2,353 件 ・ 関連度順
概要と使いどころ
Capture a correction or lesson as a persistent learning rule with category, mistake, and correction. Stores, categorises, and retrieves rules for future sessions. Use after mistakes or when the user says "remember this", "don't forget", "note this", or "learn from this".
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Runs SQL queries on CloudWatch Logs data exported as Apache Iceberg tables in S3 Tables. Covers VPC Flow Logs, WAF logs, CloudFront access logs, Route 53 resolver logs, Network Firewall logs, EKS audit logs, Verified Access logs, SES logs, VPC Lattice logs, Step Functions logs, NLB access logs, and 20+ other AWS vended data sources. Applies when analyzing network traffic, investigating security incidents, querying exported logs with SQL, enabling S3 Tables integration, configuring log export, correlating logs with other data, or running Athena queries on the aws-cloudwatch table bucket. Trigger phrases: query logs with SQL, analyze logs in Athena, SQL on VPC flow logs, investigate network traffic, run SQL on exported logs, enable S3 Tables for CloudWatch, correlate logs, historical log analysis, set up log querying.
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Routes any task involving AWS databases — choosing, comparing, recommending, getting started with, or operating a database — to the correct service-specific skill. Supersedes general training-data knowledge with post-training service updates, corrected limitations, and decision procedures for relational (Aurora, DSQL, RDS), key-value (DynamoDB), wide-column (Keyspaces), document (DocumentDB), graph (Neptune), time-series (Timestream), and in-memory/caching (ElastiCache, MemoryDB) workloads. Activates when a user describes building an application on AWS that will store, retrieve, or manage data, even if they do not mention 'database' explicitly.
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Org-grade attack-surface mapping: given a company's legal identity, discover its ENTIRE owned internet footprint — corporate family -> owned domains -> owned netblocks/ASN -> live assets — with attribution discipline, not just DNS breadth. The org-first attribution pyramid (legal entity -> LEI/registration -> corporate family -> owned domains -> owned netblocks/ASN -> live assets). Corporate-identity resolution via the GLEIF LEI API (legal name -> LEI, exact-LEI direct-children expansion, downward-only depth-capped BFS, NEVER a name re-resolution), SEC-EDGAR full-text search + Exhibit-21 subsidiary entity names, OpenCorporates entity corroboration, Wikidata SPARQL corporate graph (P856/P355/P749/P1830). Domain attribution via reverse-WHOIS (WhoisXML preview-then-purchase quota guard, SecurityTrails associated-domains — both paid), crt.sh O= certificate-transparency organization pivot (keyless), infrastructure correlation (shared NS/MX/SaaS-TXT, netblock membership, reverse-DNS PTR), and the independent-evidence combiner (1-prod(1-w_i), rule of three, OwnerTier NONE/WEAK/MODERATE/STRONG/CONFIRMED) — discover-only `related:` candidates are NEVER auto-scanned. Netblock/ASN attribution via org-first RIR queries (ARIN Whois-RWS org-handle search, RIPE DB organisation + inverse-org search) that recover 'dark netblocks' with no DNS link to the seed, ASN discovery (RIPEstat + BGPView union), the HYPERSCALER-SCOPE GUARD (never attribute a whole AWS/GCP/Azure/Cloudflare announced range to a tenant — keep only the seed-containing block, tag shared_hosting_cdn), and org-identity-seeded internet-scan-index queries (Shodan/Censys/ZoomEye/FOFA/BinaryEdge org: filters + an always-on keyless crt.sh fallback). Promote-to-scan triage ranks forgotten discover-only netblocks by remote-access exposure (gateway-vendor/KEV/control-plane/datastore port scoring) into an operator queue. Attribution confidence rubric + anti-patterns (namesake grafting via GLEIF name re-resolution, single-signal ownership, hyperscaler over-attribution, privacy-WHOIS pivot poisoning, RIR org-name collisions). Passive/keyless-first OSINT only — every paid-key dependency is enrichment on top of a keyless core, never a hard requirement. Use when mapping an organization's full corporate-family internet footprint, resolving a legal entity to its LEI/subsidiaries, discovering domains/netblocks/ASNs an org owns beyond its one seed domain, auditing M&A/shadow-IT sprawl, or scoping an engagement that starts from a company NAME rather than a domain.
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Every shot carries its own timecode and shows one visible change on a body. The dread comes from the chain — a look, veins, a bite, the next person — and the ending seals a door without settling anything. Use when the user wants a Seedance 2.5 / 2.0 video prompt for this kind of clip (Horror and suspense; 中文触发词: 恐怖悬疑短片, 恐怖, 悬疑, 惊悚), or asks how published cases of this type were prompted. Read references/cases.md before drafting.
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Perform statistical tests, hypothesis testing, correlation analysis, and multiple testing corrections using scipy and statsmodels. Works with ANY LLM provider (GPT, Gemini, Claude, etc.).
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Use when correcting batch effects in merged bulk expression matrices with sample-level batch metadata while preserving biological group structure and generating before-and-after QC plots. NOT for: single-cell integration, raw FASTQ processing, differential expression without batch labels, or datasets without biological groups.
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Self-learning system that captures corrections during sessions and reminds users to run /reflect to update CLAUDE.md. Use when discussing learnings, corrections, or when the user mentions remembering something for future sessions.
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Für Nacherfüllung Vorrang: ordnet Norm, Beweislast und Gegenargument; Ergebnis: Prüfprodukt mit Risiko und nächstem Schritt.
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Comprehensive adversarial audit of a theory, proof, math/econ paper, codebase, or set of claims — decompose into components, fan out independent skeptics that must return CONCRETE defects, adjudicate every finding with a separate judge, fix all confirmed defects, then re-verify. Use when correctness must be bulletproof and single-pass or round-by-round review is too slow and too shallow. Invoke for "audit this rigorously", "find ALL the bugs/gaps", "make this rock solid", "converge faster on correctness".
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Genre anatomy from John Truby's The Anatomy of Genres (类型解剖 / 类型节拍 / 混合类型 / 超越类型) — genres as beat systems with a life philosophy underneath; three rules (hit every beat of your genre, mix three or four genres, transcend the primary genre), the ladder and families of twelve genres (Horror 恐怖, Action 动作, Myth 神话, Memoir and Coming-of-Age 回忆录与成长, Science Fiction 科幻, Crime 犯罪, Comedy 喜剧, Western 西部, Gangster 黑帮, Fantasy 奇幻, Detective and Thriller 侦探与惊悚, Love 爱情), each with its hero/opponent/world/plot-shape template, beat list, hard rules with failure conditions, subgenres and transcendent paths, plus a genre-mixing worksheet and a diagnostic. Kept beside sw-truby-anatomy and the Field/Snyder page maps. Use when choosing or confirming a script's genre, when a genre story feels generic or misses the beats its audience expects, when mixing genres, when a horror lacks pressure, an action lacks plot, a love story lacks opposition or a detective story lacks reveals.
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Run a blameless postmortem for an incident caused by an AI agent or LLM feature — hallucinated facts shipped to users, runaway tool use, prompt injection, cost blowouts, or wrong actions taken autonomously. Use when asked to write up an AI incident, analyse why an agent did something wrong, or produce corrective actions after an LLM failure. Produces a structured postmortem with trace reconstruction, a root-cause layer analysis, and corrective actions including a permanent regression case. For non-AI production incidents use incident-postmortem.
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Use this skill when the user wants to curate the SATK library knowledge index for a Simulink project — mark commonly used blocks, correct auto-assigned block categories, or improve block descriptions so the model-building agent picks better blocks from custom libraries. Triggered by phrases like "mark blocks common", "improve block descriptions", "correct block category", "make the agent prefer certain blocks", and from Gate 3 of building-simulink-models.
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Extracts cfDNA fragmentomics features (DELFI genome-wide short/long ratios, WPS nucleosome positioning, Griffin GC-corrected accessibility profiles, end-motifs/MDS, OCF) for cancer detection and tissue-of-origin from plasma WGS. Centers on the nuclease-footprint reframe (every feature re-reads one nucleosome object), the mandatory GC correction, and the cross-protocol non-comparability that breaks naive classifiers. Runs FinaleToolkit (real CLI/Python, MIT) and the Griffin Snakemake pipeline; DELFI is a method, not a package. Use when deriving fragment-based signal from cfDNA, choosing a feature family for detection vs subtyping, or diagnosing why a fragmentomic model failed validation.
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Detects A/B chromatin compartments from balanced Hi-C contact matrices via eigenvector decomposition of the distance-normalized, Pearson-correlated cis matrix with cooltools (eigs_cis), then orients (phases) the compartment eigenvector against a GC or gene-density track so the active (A) sign is not arbitrary. Covers the eigenvector-is-a-choice problem (per-arm view_df to remove the centromere gradient; picking the eigenvector by max correlation with activity, not by eigenvalue), GC phasing with bioframe.frac_gc, resolution choice (100kb-1Mb), saddle plots and saddle_strength for compartmentalization strength, the cohesin-loss-strengthens-compartments result, subcompartments (SNIPER/Calder/dcHiC), and cross-condition compartment switching. Use when calling A/B compartments, computing E1/eigenvectors, phasing the eigenvector, building saddle plots, choosing a compartment resolution, quantifying compartment strength, or comparing compartmentalization across conditions.
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Basecalls raw Oxford Nanopore signal (POD5/FAST5) into reads with Dorado, choosing the chemistry-matched model and accuracy tier (fast/hac/sup), requesting modified bases (5mCG_5hmCG, 6mA, m6A) at basecall time, and handling duplex, demultiplexing, trimming, and HERRO read correction. Covers why the model+version is an irreversible analysis decision, why methylation cannot be recovered later, and why downstream polish/variant models must match the basecaller. Use when converting POD5/FAST5 to reads, picking a Dorado model for R9/R10 or RNA004, enabling methylation calling, basecalling duplex, demultiplexing barcoded runs, or correcting reads for assembly.
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Compares Hi-C contact maps between conditions across the right scale -- differential bin-pair contacts (multiHiCcompare, diffHic), differential A/B compartments (dcHiC), differential TAD boundaries (delta insulation), and differential loops (diffloop, DiffHiChIP) -- with distance-stratified between-sample normalization, replicate-aware NB-GLM FDR, HiCRep SCC reproducibility gating, and CNV correction for cancer/aneuploid samples. Use when comparing Hi-C between treatment and control, finding differential contacts/compartments/boundaries/loops, normalizing two maps of unequal depth, choosing a replicate-aware test, gating replicates with SCC, or correcting copy-number artifacts before a tumor-vs-normal comparison.
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Normalizes and transforms RNA-seq count matrices for DE, visualization, clustering, and ML. Covers between-sample (TMM, TMMwsp, RLE/median-of-ratios, upper quartile), within-sample (TPM, FPKM/RPKM), variance-stabilizing (VST, rlog, log-CPM), GC-content correction (cqn, EDASeq), and single-cell (scran deconvolution, scanpy normalize_total). Encodes the composition-bias rationale, the "most genes not DE" assumption and its catastrophic failure modes (MYC amplification, apoptosis, viral host shutoff, prokaryotic stress), the "lengthScaledTPM is not TPM" naming trap, the "TPM is not for DE" rule, the blind=TRUE vs FALSE decision, ERCC spike-in normalization (SBN), and the single-cell zero-inflation breakdown of TMM/RLE. Use when choosing or applying normalization, debugging shifted-MA-plot diagnostics, handling zero-heavy single-cell data, or correcting GC bias.
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Assesses genetic health of populations for conservation with Ne estimation across time horizons (LDNe NeEstimator V2 option-file API + SNeP physical-linkage correction; recent trajectory via GONE/GONE2; deep history via Stairway Plot 2 / dadi / fastsimcoal2 / PSMC), F-statistics, runs of homozygosity binned by length class to date inbreeding, genetic-load decomposition (Bertorelle 2022 realized vs masked), the modern 100/1000 Ne rule (Frankham 2014), Ne/Nc 2-6 orders of magnitude in marine fish (Hauser & Carvalho 2008), tree-sequence forward simulations (SLiM 4 + pyslim + tskit), and the Sukumaran-Knowles caveat against MSC methods for management-unit definition. Use when estimating Ne by time horizon, detecting inbreeding via F_ROH, decomposing genetic load, justifying conservation thresholds, distinguishing ESU/MU/DPS, configuring NeEstimator V2, or correcting LDNe physical linkage.
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Corrects fluorophore spillover (conventional compensation) or spectral overlap (spectral unmixing) and applies variance-stabilizing transforms (logicle/biexponential, arcsinh, log) for flow and mass cytometry. Covers spillover-matrix estimation from single-stain controls, AutoSpill, the spillover spreading matrix and why panel design (not compensation) bounds resolution, compensate-then-transform ordering, and arcsinh cofactor choice (5 for CyTOF, ~150 for fluorescence, per-channel via flowVS). Use when correcting spectral overlap, preparing data for gating/clustering, choosing logicle vs arcsinh, deciding a cofactor, or distinguishing compensation from spectral unmixing.
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Detect, date, and contextualize whole-genome duplication (WGD / paleopolyploidy) events using wgd v2 (Chen et al 2024), KsRates (Sensalari 2022 substitution-rate-corrected Ks dating), DupGen_finder (Qiao 2019), MAPS (Li 2018 phylogenomic), POInT (Conant 2008 ordered-block), SLEDGe (2024 ML-based), Whale.jl (Bayesian DL+WGD), and synteny-anchored paranome construction. Use when identifying ancient polyploidy from Ks distributions and synteny block analysis, positioning WGD events relative to speciation, distinguishing tandem from segmental from WGD duplications, dating the 2R/3R vertebrate / fish / salmonid WGDs, building paranome and Ks-age mixture models, applying KsRates substitution-rate correction across lineages, or testing alternative biased-fractionation / dosage-balance models post-WGD.
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Normalize read-depth copy-ratio profiles and segment them into copy-number regions using circular binary segmentation (CBS, DNAcopy), hidden Markov models, HaarSeg, and fused-lasso methods. Covers GC-content, mappability, and replication-timing (wave-artifact) bias correction, panel-of-normals/PCA denoising, diploid-baseline centering, and algorithm selection by sequencing depth and event size. Use when choosing a segmentation algorithm, correcting depth bias, diagnosing oversegmentation or a mis-centered baseline, tuning CBS or HMM parameters, or understanding why a downstream CNV caller produced fragmented or shifted segments.
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Estimates SNP heritability and partitions it across functional annotations, cell types, and loci from GWAS summary statistics or individual-level genotypes. Implements LDSC, stratified LDSC with the baseline-LD model, Finucane 2018 cell-type prioritization, LDAK SumHer, HDL, HESS local heritability, BOLT-REML, GCTA-GREML, graphREML, and Popcorn cross-population genetic correlation. Use when computing total h2_SNP from summary stats, partitioning heritability across functional categories, prioritizing trait-relevant tissues or cell types from ENCODE/Roadmap chromatin marks, reconciling LDSC vs LDAK enrichment estimates, computing local heritability with HESS, estimating genetic correlation between traits, or producing publication-grade enrichment with calibrated sensitivity to model assumptions.
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Detect and adjust for horizontal pleiotropy in two-sample Mendelian randomization by distinguishing uncorrelated (UHP) from correlated (CHP) pleiotropy and choosing among Egger, MR-PRESSO, MR-RAPS, CAUSE, LHC-MR, LCV, MR-Clust, MR-Mix, and contamination-mixture methods. Use when validating an MR causal claim, running the STROBE-MR sensitivity battery, suspecting a shared heritable confounder, working under weak-instrument or polygenic-exposure regimes, or reconciling discordant estimates across robust methods.
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