「structural」の検索結果

This skill covers formal identification arguments and proofs in structural and reduced-form econometrics. Use when the user needs to prove or formalize that a parameter is identified — including writing identification propositions, stating regularity conditions, deriving rank conditions, or showing observational equivalence fails. Triggers on "identification proof", "identification argument", "identify the parameter", "show identification", "identification condition", "exclusion restriction proof", "rank condition", "order condition", "identification strategy formal", "nonparametric identification", "parametric identification", "local identification", "global identification", "observational equivalence", "identification at infinity", "completeness condition", "regularity conditions", "Rothenberg", "proof of identification", "identification result", "identified parameter", "point identified", "set identified", "partial identification".

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Expert economics paper writing assistant synthesizing advice from 50+ top guides by Cochrane, McCloskey, Shapiro, Head, Bellemare, Goldin, Glaeser, Kremer, and other leading economists. USE THIS SKILL whenever the user writes, edits, reviews, rewrites, or structures any economics paper, thesis, job market paper, abstract, introduction, conclusion, results section, literature review, or referee response. Also handles LaTeX formatting, presentations, and paper audits. Covers all paper types (applied, theory, structural, mixed) and all sections.

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Use this skill when the docs-impact-classifier returns a structural verdict, signalling that the documentation TOC must change to accommodate the PR. Proposes TOC deltas (new pages, moves, merges) and emits new-page outline stubs that the doc-sync panel later fleshes out. Holds the 3-promise narrative (consume / produce / govern) and the persona ramps as hard constraints.

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Use this skill to classify the documentation impact of a pull request diff, returning one of three verdicts -- no-change, in-place edit, or structural change -- with bounded LLM cost. Activate as a sibling skill of docs-sync; the orchestrator calls this first, before any panel spawn, to keep cost floor at 1 LLM call when no docs work is needed. Reads .apm/docs-index.yml as the corpus map; never reads the full corpus.

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Use this skill whenever a pull request is opened, reopened, or synchronized in microsoft/apm to assess whether and how the documentation corpus must change to stay truthful with the proposed code change. Activate even when the PR title or body says nothing about docs -- the skill must run on every PR to detect silent drift between code and docs. Classifies impact as no-change, in-place edit (one to a few paragraphs), or structural change (new page or TOC reshape), then orchestrates a CDO + doc-writer + python-architect + editorial-owner + growth-hacker loop to produce a patch-ready advisory. Does NOT review code quality, security, or test coverage. Does NOT auto-merge or auto-push doc edits.

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Medicinal chemistry filters. Apply drug-likeness rules (Lipinski, Veber), PAINS filters, structural alerts, complexity metrics, for compound prioritization and library filtering.

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Generate multiple sequence alignments (MSAs) for protein sequences using the ColabFold MSA-Search NIM. Use for homolog search, UniRef30/ColabFold env searches, A3M or FASTA alignments, paired MSA search for complexes, PDB70 structural templates, hosted NVIDIA API calls, or local Docker deployment. For local deployment, download the databases in parallel with aria2c and launch via NIM_MODEL_NAME (the recommended default fast path, ~14 min vs over 80 min for the built-in downloader); a plain docker run uses the slow built-in downloader.

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Find and add missing cross-references between wiki pages. Use when pages are disconnected or after large ingestion. This modifies pages to add links; use wiki-lint for report-oriented structural auditing.

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Report wiki ingestion/completeness state, pending source delta, structural insights, or maintenance equilibrium. Use for remaining-work/status questions, hubs and bridges, or whether maintenance skills still have pending changes. wiki-digest summarizes learned knowledge instead.

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Re-derive your knowledge system from first principles when structural drift accumulates. Analyzes dimension incoherence, vocabulary mismatch, boundary dissolution, and template divergence. Preserves all content while restructuring architecture.

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Modernize Golang code to use recent language features, standard library improvements, and idiomatic patterns. Use when reviewing Go code with old-style patterns, when encountering a deprecation warning, or when the user asks for modernization, a Go version upgrade (e.g. to Go 1.27), or a CI/tooling refresh. Not for structural refactors, extracting functions, or moving code between packages (→ See `samber/cc-skills-golang@golang-refactoring` skill).

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Calculate an ETF's premium or discount to NAV from Yahoo Finance data (yfinance), compare or screen ETFs by premium, explain why a gap exists, and decompose a sudden ETF move into NAV-driven vs structural components (dealer gamma exposure, blocked AP arbitrage, sentiment). Use this skill whenever the user asks whether an ETF trades above or below NAV, compares ETF premiums or discounts, screens for the biggest ones, asks about ETF arbitrage or premium convergence, or wants to know why an ETF jumped or diverged from its holdings — including gamma squeezes, dealer gamma exposure (GEX), and blocked creation/redemption. Especially relevant for leveraged, inverse, international, bond, commodity, and crypto ETFs (IBIT, BITO, HYG, KWEB).

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Query the Genome Aggregation Database (gnomAD). Use when determining the rarity or allele frequency of specific genetic variants, retrieving gene constraint metrics (pLI, LOEUF) to assess loss-of-function intolerance, finding variants in a genomic region or gene, or querying structural variants. Don't use for analyzing individual patient genomes, tracking somatic mutations in cancer (use COSMIC), or requesting raw sequencing reads (use ENA).

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Searches for homologous protein sequences using MMseqs2 (fast, default) or BLAST (comprehensive, fallback). Trigger this whenever the user provides a protein sequence or FASTA file and asks to find homologues, sequence matches, or wants to infer protein function based on sequence similarity, but not when the user wants to infer protein function based on structural similarity.

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Performs multiple sequence alignment of proteins with EBI Clustal Omega. Use when you need to align multiple sequences to assess similarity, domain conservation, or key residue conservation. Supports up to 4000 sequences and a maximum file size of 4 MB. Do not use to search for homologous proteins in a database (use MMseqs2, BLAST), align non-protein sequences (DNA, RNA), perform structural alignment (use Foldseek, PyMOL), or if you only have a single sequence.

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Visualize, analyze, and render protein and molecular structures using PyMOL. Use when the user wants to create images of protein structures, perform structural alignments or superposition, measure distances or contacts, highlight binding sites or active site residues, color by B-factor/pLDDT, or analyze protein-ligand interactions. Do not use for docking, molecular dynamics, or sequence-only analysis.

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Retrieve and analyze AlphaFold predicted structures for a protein. Use when the user provides a specific UniProt Accession ID and wants structural confidence metrics (pLDDT), domain boundary analysis, or disorder assessment. Do not use if the user only has a protein name, gene name, or amino acid sequence — ask for a UniProt ID first.

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Access AlphaFold's 200M+ AI-predicted protein structures. Retrieve structures by UniProt ID, download PDB/mmCIF files, analyze confidence metrics (pLDDT, PAE), for drug discovery and structural biology.

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Predicts ADMET properties using ADMETlab 3.0 API or DeepChem models. Estimates bioavailability, CYP inhibition, hERG liability, and 119 toxicity endpoints with uncertainty quantification. Filters for PAINS and other structural alerts. Use when filtering compounds for drug-likeness or prioritizing leads by predicted safety.

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Detect backtest iteration stagnation and generate structurally different strategy pivot proposals when parameter tuning reaches a local optimum.

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Use when auditing content quality, E-E-A-T, or publish readiness; runs a typed 80-item CORE-EEAT profile with evidence coverage, veto checks, and a fix plan. Not for structural tags/headers alone — use on-page-seo-checker; not for domain/citation trust — use domain-authority-auditor. 内容质量/EEAT评分

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Use when the user asks to "optimize for AI citations"; improves citation readiness for ChatGPT, Perplexity, AI Overviews, Gemini, and Claude. Not for structural on-page SEO — use on-page-seo-checker; not for net-new drafting — use content-writer. AI引用优化/GEO优化/AI搜索

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Audit an area of the codebase and propose the smallest structural moves that improve it - untangle boundaries, kill duplication, fix seams, break cycles. Produces a prioritized plan and decision records, not a rewrite. Use when a codebase feels tangled, hard to change, or is becoming a ball of mud, or when asked to improve or refactor architecture.

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Define what content a product needs, how it is structured, and who owns it. Use when content itself is the problem. For the words in the interface use `ux-writing` (designer-toolkit); for structural hierarchy use `information-architecture`.

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