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Audit claims that work is done or shipped against the diff or repo. Use when: asked whether something really got done, even if it looks obvious.

日本語の概要は準備中です。原文の説明を表示しています。

Write, find or curate lessons and agent rules with stated evidence and limits. Use when: asked to remember something or write a rule into agent instructions.

日本語の概要は準備中です。原文の説明を表示しています。

Write or update READMEs, docs, repo instructions and handoff notes, checked against source. Use when: documenting something, writing a README or leaving a session handoff.

日本語の概要は準備中です。原文の説明を表示しています。

How AgentGuards enforces its guardrails in Codex — fully automatic, via hooks, with nothing for you to call. Load this if asked how AgentGuards works, whether you need to screen something yourself, or why no agentguards check_input / authorize_action tools are available.

日本語の概要は準備中です。原文の説明を表示しています。

Safely validate, publish, and track a local SKILL.md directory across GitHub, Awesome Codex Plugins, HOL Registry, skills.sh, SkillsMP, LobeHub, ClawHub, and Cursor Directory. Use when the user asks to publish, update, register, or synchronize an agent skill across marketplaces.

日本語の概要は準備中です。原文の説明を表示しています。

Use when targeting Environment International or deciding whether an environmental-exposure/health manuscript fits this venue. Encodes the journal's fit, the population-relevant exposure-health evidence bar, exposome/contaminant expectations, house style, official-submission re-check, and desk-reject heuristics.

日本語の概要は準備中です。原文の説明を表示しています。

Creates and inspects Fabric Activator (Reflex) alerts: rules, their data sources, conditions, and the Teams or email action they fire, plus decoding an existing ReflexEntities definition. Choose it whenever someone wants to be told, or something done, when values cross a threshold. The pipeline delivering those values is eventstream-cli.

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Extracts cfDNA fragmentomics features (DELFI genome-wide short/long ratios, WPS nucleosome positioning, Griffin GC-corrected accessibility profiles, end-motifs/MDS, OCF) for cancer detection and tissue-of-origin from plasma WGS. Centers on the nuclease-footprint reframe (every feature re-reads one nucleosome object), the mandatory GC correction, and the cross-protocol non-comparability that breaks naive classifiers. Runs FinaleToolkit (real CLI/Python, MIT) and the Griffin Snakemake pipeline; DELFI is a method, not a package. Use when deriving fragment-based signal from cfDNA, choosing a feature family for detection vs subtyping, or diagnosing why a fragmentomic model failed validation.

日本語の概要は準備中です。原文の説明を表示しています。

Unsupervised clustering and cell-type identification for high-dimensional flow, spectral, and mass cytometry - FlowSOM, PhenoGraph, FlowSOM-via-CATALYST, with UMAP/tSNE for visualization. Covers the type-vs-state marker distinction (cluster on lineage, test state within clusters), over-provision-then-metacluster, the Weber-Robinson benchmark, seed dependence and metacluster stability, why embeddings are for looking not measuring, and median-heatmap annotation/merging. Use when discovering populations without predefined gates, choosing a clustering algorithm, selecting the number of metaclusters, or annotating clusters into cell types.

日本語の概要は準備中です。原文の説明を表示しています。

Build circular genome visualizations using circlize (R), pyCirclize (Python), or Circos (Perl CLI) with ideogram tracks, multi-data tracks (scatter, histogram, heatmap), chord/link arcs for interactions, and explicit circos.clear() between plots. Covers when circular is appropriate vs when Cartesian wins (Cleveland-McGill 1984), karyograms, and chromosome adjacency in chord diagrams. Use when adjacency on the circle conveys meaning — chromosome-level overview, structural variants, Hi-C interactions, cross-genome comparisons.

日本語の概要は準備中です。原文の説明を表示しています。

Resolve the architecture of focal oncogene amplifications — extrachromosomal DNA (ecDNA), breakage-fusion-bridge (BFB) cycles, homogeneously staining regions (HSR), and linear amplification — from whole-genome sequencing with AmpliconArchitect, the AmpliconSuite pipeline, and AmpliconClassifier. Covers copy-number seed selection, breakpoint-graph reconstruction, balanced-flow optimization, ecDNA classification, and the limits of depth-only amplification calls. Use when a focal amplification needs structural characterization, when distinguishing ecDNA from chromosomal amplification, suspecting ecDNA-driven oncogene amplification or therapy resistance, or selecting copy-number seeds for amplicon reconstruction.

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Call copy number variants with the GATK best-practices workflows — the somatic CNV pipeline (CollectReadCounts, DenoiseReadCounts with tangent normalization, ModelSegments, CallCopyRatioSegments) and the germline GATK-gCNV pipeline (DetermineGermlineContigPloidy, GermlineCNVCaller cohort/case mode, PostprocessGermlineCNVCalls). Covers panel-of-normals construction, AnnotateIntervals/FilterIntervals, allelic-count integration, and QS-based filtering. Use when integrating CNV calling into a GATK variant pipeline, calling rare germline CNVs from an exome cohort, deciding between the somatic and germline GATK workflows, or diagnosing why tangent normalization removed a real event or why gCNV output has low precision.

日本語の概要は準備中です。原文の説明を表示しています。

Extracts and assigns COSMIC v3.4 mutational signatures (86 SBS / 11 DBS / 18 ID / 21 CN / 16 SV) from somatic VCFs using SigProfilerSuite, MutationalPatterns, MuSiCal mvNMF, SigNet, or HRDetect. Use when characterizing DNA-damage etiology (BRCA1/2 HRD, MMR-D, POLE, APOBEC3A, UV, tobacco, aflatoxin, 5-FU/SBS17b, platinum, colibactin SBS88), routing PARP inhibitor decisions, or auditing de novo extraction vs refit choice for cohort size.

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Runs cis-pQTL Mendelian randomization for drug-target validation using UKB-PPP (Olink), deCODE (SomaScan), Fenland, INTERVAL, ARIC, and FinnGen-PPP proteomes plus colocalization triangulation, phenome-wide on-target adverse-effect scans, cross-platform Olink/SomaScan replication, and PAV (protein-altering variant) sensitivity. Use when nominating or de-risking a drug target from plasma-proteome GWAS, mimicking pharmacological inhibition via cis-pQTL instruments, separating shared-causal from LD-confounded signal under the Schmidt 2020 cis-MR framework, screening on-target adverse phenotypes pheWAS-style, or producing publication-grade STROBE-MR plus PP.H4 evidence for a target gene.

日本語の概要は準備中です。原文の説明を表示しています。

Pick up the bugs a human flagged by pointing at them in the running app, each arriving with the element, the note they typed, and the source file and line. Use when the user says they marked or flagged something, when starting a session on an app someone has been clicking through, when a designer or PM has left feedback in the UI, or when the user describes a problem as "that button there" without saying which file.

日本語の概要は準備中です。原文の説明を表示しています。

When the user wants to use GitHub for SEO, parasite SEO, GEO, open source marketing, README optimization, or curated Awesome lists. Also use when the user mentions "GitHub," "GitHub SEO," "GitHub parasite SEO," "GitHub GEO," "awesome list," "GitHub README," "profile README," "pinned repositories," "Trending," "Explore," "repository name," "About section," "GitHub description," "GitHub topics," "Website field," "GitHub Pages," "github.io," "user site," "project site," "GitHub gist," "curated list," or "navigation list." Not for Medium or other non-GitHub platforms—use parasite-seo or medium-posts. For OSS business model, use open-source-strategy.

日本語の概要は準備中です。原文の説明を表示しています。

Market sizing and market structure work — TAM/SAM/SOM built top-down and bottom-up then reconciled, segmentation, demand triangulation, and survey design. Use when sizing a market, writing a sizing memo, or fielding a survey.

日本語の概要は準備中です。原文の説明を表示しています。

When the user wants to set up, improve, or audit analytics tracking and measurement. Also use when the user mentions "set up tracking," "GA4," "Google Analytics," "conversion tracking," "event tracking," "UTM parameters," "tag manager," "GTM," "analytics implementation," "tracking plan," "how do I measure this," "track conversions," "Mixpanel," "Segment," "are my events firing," or "analytics isn't working." Use this whenever someone asks how to know if something is working or wants to measure marketing results. For choosing attribution models, comparing multi-touch/MMM/incrementality, or reconciling conflicting numbers across tools, see attribution. For A/B test measurement, see ab-testing.

日本語の概要は準備中です。原文の説明を表示しています。

When the user wants to plan a product launch, feature announcement, or release strategy. Also use when the user mentions 'launch,' 'Product Hunt,' 'feature release,' 'announcement,' 'go-to-market,' 'beta launch,' 'early access,' 'waitlist,' 'product update,' 'how do I launch this,' 'launch checklist,' 'GTM plan,' or 'we're about to ship.' Use this whenever someone is preparing to release something publicly. For ongoing marketing after launch, see marketing-ideas. For the offer being launched (bonuses, guarantees, scarcity, naming), see offers.

日本語の概要は準備中です。原文の説明を表示しています。

Pick the right LLM for CONTRACT REVIEW — reviewing an existing agreement for risk, deviations from standard, missing protections, and internal contradictions, and proposing redlines. Vendor-neutral routing grounded in mid-2026 legal benchmarks. Contract review is a COMPOSITE skill (extraction + reasoning + redlining + conflict-detection), so this routes by the dominant sub-task. Asks up to 4 quick questions (cost, speed, accuracy/stakes, privacy/jurisdiction/ language), then recommends a primary model + fallback + what to avoid + what a human must verify. Use when someone asks "which model to review this contract / NDA / MSA", "best AI to redline", "route this contract review", or is about to review an agreement without a fixed model.

日本語の概要は準備中です。原文の説明を表示しています。

Pick the right LLM for LEGAL TRANSLATION — translating contracts, statutes, case law, and legal correspondence across languages, including Arabic/MENA. Vendor-neutral routing triangulated from mid-2026 evidence (WMT25 human eval, SwiLTra-Bench legal-MT, multilingual-reasoning proxies, ArabLegalEval). There is NO clean legal-translation leaderboard, so this vertical is directional and treats human legal-linguist review as mandatory. Asks up to 4 quick questions (language pair, cost, speed, privacy/certification), then recommends a primary model + fallback + what to avoid + what a human must verify. Use when someone asks "which model to translate this contract/statute", "best AI for legal translation", "translate this legal doc to/from Arabic", or is about to machine-translate legal text without a fixed model.

日本語の概要は準備中です。原文の説明を表示しています。

Pick the right LLM for CONTRACT DRAFTING — generating, redlining, or rewriting contract language from instructions. Vendor-neutral routing grounded in mid-2026 legal benchmarks (legalbenchmarks.ai Contract Drafting). Asks up to 4 quick questions (cost, speed, accuracy/ stakes, privacy/jurisdiction/language), then recommends a primary model + fallback + what to avoid + what a human must verify. Use when someone asks "which model should I use to draft this clause/agreement", "best AI for drafting contracts", "route this drafting task", or is about to generate/redline contract text and hasn't fixed a model.

日本語の概要は準備中です。原文の説明を表示しています。

Pick the right LLM for LEGAL INFO EXTRACTION — pulling facts, clauses, dates, parties, obligations, and structured fields out of contracts and legal documents. Vendor-neutral routing grounded in mid-2026 benchmarks (legalbenchmarks.ai Info Extraction; CUAD/MAUD/ACORD). Asks up to 4 quick questions (cost, speed, accuracy/stakes, privacy/jurisdiction/language), then recommends a primary model + fallback + what to avoid + what a human must verify. Use when someone asks "which model should I use to extract clauses/data from these documents", "best AI for contract data extraction", "route this extraction task", or is about to pull structured fields from legal docs without a fixed model.

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Pick the right LLM for LEGAL RESEARCH & ANALYSIS — issue-spotting, rule application, case/statute analysis, memos, and multi-step agentic research. Vendor-neutral routing grounded in mid-2026 benchmarks (Vals AI LegalBench across 124 models; Harvey Legal Agent Benchmark for agentic work). Asks up to 4 quick questions (cost, speed, accuracy/stakes, privacy/jurisdiction/language), then recommends a primary model + fallback + what to avoid + what a human must verify. Use when someone asks "which model for legal research / case analysis / a memo", "best AI for legal reasoning", "route this research task", or is starting legal analysis without a fixed model.

日本語の概要は準備中です。原文の説明を表示しています。