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R generic interface to Hi-C contact matrices in `.(m)cool`, `.hic` or HiC-Pro derived formats, as well as other Hi-C processed file formats. Contact matrices can be partially parsed using a random access method, allowing a memory-efficient representation of Hi-C data in R. The `HiCExperiment` class stores the Hi-C contacts parsed from local contact matrix files. `HiCExperiment` instances can be further investigated in R using the `HiContacts` analysis package.

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cogeqc aims to facilitate systematic quality checks on standard comparative genomics analyses to help researchers detect issues and select the most suitable parameters for each data set. cogeqc can be used to asses: i. genome assembly and annotation quality with BUSCOs and comparisons of statistics with publicly available genomes on the NCBI; ii. orthogroup inference using a protein domain-based approach and; iii. synteny detection using synteny network properties. There are also data visualizat

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Expert knowledge for Azure Static Web Apps development including troubleshooting, decision making, limits & quotas, security, configuration, integrations & coding patterns, and deployment. Use when wiring SWA APIs to Azure DBs, configuring custom domains/backends, Entra auth, CI/CD, or plan limits, and other Azure Static Web Apps related development tasks. Not for Azure App Service (use azure-app-service), Azure Functions (use azure-functions), Azure Container Apps (use azure-container-apps), Azure Logic Apps (use azure-logic-apps).

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Expert knowledge for Azure External Attack Surface Management development including configuration. Use when filtering EASM inventory by ASN, domains, hosts, IPs, pages, SSL certs, or exporting findings to analytics tools, and other Azure External Attack Surface Management related development tasks. Not for Azure Defender For Cloud (use azure-defender-for-cloud), Azure Security (use azure-security), Azure Sentinel (use azure-sentinel), Azure Networking (use azure-networking).

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Expert knowledge for Azure Front Door development including troubleshooting, best practices, decision making, architecture & design patterns, limits & quotas, security, configuration, integrations & coding patterns, and deployment. Use when configuring apex domains, rules engine, Private Link origins, TLS/WAF security, or tier migrations, and other Azure Front Door related development tasks. Not for Azure Application Gateway (use azure-application-gateway), Azure Traffic Manager (use azure-traffic-manager), Azure Load Balancer (use azure-load-balancer), Azure Web Application Firewall (use azure-web-application-firewall).

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Resolve a company domain to its verified official social profile URLs (LinkedIn, X, Facebook, Instagram, YouTube, TikTok). Triggers on "find their LinkedIn", "get the company LinkedIn URL", "find their Instagram", "we need social handles for this list", "which companies have a TikTok", "social links for the TAM". Outputs one canonical profile URL per platform, or an empty string when the company genuinely has no account.

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Decides whether a company publishes public self-serve pricing and extracts its plan tiers, price points and feature axis. Triggers on "do they have a pricing page", "is their pricing public", "filter out enterprise quote-only companies", "what do they charge", "find their plans", "self-serve vs sales-led". Outputs a structured pricing record per domain. The copy-ready pricing clause is OFF by default and runs only when a campaign brief asks for it.

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Complete beginner-friendly cold email toolkit. Walks from zero to launched campaign — domain purchase, inbox setup, list building, copywriting, enrichment, and sending via Smartlead or Instantly. Use when setting up cold email for the first time, launching a new campaign, teaching someone cold email, or when you need an end-to-end guide that bundles strategy, copy, infrastructure, and API references in one place.

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Pre-send quality scorecard for any lead list. Grades duplicate rate, title diversity, bad-title patterns, catch-all domain density, ICP fit, email verification coverage. Outputs a letter grade + action items BEFORE you send. Catches bad lists before they burn inboxes. Run after email enrichment, before Smartlead upload.

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Adds Smartlead-compatible spintax to cold email sequences for deliverability. Use this skill whenever the user asks to add spintax, spin text, add variations, or improve deliverability of email copy — especially when they mention Smartlead, cold email sequences, or paste HTML email content. Also trigger when the user says "spintax", "spin", "variations", "deliverability spintax", or references adding randomized alternatives to email copy. Works with both plain text and HTML input.

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Triage playbook for when cold email deliverability breaks. Decision-tree guidance for "I landed in spam", "bounce rate spiked", "domain blacklisted", "inbox blocked in warmup", "reply rate dropped". Tells you what to check first, what to fix, and how long the fix takes. Pair with /email-deliverability-audit for diagnosis.

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Autonomous cold email campaign launcher. Takes one target company domain, scrapes their website, generates an ICP with Claude, pulls matching leads via Prospeo, enriches emails + company descriptions, personalizes each lead with parallel Claude Code Task sub-agents (A/B/C variants), and uploads as a live Smartlead campaign. Uses local JSON files for state (no database required). Use for automated daily campaign launches after you have an initial `client-profile.yaml` from /icp-onboarding. Triggers on "auto-research", "launch an automated campaign", "daily campaign", "run the research loop".

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Programmatic inbox management for Smartlead. Enable/disable warmup with correct ramp settings, set signatures in bulk, tag inboxes (active vs insurance), and pull inbox health dashboards. Use after creating a new batch of inboxes via /zapmail-domain-setup-public, or when managing an existing Smartlead account at scale. Triggers on "turn on warmup", "set signatures", "tag inboxes", "inbox health", "set up new inboxes".

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Single "start here" orchestrator for new cold email operators. Asks infrastructure-status questions first, then runs /icp-onboarding → /lead-magnet-brainstorm → /campaign-strategy in sequence, producing a consolidated campaign-plan.md. Ends with an interactive menu of next skills branched on whether the user already has domains/inboxes. Use as the very first invocation on any new repo checkout or when onboarding someone to cold email from zero.

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Decides which named technologies a company actually runs on its website, verified against the live site. Triggers on "find companies using Shopify", "they're on HubSpot", "tech stack targeting", "technographics", "who uses Klaviyo", "companies running WordPress". Outputs a per-domain verdict (tech_confirmed plus the verified stack and its evidence); the copy-ready clause is OFF by default and runs only when the operator asks for one.

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Use when a user gives or references a webpage URL and wants to extract, reproduce, port, or locally replay a WebGL, WebGPU, Canvas, shader-like, animated background, interactive 3D, or web visual effect. Locks the target rendering surface group, records shader/resource/render graph/timing/input evidence, builds an evidence-matched local baseline, then projectizes it. Do not use for ordinary DOM/CSS page cloning.

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Evidence-first development — surround the implementation with an executable spec and a gauntlet of constraints (tests, types, coverage, mutation) so line-by-line review becomes optional. Use when the user explicitly asks for high-assurance or evidence-first work ("reliable", "TDD", "prove it works", "I won't read the code"), or when the change touches high-stakes domains (money, auth, data loss, concurrency, public API). For routine changes where the user just wants normal tests, write good tests directly instead of invoking this loop.

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Spot patterns appearing in 3+ domains to find universal principles

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First-tier tech company P8 capability advisor for evaluating, coaching, and giving career advice against a P8 senior expert, architect, or domain-owner profile. Use when the user asks for P8-level assessment, promotion readiness, capability gaps, project or resume review, interview preparation, or growth advice based on first-tier tech company P8 expectations.

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Map 50-200+ keywords into topical clusters for SEO domination. Build content roadmaps for topical authority. Triggers on: "keyword research", "keyword clustering", "topical authority", "keyword map", "keyword strategy", "content roadmap for SEO", "keyword grouping", "topic clusters", "SEO keyword plan", "map my keywords", "keyword cluster", "hub and spoke content", "build topical authority", "SEO content plan", "keyword universe".

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Deploy affiliate content to GitHub Pages for free hosting. Triggers on: "deploy to GitHub Pages", "host on GitHub Pages", "free hosting for my affiliate site", "push to GitHub Pages", "GitHub Pages setup", "deploy my landing page to GitHub", "host my bio link on GitHub", "free affiliate website hosting", "github pages affiliate", "set up GitHub Pages for my site", "deploy HTML to GitHub", "free static hosting", "publish my affiliate page for free", "github pages custom domain".

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Build an interactive competitive-traffic report for any company and its rivals — monthly visits (SimilarWeb), organic search traffic and Domain Rating (Ahrefs) — as one self-contained HTML page with ranked charts, a three-month trend, a multi-year overlay and a data table. Use when asked to benchmark a product against competitors, size up a market, answer "how much traffic does X get compared to Y", build a competitive landscape, or produce a traffic/authority comparison deck or page.

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Manages Ahrefs API usage in Python using `ahrefs-python` library. Use when working with SEO / marketing related tasks or with data including backlinks, keywords, domain ratings, organic traffic, site audits, rank tracking, and brand monitoring. Covers `ahrefs-python` usage including AhrefsClient / AsyncAhrefsClient, typed request/response models, error handling, and all API sections.

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Detect and investigate bulk registration abuse on SaaS platforms. Given access to a user database (or exported CSV/JSON), run a multi-dimensional anomaly analysis — email domain clustering, registration tempo, UA fingerprinting, session structure, usage patterns, and credit consumption — to produce a scored abuse report with actionable recommendations. Use when investigating suspicious sign-up spikes, credit fraud, free-tier abuse, or account farming.

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