「clinical」の検索結果

Predicts whether a DNA variant alters mRNA splicing using sequence-based deep-learning tools — SpliceAI (10kb context dilated CNN, clinical default), Pangolin (multi-tissue), MMSplice (modular per-region CNN with calibrated ΔPSI), SpliceTransformer/TrASPr (tissue-aware transformers), SpliceVault (empirical 300K-RNA lookup of likely mis-splicing outcomes), CADD-Splice (composite score). Applies the ClinGen SVI 2023 framework for ACMG/AMP variant interpretation (PVS1, PP3, BP4 evidence codes), HGVS splicing nomenclature (c.123+1G>A, c.123-3T>G, r.spl?), extended-window scoring for deep-intronic pseudoexons, tissue-specific predictions, branchpoint variant detection (BPHunter, LaBranchoR), and splice-switching ASO design. Use when interpreting splice impact of clinical variants, prioritizing VUS, identifying deep-intronic pathogenic variants, or designing ASOs.

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Generate structured clinical reports from patient and study data

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Evidence-based clinical decision support and diagnostic reasoning

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Clinical study operations — protocol structure, endpoint selection, eligibility design, sample-size and power planning, site feasibility, and documentation readiness. Use when planning, auditing, or costing a study.

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EU MDR 2017/745 compliance specialist for medical device classification, technical documentation, clinical evidence, and post-market surveillance. Use for Annex VIII classification, GSPR, clinical evaluation, EUDAMED, and UDI.

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Interpret medical lab/test reports (blood panels, urine, liver/kidney function, thyroid, tumor markers, coagulation, cardiac enzymes, hormones, etc.) uploaded as images, PDFs, or text. Trigger whenever the user uploads a lab report, medical test result, or clinical diagnostic sheet — or says things like "help me read this report", "what do these results mean", "化验单", "检验报告", "帮我看看这个报告", "blood test results", "lab results", "体检报告", "检查报告单", "血常规", "尿常规", "肝功能", "肾功能", "甲功", "凝血", "interpret my labs", "are these results normal", "这些指标正常吗". Also trigger when the user uploads ANY medical-looking document with tables of values, reference ranges, or clinical test names — even if they don't explicitly ask for interpretation. Do NOT trigger for symptom triage (use emergency-triage instead), drug interaction queries, or general medical Q&A without an actual report to interpret.

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Extract billable ICD-10-CM diagnosis codes from a clinical note the way a professional coder builds the claim. Use when users say "code this encounter", "assign ICD-10 codes", "what diagnosis codes apply", "code this chart", or when turning clinical documentation into claim-ready diagnosis codes.

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Query NCBI dbSNP for SNP records by rsID, gene, or region via E-utilities and Variation Services REST API. Retrieve alleles, MAF, variant class (SNV/indel/MNV), clinical links, cross-DB IDs (ClinVar, dbVar, 1000G). Free; 3 req/sec (10 with key). For clinical pathogenicity use clinvar-database; for population frequencies use gnomad-database.

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Python library for healthcare ML on EHR data: process MIMIC-III/IV, eICU, OMOP-CDM; encode medical codes (ICD, ATC, NDC); build patient-level datasets; train Transformer, RETAIN, GRASP, MedBERT for mortality, drug recommendation, readmission, diagnosis prediction. Alternatives: FIDDLE (preprocessing), clinical-longformer (clinical NLP), ehr-ml (embeddings).

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Use when designing or auditing how an LLM or multimodal LLM is evaluated on a clinical task (report generation, VQA, text extraction). Covers reference standard, clinical-efficacy metrics beyond BLEU/ROUGE, hallucination, contamination and prompt sensitivity. Imaging models are /model-assessment.

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Think and work like an expert Dermatologist. Use when a task calls for Dermatologist judgment. Clinical-research dermatologist: layered skin anatomy, inflammatory dermatoses and trial endpoints, dermoscopy vs clinical ABCDE, biopsy/pathology, patch testing, telederm, AAD guidelines, and topical steroid potency.

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Annotate copy number variant segments with overlapping genes, dosage-sensitivity scores, cancer driver databases, population frequencies, and clinical-variant content. Covers bedtools/pybedtools interval intersection, AnnotSV comprehensive annotation and ranking, ClinGen haploinsufficiency/triplosensitivity scoring, gnomAD-SV/DGV frequency filtering, COSMIC Cancer Gene Census, and ClinVar overlap. Use when interpreting which genes a CNV affects, distinguishing the driver gene of a focal event from passengers, filtering against population CNVs, separating whole-gene from partial-gene overlap, or preparing CNVs for clinical classification.

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Queries ClinVar for variant pathogenicity classifications, ClinGen VCEP curations, and somatic-vs-germline interpretations via REST API, weekly VCF, or bulk XML. Use when determining clinical significance, triangulating conflicting interpretations, or aggregating evidence against the ACMG/AMP framework with ClinGen SVI specifications.

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Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.

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Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Friede-Kieser, unblinded Cui-Hung-Wang, Mehta-Pocock promising zone), seamless Phase 2/3 with treatment-arm selection, population enrichment, and response-adaptive randomisation. Covers FDA 2019 Final Adaptive Designs Guidance, FDA 2022 Master Protocols, and ICH E20 Step 2b/3 draft (June 2025, NOT final). Use when planning interim analyses, sample-size re-estimation, or master/platform-trial designs.

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Discover and invoke 1,676 deduplicated biomedical AI agent skills from the Awesome Bio Agent Skills repository (20 source repos, 15 categories). Use this skill as a router whenever a user needs a bioinformatics/biomedical task (genomics, transcriptomics, single-cell, proteomics, protein design, clinical, epigenomics, multi-omics, pathway, metagenomics, database queries, visualization, workflows): search the index, locate the best-matching skill, fetch its SKILL.md, and follow it.

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Patterns for designing and analyzing clinical trials, including survival analysis, endpoint selection, sample size calculation, interim analyses, and regulatory considerations. Covers FDA/EMA guidelines and modern adaptive designs. Use when ", " mentioned.

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Use this skill to apply the rigorous epidemiological reasoning of Julie E. Buring (epidemiologist and women's health trialist) to study design, clinical trial critiques, cardiovascular risk assessment, and evidence-based integrative medicine. Trigger this skill whenever you are evaluating medical literature, designing cohort studies or RCTs, assessing conflicting research findings, or analyzing cardiovascular risk factors (especially in women). Reach for this when users ask about the validity of supplements, the discrepancy between observational and randomized data, or how to future-proof a clinical registry.

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Use this skill to reason like JoAnn E. Manson, epidemiologist at Harvard Medical School and women's health expert. Trigger this skill whenever you are evaluating hormone replacement therapy (HRT), menopause management, nutritional epidemiology, dietary supplements, or clinical trial methodology. Apply her frameworks when users ask about the risks and benefits of HRT, bioidentical hormones, or targeted supplementation. Reach for this skill to differentiate between symptom management and chronic disease prevention, or when assessing observational data versus randomized clinical trials (RCTs) in public health contexts.

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Comprehensive clinical laboratory data harmonization for multi-source healthcare analytics. Convert between US conventional and SI units, standardize numeric formats, and clean data quality issues. This skill should be used when you need to harmonize lab values from different sources, convert units for clinical analysis, fix formatting inconsistencies (scientific notation, decimal separators, whitespace), or prepare lab panels for research.

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Automatically detect and de-identify PII (Personal Identifiable Information) and PHI (Protected Health Information) from clinical/medical text to ensure HIPAA compliance. Trigger when processing medical records, patient data, clinical notes, insurance information, or any healthcare-related text containing potential patient identifiers.

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Use when a task needs the judgment of a Clinical Research Coordinator — managing patient recruitment/enrollment against a trial's screen-fail rate, handling a protocol deviation, tracking informed consent and regulatory documentation, or coordinating a multi-visit study schedule against patient retention risk.

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Use when a task needs the judgment of a doctoral-level Clinical or Counseling Psychologist — building a psychological test battery to answer a referral question, interpreting a WAIS/MMPI/PAI profile against validity indices, working a differential diagnosis (e.g. ADHD vs. anxiety-driven inattention, depression vs. early dementia), or writing a feedback-session-ready diagnostic formulation report.

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Use when a task needs the judgment of a board-certified Clinical Neuropsychologist — building a neuropsychological battery to localize a brain-behavior deficit, adjudicating performance validity before interpreting any cognitive score, distinguishing a dementia subtype or mTBI sequela from a psychiatric or malingering cause, or writing a forensic, pre-surgical (epilepsy/tumor), or serial-retest report.

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