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Annotate copy number variant segments with overlapping genes, dosage-sensitivity scores, cancer driver databases, population frequencies, and clinical-variant content. Covers bedtools/pybedtools interval intersection, AnnotSV comprehensive annotation and ranking, ClinGen haploinsufficiency/triplosensitivity scoring, gnomAD-SV/DGV frequency filtering, COSMIC Cancer Gene Census, and ClinVar overlap. Use when interpreting which genes a CNV affects, distinguishing the driver gene of a focal event from passengers, filtering against population CNVs, separating whole-gene from partial-gene overlap, or preparing CNVs for clinical classification.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes base-editing screens for variant function. Covers library design (Sanson 2020 GRACE, Hanna 2021 BRCA1/2 SNV scanning, Cuella-Martin 2021), CBE vs ABE chemistry choice (BE3/BE4 vs ABE7.10/ABE8.20/ABE8e), editing-window math (positions 4-8 from PAM-distal end, wider for ABE8e), bystander-edit quantification and the variant-call ambiguity it creates, sgRNA-efficiency filtering before hit calling, indel byproduct interpretation, the substitution-vs-indel diagnostic, variant annotation against ClinVar / COSMIC, and the Broad be-validation-pipeline. Use when designing a BE variant screen, choosing CBE vs ABE for a specific edit, interpreting bystander-confounded hits, distinguishing functional signal from indel artifact, integrating CRISPResso2 output with screen scoring, or deciding BE vs PE for SNV installation.

日本語の概要は準備中です。原文の説明を表示しています。

Integrate multiple scRNA-seq samples/batches using Harmony, scVI, Seurat anchors, and fastMNN. Remove technical variation while preserving biological differences. Use when integrating multiple scRNA-seq batches or datasets.

日本語の概要は準備中です。原文の説明を表示しています。

Generate alignment statistics using samtools flagstat, stats, depth, coverage, and mosdepth. Use when assessing alignment quality, calculating coverage, or generating QC reports.

日本語の概要は準備中です。原文の説明を表示しています。

Detect allele-specific chromatin accessibility from ATAC-seq using WASP, GATK ASEReadCounter, or RASQUAL. Use when mapping cis-regulatory genetic variants from heterozygous SNPs, separating cis from trans regulation, building chromatin QTL (caQTL) maps, validating GWAS variant function with allelic imbalance, or detecting reference allele mapping bias before downstream analysis.

日本語の概要は準備中です。原文の説明を表示しています。

Annotate CLIP-seq peaks or crosslink sites to RNA features (5'UTR, CDS, 3'UTR, intron, splice junction, snoRNA, tRNA, ncRNA, repeat elements) with ChIPseeker, RCAS, RBP-Maps (Yeo splicing regulatory maps), and bedtools, applying feature-priority hierarchies, transcript-context resolution, and metagene aggregation. Use when characterizing where in transcripts an RBP binds, comparing peak distribution across regions, generating splicing-regulatory maps relative to alternative-splicing events, or distinguishing exonic vs intronic vs UTR binding.

日本語の概要は準備中です。原文の説明を表示しています。

Workflow for orchestrating reproducible omics pipelines with workflow engines and clear execution provenance.

日本語の概要は準備中です。原文の説明を表示しています。

Proteina-Complexa flow-based protein backbone generation with fold-conditioned sampling guidance. Use this skill when: (1) Generating de novo protein backbones with hierarchical fold conditioning, (2) Exploring long-chain backbone generation beyond standard diffusion baselines, (3) Using NVIDIA Proteina-style flow matching workflows for controllable backbone design, (4) Comparing flow-based backbone generation against RFdiffusion or BoltzGen, (5) Prototyping fold-guided backbone campaigns before sequence design. This skill is based on the public NVIDIA Digital Bio Proteina project and uses "Proteina-Complexa" as the BioClaw-facing skill label. For sequence design after backbone generation, use proteinmpnn or solublempnn. For QC thresholds, use protein-design-qc.

日本語の概要は準備中です。原文の説明を表示しています。

Identify direct miRNA-target interactions from AGO HITS-CLIP, AGO-CLEAR-CLIP (chimeric reads), HEAP (Halo-Ago2 mouse), chimeric eCLIP / miR-eCLIP (deep miRNA-target profiling), or CLASH using chimeric-read processing pipelines, seed-pairing analysis, and 3' auxiliary pairing rules. Use when distinguishing direct miRNA targets from indirect, integrating CLIP-derived target maps with TargetScan / miRDB / DIANA predictions, applying canonical 7mer-8mer seed matching with 3' UTR context, or recovering miRNA-mRNA chimeras at scale.

日本語の概要は準備中です。原文の説明を表示しています。

End-to-end guidance for protein design pipelines. Use this skill when: (1) Starting a new protein design project, (2) Need step-by-step workflow guidance, (3) Understanding the full design pipeline, (4) Planning compute resources and timelines, (5) Integrating multiple design tools. For tool selection, use binder-design. For QC thresholds, use protein-qc.

日本語の概要は準備中です。原文の説明を表示しています。

Generate protein backbones using RFdiffusion, a diffusion-based generative model for de novo protein structure generation. Use this skill when: (1) Designing binder scaffolds for a target protein, (2) Generating novel protein backbones from scratch, (3) Scaffolding functional motifs into new proteins, (4) Specifying hotspot residues for interface design, (5) Creating symmetric oligomers. For sequence design after backbone generation, use proteinmpnn. For structure validation, use alphafold or chai. For QC thresholds, use protein-qc.

日本語の概要は準備中です。原文の説明を表示しています。

Workflow for integrating matched or partially matched omics layers into shared latent structure and cross-modal interpretation.

日本語の概要は準備中です。原文の説明を表示しています。

End-to-end protein design pipeline guide across preparation, generation, validation, and filtering. Use this skill when: (1) Starting a new protein design project, (2) Need step-by-step workflow guidance, (3) Understanding the full design pipeline, (4) Planning compute resources and timelines, (5) Integrating multiple design tools. For tool selection, use binder-design-tool-selection. For QC thresholds, use protein-design-qc.

日本語の概要は準備中です。原文の説明を表示しています。

Extract and analyze product reviews from e-commerce and review sites. Aggregates ratings, identifies common themes in positive and negative feedback, and surfaces actionable product insights from customer voices across platforms.

日本語の概要は準備中です。原文の説明を表示しています。

Aggregate and analyze product and business reviews from Google Maps, Amazon, Akta, and Xiaohongshu. Cross-platform review intelligence including rating patterns, common themes, competitive comparison, and customer satisfaction trends.

日本語の概要は準備中です。原文の説明を表示しています。

Prepare personalized email outreach by researching prospects, verifying email addresses, building company context, and generating relevant talking points. End-to-end outreach preparation from prospect identification to send-ready intelligence.

日本語の概要は準備中です。原文の説明を表示しています。

Analyze customer reviews for local businesses on Google Maps. Covers review extraction, sentiment patterns, rating distribution, common complaints, and competitor review comparison for local business intelligence and reputation management.

日本語の概要は準備中です。原文の説明を表示しています。

Use when preparing a Formax code handoff: selecting files, generating repomix bundles, and writing a high-quality prompt for WebGPT or another coding agent with clear constraints and validation scope.

日本語の概要は準備中です。原文の説明を表示しています。

Implement or refactor Formax tool transcript UI using the Tool UI Blocks (C-lite) pattern (ToolUiBlocks renderer + blocks presenters) to avoid touching many tool presenter files; use when adjusting ⏺/⎿ spacing, indent rules, or migrating additional tools to blocks presenters with targeted Ink/Vitest tests and Codex review before commit.

日本語の概要は準備中です。原文の説明を表示しています。

Guidance for using Generator.Equals — a C# source generator for auto-generating Equals, GetHashCode, operators, and Diff/Inequalities methods via attributes.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user needs a professional marketer's operating mindset for any marketing, growth, or client-acquisition task — finding first customers, writing an ad or landing page, designing ad creatives and visuals (how the eye works: background, scene, hero, movement), evaluating an idea, deciding whether to do X to get Y, positioning or launching a B2B or SaaS product, running cold outreach, setting up ads, or writing copy — not a tactical template.

日本語の概要は準備中です。原文の説明を表示しています。

Runtime per-test healing with evidence: multi-attribute selector healing, environment-aware diagnosis, flake classification, quarantine management, and confidence-scored auto-repair. Goes beyond simple locator fallbacks to cover action-level healing, data healing, and observable repair workflows. Use when: "flaky test," "test stability," "self-healing locator," "broken locator recovery," "unreliable test," "quarantine flaky test." Not for: bulk regenerating selectors after a planned UI refactor — use selector-drift-recovery (this skill heals ONE test at runtime; that one rewrites many tests offline). Not for: classifying/clustering CI failures into bug reports — use ai-bug-triage. Related: playwright-automation, selector-drift-recovery, ci-cd-integration, qa-metrics, ai-bug-triage.

日本語の概要は準備中です。原文の説明を表示しています。

Write production-grade Playwright tests in TypeScript: Page Object Model, fixtures, auto-waiting, user-facing locators, parallel execution, CI integration, sharding, and 2025-2026 feature awareness. Includes an explicit "do not" list for AI agents. Use when: "Playwright," "write E2E test," "page object," "new Playwright suite," "Playwright config." Not for: fixing one flaky test at runtime — use test-reliability. Not for: bulk regenerating selectors after a UI refactor — use selector-drift-recovery. Not for: visual baseline creation/management — use visual-testing. Not for: deep WCAG/axe audits — use accessibility-testing. Related: visual-testing, ci-cd-integration, api-testing, test-reliability, selector-drift-recovery, accessibility-testing.

日本語の概要は準備中です。原文の説明を表示しています。

Author and maintain MANUAL and hybrid test cases and suites in TestRail, Xray (Jira), Zephyr Scale, and Qase. Covers test-case anatomy (title, preconditions, steps, expected results, test data), suite/section organization, bulk authoring from user stories and acceptance criteria, ambiguous-step linting, CSV/API import-export payloads per tool, requirement traceability and coverage gaps, review hygiene, and when a manual case should graduate to automation. Use when: "write a test case," "manual test case," "TestRail case," "Xray test," "Zephyr Scale case," "Qase case," "import CSV into TestRail," "lint these steps," "traceability report," "should this be automated." Not for: Generating automated TEST CODE — that is ai-test-generation. Sprint-level WHAT-to-test selection — that is test-planning. Related: ai-test-generation, test-planning, exploratory-testing, qa-project-context.

日本語の概要は準備中です。原文の説明を表示しています。