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Visualize copy number profiles, segments, allele-specific tracks, and cohort patterns from CNVkit, GATK, ASCAT, FACETS, Sequenza, and other callers. Covers genome-wide and per-chromosome log2 scatter plots, B-allele-frequency/minor-allele-fraction tracks, ideograms, cohort heatmaps, circos views, and caller-native plots. Use when creating publication CNV figures, choosing which plot answers a given question, diagnosing a wrong diploid baseline visually, displaying loss of heterozygosity, or deciding what depth-only plots cannot reveal.

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Builds QSAR / QSPR models using chemprop D-MPNN, MolFormer, Uni-Mol, ChemBERTa, random forest baselines, and Gaussian processes with explicit handling of OECD 5 principles, applicability domain (kNN, leverage, conformal prediction, Mahalanobis), scaffold-balanced splits, ensemble uncertainty, calibration (Platt, isotonic), feature importance (SHAP, atomic attribution), and prospective validation. Use when building target-specific predictive models from in-house bioassay data, ADMET endpoints, or selectivity profiles.

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Analyzes differential transcript usage (DTU) and isoform switches with functional consequence prediction (NMD via 50nt rule, ORF disruption, protein domain loss/gain, signal peptide changes, IDR alterations, coding-potential shifts). Tools include IsoformSwitchAnalyzeR v2 (auto-selects satuRn for >5 reps else DEXSeq), the manual DRIMSeq -> DEXSeq/satuRn -> stageR DTU pipeline, and fishpond/swish for inferential-uncertainty-aware DTE. Distinguishes DTU from DGE and DTE; integrates external annotators (CPC2, Pfam, SignalP, IUPred2A or DeepTMHMM). Use when investigating how splicing differences alter protein function or trigger NMD-mediated degradation.

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Provides patterns to configure AWS RDS (Aurora, MySQL, PostgreSQL) with Spring Boot applications. Configures HikariCP connection pools, implements read/write splitting, sets up IAM database authentication, enables SSL connections, and integrates with AWS Secrets Manager. Use when setting up RDS connections in Spring Boot, configuring connection pooling, or managing database credentials securely.

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Use this skill whenever the user wants to do anything with PDF files. This includes reading or extracting text/tables from PDFs, combining or merging multiple PDFs into one, splitting PDFs apart, rotating pages, adding watermarks, creating new PDFs, filling PDF forms, encrypting/decrypting PDFs, extracting images, and OCR on scanned PDFs to make them searchable. If the user mentions a .pdf file or asks to produce one, use this skill.

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Use this skill any time a spreadsheet file is the primary input or output. This means any task where the user wants to: open, read, edit, or fix an existing .xlsx, .xlsm, .xltx, .csv, or .tsv file (e.g., adding columns, computing formulas, formatting, charting, cleaning messy data); create a new spreadsheet from scratch or from other data sources; or convert between tabular file formats. Trigger especially when the user references a spreadsheet file by name or path — even casually (like "the xlsx in my downloads") — and wants something done to it or produced from it. Also trigger for cleaning or restructuring messy tabular data files (malformed rows, misplaced headers, junk data) into proper spreadsheets. The deliverable must be a spreadsheet file. Do NOT trigger when the primary deliverable is a Word document, HTML report, standalone Python script, database pipeline, or Google Sheets API integration, even if tabular data is involved.

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Genera tickets profesionales de soporte para Meta Business Suite / WhatsApp Business API optimizados para recibir prioridad URGENTE 24hr resolution. Úsala SIEMPRE que el usuario mencione crear un ticket a Meta, escalar un caso WABA, apelar un ban o restricción, reportar un false positive, abrir caso de soporte WhatsApp Business, problema de onboarding, rechazo de template, errores de Cloud API, OTP delivery, verification stuck, BM restricted, display name rejection, o cualquier issue de una WhatsApp Business Account. También activa cuando el usuario dice frases como "ayúdame a redactar un caso para Meta", "necesito reportar esto a soporte", "hay que escalar esto a WhatsApp", "ticket para Meta", o describe un problema de una cuenta de cliente de Vambe sin pedir ticket explícitamente pero claramente necesita uno. También activa ante preguntas del tipo "¿cómo apelar esto?" o "¿qué hago si Meta dice X?" relacionadas con WABA, BM o verificación.

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Use this skill any time a .pptx or .potx file is involved in any way — as input, output, or both. This includes: creating slide decks, pitch decks, or presentations as PowerPoint (.pptx) files; reading, parsing, or extracting text from any .pptx or .potx file (even if the extracted content will be used elsewhere, like in an email, summary, or creating a different type of slide deck); editing, modifying, or updating existing presentations; combining or splitting slide files; working with templates (.potx), layouts, speaker notes, or comments. Trigger whenever the user asks for a PowerPoint or .pptx file, or references a .pptx or .potx filename, regardless of what they plan to do with the content afterward. However, when the user asks for a deck, slides, a slide deck, or a presentation without naming a file format, default to using a dedicated slide-deck artifact type or a separate slides skill if this session offers one; otherwise, use this skill.

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Modern Angular UI patterns for loading states, error handling, and data display. Use when building UI components, handling async data, or managing component states.

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Expert in building 3D experiences for the web - Three.js, React Three Fiber, Spline, WebGL, and interactive 3D scenes. Covers product configurators, 3D portfolios, immersive websites, and bringing depth to web experiences.

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Ingeniero de Sistemas de Andru.ia. Diseña, redacta y despliega nuevas habilidades (skills) dentro del repositorio siguiendo el Estándar de Diamante.

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Implements SwiftUI Views from Figma designs using Figma MCP tools (figma:get_design_context, figma:get_screenshot, figma:get_variable_defs, figma:get_metadata). Splits large designs into appropriately-sized components, respects existing codebase conventions, and adds previews for each component. Use when implementing SwiftUI from Figma design URLs (e.g., figma.com/design/...), converting designs to code, or building iOS UI from Figma mockups. Do NOT call Figma MCP tools directly without reading this skill first.

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CLAUDE.mdを分割ルールファイル(.claude/rules/)で管理するスキル。学習トライアドの書き込み先を分割ファイルにリダイレクトし、CLAUDE.mdには目次だけを生成する（本文は .claude/rules/ を Claude Code が自動で読み込む）。/rules-init, /rules-merge, /rules-add, /rules-status コマンドを提供。CLAUDE.mdが肥大化している場合や、学習トライアドの蓄積を分割管理したい場合に使用。

A sun-baked, clay-toned editorial interface built on warm cream surfaces, ink-brown headlines set in a display serif, and a single terracotta accent.

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A playful, energetic, cartoonesque interface inspired by friendly children's-book illustrations — warm cream backgrounds, big bold custom display typography, saturated brand color blocks, thick black outlines, generously rounded shapes

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Classic block-game inspired design with playful colors, bold display fonts, and compact, high-energy layouts.

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A friendly, hand-drawn sketch interface inspired by pencil illustrations on warm cream paper. Soft teal brand accents, hand-written display headings, rounded pill controls.

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Magazine-grade, collage-driven editorial system: warm paper canvas, surreal plaster-and-architecture imagery, oversized display type, hairline rules, and Roman-numeral section markers.

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Long-form Chinese article / blog-post template — two voices: a wildstay-style lifestyle launch piece with editorial grid + oversized display type, and a WeChat-公众号-style serif beauty/longform with measured prose and quiet hairlines.

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Chinese-first AI image-generation tool landing template — TwelveMei-style centered hero with floating icon-island nav, FlyFlowerSong serif display headline, textured pill CTAs, glass canvas mockup of the tool itself, monochrome ink palette. Built for Chinese creative-tool / generative-image / AI-工具 product pages aimed at designers and editors, not loud growth-marketing.

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AdwHeaderBar layout rules: button placement, flat/icon-only buttons, tooltips, title widgets, split buttons. Use when designing or fixing a GNOME app's header bar.

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Process, parse, create, and manipulate PDF documents using libraries like pdf-lib, PDFKit, or pdf-parse for document generation, data extraction, and PDF manipulation. Use when generating PDFs from HTML, extracting text from PDFs, merging or splitting PDFs, adding watermarks, filling PDF forms, creating invoices and reports, parsing legal documents, or building document management systems.

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Run multiple Reforge-guided section-refactor lanes in parallel, each in its own worktree/branch off origin/main, with a score-blind adversarial review panel gating every commit, one draft PR per section. Use when the user wants to reduce Reforge surface/internal score across several sections at once via architecturally-correct deletions (dead surface, entity-leak removal, cross-section read-splits) — not by relocation, parameter bags, or accessibility-dodging. Wraps the per-lane process in .codex/skills/humans-refactor. Triggers: 'refactor swarm', 'parallel section refactors', 'run reforge refactor on Users/Tickets/...', 'burn down surface score across sections'. Has an intensity dial (light|standard|deep) and a workflow|solo execution mode to trade token burn against autonomy per unit of output.

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When the user wants to plan, design, or implement an A/B test or experiment. Also use when the user mentions "A/B test," "split test," "experiment," "test this change," "variant copy," "multivariate test," "hypothesis," "should I test this," "which version is better," "test two versions," "statistical significance," or "how long should I run this test." Use this whenever someone is comparing two approaches and wants to measure which performs better. For tracking implementation, see analytics-tracking. For page-level conversion optimization, see page-cro.

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