「dan」の検索結果

Performs logistic regression for clinical trial outcomes (binary, ordinal, multinomial) with marginal-vs-conditional estimand reporting per FDA 2023 covariate adjustment guidance, g-computation/standardisation for marginal effects, modified Poisson for RR, Brant test for proportional odds, Firth penalty for separation, and Hauck-Donner detection. Use when modeling binary or ordinal endpoints in confirmatory or exploratory clinical trials.

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Implements multiplicity control for confirmatory clinical trials using graphical procedures (Bretz-Maurer-Hommel), gatekeeping (parallel, serial, mixed), Hochberg/Hommel/Holm with PRDS, and the closed-testing principle (Marcus-Peritz-Gabriel; Goeman 2021 admissibility). Covers FDA Multiple Endpoints Final Guidance (October 2022), graphical procedures via R gMCP, primary + key-secondary + subgroup hierarchies, and FWER vs FDR distinction. Use when designing the multiplicity strategy for confirmatory trials with multiple primary or key secondary endpoints.

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Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Friede-Kieser, unblinded Cui-Hung-Wang, Mehta-Pocock promising zone), seamless Phase 2/3 with treatment-arm selection, population enrichment, and response-adaptive randomisation. Covers FDA 2019 Final Adaptive Designs Guidance, FDA 2022 Master Protocols, and ICH E20 Step 2b/3 draft (June 2025, NOT final). Use when planning interim analyses, sample-size re-estimation, or master/platform-trial designs.

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Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.

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Computes and interprets treatment effect measures (OR, RR, RD, HR, NNT) with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen, MOVER, profile likelihood, Bender NNT) and reports marginal vs conditional estimands per FDA 2023 covariate adjustment guidance. Use when reporting treatment effects in confirmatory trials, comparing effect sizes across studies, or constructing forest plots.

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Analyzes CUT&RUN (Skene Henikoff 2017) and CUT&Tag (Kaya-Okur 2019) chromatin profiling data. Handles SEACR vs MACS2 peak calling (with the btaf375 2025 benchmark guidance), pA-MNase vs pA-Tn5 vs pAG-Tn5 chimera differences, E. coli spike-in carryover normalization, IgG-only control logic (no input), characteristic fragment-size signatures (25-75 bp for CUT&Tag), and lower depth requirements (5M reads typical vs 25M for ChIP). Use when calling peaks from CUT&RUN/CUT&Tag, scaling by E. coli spike-in carryover, choosing SEACR norm mode, or comparing CUT&RUN/Tag results to traditional ChIP.

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Prepares statistical reports for clinical trials following CONSORT 2025, SPIRIT 2025, ICH E9(R1) estimands, and FDA 2023 covariate adjustment guidance. Covers Table 1 generation, analysis populations (ITT/FAS/PP/Safety), the 5 ICH E9(R1) intercurrent-event strategies, MMRM under MAR (mmrm), reference-based MI (rbmi J2R/CR/CIR), Permutt tipping-point sensitivity, and Rubin's-rules vs frequentist variance debate. Use when preparing regulatory submissions, defining estimands, or implementing missing-data sensitivity analyses.

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Map nucleosome center positions, occupancy, and fuzziness from ATAC-seq fragment-size patterns using NucleoATAC, ATACseqQC, DANPOS3, or scprinter. Use when characterizing nucleosome organization at promoters and enhancers, calling +1/-1 nucleosomes flanking NFRs, generating V-plots for chromatin structure visualization, or comparing nucleosome positioning between conditions.

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Trim multiple sequence alignments using ClipKIT, trimAl, BMGE, Divvier, or HMMcleaner with mode selection guidance per downstream goal. Use when removing unreliable columns or contaminating residues before phylogenetic inference, HMM building, or selection analysis.

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Maps GWAS-implicated loci to candidate effector (causal) genes by integrating variant-to-gene (V2G) features via Open Targets L2G (Mountjoy 2021), MAGMA gene-based association (de Leeuw 2015), FUMA SNP2GENE, cS2G combined SNP-to-gene scores (Gazal 2022), Polygenic Priority Scores (PoPS, Weeks 2023), FLAMES, INQUISIT, DEPICT, and enhancer-gene predictors (ABC, ENCODE-rE2G). Use when narrowing a GWAS lead locus to a candidate causal gene, picking between proximity, eQTL-based, and similarity-based prioritizers, integrating multi-evidence streams (fine-mapping, colocalization, ABC enhancer-gene, distance, chromatin), reconciling discordant L2G vs PoPS calls, prioritizing tissue-specific eQTL evidence, or triangulating across at least three independent lines of evidence for a publication-grade effector-gene nomination.

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Detect and adjust for horizontal pleiotropy in two-sample Mendelian randomization by distinguishing uncorrelated (UHP) from correlated (CHP) pleiotropy and choosing among Egger, MR-PRESSO, MR-RAPS, CAUSE, LHC-MR, LCV, MR-Clust, MR-Mix, and contamination-mixture methods. Use when validating an MR causal claim, running the STROBE-MR sensitivity battery, suspecting a shared heritable confounder, working under weak-instrument or polygenic-exposure regimes, or reconciling discordant estimates across robust methods.

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Builds and reviews SwiftUI views with modern MV architecture, state, composition, isolated previews, and migration guidance. Covers @Observable ownership, @State/@Bindable/@Environment wiring, view decomposition, ViewModifiers, environment values, .task loading, iOS 26+ handoffs, Writing Tools, clipboard availability, and performance. Use when structuring SwiftUI state, managing @Observable, composing views, previewing meaningful UI states, or correcting SwiftUI patterns.

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Configures and enforces SwiftLint in Swift projects using build tool plugins, run scripts, and CI. Covers .swiftlint.yml configuration, disabled_rules, opt_in_rules, only_rules, analyzer_rules, baselines, autocorrect, swiftlint:disable suppressions, reporter formats (sarif, json, checkstyle), strict and lenient modes, SwiftLintBuildToolPlugin via SimplyDanny/SwiftLintPlugins, swift package plugin swiftlint, Xcode run script phases, CI integration, multiple configuration files, and rollout strategies for existing codebases. Use when setting up SwiftLint, configuring lint rules, suppressing warnings, creating baselines, choosing between build tool plugin and run script, or integrating SwiftLint into CI.

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Guidance for distinctive, intentional visual design when building new UI or reshaping an existing one. Helps with aesthetic direction, typography, and making choices that don't read as templated defaults.

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Spiral inductors, interdigital capacitors, baluns, resonators, phase shifters for impedance matching, DC blocking, and bias tees. TRIGGER: user asks to design or create a spiral inductor, interdigital capacitor, balun, resonator, phase shifter, or other passive RF component. Invoke BEFORE writing code — class names and property patterns are non-obvious. SKIP: filter design (use matlab-design-pcb-filter), coupler/splitter design (use matlab-design-pcb-coupler), transmission line design (use matlab-design-pcb-transmission-line), EM analysis (use matlab-analyze-em), material setup only (use matlab-manage-pcb-material).

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Plan manipulator motion and generate trajectories in MATLAB. Use when the task involves moving a robot arm between configurations or poses — whether the user says "trajectory," "motion," "path," "move from A to B," or "plan." This skill applies regardless of whether the user explicitly mentions collisions or obstacles; if geometry exists in the workspace, collision safety is implicit. Triggers on: manipulatorRRT, manipulatorCHOMP, dlCHOMP, contopptraj, trapveltraj, collision-free path, motion planner, RRT, CHOMP, TOPPRA, path shortening, obstacle avoidance for manipulators, time-optimal trajectory, velocity limits, acceleration limits, occupancyMap3D, meshtsdf, collision objects as environment, trajectory between waypoints, joint interpolation, move between poses, constant velocity, trapezoidal profile, feed rate. Also triggers when a user has IK solutions or waypoints and needs to connect them — whether for time-optimal motion, constant-speed welding/cutting, or any other trajectory parameterization.

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Expert guidance for simulating RoadRunner scenarios via the MATLAB programmatic API and Simulink co-simulation. Use when the user wants to run a simulation, step through a simulation, control actors during co-simulation, add observers, attach sensors, retrieve simulation logs, or read/write scenario variables. Covers simulateScenario, createSimulation, ScenarioSimulation set/get, ActorSimulation getAttribute/setAttribute, addObserver, SensorSimulation, Simulink co-sim blocks, and publishActorBehavior. NOT for project setup, scene building, scenario authoring, or trajectory export.

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Design, improve, and evaluate reusable agent skills with high-quality SKILL.md files, precise trigger descriptions, progressive disclosure, and testable behavior. This skill should be used when users ask to create a new skill, rewrite or review an existing skill, audit a skill collection such as `config/source/skills` for redundancy or overlap, improve skill trigger quality, organize skill references, or evaluate whether a skill should trigger and behave correctly.

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CloudBase PostgreSQL access-pattern and slow-query quality guidance. Use when designing how tables are read and written, eliminating per-row database calls, adding indexes for filters or joins, reviewing high-traffic data access, or explaining a slow SQL query. Not for first-time PG SDK setup, login UI, or NoSQL collections.

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Direct, generate, edit, compare, and review visual assets with current Google Gemini image models. Use for image creation, image editing, reference-based consistency, product and character visuals, text-bearing graphics, grounded diagrams, video-derived images, and multi-model image portfolios.

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Create new reusable skills from conversation context

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Generate pytest test cases for Python functions and classes

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Systematic approach to diagnosing and fixing errors

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Review Python code for quality, security, and best practices

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