「tia」の検索結果

Identifies differential m6A methylation between conditions from MeRIP-seq paired IP/input data using exomePeak2 (GC-bias-aware differential via its bam_ip/bam_input control + bam_treated_ip/bam_treated_input treatment arms), QNB beta-binomial, MeTDiff HMM, and RADAR, plus the paired-symmetric edgeR/DESeq2-on-peak-counts route when batch/lot covariates need fixed-effect handling that exomePeak2's API does not accept. Covers paired vs unpaired vs interaction designs, batch confounding and per-lot meta-analysis, the stoichiometry-vs-expression-vs-IP-efficiency confound, and effect-size filtering against under-powered N=2 designs. Use when comparing m6A across two or more conditions, choosing between exomePeak2/QNB/RADAR/MeTDiff for a design, handling batch confounding when exomePeak2's API is too rigid, distinguishing real hyper/hypo-methylation from expression shifts, applying effect-size thresholds, or planning orthogonal stoichiometry validation (GLORI/SAC-seq/m6Anet mod_ratio).

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Runs JACKS (Joint Analysis of CRISPR/Cas9 Knockout Screens; Allen et al 2019 Genome Research) which models per-sgRNA log-fold-change as the product of a treatment-dependent gene-essentiality term and a treatment-independent guide-efficacy term. Covers the Bayesian decomposition math, the hierarchical efficacy prior shared across screens performed with the same library, when JACKS outperforms MAGeCK (multi-screen joint analysis, libraries with broad efficacy variance) and when it does not (single screen, novel libraries with no prior efficacy), library-reuse efficacy transfer, downstream essentiality interpretation, and the 2.5x sample-size reduction enabled by efficacy-aware testing. Use when running multiple screens with the same library, when guide-level noise is suspected to dominate per-gene signal, when reusing published essentiality reference screens for efficacy priors, or when comparing screens performed across cell lines that share library but differ biologically.

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Analyzes differential transcript usage (DTU) and isoform switches with functional consequence prediction (NMD via 50nt rule, ORF disruption, protein domain loss/gain, signal peptide changes, IDR alterations, coding-potential shifts). Tools include IsoformSwitchAnalyzeR v2 (auto-selects satuRn for >5 reps else DEXSeq), the manual DRIMSeq -> DEXSeq/satuRn -> stageR DTU pipeline, and fishpond/swish for inferential-uncertainty-aware DTE. Distinguishes DTU from DGE and DTE; integrates external annotators (CPC2, Pfam, SignalP, IUPred2A or DeepTMHMM). Use when investigating how splicing differences alter protein function or trigger NMD-mediated degradation.

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Store, retrieve, and pass credentials securely in MATLAB using the built-in MATLAB Vault (setSecret, getSecret, importSecrets, secretID) instead of hardcoding. Handles connections to any authenticated service: REST APIs, databases, cloud storage (S3/Azure/GCS), SFTP, and others. Covers API keys, tokens, passwords, SSH passphrases, CI/batch/scheduled jobs, and "keep credentials out of code" requests. Does NOT cover third-party secret managers (HashiCorp Vault, AWS Secrets Manager), OS-level key management, or the connection/query logic itself.

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Shopify/DTC product differentiation strategy tool. Analyze competitor stores, extract pain points from reviews, identify brand positioning opportunities, and generate actionable differentiation strategies. Includes DTC-specific metrics like CAC, LTV, and brand story analysis. No API key required.

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Amazon product differentiation strategy tool. Analyze competitor weaknesses, extract pain points from negative reviews, identify unique selling points from positive reviews, and generate actionable differentiation strategies. Progressive L1-L4 analysis depth. No API key required.

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eBay product differentiation strategy tool. Analyze competitor weaknesses, extract pain points from negative feedback, identify unique selling points, and generate actionable differentiation strategies. Includes eBay-specific seller feedback analysis. No API key required.

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Generates standalone interactive HTML "deal cards" that translate complex regulations into negotiation-ready reference tools, systematically distinguishing mandatory obligations from negotiable implementation choices. Use when the user needs an interactive regulatory guide for (1) contract negotiation support, (2) client education or internal training, (3) regulatory briefings for commercial stakeholders, or (4) structured comparison between required and flexible compliance paths. Primary focus on EU digital regulation (Data Act, AI Act, CRA, DORA, NIS2, GDPR) but the structural pattern transfers to any regulation where separating hard obligations from implementation choice is the point. Supports bilingual output where the jurisdiction calls for it.

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Systematic contract negotiation strategies for technology services agreements with German/EU law specificity. Provides three-position framework (provider-favorable, balanced, client-favorable), deal-size calibration (€100K to €10M+), five-tier objection handling with regulatory leverage (GDPR, DORA, NIS2, BGB), concession packaging, and position matrices for liability, IP, payment, SLA, data protection, and termination. Use when: (1) Developing negotiation strategies for SaaS, cloud, or managed services agreements, (2) Preparing position papers and fallback positions, (3) Responding to counterparty objections, (4) Structuring concession packages that protect core economics, (5) Calibrating tactics to deal size and leverage, or (6) Applying German contract law constraints (BGB §§ 305-310 AGB, § 309 Nr. 7 liability limits, § 288 statutory interest).

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Evaluate completed mediation-competition problems consisting of general information and confidential packets for both sides. Use when asked to validate, audit, score, quality-control, or assess competition readiness; identify factual, numerical, chronological, authority, commercial-logic, or confidentiality defects; test mediation usefulness, BATNAs, settlement corridors, information asymmetry, and opportunities for firmness, cooperation, imagination, and clarification; or produce an author-only validation report. Perform a qualified partial review when packets are missing. Diagnose by default; do not generate a new problem or edit source packets unless repairs are expressly requested. Requires access to all supplied files and a host capable of reading their formats; otherwise disclose the unreviewed material and resulting limits.

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Coordinates UDL and differentiation tools through a universal-first hierarchy: barrier removal before targeted differentiation before individualised accommodation. Use when planning accessible learning.

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Adapt a classroom task for specific learner needs while preserving the core learning objective intact. Use when differentiating for SEND, EAL, gifted, ADHD, dyslexia, or anxiety.

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Designing for visionOS — spatial layout and ergonomics (60pt eye targets, field-of-view placement, dynamic scale), eyes-and-hands input with hover rules, motion and visual comfort (the 0.2 Hz rule, vection, depth-cue agreement), immersion strategy, spatial sound, and the video-format decision guide. Use when designing or reviewing any visionOS app, window, volume, or immersive experience.

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We present a statistical simulator, scDesign3, to generate realistic single-cell and spatial omics data, including various cell states, experimental designs, and feature modalities, by learning interpretable parameters from real data. Using a unified probabilistic model for single-cell and spatial omics data, scDesign3 infers biologically meaningful parameters; assesses the goodness-of-fit of inferred cell clusters, trajectories, and spatial locations; and generates in silico negative and positi

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Defines an S4 class for storing data from spatial -omics experiments. The class extends SingleCellExperiment to support storage and retrieval of additional information from spot-based and molecule-based platforms, including spatial coordina

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Spatially-aware quality control (QC) software for both spot-level and artifact-level QC in spot-based spatial transcripomics, such as 10x Visium. These methods calculate local (nearest-neighbors) mean and variance of standard QC metrics (library size, unique genes, and mitochondrial percentage) to identify outliers spot and large technical artifacts. Scales linearly with the number of spots and is designed to be used with 'SpatialExperiment' objects.

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hoodscanR is an user-friendly R package providing functions to assist cellular neighborhood analysis of any spatial transcriptomics data with single-cell resolution. All functions in the package are built based on the SpatialExperiment object, allowing integration into various spatial transcriptomics-related packages from Bioconductor. The package can result in cell-level neighborhood annotation output, along with funtions to perform neighborhood colocalization analysis and neighborhood-based ce

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Expert knowledge for Azure Kubernetes Service Edge Essentials development including troubleshooting, best practices, decision making, architecture & design patterns, limits & quotas, security, configuration, integrations & coding patterns, and deployment. Use when managing AKS Edge/Hybrid with Arc, GitOps, IoT/OPC/ONVIF, TPM/Key Vault secrets, or AI model workloads, and other Azure Kubernetes Service Edge Essentials related development tasks. Not for Azure Kubernetes Service (AKS) (use azure-kubernetes-service), Azure IoT Edge (use azure-iot-edge), Azure Stack Edge (use azure-stack-edge), Azure Container Apps (use azure-container-apps).

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Initialize a Git repository with an initial commit

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Use when gaining initial access to a target — phishing, payload delivery, HTML smuggling, ISO/IMG/MOTW bypass, supply-chain, credential stuffing, exposed-service exploitation

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AWS Bedrock AgentCore comprehensive expert for deploying and managing AI agents at scale. Use when working with any AgentCore service including Gateway, Runtime, Memory, Identity, Code Interpreter, Browser, Observability, Agent Registry, or Evaluations. Covers agent deployment, MCP tool integration, credential management, agent discovery, governance workflows, and automated quality assessment. Essential when user mentions AgentCore, agent runtime, agent registry, agent evaluation, MCP gateway, deploy agent, register MCP server, discover agents, evaluate agent quality, agent credentials, or wants to build, deploy, catalog, or monitor AI agents on AWS.

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Guides the post-Schrems II Transfer Impact Assessment process following EDPB Recommendations 01/2020 six-step methodology. Covers destination country surveillance law assessment, European Essential Guarantees evaluation, and supplementary measures determination. Keywords: TIA, transfer impact assessment, Schrems II, EDPB recommendations, supplementary measures.

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Guides the post-Schrems II Transfer Impact Assessment process following EDPB Recommendations 01/2020 six-step methodology. Covers assessment of third country legal frameworks, supplementary measures evaluation, and TIA scoring. Activate for international data transfers, SCCs, third-country adequacy, or Chapter V compliance. Keywords: TIA, Schrems II, transfer assessment, EDPB, supplementary measures, SCCs, international transfer.

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Design privacy-preserving analytics systems using differential privacy, k-anonymity, l-diversity, and t-closeness. Covers privacy budget allocation with epsilon tracking, references Google DP library, OpenDP, and Apple PPML. Includes Python differential privacy implementation for GDPR-compliant statistical analysis.

日本語の概要は準備中です。原文の説明を表示しています。