「dire」の検索結果

Infer gene regulatory networks from bulk or general expression data with mutual-information (ARACNe) and tree-ensemble (GENIE3, GRNBoost2) methods, and infer transcription-factor protein activity from regulons with VIPER and msVIPER. Covers the activity-not-edges paradigm, the undirected-association caveat, the DREAM5 wisdom-of-crowds and method-complementarity result, AUPRC-over-AUROC evaluation, and gold-standard incompleteness. Use when inferring a regulatory network from a bulk expression matrix, finding master regulators, or scoring TF activity from a signature. For single-cell motif-pruned regulons see scenic-regulons; for co-expression modules see coexpression-networks.

日本語の概要は準備中です。原文の説明を表示しています。

Aligns sample metadata with count matrices and constructs design matrices for downstream DE, handling the alphabetical-reference-level trap (relevel BEFORE DESeq), LRT reduced-model rules, the interaction-term resultsNames trap, continuous-covariate scaling and splines, repeated measures via duplicateCorrelation or dream, high-cardinality categorical pseudo-singular designs, sample swap detection via XIST/RPS4Y1 expression and somalier/NGSCheckMate genotypes, SABV (sex-as-biological-variable) mandate, Simpson's-paradox collapsing of technical replicates, and the `~ 0 + group` parameterization for clean contrasts. Use when building a design matrix, troubleshooting reversed fold-change direction, encoding paired or repeated-measures designs, detecting sample swaps, deciding sex-as-covariate, or aggregating technical replicates.

日本語の概要は準備中です。原文の説明を表示しています。

Download raw sequencing reads from NCBI SRA using sra-tools (prefetch, fasterq-dump, vdb-validate) or the ENA mirror. Use when pulling FASTQ for SRR/ERR/DRR accessions, deciding between SRA-direct, ENA mirror, or AWS/GCP cloud mirror (STRIDES), handling --include-technical for 10x and other single-cell records, validating with MD5/vdb-validate, navigating SRR/SRX/SRS/SRP/PRJNA hierarchy, or finding accessions via pysradb. Encodes SRA cloud-egress economics, the fasterq-dump uncompressed-scratch trap, and the --max-size default that silently truncates large prefetches.

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Map N6-methyladenosine (m6A) RNA modifications at single-nucleotide resolution using miCLIP (Linder 2015), miCLIP2 + m6Aboost machine learning (Kortel 2021), GLORI (Liu 2023, antibody-free chemical conversion), DART-seq (Meyer 2019, APOBEC1-YTH fusion), m6Anet (nanopore direct RNA), or MeRIP-seq with calibration. Use when distinguishing antibody-based from antibody-free m6A detection methods, applying the DRACH motif constraint, reconciling cross-method disagreements (DART 44% in DRACH vs GLORI), or detecting m6Am at the cap.

日本語の概要は準備中です。原文の説明を表示しています。

Designs novel molecules using REINVENT 4 (de novo, scaffold decoration, linker design, R-group, molecular optimization), MolMIM, Diffusion-based generators (DiGress, DiffSMol), and JT-VAE with explicit handling of multi-parameter optimization (MPO), goal-directed scoring functions, transfer/reinforcement/curriculum learning, synthetic accessibility scoring, and chemical space exploration vs exploitation. Use when designing new chemical matter against a target, decorating a scaffold, linking fragments, or optimizing a hit for multiple ADMET / activity properties simultaneously.

日本語の概要は準備中です。原文の説明を表示しています。

Estimate causal effects of an exposure on an outcome from GWAS summary statistics using genetic instruments. Implements IVW (fixed/random), MR-Egger, weighted median/mode, MR-RAPS, CAUSE, GSMR-HEIDI, MR-PRESSO, MVMR, MR-Clust, LCV, and LHC-MR via TwoSampleMR, MendelianRandomization, MR-PRESSO, cause, and lhcMR. Use when testing causal direction between traits, evaluating drug-target effects via cis-pQTL/cis-eQTL, performing multivariable mediation MR, distinguishing causation from correlated horizontal pleiotropy, or producing STROBE-MR-compliant sensitivity batteries.

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Use when implementing location services, maps, geofencing, or debugging location/MapKit issues. Covers Core Location, CLMonitor, MapKit, annotations, directions.

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Implement VoIP calling with CallKit and PushKit. Use when building incoming/outgoing call flows, registering for VoIP push notifications, configuring CXProvider and CXCallController, handling call actions, coordinating audio sessions, or creating Call Directory extensions for caller ID and call blocking.

日本語の概要は準備中です。原文の説明を表示しています。

Implements keyboard, directional, and scene-level focus behavior across SwiftUI and UIKit. Use when managing @FocusState, defaultFocus, focused values, focusable interactions, focus sections, tvOS geometric focus and Siri Remote navigation, watchOS Digital Crown input, visionOS connected-device focus versus gaze hover/input targets, macOS key view loop and Full Keyboard Access, focus restoration after presentation changes, custom focus routing with UIFocusGuide, or debugging focus with UIFocusDebugger.

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Build direct Bluetooth Low Energy workflows with Core Bluetooth. Use when implementing BLE central or peripheral GATT communication, scanning or connecting with CBCentralManager, discovering services and characteristics, reading/writing/subscribing with CBPeripheral, publishing local services with CBPeripheralManager, handling Bluetooth authorization, background BLE modes, state restoration, write flow control, or CBUUID-based workflows. For privacy-preserving accessory setup/picker flows, use accessorysetupkit first and return here for post-setup GATT communication.

日本語の概要は準備中です。原文の説明を表示しています。

Report the compatibility redirect to `ap-independent-checker`; this retired role cannot perform new work.

日本語の概要は準備中です。原文の説明を表示しています。

Report the compatibility redirect to `ap-independent-checker`; this retired role cannot perform new work.

日本語の概要は準備中です。原文の説明を表示しています。

Report the compatibility redirect to `ap-run-coordinator`; this retired role cannot perform new work.

日本語の概要は準備中です。原文の説明を表示しています。

Report the compatibility redirect to `ap-run-coordinator`; this retired role cannot perform new work.

日本語の概要は準備中です。原文の説明を表示しています。

Report the compatibility redirect to `C0`; this retired role cannot perform new work.

日本語の概要は準備中です。原文の説明を表示しています。

Report the compatibility redirect to `ap-independent-checker`; this retired role cannot perform new work.

日本語の概要は準備中です。原文の説明を表示しています。

Report the compatibility redirect to `ap-roadmap-author`; this retired role cannot perform new work.

日本語の概要は準備中です。原文の説明を表示しています。

Report the compatibility redirect to `ap-worker`; this retired role cannot perform new work.

日本語の概要は準備中です。原文の説明を表示しています。

Report the compatibility redirect to `ap-worker`; this retired role cannot perform new work.

日本語の概要は準備中です。原文の説明を表示しています。

Report the compatibility redirect to `ap-roadmap-author`; this retired role cannot perform new work.

日本語の概要は準備中です。原文の説明を表示しています。

Report the compatibility redirect to `ap-independent-checker`; this retired role cannot perform new work.

日本語の概要は準備中です。原文の説明を表示しています。

Report the compatibility redirect to `C0`; this retired role cannot perform new work.

日本語の概要は準備中です。原文の説明を表示しています。

Report the compatibility redirect to `ap-independent-checker`; this retired role cannot perform new work.

日本語の概要は準備中です。原文の説明を表示しています。

Report the compatibility redirect to `ap-worker`; this retired role cannot perform new work.

日本語の概要は準備中です。原文の説明を表示しています。