「sampling」の検索結果

Use when a task needs the judgment of an Anthropologist/Archeologist working in cultural resource management (CRM) — scoping a Section 106 Phase I identification survey, designing a shovel-test-pit sampling strategy, evaluating National Register of Historic Places eligibility under Criteria A-D, interpreting excavation stratigraphy via a Harris matrix and radiocarbon results, or running the ethnographic field-methods branch (participant observation, informant interviewing) for a cultural-anthropology component of a project.

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Use when a task needs the judgment of an Agricultural Technician — designing a soil, tissue, or seed sampling plan, interpreting pest scouting counts against an economic threshold, calibrating spray/seeding equipment, or troubleshooting a field data discrepancy before it reaches the agronomist or scientist who acts on it.

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Audit and score blog posts on a 5-category 100-point scoring system covering content quality, SEO optimization, E-E-A-T signals, technical elements, and AI citation readiness. Includes advisory editorial style diagnostics (sentence-length variation, configured phrase lists, vocabulary sampling) that never infer authorship or affect scoring. Supports export formats (markdown, JSON, table) and batch analysis with sorting. Generates prioritized recommendations (Critical/High/Medium/Low) with specific fixes. Works with any format (MDX, markdown, HTML, URL). Use when user says "analyze blog", "audit blog", "blog score", "check blog quality", "blog review", "rate this blog", "blog health check".

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Configure single-project Google Cloud Logging: regional log buckets, log sinks, log views, restricting or hiding sensitive logs in the default view (_Default) filter, IAM permissions for views (Logs View Accessor, IAM conditions), logs-based metrics, log exclusions, and sampling. Don't use for cross-project logging or multi-project setups.

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Analyzes audit readiness systems for internal control testing, evidence collection workflows, statistical sampling methodology, audit finding documentation, and remediation tracking using PCAOB, ISA, and SOX compliance frameworks..

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ผู้ช่วย internal audit — audit plan, sampling, test of controls, finding documentation, SOX/ISO 27001 checklist

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Research current job markets and hiring requirements, analyze recent job descriptions (JDs), compare them with a user's resume, projects, skills, and constraints, and turn evidence gaps into prioritized career actions. Use when students, job seekers, or career changers ask about current role or industry outlook (including “现在行情怎么样”), whether a role or JD fits them (including “这个JD适合我吗”), cross-platform JD sampling, resume evidence gaps or truthful tailoring, what career skill to learn next, target-role course or certificate decisions, application readiness, or a capacity-bounded 30/60/90-day job-search plan. Do not use for unrelated personal or education advice, simple factual lookups, automatic job applications, or unsupported resume rewriting.

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Instrument applications with Azure Application Insights and OpenTelemetry for end-to-end observability. Use this skill when users ask about telemetry, tracing, metrics, logging, or monitoring setup. Covers SDK setup, correlation, sampling, dashboards, and alerts per OpenTelemetry standards.

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Test-to-requirement coverage mapping. Reads plan acceptance criteria and test files, produces a coverage gap report showing which requirements have no tests. Use during Phase 2 (Test) or Phase 4 (Review) to verify test completeness. Named after the Nyquist sampling theorem — sufficient test coverage prevents aliased (missed) requirements. NOT for running tests (see mk:testing); NOT for structural code review (see mk:review).

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Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda scheduling, soft-core potentials, MBAR/BAR analysis, cycle-closure validation, and protocol-appropriate enhanced sampling. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.

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Quantifies biodiversity from species abundance/incidence tables using Hill numbers (iNEXT) with coverage-based rarefaction-extrapolation (Chao & Jost 2012), asymptotic richness via Chao1/ACE/jackknife as a lower bound, Baselga turnover/nestedness partition with the Podani alternative as sensitivity check, mandatory Hellinger transformation before ordination (Legendre & Gallagher 2001), Faith PD and SES_MPD/SES_MNTD with explicit null-model choice, and Maire 2015 functional-diversity dimensionality optimization. Use when comparing diversity across sites with unequal sampling effort, picking the right richness estimator for singleton-heavy amplicon data, partitioning beta diversity into turnover vs nestedness, reporting Hill-number effective species counts rather than raw entropies, computing SES_MPD with explicit null-model justification, or deciding whether to apply standard metrics to compositional amplicon data. Not for clinical 16S microbiome diversity (see microbiome/diversity-analysis).

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Estimates time-scaled phylogenies, molecular-clock rates, effective reproduction number R_e, and population dynamics from dated pathogen genomes using TreeTime (maximum-likelihood) and BEAST2 (Bayesian; strict/relaxed clocks; coalescent, Bayesian-Skyline, Skygrid, Birth-Death-Skyline, and sampled-ancestor priors; structured coalescent via MASCOT). Covers root-to-tip clock QC via TempEst, date-randomisation tests, recombination masking via Gubbins/ClonalFrameML before clock inference for recombining bacteria, BDSKY origin-vs-rootHeight pitfalls, sampling-bias correction, multi-chain convergence diagnostics, and reconciling phylodynamic R_e with case-based R_t. Use when dating outbreak origins, estimating substitution rates, inferring R_e through time, building time-calibrated Nextstrain Augur trees, choosing between strict and relaxed clocks, fitting Birth-Death-Skyline models, diagnosing temporal-signal failure, running MASCOT for structured-population analyses, or using UShER for pandemic-scale placement.

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Generates 3D conformer ensembles using RDKit ETKDGv3 with knowledge-enhanced distance geometry, MMFF94/UFF force-field optimization, CREST + GFN2-xTB semi-empirical refinement, and macrocycle-aware torsion preferences. Provides explicit decision rules for single vs ensemble conformer use, RMSD pruning, energy windows, conformer count, and force-field choice. Use when preparing 3D ligands for docking, generating descriptor input for 3D QSAR, or sampling macrocycle/peptide conformational ensembles.

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Treats a ctDNA assay as a molecule-counting experiment at the Poisson edge and builds its analytical-validation case the measurement-science way. Covers the genome-equivalent currency (~330 haploid copies/ng), the lambda = input_GE x VAF sampling ceiling (lambda>=3 for ~95% detection), the error-suppression ladder (raw NGS ~1e-3 -> single-strand UMI ~1e-4/1e-5 -> duplex <1e-7), the CLSI EP17 LoB/LoD/LoD95/LoQ framework, the per-locus-vs-panel-integrated LoD distinction that lets bespoke MRD reach ppm, contrived/SEQC2 reference standards, and honest LoD reporting conditioned on input mass + consensus depth + replicate detection rate. Use when stating or trusting a sensitivity claim, designing a dilution-series validation, deciding how many genome equivalents are needed at a target VAF, choosing a single-locus vs panel-integrated LoD, or auditing a "detects 0.1% VAF" claim.

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Determines successful catheterization in adrenal venous sampling by applying selectivity index cut‑offs with and without ACTH stimulation. Triggered during AVS when measuring cortisol levels and asking “Is the catheter properly positioned?” or when reviewing results for technical adequacy.

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Identifies young patients with classic primary aldosteronism features who may proceed directly to unilateral adrenalectomy without adrenal venous sampling based on high probability of unilateral disease. Triggered when a clinician sees a patient <35 years with hypokalemia, unilateral adrenal tumor on CT, and high plasma aldosterone concentration and asks whether AVS can be bypassed.

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Provides a checklist of five evidence-based measures to enhance the technical success of adrenal venous sampling procedures. Triggers include when preparing for AVS and asking 'How can I maximize success rate?' or troubleshooting failed attempts.

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Determines when adrenal venous sampling (AVS) is indicated for functional subtyping of primary aldosteronism (PA) when surgical treatment is feasible and desired by the patient. Triggered when a clinician confirms PA diagnosis and asks 'Do I need AVS for subtyping?' or evaluates surgical candidacy.

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This skill provides criteria to distinguish unilateral from bilateral primary aldosteronism using adrenal venous sampling results, including lateralization index, contralateral ratio, and clinical factors. It is triggered after AVS when clinicians analyze results and ask 'Is this unilateral or bilateral PA?' or need to guide treatment decisions.

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Determines when adrenal venous sampling may be skipped in primary aldosteronism. Applies to patients <35 years with spontaneous hypokalemia, marked aldosterone excess, and unilateral adrenal lesions suggestive of cortical adenoma on CT.

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Determines whether adrenal venous sampling (AVS) is needed in addition to CT for lateralizing primary aldosteronism before surgery. Trigger phrases include "patient with primary aldosteronism considering surgery", "unilateral adrenal adenoma on CT", "surgical candidate", and "age <35 with hypokalemia and >1‑cm adenoma".

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Determines whether to perform adrenal venous sampling (AVS) to lateralize aldosterone excess in patients with confirmed primary aldosteronism (PA) who are being evaluated for surgical treatment. Indicated when surgery is feasible and desired by the patient, or when subtype workup is planned for a surgical candidate, especially in those younger than 35 years with spontaneous hypokalemia, marked aldosterone excess, and unilateral adrenal lesions on CT.

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Interprets the saline infusion test (SIT) to assess the probability of primary aldosteronism when a patient has a positive aldosterone-to-renin ratio (ARR) and requires confirmatory testing. Triggers include evaluating post‑infusion plasma aldosterone concentration (PAC) after a positive ARR, hypertension work‑up, or when deciding whether to proceed to adrenal venous sampling (AVS).

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Splits scarce time, budget or traffic across competing products, channels, campaigns or variants by treating them as a multi-armed bandit - Thompson sampling over beta posteriors, with optimism for anything not yet tried enough to judge. Use when deciding what to work on next, how to divide a marketing budget, which product to prioritise, whether to kill something that is underperforming, or when picking a winner among test variants.

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