「number」の検索結果

Visualize copy number profiles, segments, allele-specific tracks, and cohort patterns from CNVkit, GATK, ASCAT, FACETS, Sequenza, and other callers. Covers genome-wide and per-chromosome log2 scatter plots, B-allele-frequency/minor-allele-fraction tracks, ideograms, cohort heatmaps, circos views, and caller-native plots. Use when creating publication CNV figures, choosing which plot answers a given question, diagnosing a wrong diploid baseline visually, displaying loss of heterozygosity, or deciding what depth-only plots cannot reveal.

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End-to-end copy number variant detection workflow from BAM files. Covers CNVkit analysis for exome/targeted sequencing with visualization and annotation. Use when detecting copy number alterations from sequencing data.

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Annotate copy number variant segments with overlapping genes, dosage-sensitivity scores, cancer driver databases, population frequencies, and clinical-variant content. Covers bedtools/pybedtools interval intersection, AnnotSV comprehensive annotation and ranking, ClinGen haploinsufficiency/triplosensitivity scoring, gnomAD-SV/DGV frequency filtering, COSMIC Cancer Gene Census, and ClinVar overlap. Use when interpreting which genes a CNV affects, distinguishing the driver gene of a focal event from passengers, filtering against population CNVs, separating whole-gene from partial-gene overlap, or preparing CNVs for clinical classification.

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Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

日本語の概要は準備中です。原文の説明を表示しています。

Workflow for copy-number estimation, segmentation, annotation, and visualization in sequencing-based assays.

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Build the deterministic evidence ledger (artifact_manifest.json + claims.json) that every other Anti-Autoresearch auditor reads. One pass inventories artifacts, derives the observability level (L0 PDF-only / L1 +LaTeX / L2 +repo+results) by fixed rule, and extracts span-anchored, hashed, checkable claims (numbers, comparisons, scope, method, baselines, citations, captions, table cells) into claims.json. An OPTIONAL additive cross-model pass ADDS span-anchored semantic claims — method, theorem statements with their assumptions, definitions, proof/derivation steps and equations, scope, baselines, conclusions, the motivation span, and reproducibility-artifact references (the proof, derivation, and structure anchors the family B/D/G auditors need) — it never invents a number, emits a finding, or computes a verdict. Run FIRST, before any audit skill. Triggers: "build the ledger", "extract claims", "prep for integrity audit", "evidence ledger", "建证据账本".

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Audit experiment integrity against the evidence ledger. At L2 (repo + result files present) a fresh cross-model reviewer reads the eval code line-by-line for fake/derived ground truth, score self-normalization, phantom results (a paper number with no backing file/key), dead/uncalled metric code, verified-scope inflation, method-described ≠ method-evaluated drift, synthesized-looking results, placeholder/fake data still wired into a released result, code-output ≠ reported-number mismatch, and missing reproducibility artifacts (an empirical/agent/LLM paper shipping neither code nor the prompts/configs its results need) — every finding span-anchored to a ledger claim_id. At L0/L1 (PDF / source only) the same patterns are surfaced as info-level 'could-not-verify' signals where the ledger gives an anchor (observability_level_required:2) — NEVER a fraud verdict from a PDF. The reviewer PROPOSES findings; tools/adjudicate_findings.py computes the verdict. Detect-only. Triggers: "experiment forensics", "audit the results", "check the eval code", "实验诚实度".

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AgentPhone workflow skill. Use this skill when the user needs Build AI phone agents with AgentPhone API. Use when the user wants to make phone calls, send/receive SMS, manage phone numbers, create voice agents, set up webhooks, or check usage — anything related to telephony, phone numbers, or voice AI and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.

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AgentPhone workflow skill. Use this skill when the user needs Build AI phone agents with AgentPhone API. Use when the user wants to make phone calls, send/receive SMS, manage phone numbers, create voice agents, set up webhooks, or check usage — anything related to telephony, phone numbers, or voice AI and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.

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企业财务与 CFO 视角 (企业财务与 CFO 视角 (Corporate Finance & the CFO Lens) — 面向创业公司与中小企业主/创始人/业务负责人的『看懂钱、管住钱、用好钱』的财务判断,不是考注会/中级职称的准则背诵,也不是投行卖方并购执行或 VC 投资人的看项目视角。覆盖: (a) 第一性张力 — 这行的核心世界观分歧: **利润是观点,现金是事实(权责发生制下的利润由收入确认时点、折旧摊销年限、存货计价、资本化与费用化的选择拼出来,是一组可辩论的判断;银行户头的钱是唯一不能辩论的事实——所以 CFO 看三张表的顺序是现金流量表→资产负债表→利润表,与外行相反) ⇄ 增长本身要烧钱(账面盈利的公司照样会因营运资金被增长吸干而倒闭:先付供应商、后收客户钱,规模越大缺口越大,这是『增长性破产』;所以现金转换周期比毛利率更早预警) ⇄ 记账合规派 vs 管理决策派(一套账是给税局与审计看的准则语言,另一套视图是给经营者看的贡献边际与单位经济;同一笔成本在两种语言里归属不同,把合规科目直接拿来做定价决策是中小企业最常见的错) ⇄ 全成本分摊 vs 贡献边际(把固定成本按产量分摊进单件成本,会在淡季得出『卖一件亏一件所以停产』的错误结论;边际思维只问增量收入是否覆盖增量成本,但长期只看边际会让公司永远收不回固定成本) ⇄ 预算是承诺 vs 预算是地图(传统年度预算把数字变成考核契约,导致部门年底突击花钱与藏预算;滚动预测与超越预算派主张预算只是当前最好的猜测,该月月刷新) ⇄ 融资是里程碑 vs 融资是负债(融资新闻稿把估值当成绩,但优先股、优先清算权、对赌与回购条款让创始人在低价退出时可能一分不拿;自筹派认为最便宜的钱是客户的预付款) ⇄ 估值方法之争(DCF 的数学严谨但对增长率与折现率假设极敏感,业内讥为『垃圾进垃圾出』;可比公司倍数简单但把市场情绪打包进来;早期公司两者都不成立,实际靠谈判与稀释目标倒推) ⇄ EBITDA 是不是有用(PE 与并购圈把它当经营现金流代理,巴菲特与芒格公开斥其忽略了折旧背后真实的资本开支;调整后 EBITDA 的『加回』项在业内被视为高危信号) ⇄ 财务是记分员 vs 财务是业务伙伴(传统财务事后出报表,财务 BP/FP&A 主张财务应在决策前进场做定价、投产、招人的经济性测算) ⇄ 中国中小企业的两套账现实 vs 合规红线(金税四期与社保入税之后,业内公认的做法是尽早并账,但这条张力必须如实呈现而不是装作不存在,也绝不给出规避税收的操作建议)); (b) 工具栈(记账层与决策层是两套东西) — 记账与 ERP(用友、金蝶、Odoo、QuickBooks、Xero、NetSuite、SAP Business One)、中国财税合规(电子税务局、金税四期发票与进销项比对、百望/航天信息电子发票、慧算账等代账 SaaS、个税与社保申报)、FP&A 与预算(Excel 与 Google Sheets 仍是绝对主力,之上是 Cube、Causal、Jirav、Mosaic、Runway、Abacum、Pigment、Anaplan、Planful)、现金流预测(Float、Fathom、13 周滚动现金流模板)、股权与 cap table(Carta、Pulley、AngelList、Excel 稀释模型,中国的股权代持与持股平台)、订阅计费与收入确认(Stripe Billing、Chargebee、Maxio)、费控报销(Ramp、Brex、Expensify、汇联易、分贝通)、BI 与看板(Power BI、Tableau、Metabase、帆软)、以及最被低估的纸笔工具(一页纸的驱动因素模型、贡献边际表、13 周现金日历)—— 选型的真正分岔是『公司在哪个阶段、由谁来维护这个模型』,不是厂商功能清单; (c) 心智模型层 — 三张表的勾稽关系(利润表的净利经现金流量表调整后落到资产负债表的未分配利润)、权责发生制与收付实现制的差、现金转换周期 CCC 与 DSO/DIO/DPO、营运资金与增长的耦合、贡献边际与盈亏平衡点、经营杠杆与固定成本结构、单位经济与 LTV/CAC 及回本周期、烧钱率与现金跑道 runway、自由现金流与业主收益 owner earnings、资本成本与机会成本、净现值与内部收益率、投入资本回报率 ROIC 与增长的价值条件(只有 ROIC 高于资本成本时增长才创造价值)、股权稀释与优先清算权的退出瀑布、递延收入是负债不是收入; (d) 工作流/SOP — 月度关账与管理报表包(关账日历、计提、对账、出具一页纸经营分析)、13 周滚动现金流预测的搭建与每周刷新、年度预算与滚动预测(自上而下目标与自下而上驱动因素模型的对撞)、定价与成本核算(标准成本、作业成本法、贡献边际定价与报价审批)、应收账款与账期管理(信用政策、账龄表、催收节奏、保理与供应链金融)、融资轮次建模(投前投后估值、期权池扩容对创始人的额外稀释、SAFE 与可转债转股、优先清算权下的退出分配)、投资决策与产能/招人测算(增量现金流、回收期、敏感性分析)、税务合规日历与汇算清缴、董事会与投资人财务包、尽调与数据室准备、以及财务模型的三表联动搭建; (e) 知识正典(en 一手极厚,中文一手集中在高校教授与准则原文) — 《Financial Intelligence》Berman & Knight(给非财务经理的入门标准)、《Financial Statements》Thomas Ittelson、Brealey·Myers·Allen《Principles of Corporate Finance》(公司金融教科书)、Damodaran 的估值三部曲与《Narrative and Numbers》及其 NYU 公开课与免费数据集、《Simple Numbers, Straight Talk, Big Profits!》Greg Crabtree(中小企业实操)、《Venture Deals》Feld & Mendelson(条款与稀释)、《Financial Shenanigans》Howard Schilit(识别财务粉饰)、《The Outsiders》Thorndike(资本配置)、《Accounting for Value》Penman、伯克希尔股东信中的业主收益与商誉摊销讨论、《The Essays of Warren Buffett》、《Profit First》Michalowicz(流行但有争议)、IFRS 15/16 与 ASC 606 收入与租赁准则原文、中国企业会计准则 CAS 与小企业会计准则、肖星《一本书读懂财报》与清华的财务分析公开课、张新民的财务报表分析体系; (f) 行业大佬/figures — Aswath Damodaran(NYU,估值教父,博客与公开课与数据集全免费开放,一手素材极厚)、Michael Mauboussin(ROIC 与资本配置的实证写作)、Howard Schilit(财务舞弊识别)、Karen Berman 与 Joe Knight(财务素养普及)、Greg Crabtree(中小企业现金与利润实操)、Brad Feld 与 Jason Mendelson(创业融资条款)、David Skok 与 Jason Lemkin 与 David Sacks(SaaS 单位经济与烧钱效率指标)、Warren Buffett 与 Charlie Munger(对 EBITDA 与股权激励费用化的著名批评)、CJ Gustafson 等现役 CFO 的时事通讯作者、以及中文圈的肖星与张新民等高校学者; (g) 争议/批判(必须保留不洗白) — 调整后 EBITDA 与非公认会计准则指标的滥用(把股权激励与一次性费用年年加回)、DCF 对假设的极端敏感与被用来事后合理化结论、独角兽估值与优先清算权造成的『纸面身价』幻觉、对赌与回购条款把股权融资变成隐性债务、Profit First 现金分桶法被专业会计批评为回避真实成本结构、作业成本法的实施失败率高、预算游戏与年底突击花钱、财务 BP 沦为报表美化、中国中小企业两套账的历史现实与金税四期后的合规收敛(如实呈现风险,不提供规避操作)、以及『融资额等于成功』的媒体叙事对创始人的误导; (h) 流派/思想谱系 — **准则与合规派(IASB/FASB/财政部,信可比性与审计留痕,语言是准则条文)** vs **管理会计/决策派(IMA 与贡献边际、作业成本法、有效产出会计,信决策相关性高于合规一致性)** vs **公司金融/估值派(Brealey-Myers-Allen 与 Damodaran,信现金流折现与资本成本)** vs **价值投资/资本配置派(巴菲特-芒格-Thorndike-Mauboussin,信业主收益与 ROIC,公开鄙视 EBITDA)** vs **创业与 SaaS 指标派(Skok-Lemkin-Sacks-Bessemer,信单位经济、回本周期与烧钱倍数)** vs **中小企业现金实操派(Crabtree、Profit First 一脉,信老板看得懂的少数几个数)**。不含: 投行卖方并购执行与尽调建模(已由 investment-banking-mna 覆盖)、VC 投资人的看项目与投后视角(已由 vc-investor 覆盖)、个人理财与二级市场投资(已由 personal-investing 覆盖)、注册会计师考证与准则条文背诵、以及任何税收规避操作建议。) Master O

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Use when 王建硕 wants to systematically grow his X (Twitter) followers by running numbered, A/B-testable growth experiments and tracking which ones actually work. Every action gets a number, a hypothesis, a target metric, a before-state (for rollback), and a verdict. The North-Star metric is the new-follower ÷ profile-visit ratio (conversion) — every profile change is judged against it. Daily it ingests the X Analytics CSV export, scores each running experiment, and recommends keep / rollback. Triggers — "涨粉", "增加 X 粉丝", "X 涨粉实验", "follower growth", "A/B test my profile", "今天的涨粉检查", "/wjs-x-increasing-follower".

日本語の概要は準備中です。原文の説明を表示しています。

Plan, draft, audit, and publish posts and threads for X (Twitter). Use when the user wants to write a single tweet or an auto-numbered thread, build a long-form tweetstorm, remove AI tells from a draft, reverse-engineer the hook from a viral tweet, draft a reply or quote tweet, or plan a week of X content. Tweets and threads publish via the Publora API, which auto-splits long content into a numbered thread. User provides notes or a tweet URL, the skill drafts, the user approves, then it publishes.

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Use when you are about to hand off any number, table, chart or analysis someone will act on (a metric query, a dbt mart, a report, an experiment readout) — the pre-delivery checklist for data quality, calculation, reasonableness and presentation, and the pitfalls that produce plausible wrong numbers

日本語の概要は準備中です。原文の説明を表示しています。

Rewrites the prompt typed after the command before any work starts, then works from the rewrite. Splits a mixed-up message into a numbered list of asks, turns words like "be 100% sure", "cover all cases" or "don't break anything" into the checks they stand for, keeps every name, path, number and quote exactly, and stops to ask only where it would have to guess. Runs only when the user types it.

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Establishes a project's quality bar as a written contract and stops agents quietly lowering it. Interviews the user on which dimensions matter, supplies sane default thresholds when they have no number in mind, records everything in CONSTRAINTS.md, and watches the diff for a weakened bar — new @ts-ignore or eslint-disable suppressions, skipped or deleted tests, assertions stripped out, unimplemented stubs, thresholds edited down. Use when no quality bar is written down, when the user says "set up constraints" or "define our standards", when the user wants dimensions they care about — accessibility, web performance, coverage — set up as enforced constraints, when an agent keeps silencing checks or skipping tests to get to green, when you need a coverage or performance threshold and don't know what number to pick, or when an agent writes more code than anyone will read.

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Query patent bibliographic (catalog) information from the Nexscope patent database by patent ID or publication number. Triggered when users mention patent bibliographic info queries, patent catalog information, patent applicant queries, patent inventor queries, patent classification codes, patent abstract retrieval, patent citation analysis, patent priority claims, patent application citations, patent examiner information, patent bibliographic data, inventor lookup, applicant lookup, patent classification, patent metadata, Nexscope, or patent citations. Even if the user does not explicitly mention "bibliographic info," this skill should be triggered whenever their need involves querying detailed metadata for a specific patent by patent ID or publication number.

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FIRE (Financial Independence Retire Early) calculator covering Lean FIRE, Fat FIRE, Coast FIRE, and Barista FIRE. Calculates FI number, years to FIRE based on savings rate, geographic arbitrage opportunities, sequence of returns risk, and withdrawal strategies (4% rule, dynamic withdrawal, guard rails). Use when the user says "/finance fire", "financial independence", "retire early", "FI number", "Coast FIRE", or any early retirement question.

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Personal assistant for the [YOUR LAST NAME] family. Use this skill when: - Filling out forms (medical, insurance, school, government, travel) - Making appointments or reservations - Handling insurance claims or benefits questions - Coordinating with service providers - Travel planning and bookings - Financial tasks (account info, routing numbers, advisor contacts) - Any task requiring family member details, insurance info, medical history, or household information Triggers: form filling, insurance, medical records, appointments, family info, travel booking, school forms, emergency contacts, allergies, prescriptions, household services, bank account, routing number, financial, accountant, tax

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Conjecture generation, sequence analysis, and experimental mathematics for mathematical discovery. Covers sequence analysis (OEIS lookups, recurrence relations, generating functions), pattern detection methods (finite differences, ratio analysis, modular patterns), conjecture generation workflow, classical integer sequences (Fibonacci, Catalan, partition numbers, Bernoulli numbers), combinatorial identities, the probabilistic method (Erdos, expected value arguments, Lovasz Local Lemma), AI-assisted discovery (FunSearch, Ramanujan Machine), and confidence calibration with cautionary tales (Mertens conjecture, Polya conjecture). Use when discovering patterns, analyzing sequences, generating conjectures, or working with combinatorial identities.

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Creates a GitHub milestone on the current repository and returns its number for downstream use. Use when starting a new sprint, release, or theme grouping of backlog items. No args triggers guided intake (title, due date, description); 'quick {title}' skips to description only. Checks for duplicates before creating. Returns milestone number for /group-items-to-milestone.

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Runs end-stage QA on a finished figure and table set. Checks callouts, numbering, and cross-references, whether numbers in the text match the exhibits, self-contained captions and statistical notes, accessibility and production quality, and links to the SI and replication package. Values that could only be read off an image are marked for author verification rather than estimated. Use when preparing a submission. Design guidance during drafting belongs to figures and tables.

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Run the oncall handoff for a rotation window — the whole handoff, not just a document: build the summary (what the incoming oncall needs first, what's still open, incidents with impact numbers, alert and page counts, hygiene suggestions, every number traceable to a source), post it for the outgoing oncall to correct, walk the incoming oncall through the open items in the thread, update the list as they respond, and note when they acknowledge. Runs mainly in the team's standing oncall / monitoring channel, normally as a scheduled routine firing at rotation change so the report is waiting when the shift turns over; can also be run by hand and works from an incident channel. Use when a handoff routine fires, or on "handoff", "hand over", "oncall summary", "weekly oncall report", "what happened this shift / this week". Re-running for the same window updates the report rather than duplicating it. Unattended runs carry a run-summary block and at least one chart.

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Insert, format, and number math formulas in Word and LaTeX academic papers. Supports Chinese core journals and international journal formats. Invoke when user needs to insert LaTeX formulas into Word (OMML), validate formula formats per journal standards, or auto-number equations.

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Wrap a raster image in an SVG and overlay a numbered red "step" circle for course screenshots. Use when running /create-svg-image, or when asked to add a numbered callout badge to an image (e.g. a red circle with a "1" pointing at a UI control) that must still render on a GitHub README.

日本語の概要は準備中です。原文の説明を表示しています。