「dire」の検索結果

Generates complete dual-disease shared-transcriptome biomarker and hub-gene research designs from a user-provided disease pair and shared-biology direction. Always use this skill whenever a user wants to design, plan, or build a non-oncology two-disease transcriptome study centered on per-disease differential expression, shared-signal intersection or concordance, PPI-based hub-gene prioritization, diagnostic evaluation across both diseases, immune infiltration context, pathway interpretation, and optional orthogonal validation. Covers five study patterns (shared-DEG-first workflow, hub-gene-first shared-biomarker workflow, hybrid shared-biomarker compression workflow, immune-context shared-biomarker workflow, orthogonal validation workflow) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path...

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Generates complete comorbidity-oriented shared-biomarker bioinformatics research designs from a user-provided disease pair and validation direction. Use when a study links two clinically related diseases through shared DEGs, enrichment, PPI hub genes, machine-learning feature selection, public diagnostic validation, gene-regulatory networks, immune infiltration, and optional downstream follow-up. Covers five study patterns (shared-DEG discovery, hub-gene prioritization, machine-learning biomarker selection, immune/regulatory interpretation, multi-layer validation) and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

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Generates complete two-sample Mendelian randomization research designs from a user-provided outcome, exposure or exposure family, and robustness direction. Use when a study centers on summary-statistics causal inference with instrument selection, harmonization, IVW-primary estimation, complementary estimators, sensitivity analyses, optional multivariable upgrades, and conservative evidence interpretation. Covers five study patterns and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

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Designs complete integrated research plans for bulk transcriptomics, proteomics, metabolomics, and related omics from a user-provided biomedical direction. Always use this skill whenever a user wants to design, scope, or structure a bulk multi-omics or single-omics-plus-clinical study — including disease-focused, mechanism-focused, biomarker-focused, stratification-oriented, or translational projects. It should define the research question, choose the best-fit study pattern, recommend example datasets as reference candidates only, specify the core analysis modules and method choices, propose a validation ladder, and output four workload configurations (Lite / Standard / Advanced / Publication+). Never fabricate datasets, accession numbers, sample counts, metadata completeness, cohort availability, assay coverage, literature references, PMIDs, DOIs, or validation status. Always include the mandatory Dataset Disclaimer immediately before any workflow section that mentions datasets or public resources.

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Tracks the latest preprints and emerging research topics related to your topic across bioRxiv, medRxiv, and arXiv. Use when a user wants to discover what is being published right now before it reaches journals, monitor competitor directions, spot new methodology trends, or get an early-warning scan of a research area. Triggers on phrases like "what's new in X", "latest preprints on Y", "emerging topics in Z", "monitor bioRxiv for", or "what are people working on in this field".

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Rapidly maps the evidence landscape around a medical topic by organizing major research streams, target populations, endpoints, methods, evidence density, and thin areas. Use this skill BEFORE medical-research-gap-finder — it provides the structured landscape that makes formal gap analysis more rigorous. Do not use for formal gap identification, study design, or protocol planning directly.

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Use when performing time-dependent ROC curve analysis for survival data with follow-up time, event status, and a numeric marker. Supports CSV/TXT/TSV/Excel input, `risk_score` as the default marker unless `--marker_col` is provided, parameter validation, standardized output directories, AUC table export, ROC point export, and PDF figure generation.

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Use when performing correlation analysis between two variables including Pearson and Spearman correlation methods. Supports command-line parameter input, automatic data format detection, parameter validation, result directory creation, and CSV or TXT format result export.

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Finds translational opportunities that connect basic-research discoveries to clinically meaningful use cases such as diagnosis, stratification, prognosis, treatment response prediction, monitoring, or therapeutic development. Use this skill when a user wants to turn a mechanism finding, pathway signal, cellular phenotype, experimental observation, or omics discovery into a stronger translational research direction. Always separate mechanistic relevance from translational usability, and never present a basic finding as clinically actionable unless the evidence supports that level.

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Use when performing PCA principal component dimensionality reduction on tabular numeric data. Supports command-line parameter input, automatic numeric feature selection, parameter validation, result directory creation, and CSV or TXT format result export.

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Maps whether a biomedical research topic, subtopic, or study angle is truly saturated, superficially crowded, strategically occupied, or still open for differentiated entry. Use this skill when a user wants to know whether a hot medical research direction is already overworked, whether meaningful whitespace remains, whether major groups have already occupied the obvious claims, and whether the timing window is still open. Always distinguish popularity from true saturation, and distinguish cosmetic novelty from meaningful differentiating entry.

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Use when filtering genes with high missingness and then imputing missing values in a bulk expression matrix with group-aware KNN through DMwR2, where donor samples are restricted by one annotation column before imputation. For strata with 10 or fewer samples, the script falls back to row-wise direct filling with mean or median. NOT for: single-cell data, multi-column stratification, non-tabular inputs, network access, or interactive workflows.

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Use when building a ceRNA regulatory network from a key gene list by combining bundled miRNA-mRNA and miRNA-lncRNA database files, with flat-file CSV exports and PDF visualization in a single output directory. NOT for: differential expression, single-cell analysis, enrichment analysis, or workflows without a key gene list.

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Helps users send funds to another Stripe business, transfer money to a Stripe Profile handle or network ID, or ask whether an agent can pay a Stripe business. Use Stripe Directory to find or verify a recipient when the user doesn't provide an exact Stripe Profile handle or network ID.

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Use when evaluating macro trends through Shi Hanbing's interest-analysis (利益分析法) lens: trace who benefits from what policy, follow the money, and predict macro direction from incentive structures.

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Use when evaluating growth stocks through O'Neil CAN SLIM: earnings acceleration, relative strength, institutional demand, market direction, base quality, and breakout discipline.

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Nuxt adapter for embedding emulators directly in a Nuxt app via @emulators/adapter-nuxt. Use when the user needs to embed emulators in Nuxt, set up same-origin OAuth for preview deployments, create an emulate catch-all server route, configure persistence for embedded Nuxt emulators, or wrap nuxt.config with withEmulate. Triggers include "Nuxt emulator", "adapter-nuxt", "embedded emulator", "same-origin OAuth", "createEmulateHandler", "withEmulate", or any task requiring emulators inside a Nuxt app.

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Next.js adapter for embedding emulators directly in a Next.js app via @emulators/adapter-next. Use when the user needs to embed emulators in Next.js, set up same-origin OAuth for Vercel preview deployments, create an emulate catch-all route handler, configure Auth.js/NextAuth with embedded emulators, add persistence to embedded emulators, or wrap next.config with withEmulate. Triggers include "Next.js emulator", "adapter-next", "embedded emulator", "same-origin OAuth", "Vercel preview", "createEmulateHandler", "withEmulate", or any task requiring emulators inside a Next.js app.

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Use this skill when visualising drone simulation results. Produces three matplotlib figures — desired vs actual trajectories, instantaneous error, and cumulative absolute error — for all 5 state groups (position, orientation, velocity, angular velocity, acceleration). Saves figures to a plots/ directory automatically.

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AC branch pi-model power flow equations (P/Q and |S|) with transformer tap ratio and phase shift, matching `acopf-math-model.md` and MATPOWER branch fields. Use when computing branch flows in either direction, aggregating bus injections for nodal balance, checking MVA (rateA) limits, computing branch loading %, or debugging sign/units issues in AC power flow.

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Configure WebSocket transport for bidirectional MCP communication with connection management and reconnection handling.

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Scaffolds MCP App project structure with correct directory layout, dependencies, entry points, and framework-specific templates. Handles React (useApp hook), Vanilla JS, Vue, Svelte, Preact, and Solid.

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Atlas turns your STATED NEED into a real systems atlas by SCANNING your actual sources (Azure via `az`, git repos, local dirs) and process/data mining them, THEN enriching against the Atlas knowledge graph. Use this skill when asked to inventory/map your real systems, scan your cloud + repos + directories, mine the real processes or data they contain, or collect their real constraints/gotchas. (atlas, scan my systems, inventory our azure account, map my repos, real systems atlas, process mining, data mining, collect nuances, system discovery)

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Cross-reference GitHub, Linear, Slack, and PostHog with bidirectional sync for team briefs

日本語の概要は準備中です。原文の説明を表示しています。