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Runs JACKS (Joint Analysis of CRISPR/Cas9 Knockout Screens; Allen et al 2019 Genome Research) which models per-sgRNA log-fold-change as the product of a treatment-dependent gene-essentiality term and a treatment-independent guide-efficacy term. Covers the Bayesian decomposition math, the hierarchical efficacy prior shared across screens performed with the same library, when JACKS outperforms MAGeCK (multi-screen joint analysis, libraries with broad efficacy variance) and when it does not (single screen, novel libraries with no prior efficacy), library-reuse efficacy transfer, downstream essentiality interpretation, and the 2.5x sample-size reduction enabled by efficacy-aware testing. Use when running multiple screens with the same library, when guide-level noise is suspected to dominate per-gene signal, when reusing published essentiality reference screens for efficacy priors, or when comparing screens performed across cell lines that share library but differ biologically.

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Test whether two or more traits share a causal variant at a locus using Bayesian colocalization (coloc.abf, coloc.susie, HyPrColoc, moloc, eCAVIAR, SMR/HEIDI, PWCoCo, SharePro). Use when integrating GWAS with eQTL/sQTL/pQTL/mQTL, distinguishing shared causal variants from LD-driven coincidence, handling allelic heterogeneity, choosing between single-causal vs multi-causal methods, picking PP.H4 thresholds, running sensitivity over p12, or harmonising summary statistics for colocalization.

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Relentlessly interview the user about THEIR plan or design — one question at a time — resolving each branch of a decision tree until shared understanding. Claude is the interviewer; the user is the interviewee. Triggers on "grill me", "stress-test this plan", "get grilled on my design", "interrogate my plan". Checkpoints every answer to docs/knowledge/<slug>.md so progress survives a context-window reset. Flags knowledge the user cannot answer as a gap to chase. Do NOT use to PROPOSE solutions or compare approaches (→ mk:brainstorming). Do NOT use to validate "is this worth building?" (→ mk:office-hours). Do NOT use when Claude should ANSWER questions about the repo (→ mk:ask-me). Do NOT use for a one-shot review of an existing plan (→ mk:plan-ceo-review). Do NOT use to apply named reasoning lenses to findings (→ mk:elicit).

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Plan and run safe reverse engineering, decompilation, disassembly, instrumentation, de-obfuscation, and anti-analysis countermeasures for binaries, firmware, mobile apps, WebAssembly, JavaScript bundles, and .NET assemblies. Use for behavior reconstruction, cross-layer Electron tracing, REA, reversing strategy, decompiler selection, binary analysis, malware-style triage, unpacking, deobfuscation, defeating anti-debug or anti-VM checks, Wakaru, Ghidra, IDA, RetDec, radare2, Rizin, Frida, angr, YARA, or command scripts that capture analysis stats.

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Passive, pattern-calibrated risk discovery for authorized security research over an open-source project, repository URL, dependency, release, or local checkout. Use when the security research agent needs to find highest-risk areas, map attack surface, identify likely bug-hunting targets, prioritize security review, inspect structural/logical/security-critical code, compare vulnerable versus patched versions, reason from broad high-severity vulnerability families, or remember areas of interest for later attack-chain research.

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This skill screens for pregnancy intention in individuals with preexisting diabetes at every reproductive, diabetes, primary care, and urgent care/ER visit when clinically appropriate. Trigger phrases include reproductive planning, preconception care, or pregnancy intention discussion.

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Look up NHS England genomic tests for rare and inherited diseases. Use this skill whenever a clinician asks what genetic test to order for a condition, which genes are covered for a specific diagnosis, what commissioning category a genomic test falls under (Core, Specialised, or Highly Specialised), or which tests belong to a specialty group (Neurology, Cardiology, Endocrinology, etc.). Also trigger for questions like what panel is used for a condition, whether there is an NHS test for something, what the R number is for a condition, or whether anything has changed in the genomic test directory. Source: NHS England National Genomic Test Directory for Rare and Inherited Disease v9.0 (April 2026).

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Inspect scoped Autodesk data, compare versioned BOMs, and prepare ownership-aware drafts or approved custom-property changes. Not for implicit PLM release, membership changes or CAD geometry editing.

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Generate guided Chinese software copyright application materials from a real project. Use this skill when the user asks for 软件著作权, 软著申请资料, 软著代码材料, 操作手册, 申请表信息, or wants Word/TXT materials for software copyright registration. The workflow analyzes the imported project, extracts real source code, creates Markdown drafts for user confirmation, then uses bundled DOCX tooling to produce final Word documents and TXT.

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Prepare and risk-check the next rolling-wave slice for implementation. Use when the user wants to continue a rolling-wave project, draft one bounded slice in the main context by default, use a fresh planning author only when context or discovery cost warrants it, use a fresh preparation reviewer when semantic risk or uncertainty warrants independent pressure-testing, decompose parallel implementation chunks where appropriate, identify agent, human, either, or hybrid execution fit, write or update docs/rolling-wave/{project}/slices/NNN-slug.md, and mark that slice ready even when other slices are active.

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Use when creating or modifying Laravel middleware — request/response filtering, groups, priority, terminable middleware, or route-level assignment.

日本語の概要は準備中です。原文の説明を表示しています。

Investigate and fix failing CI. Takes a PR reference, one or more CI run/job URLs, or freeform text describing where the failures are, then enumerates failing workflows/jobs/steps, determines the root cause (often one shared cause behind several red checks), proposes a fix plan, applies code changes, commits, pushes, watches the new runs, and repeats until checks pass. Use when the user says "fix CI", "CI is red", "checks are failing", "the build is broken on my PR", "fix the failing jobs", or pastes a failing CI run URL. Do NOT use for authoring new workflows, or for read-only diagnosis with no fix intent — use gha-log-reader for that.

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Skill for the _shared area of paddock. 33 symbols across 6 files.

日本語の概要は準備中です。原文の説明を表示しています。

Run a GitHub issue digest for openai/codex by feature-area labels, all areas, and configurable time windows. Use when asked to summarize recent Codex bug reports or enhancement requests, especially for owner-specific labels such as tui, exec, app, or similar areas.

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Monthly delta tracking and progress reporting for GEO clients. Compares two GEO audits (baseline vs. current), calculates score improvements across all categories, tracks action item completion, and generates a "here's your progress" client report. Use when user says "compare", "delta", "monthly report", "progress", "confronta", "progressi", "report mensile", or when running a monthly client check-in.

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Publishes HTML or Markdown as display.dev URLs with public, company, or private access. Supports signup, claiming, sharing, browsing, bounded reads, exact edits, and comment iteration. Use when the user asks to "publish this", "share this", "share with the org", "post this online", "make a private link", "share with [email]", "publish a report", "list my artifacts", "find an artifact", "publish a large file", "publish this generated HTML file", "read this artifact", "search inside this artifact", "change this passage", "make a copy of this artifact", "duplicate version", "create a display.dev account", "claim this publish", "add a company email domain", "transfer an email domain", "change the email domains add-on", "watch comments on this artifact", "respond to comments", or "resolve this comment thread". Use whenever a request contains a display.dev artifact URL (`*.dsp.so/*`). Anonymous publishing returns a 30-day preview and browser claim URL.

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Brutally honest AGENTS.md/CLAUDE.md review backed by real A/B test evidence. Not just opinions — actual proof that your rules are dead weight. Roasts instruction files for bloat, slop, and redundancy, then proves it by running evals. Use when user says "roast my agents.md", "roast my CLAUDE.md", "prove my rules are useless", "eval roast", or wants entertaining evidence-based feedback on their AI config files. Also triggers on "audit my instructions" or "are my rules helping".

日本語の概要は準備中です。原文の説明を表示しています。

Implante aplicações e infraestrutura na Cloudflare usando Workers, Pages e serviços relacionados da plataforma. Use quando o usuário pedir para implantar, hospedar, publicar ou configurar um projeto na Cloudflare.

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Guia completo para criar diagramas de software usando sintaxe Mermaid. Use quando usuários precisarem criar, visualizar ou documentar software por meio de diagramas, incluindo diagramas de classe (modelagem de domínio, design orientado a objetos), diagramas de sequência (fluxos de aplicação, interações de API, execução de código), fluxogramas (processos, algoritmos, jornadas do usuário), diagramas de relacionamento de entidades (esquemas de banco de dados), diagramas de arquitetura C4 (contexto do sistema, containers, componentes), diagramas de estado, git graphs, gráficos de pizza, gráficos de Gantt ou qualquer outro tipo de diagrama. Acionadores incluem solicitações para "diagram", "visualize", "model", "map out", "show the flow" ou ao explicar arquitetura de sistema, design de banco de dados, estrutura de código ou fluxos de usuário/aplicação.

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Gerar memes usando a API memegen.link. Use quando usuários solicitarem memes, quiserem adicionar humor ao conteúdo ou precisarem de recursos visuais para redes sociais. Suporta 100+ templates populares com texto e estilo personalizados.

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Protected Health Information (PHI) and Personally Identifiable Information (PII) compliance patterns for healthcare applications. Covers data classification, access control, audit trails, encryption, and common leak vectors. Use when code touches PHI or PII in a healthcare system, or when auditing access control, audit trails, or leak vectors.

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Patient safety evaluation harness for healthcare application deployments. Automated test suites for CDSS accuracy, PHI exposure, clinical workflow integrity, and integration compliance. Blocks deployments on safety failures. Use when a healthcare deployment must be gated on patient-safety tests for CDSS accuracy, PHI exposure, and workflow integrity.

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Create or refresh screenshot-led product hero images, localized interface captures, and image-led README sections for GitHub repositories. Use whenever a user asks to make a GitHub README show a GUI product visually, add software screenshots, design a README hero image, reproduce a screenshot-collage reference, or prepare repository-bound visual documentation. For GUI applications, default to the deterministic product-proof split hero with real software screenshots unless the user explicitly requests another visual direction.

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Use the HyperFrames CLI development loop: init, add, catalog, capture, lint, check, snapshot, compare, grade-compare, preview, play, present, beats, keyframes, single or batch render, publish, cloud, cloudrun, feedback, lambda, doctor, browser, info, upgrade, skills, compositions, docs, benchmark, telemetry, transcribe, auth, tts, and remove-background. Also use when diagnosing build or render failures. validate, inspect, and layout are deprecated aliases; use check. Covers local, HeyGen-hosted cloud, AWS Lambda, and Google Cloud Run rendering.

日本語の概要は準備中です。原文の説明を表示しています。