「guidance」の検索結果

Expert guidance for building modern Android UIs with Jetpack Compose, covering state management, navigation, performance, and Material Design 3.

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You are an accessibility expert specializing in WCAG compliance, inclusive design, and assistive technology compatibility. Conduct audits, identify barriers, and provide remediation guidance.

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Constrain LLM output with grammars; guarantee valid JSON.

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Pitfalls, examples, and edge cases for FETIH Kanban workers. The lifecycle itself is auto-injected into every worker's system prompt as KANBAN_GUIDANCE (from agent/prompt_builder.py); this skill is what you load when you want deeper detail on specific scenarios.

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3D print models generated with Meshy AI. Handles printability analysis, slicer integration, multi-color printing guidance, and print-optimized download workflows. Use when the user mentions 3D printing, slicing, Bambu, OrcaSlicer, Prusa, Cura, Creality Print, or wants to print a figurine, miniature, or physical model.

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Guidance on using and integrating official reference servers. Use when building custom servers or deploying standard configurations. For server listings, see mcp-server-registry.

日本語の概要は準備中です。原文の説明を表示しています。

Next.js App Router expert guidance. Use when building, debugging, or architecting Next.js applications — routing, Server Components, Server Actions, Cache Components, layouts, middleware/proxy, data fetching, rendering strategies, and deployment on Vercel.

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Perform language and framework specific security best-practice reviews and suggest improvements. Trigger only when the user explicitly requests security best practices guidance, a security review/report, or secure-by-default coding help. Trigger only for supported languages (python, javascript/typescript, go). Do not trigger for general code review, debugging, or non-security tasks.

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shadcn/ui expert guidance — CLI, component installation, composition patterns, custom registries, theming, Tailwind CSS integration, and high-quality interface design. Use when initializing shadcn, adding components, composing product UI, building custom registries, configuring themes, or troubleshooting component issues.

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Vercel AI SDK expert guidance. Use when building AI-powered features — chat interfaces, text generation, structured output, tool calling, agents, MCP integration, streaming, embeddings, reranking, image generation, or working with any LLM provider.

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Best practices for agents managing PostHog skills via the MCP `llma-skill-*` tools — how to discover, read, create, update, and refactor skills efficiently, especially large skills with many bundled files. Use whenever you are about to call any `llma-skill-*` tool, asked to author or edit a shared skill, or troubleshoot why a skill write was rejected. Pairs with `skills-store` (which covers the raw tool surface) by adding the decision-tree, efficiency, and pitfall guidance.

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Guidance for distinctive, intentional visual design when building new UI or reshaping an existing one. Helps with aesthetic direction, typography, and making choices that don't read as templated defaults.

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Prepares statistical reports for clinical trials following CONSORT 2025, SPIRIT 2025, ICH E9(R1) estimands, and FDA 2023 covariate adjustment guidance. Covers Table 1 generation, analysis populations (ITT/FAS/PP/Safety), the 5 ICH E9(R1) intercurrent-event strategies, MMRM under MAR (mmrm), reference-based MI (rbmi J2R/CR/CIR), Permutt tipping-point sensitivity, and Rubin's-rules vs frequentist variance debate. Use when preparing regulatory submissions, defining estimands, or implementing missing-data sensitivity analyses.

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Implements multiplicity control for confirmatory clinical trials using graphical procedures (Bretz-Maurer-Hommel), gatekeeping (parallel, serial, mixed), Hochberg/Hommel/Holm with PRDS, and the closed-testing principle (Marcus-Peritz-Gabriel; Goeman 2021 admissibility). Covers FDA Multiple Endpoints Final Guidance (October 2022), graphical procedures via R gMCP, primary + key-secondary + subgroup hierarchies, and FWER vs FDR distinction. Use when designing the multiplicity strategy for confirmatory trials with multiple primary or key secondary endpoints.

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Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.

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Strategic clinical trial design feasibility assessment. Analyzes 6 dimensions (endpoint, population, comparator, effect size, duration, regulatory pathway) using precedent trials and FDA guidance. Produces enrollment projections, endpoint recommendations, and approval-pathway analysis. Use for trial-protocol design, power/sample-size estimation, comparator selection, and FDA submission strategy. Driven by precedent-based reasoning rather than first-principles math.

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Computes and interprets treatment effect measures (OR, RR, RD, HR, NNT) with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen, MOVER, profile likelihood, Bender NNT) and reports marginal vs conditional estimands per FDA 2023 covariate adjustment guidance. Use when reporting treatment effects in confirmatory trials, comparing effect sizes across studies, or constructing forest plots.

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Performs logistic regression for clinical trial outcomes (binary, ordinal, multinomial) with marginal-vs-conditional estimand reporting per FDA 2023 covariate adjustment guidance, g-computation/standardisation for marginal effects, modified Poisson for RR, Brant test for proportional odds, Firth penalty for separation, and Hauck-Donner detection. Use when modeling binary or ordinal endpoints in confirmatory or exploratory clinical trials.

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Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Friede-Kieser, unblinded Cui-Hung-Wang, Mehta-Pocock promising zone), seamless Phase 2/3 with treatment-arm selection, population enrichment, and response-adaptive randomisation. Covers FDA 2019 Final Adaptive Designs Guidance, FDA 2022 Master Protocols, and ICH E20 Step 2b/3 draft (June 2025, NOT final). Use when planning interim analyses, sample-size re-estimation, or master/platform-trial designs.

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Expert guidance for fine-tuning LLMs with LLaMA-Factory - WebUI no-code, 100+ models, 2/3/4/5/6/8-bit QLoRA, multimodal support

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Provides guidance for interpreting and manipulating neural network internals using nnsight with optional NDIF remote execution. Use when needing to run interpretability experiments on massive models (70B+) without local GPU resources, or when working with any PyTorch architecture.

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Provides guidance for mechanistic interpretability research using TransformerLens to inspect and manipulate transformer internals via HookPoints and activation caching. Use when reverse-engineering model algorithms, studying attention patterns, or performing activation patching experiments.

日本語の概要は準備中です。原文の説明を表示しています。

Expert guidance for distributed training with DeepSpeed - ZeRO optimization stages, pipeline parallelism, FP16/BF16/FP8, 1-bit Adam, sparse attention

日本語の概要は準備中です。原文の説明を表示しています。

Expert guidance for GRPO/RL fine-tuning with TRL for reasoning and task-specific model training

日本語の概要は準備中です。原文の説明を表示しています。