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Quality control metrics and filtering thresholds for protein design. Use this skill when: (1) Evaluating design quality for binding, expression, or structure, (2) Setting filtering thresholds for pLDDT, ipTM, PAE, (3) Checking sequence liabilities (cysteines, deamidation, polybasic clusters), (4) Creating multi-stage filtering pipelines, (5) Computing PyRosetta interface metrics (dG, SC, dSASA), (6) Checking biophysical properties (instability, GRAVY, pI), (7) Ranking designs with composite scoring. This skill provides research-backed thresholds from binder design competitions and published benchmarks.

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健身私教 — 为客户设计、指导和推进个性化训练方案的专业工艺, 有别于团课教练、物理治疗师或运动队教练: (a) 训练方案设计与周期化 (线性 / 波动 / 板块周期化 Bompa & Haff; NSCA《力量训练与体能训练精要》行业圣经; Schoenfeld 肌肥大机制; Helms/Valdez/Morgan 肌肉与力量金字塔; 共轭训练法 Simmons/Westside; Starting Strength 线性渐进 Rippetoe; Renaissance Periodization 训练量地标 Israetel); (b) 动作评估与筛查 (FMS 功能性动作筛查 Gray Cook; NASM CEx 纠正性训练连续体 抑制-拉伸-激活-整合; 关节逐级方法 Cook/Boyle; 姿势与代偿模式识别; PAR-Q+ 与 ACSM 运动前筛查指南); (c) 教学与指令 (外部 vs 内部注意焦点 Wulf; 差异化学习 Schöllhorn; 约束导向方法 Davids/Renshaw; RIR/RPE 自动调节 Zourdos/Helms; 动机访谈在健身中的应用 Rollnick/Miller); (d) 营养指导的执业边界 (宏量营养素周期化; Precision Nutrition / ISSN 立场声明的循证建议; 边界: 私教提供一般性指导, 医学营养治疗需 RD/RDN 资质; 能量可用性与 RED-S Mountjoy IOC 共识); (e) 商业与客户管理 (客户留存与方案依从; 咨询与销售伦理; 线上教练平台与规模化 Goodman PTDC; 方案交付工具 TrueCoach/Trainerize/TrainHeroic; 课时定价模型; 独立教练 vs 健身房雇员); (f) 专项方向 (运动表现 CSCS; 纠正性训练 CES; 老年健身 SFN; 产前产后; 青少年 YSCA; 适应性 / 无障碍健身; 健美 / 形体; 力量举; 耐力运动 S&C)。诚实处理: 兄弟科学 vs 循证之争, 补剂行业利益冲突, 合成代谢激素使用现状 (诚实但不推广: 匿名调查约 30% 有经验男性健身者使用过 — 业内估, Kanayama/Pope/Hudson 记录健康风险, WADA 禁用清单用于竞技语境), 体型焦虑与进食障碍风险 (男性私教肌肉变形症, 正食症倾向, NEDA 负责任语言指南), 健身房掠夺性销售 (高压推销、误导性对比照、长约锁定), 执业边界违规 (私教诊断伤病或超范围开饮食处方), 线上教练认证造假 (周末速成、未经认可的认证)。不含: 物理治疗 / 康复治疗 (持照医疗职业), 不含: 团课教练 (Les Mills/Zumba/CrossFit 分馆教练 — 相邻但不同), 不含: 精英竞技运动教练 (团队项目周期化, 不同职业路径), 不含: 营养作为主业 (临床营养学需单独资质)。 (Personal Trainer — the craft of designing, coaching, and progressing individualized exercise programs for clients, distinct from group fitness instruction, physiotherapy, or sports coaching: (a) exercise programming and periodization (linear / undulating / block periodization per Bompa & Haff; NSCA Essentials of Strength Training and Conditioning as industry bible; Schoenfeld on hypertrophy mechanisms; Helms/Valdez/Morgan Muscle & Strength Pyramids; conjugate method Simmons/Westside; Starting Strength linear progression Rippetoe; Renaissance Periodization volume landmarks Israetel); (b) movement assessment and screening (FMS Gray Cook; NASM CEx corrective exercise continuum inhibit-lengthen-activate-integrate; joint-by-joint approach Cook/Boyle; posture and compensation pattern identification; PAR-Q+ and pre-exercise screening ACSM guidelines); (c) coaching and cueing (external vs internal cueing Wulf attentional focus research; differential learning Schöllhorn; constraints-led approach Davids/Renshaw; RIR/RPE autoregulation Zourdos/Helms; motivational interviewing for adherence Rollnick/Miller adapted to fitness); (d) nutrition guidance within scope of practice (macronutrient periodization; evidence-based recommendations per Precision Nutrition / ISSN position stands; scope boundary: PT gives general guidance NOT medical nutrition therapy which requires RD/RDN credential; energy availability and RED-S awareness Mountjoy IOC consensus); (e) business and client management (client retention and programming adherence; consultation and sales ethics; online coaching platforms and scaling Goodman PTDC; programming delivery tools like TrueCoach/Trainerize/TrainHeroic; session pricing models; independent contractor vs gym employee dynamics); (f) specialization tracks (sports performance CSCS; corrective exercise CES; senior fitness SFN; pre/postnatal; youth YSCA; adaptive/inclusive fitness; bodybuilding/physique coaching; powerlifting/strength sports; endurance athlete S&C). Evidence-based practice as the core ethos: Schoenfeld/Krieger meta-analyses on volume-response, Helms systematic reviews on protein/resistance training, Brad Schoenfeld's MASS journal bridging research to practice, Menno Henselmans and Eric Helms as practitioner-researchers, Greg Nuckols Stronger By Science as translation layer. Chinese fitness industry context: rapid growth of personal training in commercial gyms (Keep/Lefit/Megafit chains), NSCA-CPT and ACE-CPT as dominant certifications alongside local CSFA (China Sport and Fitness Association) credential, '体适能' (physical fitness) as formal term, online coaching boom post-COVID, PT business models in tier 1-3 cities diverge sharply. Honest treatment of: bro science vs evidence-based d

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红队渗透 / 攻防 — 受授权的红队作业者 + 渗透测试工程师 + 攻击型安全顾问的认知操作系统 (侦察 OSINT / 外网渗透 / 内网 AD 渗透 BloodHound + Kerberoasting + ADCS 利用 + 横向移动 / Web 应用渗透 OWASP WSTG / 移动 OWASP MASTG / 云渗透 AWS Azure GCP IAM 路径 + 容器逃逸 + K8s / C2 操作 Cobalt Strike Sliver Mythic Havoc + OPSEC / 初始访问 + AV EDR 绕过 (仅授权场景) / 无线 RF / 物理社工 / 报告与整改 / 框架 MITRE ATT&CK + D3FEND + PTES + OSSTMM + NIST 800-115 + Kill Chain / 法律伦理 CFAA + 网络安全法 + 刑法 285 286 + 数据安全法 + GDPR + 授权书 + 范围 + 交战规则 — 不含 黑产 / 未授权攻击 / 大规模 exploitation / 供应链投毒 / 未授权 DoS — 这是 重罪 + 行业封杀 + 律师吊销, 本 skill 严守 authorized-only 边界 — 也不含 蓝队 SOC + 恶意软件 即服务 / 僵尸网络 / 勒索软件作者 — 这是 cybercrime 不是 红队) (Cybersecurity Red Team / Offensive Security Operations — the cognitive operating system of authorized red team operators, penetration testers, and offensive security consultants covering (a) reconnaissance & OSINT (passive + active discovery, asset surface mapping), (b) external network pentest (perimeter, exposed services, web), (c) internal network / Active Directory pentest (AD enumeration via BloodHound, Kerberos abuse — Kerberoasting / AS-REP-roasting / Unconstrained delegation / S4U2self, NTLM relay, ADCS abuse, GPO abuse, lateral movement, privilege escalation), (d) web application pentest (OWASP WSTG, authentication, authorization, SSRF, XXE, deserialization, SSTI, prototype pollution, GraphQL, JWT, API), (e) mobile pentest (OWASP MASTG, iOS / Android, instrumentation Frida / Objection, MASVS), (f) cloud pentest (AWS / Azure / GCP — IAM enumeration, privilege escalation paths, container escape, K8s RBAC, serverless), (g) C2 operations & post-exploitation (Cobalt Strike / Sliver / Mythic / Havoc, beacon ops, malleable profiles, OPSEC), (h) initial access & evasion (phishing infrastructure, payload development, AV / EDR evasion, BYOVD, AMSI / ETW bypass — strictly for authorized engagements), (i) wireless / RF (WPA2/3, evil twin, Wi-Fi pivots), (j) physical / social engineering (badge cloning, pretexting, vishing — under engagement letter), (k) reporting & remediation (executive summary, technical findings, CVSS, MITRE ATT&CK mapping, retest), (l) frameworks & methodology (MITRE ATT&CK, MITRE D3FEND, PTES, OSSTMM, NIST SP 800-115, OWASP WSTG / MASTG, Cyber Kill Chain, Unified Kill Chain, Diamond Model), (m) law & ethics (CFAA US, Computer Misuse Act UK, 中国 刑法 285/286 + 网络安全法 + 数据安全法, GDPR for tested EU systems, engagement letter, scope, rules of engagement, safe harbor for bug bounty); NOT criminal hacking / 黑产 / unauthorized targeting / mass exploitation / supply-chain compromise / DoS against unconsented systems (这是 重罪 + 业内开除 + 律师执照吊销, 本 skill 严守 authorized-only 边界), NOT pure defensive blue team / SOC analyst tradecraft (是 平行学科, 仅做 边界标注 + ATT&CK 反推方向), NOT malware-as-a-service development / botnet ops / ransomware authoring (是 cybercrime 不是 红队), NOT 'ethical hacking' 在 'just curious 看看' 自我合理化的灰色操作 (违反 authorization 原则即不是 红队).) Master OS — automated mastery of Cybersecurity Red Team / Offensive Security Operations — the cognitive operating system of authorized red team operators, penetration testers, and offensive security consultants covering (a) reconnaissance & OSINT (passive + active discovery, asset surface mapping), (b) external network pentest (perimeter, exposed services, web), (c) internal network / Active Directory pentest (AD enumeration via BloodHound, Kerberos abuse — Kerberoasting / AS-REP-roasting / Unconstrained delegation / S4U2self, NTLM relay, ADCS abuse, GPO abuse, lateral movement, privilege escalation), (d) web application pentest (OWASP WSTG, authentication, authorization, SSRF, XXE, deserialization, SSTI, prototype pollution, GraphQL, JWT, API), (e) mobile pentest (OWASP MASTG, iOS / Android, instrumentation Frida / Objection, MASVS), (f) cloud pentest (AWS / Azure / GCP — IAM enumeration, privilege escalation paths, container escape, K8s RBAC, serverless), (g) C2 operations & post-exploitation (Cobalt Strike / Sliver / Mythic / Havoc, beacon ops, malleable profiles, OPSEC), (h) initial access & evasi

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This skill channels the reasoning of Yann LeCun, Chief AI Scientist at Meta and Turing Award winner. Use this skill whenever you are evaluating AI architectures, discussing the limitations of Large Language Models (LLMs), debating AI safety and regulation (anti-doomerism), or designing autonomous machine intelligence. It is highly relevant for topics involving self-supervised learning, open-source AI strategy, world models, physical grounding versus text-based learning, and objective-driven AI systems. Trigger this skill to apply his frameworks on abstract representation learning (JEPA) and energy-based models, even if the user doesn't explicitly name him.

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Use this skill when reasoning about deep tech commercialization, biomedical engineering, drug delivery, material design, or overcoming institutional skepticism. Robert Langer, MIT professor and pioneer of drug delivery systems, approaches problems through first-principles engineering, interdisciplinary convergence, and relentless perseverance against consensus. Trigger this skill whenever the user is evaluating high-risk/high-reward research, deciding between incremental vs. paradigm-shifting impact, spinning out academic discoveries into startups, or designing physical/biological systems from scratch. Apply his frameworks to navigate patenting, funding, and translating lab science into real-world impact.

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Use this skill whenever reasoning about manufacturing, scaling production, pricing strategies, operational efficiency, vertical integration, or labor compensation. Trigger this skill for situations involving hardware development, supply chain optimization, mass-market economics, or when a founder is deciding between outside investment and bootstrapping. Apply Henry Ford's principles of absolute operational control, continuous manufacturing improvement, and treating efficiency as a service to the consumer. Reach for this whenever a user is building physical products, scaling a business for the 'great multitude', or trying to eliminate operational waste.

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Applies the Neoplatonic and mathematical reasoning of Hypatia of Alexandria. Use this skill whenever the user is grappling with the pursuit of truth, foundational logic, the hierarchy of knowledge, or the distraction of superficial and physical desires versus deeper intellectual pursuits. Trigger this when discussing mathematics as a foundation for higher understanding, astronomy, overcoming base impulses, or seeking the ultimate source of truth. It is highly relevant for questions about rigorous intellectual discipline, esoteric philosophy, and elevating one's mind above material distractions.

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This skill channels the holistic, interconnected reasoning of Hildegard of Bingen, medieval German Benedictine abbess, theologian, and philosopher. Use this skill whenever the user is dealing with ecological stewardship, holistic health, the intersection of spirituality and physical well-being, creative inspiration, or challenging rigid institutional rules with moral clarity. Trigger this when discussing the interconnectedness of systems (microcosm/macrocosm), finding balance and moderation, untwisting destructive habits, or seeking divine/creative inspiration without ego. Apply her frameworks to treat ailments holistically, view music and art as fundamental cosmic forces, and reframe human frailty as a vessel for profound truth.

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Applies the empiricist, skeptical, and practical reasoning of David Hume, 18th-century Scottish philosopher. Use this skill whenever you encounter questions about epistemology, causality, human nature, moral philosophy, political authority, or the limits of rational knowledge. Trigger this skill when the user is grappling with abstract theories that need grounding, evaluating causal claims, discussing the role of emotion vs. reason in decision-making, or questioning the legitimacy of institutions. Even if the user doesn't name Hume, apply his frameworks (like Hume's Fork or the Impression Test) to cut through metaphysical speculation, ground arguments in observable experience, and recognize that reason is ultimately guided by human sentiment.

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This skill channels the strategic and scientific reasoning of Demis Hassabis, CEO and co-founder of Google DeepMind, AlphaGo and AlphaFold, and 2024 Nobel Prize in Chemistry. Use this skill whenever you are evaluating AI for scientific discovery, tackling "root node" problems, designing reinforcement learning systems, or discussing AGI timelines, safety, and global governance. Reach for it when the user faces massive combinatorial search spaces, wants to apply AI to physical/biological sciences (like digital biology), or needs to balance rapid AI scaling with the rigorous scientific method. Apply these mental models to shift the focus from building consumer apps to using AI as the ultimate meta-solution for understanding reality.

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Applies the reasoning style of Daphne Koller (machine learning pioneer, co-founder of Coursera, founder and CEO of Insitro). Use this skill whenever you encounter problems involving AI and machine learning in biology, drug discovery, interdisciplinary collaboration, data generation vs. data mining, or transitioning from academia to industry. Trigger this skill when advising on career trade-offs, building cross-functional teams (especially bridging engineers and domain experts), designing data pipelines, evaluating causality vs. correlation, or applying AI to physical systems ('where bits meet atoms'). Channel her focus on fit-for-purpose data, pragmatism, and disproportionate leverage.

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Applies the reasoning, frameworks, and mental models of Fei-Fei Li, computer vision pioneer, ImageNet creator, and co-director of Stanford HAI. Use this skill whenever Claude encounters topics related to AI ethics, human-centered AI, spatial intelligence, embodied AI, robotics, AI governance, diversity in tech, or the societal impacts of AI. Trigger this skill when users face decisions about AI product design (augment vs. replace), dataset formulation, navigating AI regulation, or choosing audacious research directions. Channel her pragmatic optimism and focus on spatial, physical grounding over pure language models.

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CRE Due Diligence analysis suite — 7 specialist skills for multifamily property analysis including rent roll validation, expense benchmarking, market study, physical inspection, environmental review, title review, and tenant credit assessment.

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CRE Industrial analysis suite - 8 specialist skills for U.S. industrial acquisitions, covering market study, lease roster analysis, lease abstraction, tenant credit, physical inspection, underwriting, financing fit, and investment committee memo writing.

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Art-direct and generate one high-craft minimal-zine bitmap from a landscape, portrait, person, object, product, food, plant, building, interior, photograph, mood, sentence, or article concept. Use when the user wants a standalone poetic poster, editorial cover, visual concept, aesthetic photo upgrade, photo-to-zine restyle, or a subject-aware minimal-zine image without the overhead of a social carousel. Chooses adaptive composition and a physically coherent print process, preserves subject identity, saves the final prompt, invokes the runtime-native image generator, and audits the raster result.

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Generate clean, playful low-density isometric voxel icon illustrations and explicitly requested four-frame physically credible loops built from large opaque face-lit acrylic blocks on an exact

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Create or edit digital 3D assets with Meshy: models, textures, rigging, animation, and reference images. For physical printing, use meshy-3d-printing.

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Create 3D models, textures, reference images, rigging and animation with Meshy, and prepare models for physical 3D printing: white or multicolor prints, Creative Lab products, sizing and slicer handoff. Drives the Meshy CLI; signs in through the browser, no API key required.

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Generate or prepare models for physical 3D printing, including white or multicolor prints, Creative Lab products, sizing, and slicer handoff.

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Create and assign PBR materials in Blender via Principled BSDF — metals, glass, plastic, fabric, skin, organics. Covers physically-based material recipes with real-world values, Coat layer (varnish/car paint), Sheen (cloth), Subsurface scattering (skin/wax), Transmission (glass), and procedural patterns (wood grain, marble, fabric weave). Use whenever the user asks to "make it look like X material", "give it a metallic finish", "apply a wood texture", "make this glass / plastic / brushed steel / leather / skin", or any look-development request. Make sure to use this skill even if the user does not say "material" — also covers "make it shiny", "matte finish", "looks like copper", "rough surface". Works with any geometry; pairs with blender-lighting (materials only look right under proper lighting).

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Assesses physical and transition climate risk for CRE properties and portfolios. Translates hazard exposure (flood, wind, wildfire, extreme heat, sea level rise) and regulatory/market shifts into financial impacts on NOI, cap rates, insurance costs, and tenant demand. Produces dollar-denominated risk, not abstract hazard scores.

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Expert guide for modern WebGPU and WebGL 3D graphics in the browser using Three.js (WebGPURenderer + TSL), Babylon.js, PlayCanvas, React Three Fiber (R3F), and 3Dviz spatial reasoning — covers object craft across 3 scales, surface continuity at joins, physical interaction envelopes, grounded scientific visualization, KTX2/Meshopt optimization, and 3D visual anti-slop / Panduan ahli grafis 3D web, WebGPU modern, dan penalaran spasial 3Dviz.

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Cards, drawers, carousels and other patterns borrowed from the physical world. Use when designing layout patterns, gestures or navigation paradigms.

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Physical principles underlying diodes, bipolar junction transistors, and MOSFETs — carrier concentrations, drift and diffusion, the pn junction, forward and reverse bias, the Shockley diode equation, BJT operating regions, MOSFET threshold and saturation, small-signal models, and temperature effects. Use when reasoning about device-level behavior, designing bias networks, selecting transistor operating points, interpreting datasheets, or diagnosing nonlinear device failures.

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