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概要と使いどころ
The package implements a method for normalising microarray intensities from single- and multiple-color arrays. It can also be used for data from other technologies, as long as they have similar format. The method uses a robust variant of th
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Dino normalizes single-cell, mRNA sequencing data to correct for technical variation, particularly sequencing depth, prior to downstream analysis. The approach produces a matrix of corrected expression for which the dependency between sequencing depth and the full distribution of normalized expression; many existing methods aim to remove only the dependency between sequencing depth and the mean of the normalized expression. This is particuarly useful in the context of highly sparse datasets such
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A post hoc cell type classification tool to fine-tune cell type annotations generated by any cell type classification procedure with semi-supervised learning algorithm AdaSampling technique. The current version of scReClassify supports Support Vector Machine and Random Forest as a base classifier.
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This R package supports interactive visualization of multi-channel images and segmentation masks generated by imaging mass cytometry and other highly multiplexed imaging techniques using shiny. The cytoviewer interface is divided into image-level (Composite and Channels) and cell-level visualization (Masks). It allows users to overlay individual images with segmentation masks, integrates well with SingleCellExperiment and SpatialExperiment objects for metadata visualization and supports image do
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epigraHMM provides a set of tools for the analysis of epigenomic data based on hidden Markov Models. It contains two separate peak callers, one for consensus peaks from biological or technical replicates, and one for differential peaks from multi-replicate multi-condition experiments. In differential peak calling, epigraHMM provides window-specific posterior probabilities associated with every possible combinatorial pattern of read enrichment across conditions.
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seqLogo takes the position weight matrix of a DNA sequence motif and plots the corresponding sequence logo as introduced by Schneider and Stephens (1990).
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Expert guidance for designing Azure solutions using Azure Architecture. Covers reference architectures, solution ideas, design patterns, technology choices, architecture styles, best practices, anti-patterns, example workloads, and migration guides. Use when designing AKS/microservices, hybrid/Arc, SAP or mainframe migrations, IoT/Edge, or mission-critical BCDR, and other Azure Architecture related development tasks.
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Daily on-page and technical SEO audit of every page on a site - discovers URLs from the sitemap, scores each page, adds cross-page checks (duplicate titles, canonicals, sitemap gaps), diffs against yesterday, and sends the score line plus any regressions
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Cross-platform social research - narrative-first intelligence on what people are saying about a topic across Reddit, X, HN, Polymarket, and the web over the last 30 days
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This skill should be used when searching for people/leads using the Prospeo Search Person API. It provides the correct API format, filter types, rate limiting patterns, and state-by-state crawling techniques to overcome the 25K result limit. Use when building lead lists, searching by job title/industry/location, or integrating with Prospeo.
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An SEO agent skill for quick, lightweight, default single-page SEO audits. Performs basic on-page and site-level checks and outputs a structured basic SEO audit report. Use when the user asks for "SEO audit", "SEO check", "check my page SEO", "page analysis", or wants a first-pass review of a URL. If the user requests "deep audit", "full report", "technical SEO audit", or "advanced SEO", use seo-audit-full instead.
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Capture an architectural decision so the next session (or engineer) knows WHY. Use after any non-obvious technical choice.
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Applies Neil Rackham's SPIN methodology (Situation/Problem/Implication/Need-payoff questions) to major B2B sales. Use for complex multi-call sales cycles, enterprise deals where the customer must justify the decision to others, when objections are mounting, when calls end in vague continuations instead of advances, when traditional closing techniques are backfiring on large deals, or when designing discovery-call structure. Triggers include 'my deal isn't closing', 'too many objections', 'B2B sales coaching', 'discovery call structure', 'stuck in the middle of the sale'. Not for transactional sub-$50 sales, pure consumer impulse, or PLG self-serve products.
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Receive and act on code review feedback with technical rigor, not performative agreement or blind implementation
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Dispatch to the right problem-solving technique based on how you're stuck
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First-tier tech company P7 capability advisor for evaluating, coaching, and giving career advice against a P7 technical/product/expert profile. Use when the user asks for P7-level assessment, promotion readiness, capability gaps, resume/project review, interview preparation, or concrete growth advice based on first-tier tech company P7 expectations.
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Use this skill when the user wants an evidence-based research memo, literature review, market/policy/technical landscape, or a multi-source decision brief with citations, trade-offs, and a clear conclusion. Best for tasks that need synthesis across multiple external sources, iterative follow-up research, or a reusable written artifact. Do not use for quick factual lookups, single-source summaries, simple Q&A, summarizing one document the user already provided, plan-only requests where the user explicitly defers the actual research, or when the user wants a short answer with no need for cited evidence (a short but evidence-backed conclusion is still a brief memo, which this skill covers). Chinese trigger examples: "帮我调研", "深度研究", "综述报告", "技术选型分析", "竞品研究", "政策分析".
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Audit affiliate blog posts and landing pages for SEO issues. Triggers on: "audit my blog post for SEO", "check my SEO", "SEO review", "improve my rankings", "SEO checklist", "on-page SEO audit", "keyword optimization check", "why isn't my page ranking", "SEO score", "content quality audit", "check my meta tags", "internal linking audit", "quick SEO wins".
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Use when analyzing suspected malware through static, dynamic, and behavioral techniques, including IOC extraction, YARA or Sigma rules, sandboxing, and anti-analysis behavior.
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Creates task-oriented technical documentation with progressive disclosure. Use when writing READMEs, API docs, architecture docs, or markdown documentation. Also use this skill at the END of any completed reverse engineering, penetration testing, CTF, or security analysis task to generate a formal report in the user's project directory. Trigger keywords: 写报告, 写文档, 出报告, writeup, 技术文档, report, documentation.
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Provides reverse engineering techniques. Use when the main job is to understand how a compiled, obfuscated, packed, or virtualized target works before exploiting or solving it, including binaries, APKs, WASM, firmware, custom VMs, bytecode, malware-like loaders, and anti-debug or anti-analysis logic. Do not use it when the vulnerability is already understood and the remaining task is exploitation; use pwn instead. Do not use it for pure web workflows, log or disk forensics, or standalone crypto problems unless reversing the implementation is the real blocker.
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All animation knowledge for HyperFrames — atomic motion rules, multi-phase scene blueprints, scene transitions, broader motion-design techniques, AND the seven runtime adapters (GSAP default, plus Lottie, Three.js, Anime.js, CSS keyframes, Web Animations API, TypeGPU). Use for any motion or animation task: pick 2-4 rules and compose, or load a blueprint, or look up runtime-specific API (e.g. GSAP eases / Lottie player / Three.js mixer). Also covers auditing an existing composition's choreography (animation map) and 24 named text-animation effects. HyperFrames-native: single paused timeline, seek-safe, deterministic.
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Generate self-contained HTML visual explanations for systems, code changes, plans, data, and technical concepts. Use for diagrams, architecture overviews, diff or plan reviews, project recaps, comparison tables, slide decks, and other visual explanations.
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Use when facing architectural decisions, complex trade-offs, strategic technology choices, or scaling and migration questions that deserve more than a quick answer. Lays out options with trade-offs, then a recommendation.
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