「zat」の検索結果

Normalizes and transforms RNA-seq count matrices for DE, visualization, clustering, and ML. Covers between-sample (TMM, TMMwsp, RLE/median-of-ratios, upper quartile), within-sample (TPM, FPKM/RPKM), variance-stabilizing (VST, rlog, log-CPM), GC-content correction (cqn, EDASeq), and single-cell (scran deconvolution, scanpy normalize_total). Encodes the composition-bias rationale, the "most genes not DE" assumption and its catastrophic failure modes (MYC amplification, apoptosis, viral host shutoff, prokaryotic stress), the "lengthScaledTPM is not TPM" naming trap, the "TPM is not for DE" rule, the blind=TRUE vs FALSE decision, ERCC spike-in normalization (SBN), and the single-cell zero-inflation breakdown of TMM/RLE. Use when choosing or applying normalization, debugging shifted-MA-plot diagnostics, handling zero-heavy single-cell data, or correcting GC bias.

日本語の概要は準備中です。原文の説明を表示しています。

Build interactive HTML/web visualizations with plotly (Python/R), bokeh (Python), and gganimate/plotly frames for animation, with awareness of current Kaleido static-export model (post-orca-EOL), HTML file-size bloat, and the limits of interactive-only output for journal submission. Use when producing zoomable/hoverable plots for notebook EDA, supplementary HTML, dashboards, or animated time-course / iteration visualizations.

日本語の概要は準備中です。原文の説明を表示しています。

Creates DE-specific diagnostic and result visualizations using DESeq2/edgeR built-in functions and lightweight ggplot2 wrappers. Covers MA plot (with the shrunken-LFC compression effect), volcano (with the apeglm caveat that p-values are unchanged), PCA on VST/rlog (never raw counts), sample distance heatmaps, top-DE-gene heatmaps with the row-scaling trap, dispersion / BCV plot interpretation, p-value histogram diagnostics, plotCounts for individual genes, blind=TRUE vs FALSE rationale, and the n=3 visualization stake. Use when generating DE diagnostic plots, choosing VST vs rlog for visualization, troubleshooting suspicious plot patterns (shifted MA cloud, batch-dominated PCA, anti-conservative p-value histogram), or building a standard QC figure panel.

日本語の概要は準備中です。原文の説明を表示しています。

Systematically find and fix performance problems in applications, frontend and backend, by measuring first. Use this skill whenever the user reports slow endpoints, high latency, poor throughput, memory leaks, large bundles, or slow page loads; wants to profile with cProfile, py-spy, Chrome DevTools, Node --cpu-prof, or perf; run load tests with locust or k6; set performance budgets or SLOs; optimize database queries (EXPLAIN, indexes, N+1); add caching (Redis); improve frontend performance (code splitting, lazy loading, image optimization, memoization, virtualization); or tune the network (CDNs, gzip/br, HTTP/2/3). Also trigger for p50/p95/p99 latency, throughput, error rate, connection pooling, async vs threads, GIL, and memory leak investigations.

日本語の概要は準備中です。原文の説明を表示しています。

Quantização pós-treinamento em 4-bits para LLMs com perda mínima de precisão. Use para implantar modelos grandes (70B, 405B) em GPUs de consumo, quando você precisa de redução de memória 4× com <2% de degradação de perplexidade, ou para inferência mais rápida (aceleração de 3-4×) vs FP16. Integra com transformers e PEFT para fine-tuning QLoRA.

日本語の概要は準備中です。原文の説明を表示しています。

Quantização de pesos consciente da ativação para compressão de LLM de 4-bit com aceleração 3x e perda mínima de acurácia. Use ao implantar modelos grandes (7B-70B) em memória GPU limitada, quando precisa de inferência mais rápida que GPTQ com melhor preservação de acurácia, ou para modelos com instruções ajustadas e multimodais. Vencedor do Prêmio Melhor Artigo MLSys 2024.

日本語の概要は準備中です。原文の説明を表示しています。

Professional data visualization skill specialized in creating reader-friendly, accessible, and aesthetically pleasing charts and dashboards. Use this skill when you need to create visualizations, choose appropriate chart types, design color schemes, create dashboards, or apply design best practices for data communication. Expertise includes visualization principles, color theory, typography, layout design, and accessibility guidelines.

日本語の概要は準備中です。原文の説明を表示しています。

組織変革管理の専門コンサルタントスキル。システム導入、組織変革、DXプロジェクトにおける変革管理を支援。 ADKAR、Kotter 8-Stepフレームワークに基づき、ステークホルダー影響度分析、コミュニケーション計画、抵抗管理戦略を提供。 Use when managing organizational change, system implementations, digital transformation projects, or improving user adoption rates. Triggers: "change management", "organizational change", "system implementation", "user adoption", "change strategy", "stakeholder engagement".

Use when working with Aws Organizations — aWS Organizations account management, OU structure analysis, SCP policy review, and service access control. Covers organizational hierarchy, account inventory, policy inheritance analysis, delegated administrator status, and service control boundary assessment.

日本語の概要は準備中です。原文の説明を表示しています。

Community monetization — Discord monetization, courses, memberships, premium tiers

日本語の概要は準備中です。原文の説明を表示しています。

When the user wants to design or optimize their app's monetization — pricing, paywalls, subscriptions, or in-app purchases. Also use when the user mentions "pricing", "paywall", "subscription", "IAP", "how to monetize", "revenue optimization", "free trial", or "conversion to paid". For retention impact, see retention-optimization. For competitive pricing, see competitor-analysis.

日本語の概要は準備中です。原文の説明を表示しています。

Implement iOS authentication patterns including Sign in with Apple (ASAuthorizationAppleIDProvider, ASAuthorizationController, ASAuthorizationAppleIDCredential), credential state checking, identity token validation, ASWebAuthenticationSession for OAuth and third-party auth flows, ASAuthorizationPasswordProvider for AutoFill credential suggestions, and biometric authentication with LAContext. Use when implementing Sign in with Apple, handling Apple ID credentials, building OAuth login flows, integrating Password AutoFill, checking credential revocation state, or validating identity tokens server-side.

日本語の概要は準備中です。原文の説明を表示しています。

Implement GCP Organization Policy constraints to enforce security guardrails across the entire resource hierarchy, restricting risky configurations and ensuring compliance at organization, folder, and project levels.

日本語の概要は準備中です。原文の説明を表示しています。

Tests APIs for Broken Function Level Authorization (BFLA) vulnerabilities where regular users can invoke administrative functions or access privileged API endpoints by directly calling them. The tester identifies admin and privileged endpoints, then attempts to access them with regular user credentials by manipulating HTTP methods, URL paths, and request parameters. Maps to OWASP API5:2023 Broken Function Level Authorization. Activates for requests involving BFLA testing, admin endpoint bypas...

日本語の概要は準備中です。原文の説明を表示しています。

Build interactive HTML/web visualizations with plotly (Python/R), bokeh (Python), and gganimate/plotly frames for animation, with awareness of current Kaleido static-export model (post-orca-EOL), HTML file-size bloat, and the limits of interactive-only output for journal submission. Use when producing zoomable/hoverable plots for notebook EDA, supplementary HTML, dashboards, or animated time-course / iteration visualizations.

日本語の概要は準備中です。原文の説明を表示しています。

Half-Quadratic Quantization for LLMs without calibration data. Use when quantizing models to 4/3/2-bit precision without needing calibration datasets, for fast quantization workflows, or when deploying with vLLM or HuggingFace Transformers.

日本語の概要は準備中です。原文の説明を表示しています。

GGUF format and llama.cpp quantization for efficient CPU/GPU inference. Use when deploying models on consumer hardware, Apple Silicon, or when needing flexible quantization from 2-8 bit without GPU requirements.

日本語の概要は準備中です。原文の説明を表示しています。

Activation-aware weight quantization for 4-bit LLM compression with 3x speedup and minimal accuracy loss. Use when deploying large models (7B-70B) on limited GPU memory, when you need faster inference than GPTQ with better accuracy preservation, or for instruction-tuned and multimodal models. MLSys 2024 Best Paper Award winner.

日本語の概要は準備中です。原文の説明を表示しています。

Add authorization methods for a new entity to AuthorizationService. Use after creating a resource service. Triggers on "add permissions", "authorization methods", "entity permissions", "add auth methods".

日本語の概要は準備中です。原文の説明を表示しています。

Implements permission-based authorization with custom attributes, policy providers, and authorization handlers. Provides granular access control beyond simple role-based authorization.

日本語の概要は準備中です。原文の説明を表示しています。

Creates DE-specific diagnostic and result visualizations using DESeq2/edgeR built-in functions and lightweight ggplot2 wrappers. Covers MA plot (with the shrunken-LFC compression effect), volcano (with the apeglm caveat that p-values are unchanged), PCA on VST/rlog (never raw counts), sample distance heatmaps, top-DE-gene heatmaps with the row-scaling trap, dispersion / BCV plot interpretation, p-value histogram diagnostics, plotCounts for individual genes, blind=TRUE vs FALSE rationale, and the n=3 visualization stake. Use when generating DE diagnostic plots, choosing VST vs rlog for visualization, troubleshooting suspicious plot patterns (shifted MA cloud, batch-dominated PCA, anti-conservative p-value histogram), or building a standard QC figure panel.

日本語の概要は準備中です。原文の説明を表示しています。

Normalizes and transforms RNA-seq count matrices for DE, visualization, clustering, and ML. Covers between-sample (TMM, TMMwsp, RLE/median-of-ratios, upper quartile), within-sample (TPM, FPKM/RPKM), variance-stabilizing (VST, rlog, log-CPM), GC-content correction (cqn, EDASeq), and single-cell (scran deconvolution, scanpy normalize_total). Encodes the composition-bias rationale, the "most genes not DE" assumption and its catastrophic failure modes (MYC amplification, apoptosis, viral host shutoff, prokaryotic stress), the "lengthScaledTPM is not TPM" naming trap, the "TPM is not for DE" rule, the blind=TRUE vs FALSE decision, ERCC spike-in normalization (SBN), and the single-cell zero-inflation breakdown of TMM/RLE. Use when choosing or applying normalization, debugging shifted-MA-plot diagnostics, handling zero-heavy single-cell data, or correcting GC bias.

日本語の概要は準備中です。原文の説明を表示しています。

Build interactive HTML/web visualizations with plotly (Python/R), bokeh (Python), and gganimate/plotly frames for animation, with awareness of current Kaleido static-export model (post-orca-EOL), HTML file-size bloat, and the limits of interactive-only output for journal submission. Use when producing zoomable/hoverable plots for notebook EDA, supplementary HTML, dashboards, or animated time-course / iteration visualizations.

日本語の概要は準備中です。原文の説明を表示しています。

Normalizes and transforms RNA-seq count matrices for DE, visualization, clustering, and ML. Covers between-sample (TMM, TMMwsp, RLE/median-of-ratios, upper quartile), within-sample (TPM, FPKM/RPKM), variance-stabilizing (VST, rlog, log-CPM), GC-content correction (cqn, EDASeq), and single-cell (scran deconvolution, scanpy normalize_total). Encodes the composition-bias rationale, the "most genes not DE" assumption and its catastrophic failure modes (MYC amplification, apoptosis, viral host shutoff, prokaryotic stress), the "lengthScaledTPM is not TPM" naming trap, the "TPM is not for DE" rule, the blind=TRUE vs FALSE decision, ERCC spike-in normalization (SBN), and the single-cell zero-inflation breakdown of TMM/RLE. Use when choosing or applying normalization, debugging shifted-MA-plot diagnostics, handling zero-heavy single-cell data, or correcting GC bias.

日本語の概要は準備中です。原文の説明を表示しています。