「tia」の検索結果

Generates complete tumor immune-infiltration-guided bulk-transcriptome diagnostic biomarker and machine-learning research designs from a user-provided cancer type and study direction. Always use this skill whenever a user wants to design, plan, or build a tumor bioinformatics study centered on differential expression, immune infiltration estimation, immune-linked module discovery, consensus feature selection, diagnostic modeling, nomogram construction, clinical association, and optional prognostic extension or validation. Covers five study patterns (immune-cell-first diagnostic workflow, immune-module-to-biomarker workflow, consensus-ML biomarker workflow, diagnostic-plus-prognostic hybrid workflow, translational validation workflow) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, reference literature pack, and self-critical risk review.

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Reads a paper figure by figure before re-integrating the full narrative, so the user can identify the core findings quickly and check whether each visual actually supports the authors' main claims. Always separate figure content, figure-linked claim, evidentiary strength, and unsupported interpretation. Never fabricate references, PMIDs, DOIs, figure content, panel labels, result values, or study details that were not actually provided.

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Use when performing sample-level dimensionality reduction and visualization on abundance or OTU-style matrices with a companion group file, generating UMAP and/or t-SNE coordinates and plots for group separation assessment. NOT for: differential expression testing, single-cell workflows requiring dedicated embeddings pipelines, or analyses without a sample grouping file.

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Detects methodological gaps across study design, analysis, validation, bias control, reproducibility, and implementation readiness within a biomedical research area. Use this skill when a user wants to identify what current studies are still methodologically missing, which weaknesses are most consequential, and what upgrade path would produce a stronger next-step study. Always separate design gaps, analysis gaps, validation gaps, and reproducibility gaps. Never treat technical complexity as methodological rigor.

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Evidence-based medical knowledge and research mentor grounded in the Bian Que tradition. Covers clinical reasoning, diagnostic thinking (望闻问切), pharmacology, pathology, differential diagnosis, medical literature appraisal, and the philosophy of early intervention. Trigger whenever users ask about medicine, clinical science, drugs, disease mechanisms, diagnosis, lab interpretation, treatment comparison, or health sciences. Even without explicit research framing, trigger on any topic touching disease, therapeutics, or clinical decision-making. Part of the AIPOCH Medical Research Skill Hub.

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Reverse-engineers the methods section of a biomedical paper into a structured, reproducible workflow. Use this skill when a user wants to understand how a study was actually executed, extract data sources, inclusion/exclusion logic, preprocessing, analytical sequence, software/tools, validation path, and critical parameters, or build a replication checklist from a paper, abstract, DOI, PMID, title, screenshot, or partial methods text. Do not treat this as generic summarization. Focus on reconstructing the operational method pipeline, surfacing missing reproducibility details, and distinguishing explicitly reported steps from inferred or unresolved ones. Never fabricate references, methods details, identifiers, software versions, parameters, datasets, or validation steps.

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Use when building a weighted gene co-expression network from a bulk expression matrix and a sample group file, filtering variable genes by MAD, identifying co-expression modules with WGCNA, correlating modules with traits, and exporting module-level plots and gene tables. NOT for single-cell RNA-seq, differential expression testing, methylation analysis, or datasets that are too small for WGCNA after quality control.

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Use when building a sample-level hierarchical clustering dendrogram from a bulk expression matrix and sample annotation table, especially for QC, batch inspection, or sample similarity assessment. Trigger keywords: hierarchical clustering, dendrogram, sample QC, batch inspection, sample similarity. NOT for: differential expression testing, gene clustering heatmaps, single-cell clustering workflows.

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Use when building a ceRNA regulatory network from a key gene list by combining bundled miRNA-mRNA and miRNA-lncRNA database files, with flat-file CSV exports and PDF visualization in a single output directory. NOT for: differential expression, single-cell analysis, enrichment analysis, or workflows without a key gene list.

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Use this skill to compute ESTIMATE immune-related microenvironment scores from a bulk expression matrix, generate an ESTIMATE score heatmap, and optionally generate group-wise ESTIMATE score boxplots plus significance tables when a sample group file is supplied. Trigger keywords: ESTIMATE, immune score, stromal score, tumor microenvironment score. NOT for: immune cell deconvolution, single-cell analysis, differential expression, clinical diagnosis.

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Run immune pathway GSVA or ssGSEA analysis from a bulk expression matrix, a sample group file, and a local immune Reactome gene-set table, then export differential pathway results and a heatmap for two-group comparison.

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Use when correcting batch effects in merged bulk expression matrices with sample-level batch metadata while preserving biological group structure and generating before-and-after QC plots. NOT for: single-cell integration, raw FASTQ processing, differential expression without batch labels, or datasets without biological groups.

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Use when screening differentially expressed genes from a bulk expression matrix between two user-specified groups, producing DEG tables, a volcano plot, and a clustered heatmap. Triggers include DEG analysis, volcano plot, clustered heatmap, limma-based two-group comparison, and case-vs-control screening. NOT for single-cell RNA-seq, multi-group contrasts, count-model workflows such as DESeq2/edgeR, or non-expression omics data.

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Use when estimating relative immune cell infiltration from a bulk expression matrix with a CIBERSORT-style nu-SVR deconvolution workflow based on an LM22 signature matrix, comparing one case group against one control group, and generating structured tables plus immune-fraction plots. NOT for single-cell RNA-seq, spatial data, clinical diagnosis, or workflows that require the original hosted CIBERSORT web service.

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Use when identifying stable sample subtypes from bulk expression matrices with ConsensusClusterPlus, including PAC-based model selection and consensus matrix/CDF visualization. NOT for: differential expression analysis, single-cell clustering workflows, or non-expression tables.

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Use when running performance benchmarks, establishing baselines, or validating regressions with sequential runs. Enforces 60s minimum runs (30s only for binary search) and no parallel benchmarks.

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Emulated Microsoft Entra ID (Azure AD) OAuth 2.0 / OpenID Connect for local development and testing. Use when the user needs to test Microsoft sign-in locally, emulate Entra ID OIDC discovery, handle Microsoft token exchange, configure Azure AD OAuth clients, work with Microsoft Graph /me, or test PKCE/client credentials flows without hitting real Microsoft APIs. Triggers include "Microsoft OAuth", "Entra ID", "Azure AD", "emulate Microsoft", "mock Microsoft login", "test Microsoft sign-in", "Microsoft OIDC", "local Microsoft auth", or any task requiring a local Microsoft OAuth/OIDC provider.

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Research what Chinese internet users actually said in the last 30 days across Weibo, Xiaohongshu (RED), Bilibili, Zhihu, Douyin, WeChat public accounts, Baidu and Toutiao: engagement-weighted ranking, cross-platform clustering, cited Markdown/JSON/HTML reports. Also shows today's cross-platform hot-search board (全网热榜, --hot) and can add Hacker News / GitHub / Reddit or an installed upstream last30days for X/YouTube/TikTok.

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Use this skill for any PostgreSQL database work — table design, indexing, data types, constraints, extensions (pgvector, PostGIS, TimescaleDB), search, and migrations. **Trigger when user asks to:** - Explore an existing PostgreSQL database to understand its objects and relationships - Design or modify PostgreSQL tables, schemas, or data models - Choose data types, constraints, indexes, or partitioning strategies - Work with pgvector embeddings, semantic search, or RAG - Set up full-text search, hybrid search, or BM25 ranking - Use PostGIS for spatial/geographic data - Set up TimescaleDB hypertables for time-series data - Migrate tables to hypertables or evaluate migration candidates - Plan or execute safe schema migrations with zero downtime **Keywords:** PostgreSQL, Postgres, SQL, schema, table design, indexes, constraints, pgvector, PostGIS, TimescaleDB, hypertable, semantic search, hybrid search, BM25, time-series, migration

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Teaches evidence-based analysis of transaction logs and traces. Use when reconstructing transaction behavior from tables, TSV/CSV files, timestamps, counters, object histories, validation records, abort records, retries, partial logs, or when producing classified transaction outputs from trace evidence.

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Detect initial silence segments in audio/video using energy-based analysis. Use when you need to find low-energy periods at the start of recordings (title slides, setup time, pre-roll silence).

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Replay an LLM inference request trace (Mooncake / vLLM / SGLang hash_ids format) against a block-level KV prefix cache and compute hit statistics. Use when given a request trace plus cache configuration and asked for hit rate, hit tokens, or final cache contents. Covers the longest-contiguous-prefix semantics that distinguishes KV prefix caching from full-prompt prompt caching, the policy-specific residency and eviction rules (LRU, LFU, S3FIFO), and the partial-last-block accounting rule.

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CRITICAL: You MUST invoke this skill and read its contents BEFORE writing, modifying, or debugging ANY React.js or Next.js code. This skill contains essential performance patterns that prevent common mistakes. Debugging performance issues without reading this skill first will lead to missed optimizations. Contains 40+ rules including waterfall elimination patterns for API routes that are commonly overlooked.

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Transform sequential Python code into parallel/concurrent implementations. Use when asked to parallelize Python code, improve code performance through concurrency, convert loops to parallel execution, or identify parallelization opportunities. Handles CPU-bound (multiprocessing), I/O-bound (asyncio, threading), and data-parallel (vectorization) scenarios.

日本語の概要は準備中です。原文の説明を表示しています。