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概要と使いどころ
Apply the Law of Similarity — shared colour, shape, or size signals that elements belong to one category. Use when signalling relationships across distance. For grouping by position, use `law-of-proximity`.
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Builds, configures, debugs, and optimizes AWS observability - operator-symptom questions and detecting Omni vs classic CloudWatch. CloudWatch on an already-reporting service: Log Insights, metric/composite/anomaly alarms, custom metrics/EMF, dashboards, X-Ray/ADOT tracing, canaries, CloudTrail, Dynamic Instrumentation (live breakpoints/snapshots), the Application Signals service map, and fleet health views. CloudWatch Omni on an existing Space: SQL over logs and traces, PromQL over metrics, Omni dashboards, Omni alerts, context graph for root cause, programmatic/IaC access (API/SDK/CLI/CloudFormation), driving Omni from a coding agent or skills, and evaluating AI agent quality from traces - on-demand and online scoring of live traffic, readback, custom evaluators. For first-time setup - creating an Omni Space, granting access, ingestion, or ADOT instrumentation for Application Signals (ServiceEvents, CI/CD metadata) or Omni - use setting-up-cloudwatch-observability. Not for app logging or threat detection.
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Designs QTL colocalization studies that connect eQTL, pQTL, sQTL, or related molecular QTL signals with GWAS loci. Always use this skill whenever a user wants to plan, scope, or structure a locus-level study asking whether a GWAS association and a molecular QTL association may reflect the same underlying causal signal. Covers locus definition, QTL/GWAS source architecture, ancestry and LD alignment, single-locus vs multi-locus strategy, candidate-gene prioritization, optional fine-mapping, linked MR/SMR follow-up, and functional annotation. Always output four workload configurations (Lite / Standard / Advanced / Publication+) with a recommended primary plan, stepwise workflow, method rationale, evidence hierarchy, figure plan, minimal executable version, and strictly verified literature guidance with no fabricated references. Never equate colocalization with causality proof, mediation proof, or automatic target validation. Always include the mandatory Dataset Disclaimer immediately before any workflow section that mentions datasets, repositories, consortia, or public resources.
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Use when evaluating Jim Simons / Renaissance-style quantitative strategies: many weak signals, statistical validation, signal decay, portfolio construction, execution cost, and model risk.
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Parse raw radar I/Q captures (CW or FMCW mmWave) and produce a cleaned 1-D slow-time signal ready for motion or vital-signs analysis. Use when Claude needs to read interleaved I/Q binary, do a Range FFT on FMCW chirps, remove static clutter, pick a subject range bin, extract phase with unwrapping, or debug why a radar pipeline is returning garbage. Not for pulse/UWB range gating, MIMO beamforming, or Doppler-only gesture radar.
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Design effective excitation signals (step tests) for system identification and parameter estimation in control systems.
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Use C#/.NET in Godot 4.7: partial classes extending nodes, the PascalCase lifecycle (_Ready/_Process/_PhysicsProcess), [Export] fields, [Signal] delegates as C# events, type-safe node lookup, and calling between C# and GDScript. Use when writing Godot game code in C# (.cs files, .csproj), needing the Godot .NET build, converting GDScript patterns to C#, or wiring Godot signals as C# events.
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Analyse competitor moves and translate them into strategic implications for your product roadmap. Use when a competitor announces a new feature, pricing change, partnership, or strategic shift, or when producing a periodic competitive intelligence report. Produces a categorised signal analysis with reactive-vs-proactive assessment, threat ratings, specific roadmap implications, and recommended responses with owners. For a recurring whole-market briefing use competitive-intelligence-monitor instead.
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Fix a team's chat sprawl — the channel map with one purpose per channel, the naming scheme that makes purpose findable, the archive pass for the dead and duplicated, and the posting norms (threads, @-discipline, urgency signals) that keep signal findable. Use when asked clean up our Slack/Teams, we have 90 channels and nothing is findable, set channel norms, or where should things get posted. Produces the channel audit and map, the naming scheme, the norms card, and the archive pass.
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Extract leads from developer forums (Hacker News, Reddit) by detecting intent signals — alternative seeking, competitor pain, scaling challenges, DIY solutions, and migration intent. Scores users by intent strength and cross-platform presence.
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Extract leads from competitor product activity — Product Hunt commenters/upvoters, HN posts about competitors, case studies, testimonials, tech press, and switching signals. Detects people actively switching from competitors as highest-priority leads.
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Monitor existing customer accounts for upsell and cross-sell signals: team growth on LinkedIn, new job postings, product usage patterns, funding announcements, and public company news. Produces a weekly expansion opportunity list with context and talk tracks. Chains web search, LinkedIn profile monitoring, and job posting detection.
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Detect buying signals from multiple sources, qualify leads, and generate outreach context
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Monitor web sources for Series A-C funding announcements. Aggregates signals from TechCrunch, Crunchbase (via web search), Twitter, Hacker News, and LinkedIn. Filters by stage, amount, and industry. Returns qualified recently-funded companies ready for outreach.
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End-to-end funding signal composite. Takes any set of companies, detects recent funding events, qualifies against your company context, finds relevant people (buyers, champions, users), and drafts personalized outreach. Tool-agnostic — works with any company source, contact finder, and outreach platform.
日本語の概要は準備中です。原文の説明を表示しています。
Scan an AgentMail inbox for newsletter signals using configurable keyword campaigns. Extracts matched keywords, context snippets, and company mentions from incoming emails. Use for monitoring accounting industry newsletters for buying signals like acquisitions, migrations, and staffing news.
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End-to-end hiring signal composite. Takes any set of companies, detects job postings that your product augments or replaces, finds relevant people (the hiring manager, buyers, champions, users), and drafts personalized outreach using the job role as the hook. Tool-agnostic — works with any company source, job board, contact finder, and outreach platform.
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Synthesize new waveforms from scratch for Simulink inports using createInputDataset. Use ONLY when the user asks to generate, create, or synthesize signals (step, ramp, sine, chirp, pulse, noise) to populate a Dataset for External Inputs or Signal Editor. Covers timeseries and timetable formats with correct data type, interpolation, units, and dimensions. Also covers function-call and trigger inport timing setup. Do NOT use when the user wants to load, import, or read existing data from files (MAT, CSV, spreadsheet) — even if that data will be used as model input. Do NOT use for running simulations or plotting outputs.
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Add, configure, and manage faults on Simulink, Simscape, and System Composer model signals for robustness analysis and safety validation. Use when injecting faults (stuck, noise, gain, offset) onto block inports/outports, enabling fault simulation, or analyzing fault effects. Covers sensor failures, signal corruptions, actuator faults, FMEA validation, and robustness testing. Requires Simulink Fault Analyzer.
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Generates, normalizes, and converts bedGraph signal tracks (4-column chrom/start/end/value, 0-based half-open) with bedtools genomecov, deepTools bamCoverage/bamCompare/bigwigCompare, bedtools unionbedg, and UCSC bedGraphToBigWig. Covers why a raw coverage bedGraph is not comparable across samples until normalized, the CPM/RPKM/BPM/RPGC normalization menu and the conserved-total assumption that makes them wrong under a global perturbation, the strict sorted-non-overlapping-chrom.sizes bedGraphToBigWig contract that silently corrupts a bigWig, effective-genome-size selection, and bin-size aliasing. Use when building or normalizing a coverage/signal track from a BAM, comparing tracks across samples or conditions, converting bedGraph to a browser-ready bigWig, or diagnosing a track that looks plausible but reports wrong heights.
日本語の概要は準備中です。原文の説明を表示しています。
Bead-based signal normalization and cross-batch harmonization for CyTOF and high-parameter cytometry - EQ four-element bead normalization of instrument sensitivity drift (CATALYST normCytof, premessa), and reference-anchor cross-batch normalization (CytoNorm, per-cluster quantile splines). Covers the distinction between within-run drift correction and between-batch correction, the mandatory anchor/reference sample, why normalization is per-cluster with many quantiles, and the over-correction risk. Use when correcting CyTOF signal drift, harmonizing multi-batch or multi-site studies, or deciding whether to normalize data versus model batch in the design.
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Detects m6A modifications from Oxford Nanopore direct-RNA-seq (DRS) signal using m6Anet (multiple-instance-learning over DRACH 5-mer signal). Covers the upstream pipeline (Dorado/Guppy basecalling -> minimap2 map-ont -> nanopolish eventalign -> m6anet dataprep -> m6anet inference), per-site vs per-read probability including the mod_ratio stoichiometry column, the DRACH-only constraint, minimum-coverage thresholds (20-50 reads/site), multi-condition comparison via xPore/Nanocompore/ELIGOS, Dorado native modification calling (RNA004, 2024+), and the cDNA-vs-DRS distinction (cDNA Nanopore CANNOT detect modifications). Use when calling m6A from ONT DRS without immunoprecipitation, choosing m6Anet vs xPore vs Nanocompore vs ELIGOS vs Dorado native, interpreting probability_modified vs mod_ratio vs per-read probabilities, deciding between m6Anet (known DRACH sites) and Dorado/Remora (genome-wide screening), pinning RNA002 vs RNA004 chemistry and basecaller versions, or troubleshooting eventalign/dataprep failures.
日本語の概要は準備中です。原文の説明を表示しています。
Segments the genome into chromatin states from combinatorial histone modification and chromatin factor ChIP-seq data. Uses ChromHMM (multivariate HMM on binarized signal, v1.27), Segway (Dynamic Bayesian Network on continuous signal), EpiSegMix (flexible-distribution HMM with duration modeling, 2024), EpiLogos (multi-biosample visualization), IDEAS (cell-type-aware joint), and full-stack ChromHMM (Vu Ernst 2022) for cross-cell-type segmentations. Handles state-count selection (15 vs 18 vs 25 states), binarization choice, OverlapEnrichment / NeighborhoodEnrichment downstream analysis, and cross-biosample integration. Use when learning chromatin states from a histone mark panel, characterizing learned states by genomic feature enrichment, or comparing chromatin landscapes across cell types.
日本語の概要は準備中です。原文の説明を表示しています。
Analyzes differential transcript usage (DTU) and isoform switches with functional consequence prediction (NMD via 50nt rule, ORF disruption, protein domain loss/gain, signal peptide changes, IDR alterations, coding-potential shifts). Tools include IsoformSwitchAnalyzeR v2 (auto-selects satuRn for >5 reps else DEXSeq), the manual DRIMSeq -> DEXSeq/satuRn -> stageR DTU pipeline, and fishpond/swish for inferential-uncertainty-aware DTE. Distinguishes DTU from DGE and DTE; integrates external annotators (CPC2, Pfam, SignalP, IUPred2A or DeepTMHMM). Use when investigating how splicing differences alter protein function or trigger NMD-mediated degradation.
日本語の概要は準備中です。原文の説明を表示しています。