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概要と使いどころ
Analyze DEX liquidity pools for TVL, volume, fees, impermanent loss, and LP profitability. Use when analyzing liquidity pools, calculating impermanent loss, or comparing DEX pools. Trigger with phrases like "analyze liquidity pool", "calculate impermanent loss", "LP returns", "pool TVL", "DEX pool metrics", or "compare pools".
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Turns one-shot external recon into a continuous monitoring program. Covers the scheduled re-scan-and-diff loop (baseline snapshot -> interval sleep -> re-scan -> asset/finding delta -> threshold-gated webhook alert), the scan-to-scan diff engine (new/removed/changed assets by a tracked-attribute table, new/resolved findings by a stable cross-scan fingerprint), adversary CTI / chatter monitoring across six public feeds (ransomwatch, ransomware.live, HackerNews Algolia search, Reddit security-subreddit RSS, GitHub Gist code-search, public Telegram channel scraping) with a source-kind-aware severity engine (leak-site/forum/telegram/paste tiers, CRITICAL through INFO), literal/glob/regex watchlist pattern matching, full-corpus capture with retroactive rescan on new watchlist entries, infrastructure-tracking-over-time discipline (certificate-transparency, passive-DNS, port/service, and typosquat re-enumeration cadence, and what a genuine 'perimeter drift' event looks like in the diff output), a five-state finding-lifecycle state machine (open/triaged/risk_accepted/resolved/false_positive) with per-severity SLA and fingerprint-based cross-scan dedup and auto-resolve/reopen rules, the alert-fatigue trap where a lifecycle-unaware rule re-fires on an already-accepted finding, a durable retry/backoff alert-outbox pattern ('queued is not delivered'), and copy-paste bash-cron plus PowerShell-Scheduled-Task recipes for a re-scan+diff loop with the Slack-compatible webhook payload shape. Passive OSINT and analysis only -- no new active-intrusion technique. Use when setting up ongoing monitoring for a retainer or MSSP engagement, tuning alert thresholds to avoid fatigue, triaging a finding's lifecycle status, investigating adversary chatter about a brand, building a 'what changed on the perimeter since last week' report, or deciding whether a persisting finding should re-alert.
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Create cross-platform agent skills from workflow descriptions. Activates when users ask to create an agent, automate a repetitive workflow, create a custom skill, or need advanced agent creation. Triggers on phrases like create agent for, automate workflow, create skill for, every day I have to, daily I need to, turn process into agent, need to automate, create a cross-platform skill, validate this skill, export this skill, migrate this skill, audit this skill, is this skill safe, vet a skill before installing, what does this skill access. Supports single skills, multi-agent suites, transcript processing, template-based creation, interactive configuration, cross-platform export, spec validation, and security auditing of third-party skills before install.
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Train and run models on Tinker (Thinking Machines) — LoRA and full fine-tuning, SFT with correct loss masking, RL/RFT with group-relative advantages and importance sampling, agentic RL over multi-turn tool-using agents, inference via the SamplingClient or the OpenAI-compatible endpoint, checkpoint management and export, every hyperparameter, and cost estimation from the live price table. Use this skill whenever the user mentions Tinker, tinker://, TINKER_API_KEY, console.tinker.ai, or the tinker CLI; wants to fine-tune, SFT, RFT, or RL a model on Tinker; asks about Tinker models, context windows, LoRA rank, sampling params, loss functions (cross_entropy, importance_sampling, ppo, cispo, dro), Datum construction, forward_backward or optim_step; wants to sample from, download, resume, merge, or export a Tinker checkpoint; or asks what a Tinker run will cost. Whenever Tinker work is initialized in a project, this skill also creates a TINKER_PRICING.md there so prices sit next to the training code. Reach for it even on vague asks like "train a model on this data" or "get inference working" when Tinker is the platform in play.
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Rewrites technical research content into a structured lay summary that cross-disciplinary teams can quickly understand and act on. Use when the user wants to explain research to colleagues outside their specialty — clinicians, wet-lab scientists, bioinformaticians, product managers, or leadership. Trigger on: "lay summary", "explain my research to the team", "non-technical summary", "cross-disciplinary summary", "translate my findings", "align our team on the study", or any request to communicate research goals, findings, or next steps to a mixed or non-specialist audience. Part of the AIPOCH Academic Writing skill hub. Sits midstream: after research content is clarified, before downstream deliverables like slide decks or graphical abstracts.
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Research what Chinese internet users actually said in the last 30 days across Weibo, Xiaohongshu (RED), Bilibili, Zhihu, Douyin, WeChat public accounts, Baidu and Toutiao: engagement-weighted ranking, cross-platform clustering, cited Markdown/JSON/HTML reports. Also shows today's cross-platform hot-search board (全网热榜, --hot) and can add Hacker News / GitHub / Reddit or an installed upstream last30days for X/YouTube/TikTok.
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Use when evaluating Walter Schloss-style cigar-butt value: cheap stocks, balance sheets, diversification across many bargains, and avoiding glamorous stories.
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Configure cross-env for cross-platform environment variable setting in npm scripts and CLI commands.
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Perform cross-artifact consistency and coverage analysis across constitution, specification, plan, and task artifacts to detect gaps, conflicts, and misalignments before implementation.
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Use when asked Temu 全托管还是半托管, TikTok Shop 怎么入驻, 亚马逊和 Temu 选哪个, 跨境电商平台怎么选, 产品出海要哪些认证, or choose and launch on cross-border marketplaces (Temu, TikTok Shop, Amazon, SHEIN, AliExpress). Produces a platform fit matrix for the seller's product and capacity, the operating model of each shortlisted platform (fully managed, semi-managed or self-operated), the compliance checklist by target market, a 90-day launch plan, and the questions to ask each platform's account manager. For the product listing copy itself, use cross-border-listing.
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Detects TAD boundaries from balanced Hi-C contact matrices via the diamond-window insulation score (cooltools insulation) and HiCExplorer hicFindTADs, returning a continuous log2 insulation track, valley-prominence boundary_strength, and Li/Otsu-thresholded is_boundary flags across a list of window sizes. Covers the multi-scale window sweep (sub-TAD to compartment-domain), why the boundary is reproducible but the domain partition is not, cross-condition comparison via differential SCORE not differential partition, and the insulation-vs-compartment orthogonality. Use when calling TADs or domain boundaries, computing insulation scores, choosing a window size, ranking boundary strength, comparing boundaries across conditions, or annotating CTCF-backed boundaries; route domain rendering to hic-visualization and boundary-feature overlap to genome-intervals.
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Detects A/B chromatin compartments from balanced Hi-C contact matrices via eigenvector decomposition of the distance-normalized, Pearson-correlated cis matrix with cooltools (eigs_cis), then orients (phases) the compartment eigenvector against a GC or gene-density track so the active (A) sign is not arbitrary. Covers the eigenvector-is-a-choice problem (per-arm view_df to remove the centromere gradient; picking the eigenvector by max correlation with activity, not by eigenvalue), GC phasing with bioframe.frac_gc, resolution choice (100kb-1Mb), saddle plots and saddle_strength for compartmentalization strength, the cohesin-loss-strengthens-compartments result, subcompartments (SNIPER/Calder/dcHiC), and cross-condition compartment switching. Use when calling A/B compartments, computing E1/eigenvectors, phasing the eigenvector, building saddle plots, choosing a compartment resolution, quantifying compartment strength, or comparing compartmentalization across conditions.
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Maps between gene identifier systems (Ensembl, Entrez, HGNC symbol, UniProt, RefSeq, MANE) using AnnotationDbi, biomaRt, mygene, pyensembl, and Ensembl REST. Encodes Ensembl version stripping with GENCODE _PAR_Y preservation, the Ziemann 2016 Excel autocorrect debacle and Bruford 2020 HGNC renames (SEPT*->SEPTIN*, MARCH*->MARCHF*, MARC*->MTARC*, DEC1->DELEC1), OCT4/POU5F1 alias resolution, biomaRt archive endpoints for release pinning, the `filters` (plural) gotcha, MANE Select for clinical reporting, cross-species orthology via Ensembl Compara / OMA / OrthoDB, and tx2gene construction for tximport. Use when converting gene IDs across systems, handling renamed symbols, building tx2gene, pinning to a specific Ensembl release for reproducibility, or mapping cross-species orthologs.
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Cross-method decision tree for calling hits in pooled CRISPR screens. Catalogs statistical models (MAGeCK RRA, MAGeCK MLE, BAGEL2, drugZ, JACKS, Chronos, CERES), experimental designs each is built for, failure modes outside design domain, reconciliation when methods disagree, multiple-testing and effect-size thresholds, the order of operations (count -> QC -> CN-correct -> hit-call -> validate), the second-best-sgRNA conservative rule, and consensus-hit strategy. Use when choosing among MAGeCK / BAGEL2 / drugZ / JACKS / Chronos for a given design, reconciling disagreement across two or three methods on the same screen, deciding whether to require consensus, gating downstream validation by hit-confidence tier, or interpreting unstable hit lists across reruns.
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Segments the genome into chromatin states from combinatorial histone modification and chromatin factor ChIP-seq data. Uses ChromHMM (multivariate HMM on binarized signal, v1.27), Segway (Dynamic Bayesian Network on continuous signal), EpiSegMix (flexible-distribution HMM with duration modeling, 2024), EpiLogos (multi-biosample visualization), IDEAS (cell-type-aware joint), and full-stack ChromHMM (Vu Ernst 2022) for cross-cell-type segmentations. Handles state-count selection (15 vs 18 vs 25 states), binarization choice, OverlapEnrichment / NeighborhoodEnrichment downstream analysis, and cross-biosample integration. Use when learning chromatin states from a histone mark panel, characterizing learned states by genomic feature enrichment, or comparing chromatin landscapes across cell types.
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Estimates SNP heritability and partitions it across functional annotations, cell types, and loci from GWAS summary statistics or individual-level genotypes. Implements LDSC, stratified LDSC with the baseline-LD model, Finucane 2018 cell-type prioritization, LDAK SumHer, HDL, HESS local heritability, BOLT-REML, GCTA-GREML, graphREML, and Popcorn cross-population genetic correlation. Use when computing total h2_SNP from summary stats, partitioning heritability across functional categories, prioritizing trait-relevant tissues or cell types from ENCODE/Roadmap chromatin marks, reconciling LDSC vs LDAK enrichment estimates, computing local heritability with HESS, estimating genetic correlation between traits, or producing publication-grade enrichment with calibrated sensitivity to model assumptions.
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Estimates bivariate genetic correlation (rg) between traits from GWAS summary statistics or individual-level genotypes using cross-trait LDSC, HDL, LAVA, rho-HESS, GREML-bivariate, Popcorn, and HDL-L. Use when quantifying shared genetic architecture between two traits, screening MR validity before causal inference, distinguishing global from locus-level rg, estimating trans-ancestry rg, separating partial from full causation via LCV gcp, or producing a STROBE-MR-compliant cross-trait sensitivity battery. Cross-trait LDSC intercept absorbs sample overlap and is NOT a bias; HDL is biased under sample overlap above ~5%. High rg between exposure and outcome motivates CHP-aware MR sensitivity (CAUSE, LHC-MR).
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Use when building reusable Obsidian glossary notes from an existing paper source manifest, optionally with a raw-sections override, especially when a reader needs a reviewed shortlist before glossary notes and article links are changed.
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Optimize RF PCB dimensions for bandwidth, return loss, or area via patternsearch and surrogateopt with constraints. TRIGGER: user asks to optimize an RF PCB component for performance (bandwidth, return loss, insertion loss, area) or apply constraints to a design. Invoke BEFORE writing optimization code — RF PCB Toolbox has a built-in optimize() function that differs from generic fmincon/ga approaches. SKIP: designing a component from scratch without an optimization objective (use the specific matlab-design-pcb-* skill), EM analysis without optimization (use matlab-analyze-em), material/stackup setup only (use matlab-manage-pcb-material).
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Microstrip, stripline, CPW, differential pairs, and crosstalk analysis for impedance-controlled PCB interconnects. TRIGGER: user asks to design or analyze a transmission line (microstrip, stripline, CPW, coplanar, differential pair), extract RLGC or per-unit-length parameters, compute trace impedance, analyze a PCB trace cross-section, or perform crosstalk/coupling analysis. Invoke BEFORE writing code — preferred over RF Toolbox analytical functions (txlineMicrostrip, txlineStripline, txlineCPW). SKIP: EM simulation/S-parameter extraction of an existing component (use matlab-analyze-em), material/stackup definition only (use matlab-manage-pcb-material), building custom non-catalog geometry (use matlab-assemble-pcb-layout), optimization sweeps (use matlab-optimize-pcb-design).
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Verify claims, quotations, citations and references against live primary sources, and produce a reproducible audit record instead of an assertion. Use when asked to: check whether a quotation, verse, statistic, date, attribution or citation is accurate; verify references before publishing a report, thesis, article, slide deck or legal filing; confirm a text against an authoritative database; cross-check a claim across independent sources; build a citation register or verification appendix; find out whether two datasets agree; detect a misattributed or fabricated quotation; or audit a document's existing citations. Source-agnostic by design, with working providers for REST/JSON APIs, scraped HTML, bulk corpora, bibliographic catalogues (OpenLibrary), DOI resolution (Crossref) and reference works (Wikipedia) -- including scriptural tiers (Qur'an.com, sunnah.com and an independent hadith corpus) with full diacritic handling for Arabic, Hebrew, Greek and any script with optional marks. Covers content-addressed matching when sources disagree on numbering, graded match verdicts, byte-level integrity checks, published-string verification, and a catalogue of silent failure modes (identifier divergence, mojibake, scraper blocking, false-positive keyword rules, missing glyphs, unreliable PDF text layers).
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Cross-border selling on TikTok Shop. Market selection, logistics setup, localization strategy, compliance requirements, and international expansion. Use when the user asks about TikTok Shop international selling, cross-border ecommerce, global expansion, or selling in multiple countries.
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Cross-platform PPC strategy planner for ecommerce businesses. Analyzes your product and margins, recommends the right advertising platforms (Google Ads, Meta Ads, TikTok Ads), calculates ROAS targets, allocates budget across channels, and generates platform-specific campaign briefs with ad copy and creative direction. Two modes: (A) Build — design a multi-platform ad strategy from scratch, (B) Optimize — audit existing cross-platform campaigns and reallocate budget. Works for Shopify, WooCommerce, standalone stores, and marketplace sellers expanding to external traffic. No API key required.
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Cross-border e-commerce expansion advisor. Scores target markets on 8 weighted dimensions (market size, ecommerce penetration, competition, regulatory complexity, logistics infrastructure, payment ecosystem, cultural distance, IP protection), compares 5 fulfillment models with cost and transit data, provides country-by-country tax/duty compliance guides (EU VAT/IOSS, UK VAT, US sales tax, CA GST, AU GST, JP consumption tax), maps local payment preferences by market, and builds a phased expansion roadmap. No API key required.
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