, or mass assignment vulnerabilities, (6) create API security checklists or verification plans, (7) fix API security bugs or harden existing APIs, (8) set up API security testing (OWASP ZAP, Schemathesis, Burp Suite), or (9) handle any API security concern including SSRF prevention, resource consumption limits, business flow protection, API inventory management, and secure third-party API consumption.

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Guideline for designing, implementing, and verifying secure TypeScript and JavaScript applications following OWASP Top 10 best practices. Use when the user wants to: (1) review TypeScript or JavaScript code for security vulnerabilities, (2) design a secure Node.js, Deno, or browser application architecture, (3) implement security features (authentication, authorization, cryptography, input validation), (4) audit npm/yarn/pnpm dependencies for known vulnerabilities, (5) create security checklists or verification plans, (6) fix security bugs or harden existing TypeScript or JavaScript code, (7) set up security testing and static analysis (ESLint security plugins, Semgrep, Snyk), or (8) handle any TypeScript/JavaScript security concern including injection prevention, prototype pollution, XSS protection, SSRF prevention, secrets management, and secure deployment.

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Guideline for designing, implementing, and verifying secure Python applications following OWASP Top 10 best practices. Use when the user wants to: (1) review Python code for security vulnerabilities, (2) design a secure Python application architecture, (3) implement security features (authentication, authorization, cryptography, input validation), (4) audit Python dependencies for known vulnerabilities, (5) create security checklists or verification plans, (6) fix security bugs or harden existing Python code, (7) set up security testing and static analysis (bandit, safety, semgrep), or (8) handle any Python security concern including injection prevention, secure deserialization, SSRF protection, secrets management, and secure deployment.

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Security audit of a codebase — web apps, APIs, services, CLI tools, libraries, daemons, and more. Use when asked to find security bugs, do a security review, audit for vulnerabilities, or pen-test the code. Focuses on exploitable issues with real impact, not theoretical concerns or industry-standard behavior.

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Evaluate architecture and module boundaries for volatility-based decomposition using Juval Lowy's framework (from "Righting Software", building on Parnas 1972). Use when reviewing module splits, service boundaries, new abstractions, or any decomposition decision. Trigger on phrases like "where should this boundary be", "how to split this", "module boundaries", "encapsulate change", "volatility", or references to Lowy, Parnas, or "Righting Software". Complements /hickey (interleaved concerns) with a different lens (change encapsulation).

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Audit a codebase against well-known software design principles: SOLID, DRY, YAGNI, KISS, Law of Demeter, Separation of Concerns, Composition over Inheritance, and the code-relevant 12-Factor subset. Scores findings by impact and effort, runs adversarial debate on contested violations, and generates a prioritized DESIGN_AUDIT.md. Use when reviewing code quality beyond what linters catch, assessing design health before a refactor, or onboarding to an unfamiliar codebase. Can be invoked standalone or delegated from tech-debt.

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Comprehensive security audit covering OWASP Top 10, secrets detection, supply chain security, threat modeling, and language-specific vulnerability patterns. Investigates actual code paths rather than grep-matching keywords. Generates a scored SECURITY_AUDIT.md with prioritized remediation. Use when assessing application security, preparing for a security review, or onboarding to a codebase with security concerns.

日本語の概要は準備中です。原文の説明を表示しています。