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Predict RBP binding from RNA sequence using deep learning models (RBPNet sequence-to-signal, RNAProt RNN, GraphProt2 GCN with structure, DeepCLIP, DeepRiPe multi-modal CNN) for variant-effect prediction, in silico binding-site discovery, model interpretation, and transfer learning from CLIP and RBNS datasets. Use when computational prediction of RBP binding from sequence is needed, evaluating variant effects on binding without further wet-lab experiments, comparing model performance, or training a custom model on ENCODE eCLIP data.

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Design guides for cytosine and adenine base editing using editing window optimization and BE-Hive outcome prediction. Select optimal positions for C-to-T or A-to-G conversions without double-strand breaks. Use when designing base editor experiments for precise nucleotide changes.

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Access and analyze AlphaFold protein structure predictions. Use when predicted structures are needed for proteins without experimental structures, or for confidence scores (pLDDT).

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Maps query single-cell data to reference atlases using scArches transfer learning with scVI and scANVI models. Transfers cell type labels without retraining on combined data. Use when annotating new single-cell datasets using pre-trained reference models.

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Use when code has gone through repeated rework and may contain redundant logic, style drift, or tangled structure. Trigger when user asks for "返工收敛", "cleanup-pass", or requests a focused cleanup pass that reduces churn without changing behavior.

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Use when a sponsor has rebranded or sent an updated logo and it must change on current and future events without altering how they appeared at past devopsdays events.

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Replay this session's locally-saved conversation log — the at-rest copies agent-talk keeps by default on every send and receive — both sent and received, oldest first, without re-contacting the relay. Use to review the conversation with a peer. `<user>` is this session's user directory (absolute path; from init).

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Safe refactoring workflow using trace-mcp — assess risk, find candidates, check impact, and rename symbols across all files without missing import sites or cross-file references.

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CesiumJS primitives and geometry - Primitive, GeometryInstance, Appearance, BufferPrimitive collections, GeoJsonPrimitive, Billboard/Label/PointPrimitive collections, built-in geometry shapes, ground primitives, classification. Use when rendering performance-critical static or vector geometry, loading GeoJSON without entities, creating custom shapes, batching draw calls, or using low-level collections.

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End-to-end testing of email-dependent flows — signup confirmation, password reset, magic-link login, OTP/MFA codes, and notification emails. Covers the capture-inbox decision tree (Mailpit, Mailosaur, MailSlurp, Ethereal), Playwright polling without fixed sleeps, regex extraction of links/OTPs from the email body, deterministic per-test addresses (plus-addressing, per-inbox), subject/from/header/link assertions, and SPF/DKIM/DMARC deliverability checks as a separate suite. Use when: "test the signup confirmation email," "password reset email test," "magic-link login test," "capture OTP from email," "Mailpit," "Mailosaur," "MailSlurp," "email arrives flaky in CI," "assert email subject/from/links." Not for: Sending transactional email from your app code, or API-only contract tests of an email provider — those are api-testing / app concerns. Email HTML rendering across clients (Outlook/Gmail dark mode) is out of scope (note it as a gap; use visual-testing or Litmus). Related: playwright-automation, api-testing, test-data-management, qa-project-context.

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Turn a vague bug report into a VERIFIED minimal reproduction and then a failing regression test, agent-driven end to end. Covers extracting the implicit repro from a thin report (env, build, steps, data), the reproduce-minimize-isolate-capture loop, git bisect to find the introducing commit, building a deterministic minimal repro (fixed seeds, frozen time, stubbed network), writing the failing regression test BEFORE the fix (red) and confirming the fix flips it green, and writing repro evidence back into the ticket. Distinguishes flaky-not-reproducible from environment-specific. Use when: "reproduce this bug," "minimal reproduction," "repro steps," "find the commit that broke it," "git bisect," "make the repro deterministic," "write a failing test for this bug," "regression test for a defect," "can't reproduce this bug." Not for: Classifying/deduplicating/severity-routing existing failures without reproducing them — that is ai-bug-triage. Generating tests from specs rather than from a defect — that is ai-test-generation. Related: ai-bug-triage, ai-test-generation, test-reliability, systematic-debugging, qa-project-context.

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Remove AI-generated patterns from QA reports, bug reports, test summaries, status updates, and quality communications. Detects and rewrites robotic test-result language, template-sounding status updates, inflated severity descriptions, and generic stakeholder reports — without inventing facts. Makes QA writing sound like a real engineer wrote it. Use when: "humanize report," "rewrite QA summary," "fix test report," "make this sound human," "clean up status update." Not for: general prose, blog, or marketing-copy cleanup — use the global humanizer skill. Not for: classifying or routing CI failures — use ai-bug-triage. Related: ai-bug-triage, qa-metrics, qa-dashboard, quality-postmortem.

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60-Second Property Snapshot — quick assessment without subagents for fast property evaluation with signal, key factors, and CTA for full analysis

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Install the PRD-Driven Context Engineering methodology into a fresh OR existing repository — the subscription-native alternative to forking the whole repo. Runs an interactive wizard that seeds the framework (.claude/ hooks, skills, agents, rules, scripts) without clobbering product content. Triggers on "install the methodology", "adopt this into my repo", "self-install", "set up PRD lifecycle here", "onboard existing project". Outputs an installed framework + a verification report.

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Apply Rob Fitzpatrick's Mom Test discipline to customer interviews during PRD v1.0 Market Adoption. Triggers on requests to interview customers, run discovery calls, validate ideas with users, or when user asks "how do I interview customers?", "Mom Test", "Rob Fitzpatrick", "customer interview", "user research without lies", "talking to humans", "discovery conversation". Outputs CFD-* discovery entries with Mom Test-calibrated confidence.

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Symfony UX TwigComponent for reusable UI building blocks -- server-rendered components with PHP classes and Twig templates. Use when creating buttons, cards, alerts, badges, navbars, or any reusable UI element with props, blocks/slots, computed properties, or anonymous (template-only) components. Code triggers: AsTwigComponent, #[AsTwigComponent], ExposeInTemplate, PreMount, PostMount, <twig:Alert />, <twig:Button>, component(), computed properties, anonymous component, HTML syntax. Also trigger when the user asks "how to create a reusable component", "how to make a component library", "how to pass props to a component", "how to use slots/blocks in a component", "how to build a design system in Symfony", "what is the HTML syntax for components", "how to create a component without a PHP class". Do NOT trigger for components that re-render dynamically on user input (use live-component), for JS behavior (use stimulus), or for page navigation (use turbo).

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Stimulus JS framework for Symfony UX -- client-side behavior via HTML data attributes, zero server round-trips. Use when creating controllers for DOM manipulation, handling click/input/submit events, managing targets and values, wiring outlets between controllers, wrapping third-party JS libraries, or building toggles, dropdowns, modals, tabs, clipboard interactions. Code triggers: data-controller, data-action, data-target, data-*-value, data-*-class, data-*-outlet, stimulusFetch lazy, connect(), disconnect(), static targets, static values. Also trigger when the user asks "how do I add a click handler", "how to toggle a class", "how to build a dropdown/modal/tabs", "how to wrap a JS library in Symfony", "add keyboard shortcuts", "lazy-load a controller", "listen to global events", "communicate between controllers". Do NOT trigger for partial page updates without JS (use turbo), server-rendered reactivity (use live-component), or reusable Twig templates (use twig-component).

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Symfony UX LiveComponent for reactive server-rendered UI -- components that re-render via AJAX on user interaction, zero JavaScript required. Use when building live search, real-time filtering, dynamic forms, inline validation, dependent selects, auto-save, polling, deferred/lazy rendering, or any UI that updates itself based on user input. Code triggers: AsLiveComponent, LiveProp, LiveAction, data-model, data-loading, data-live-action-url, ComponentWithFormTrait, LiveListener, emit, defer, lazy, polling. Also trigger when the user asks "how to build a search that filters as I type", "how to validate a form in real-time", "how to make a reactive component in PHP", "how to build dependent selects", "how to defer component rendering", "how to communicate between components via emit", "how to bind a form to a LiveComponent". Do NOT trigger for static reusable UI without reactivity (use twig-component), pure client-side JS behavior (use stimulus), or page-level navigation (use turbo).

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Use this skill whenever the user wants to read, create, or edit Korean Hangul Word Processor documents (.hwp or .hwpx files). Triggers include any mention of 'hwp', 'hwpx', '한글 문서', '아래한글', '한컴오피스', or uploading/attaching .hwp/.hwpx files. Also use when extracting text from Korean reports or producing Korean-formatted official documents (공문, 보고서, 계약서, 사업계획서). Do NOT use for Word .docx files (use the docx skill instead) or general Korean text without Hangul Word Processor format. ⚠️ SECURITY: if the task fills a form with personal data (주민등록번호·계좌·연락처·주소 등), LOAD THIS SKILL FIRST — before any `ls`/`cat`/`Read`/`grep` of the working dir or home — and NEVER directly cat/Read/grep a profile or 내정보 file (e.g. ~/.claw-hwp/profile.txt), even "to check it". Its SECURE FILL flow reads values in-process only; reading them yourself leaks them into context.

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Compile the TMDb package AND all test targets (without running the tests) to catch test-code compile errors. Use after changing tests or shared code to check everything still builds — delegates to the tooling-runner agent (Haiku) and returns a concise pass/fail + errors-as-file:line summary. Differs from /build, which compiles only the library; to run the tests, use /test.

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Guide for implementing smooth, native-feeling animations using React's View Transition API (`<ViewTransition>` component, `addTransitionType`, and CSS view transition pseudo-elements). Use this skill whenever the user wants to add page transitions, animate route changes, create shared element animations, animate enter/exit of components, animate list reorder, implement directional (forward/back) navigation animations, or integrate view transitions in Next.js. Also use when the user mentions view transitions, `startViewTransition`, `ViewTransition`, transition types, or asks about animating between UI states in React without third-party animation libraries.

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E2B is a cloud platform that gives AI agents secure, isolated sandboxes — ephemeral Linux VMs with a filesystem, package managers, and internet access — to run AI-generated code safely. Use when a user wants an agent to execute Python or JavaScript, install packages, read/write files, or run a long process without risking the host machine, or wants to wire code execution into a LangChain, CrewAI, or custom agent loop.

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Build backends and APIs with Directus headless CMS. Use when a user asks to create a headless CMS, build a content API without coding, set up a backend admin panel, create REST or GraphQL APIs from a database, manage content with roles and permissions, build a data platform with auto-generated APIs, or replace traditional CMS with a headless solution. Covers data modeling, auto-generated REST/GraphQL APIs, roles/permissions, flows (automation), file storage, and SDK integration.

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Expert guidance for Evidence, the open-source BI framework that generates beautiful, interactive dashboards from SQL queries and Markdown. Helps developers build data reports as code, deploy them as static sites, and create self-service analytics without heavy BI tools.

日本語の概要は準備中です。原文の説明を表示しています。