「yc」の検索結果

Prioritizes rare-disease variants from trio/quad WES/WGS with de novo (DeNovoGear, Triodenovo), compound-heterozygous phasing (WhatsHap), mosaic VAF tiering, phenotype-driven ranking (Exomiser, Phen2Gene, AMELIE), ClinGen gene-disease validity gating, and ACMG SF v3.2 secondary findings reporting. Use when running diagnostic exome / genome pipelines, identifying candidate Mendelian disease genes, screening for incidental findings, or auditing VUS reclassification cycles. The ACMG/AMP classification framework (PVS1 decision tree, Pejaver PP3/BP4 calibration, Tavtigian point system) is in clinical-databases/acmg-classification.

日本語の概要は準備中です。原文の説明を表示しています。

Resolve the architecture of focal oncogene amplifications — extrachromosomal DNA (ecDNA), breakage-fusion-bridge (BFB) cycles, homogeneously staining regions (HSR), and linear amplification — from whole-genome sequencing with AmpliconArchitect, the AmpliconSuite pipeline, and AmpliconClassifier. Covers copy-number seed selection, breakpoint-graph reconstruction, balanced-flow optimization, ecDNA classification, and the limits of depth-only amplification calls. Use when a focal amplification needs structural characterization, when distinguishing ecDNA from chromosomal amplification, suspecting ecDNA-driven oncogene amplification or therapy resistance, or selecting copy-number seeds for amplicon reconstruction.

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Classify constitutional (germline) copy number variants for clinical reporting using the 2019 ACMG/ClinGen technical standards points-based framework, with ClassifyCNV and AnnotSV for semi-automated scoring. Covers the separate copy-number-loss and copy-number-gain rubrics, the five-tier classification, ClinGen haploinsufficiency/triplosensitivity and dosage-sensitive regions, de novo and segregation evidence, and population-frequency benign evidence. Use when assigning pathogenic/likely-pathogenic/VUS/likely-benign/benign to a constitutional CNV, scoring a CNV against ACMG/ClinGen criteria, or distinguishing the automatable evidence from the case-specific evidence requiring manual input.

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Reads, writes, and converts molecular file formats (SMILES, InChI, SDF V2000/V3000, MOL2, PDB, and BinaryCIF) using RDKit and Open Babel with rigorous handling of aromaticity perception, stereochemistry, implicit/explicit hydrogens, kekulization, and salt/fragment separation. Use when loading chemical libraries, debugging parse failures, or preparing molecules for downstream standardization, descriptor calculation, or docking.

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Analyzes chemical libraries by scaffold using Bemis-Murcko scaffolds, generic frameworks, cyclic skeletons, matched molecular pair (MMP) analysis via mmpdb, R-group decomposition, Free-Wilson analysis, scaffold hopping, and chemotype-aware ML train/test splits. Use when identifying chemotype clusters in a library, deriving SAR transformation rules, decomposing series into R-groups, performing scaffold-balanced QSAR splits, or planning analog campaigns.

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Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda scheduling, soft-core potentials, MBAR/BAR analysis, cycle-closure validation, and protocol-appropriate enhanced sampling. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.

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Use when bridging UIKit and SwiftUI, modernizing UIKit apps (scene lifecycle, resizability), debugging Auto Layout, Combine, TextKit, PencilKit, or UIKit animations.

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Use when an Apple-platform app feels slow, memory grows, battery drains, or ANY performance issue needs diagnosing. Covers memory leaks, profiling, Instruments workflows, retain cycles, optimization.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user mentions memory leak prevention, code review for memory issues, or proactive leak checking — retain cycles, leaks, and Timer/observer patterns.

日本語の概要は準備中です。原文の説明を表示しています。

Build iOS augmented reality and 3D experiences with RealityKit and ARKit. Use when adding RealityView content, loading entities or USDZ models, anchoring objects to planes or world positions, distinguishing entity hit tests from ARKit real-world raycasts, handling AR camera availability, world tracking, scene updates, or RealityKit entity gestures and interactions.

日本語の概要は準備中です。原文の説明を表示しています。

Use when capturing or analyzing an iOS .memgraph, especially when the task mentions a memory leak, heap growth, persistent memory increase, ownership path, or matched-capture comparison with Apple CLI tools. Covers unambiguous Simulator capture, leaks/heap/vmmap/malloc_history evidence, raw artifact preservation, and same-flow verification. Use debugging-instruments for interactive Xcode Memory Graph, Instruments, generic retain-cycle inspection, or LLDB work.

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Access Core Motion accelerometer, gyroscope, magnetometer, device-motion, pedometer, activity-recognition, altitude, headphone motion, batched high-frequency workout motion, and water-submersion/depth data. Use when reading device sensors, counting steps, detecting walking/running/driving/cycling, tracking altitude, building motion interactions, handling AirPods head tracking, or implementing watchOS dive/depth features.

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Support automatic audio switching for paired third-party Bluetooth headphones or earbuds with AudioAccessoryKit. Use when a companion app registers an audio accessory, an app extension reports worn/removed placement or connected source-device changes, or AccessoryControlDevice capabilities and errors need handling. Do not use for general AVAudioSession routing, Bluetooth transport, or initial accessory pairing.

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Manages iOS Simulator devices and app tests with xcrun simctl: lifecycle, install/launch, push and location simulation, privacy permissions, deep links, status-bar overrides, screenshots/video, log streaming, app containers, and targetEnvironment(simulator). Use when scripting Simulator workflows, debugging CoreSimulator boot failures, or deciding which hardware, performance, networking, memory-pressure, and security behaviors require a physical device.

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Implement iOS authentication flows with AuthenticationServices and LocalAuthentication. Use when building Sign in with Apple, passkey/WebAuthn registration or sign-in with ASAuthorizationPlatformPublicKeyCredentialProvider, ASAuthorizationController credential state and revocation handling, ASWebAuthenticationSession OAuth or third-party login, Password AutoFill, identity-token server validation, or local biometric re-authentication with LAContext.

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Implement, review, or improve Live Activities and Dynamic Island experiences in iOS apps using ActivityKit. Use when building real-time updating widgets for the Lock Screen and Dynamic Island — delivery tracking, sports scores, ride-sharing status, workout timers, media playback, or any time-sensitive information that updates in real time. Also use when working with ActivityKit, ActivityAttributes, Activity lifecycle (request/update/end), Dynamic Island layouts (compact/minimal/expanded), push-to-update Live Activities, or Lock Screen live widgets.

日本語の概要は準備中です。原文の説明を表示しています。

Build iOS App Clips with invocation URLs, App Clip Codes, NFC, QR codes, Safari banners, Maps, Messages, target setup, App Store Connect experiences, size/capability constraints, NSUserActivity routing, SKOverlay promotion, App Group/keychain handoff, ephemeral notifications, location confirmation, and full-app migration. Use when creating App Clips or wiring App Clip invocation, experience configuration, or full-app handoff.

日本語の概要は準備中です。原文の説明を表示しています。

Access security tokens and smart cards using CryptoTokenKit. Use when building TKTokenDriver or TKSmartCardTokenDriver extensions, communicating with smart cards via TKSmartCard/TKSmartCardSlotManager, using iOS 26+ NFC smart-card sessions, registering smart cards, querying token-backed keychain items with kSecAttrTokenID, monitoring TKTokenWatcher, or configuring certificate-based smart-card authentication.

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Build, review, or improve Core Data persistence in apps that have not adopted SwiftData. Use when working with NSManagedObject subclasses, NSFetchedResultsController for list-driven UI, NSBatchInsertRequest / NSBatchDeleteRequest / NSBatchUpdateRequest for bulk operations, NSPersistentHistoryChangeRequest for persistent history tracking and multi-target sync, NSStagedMigrationManager for staged schema migrations (iOS 17+), NSCompositeAttributeDescription for composite attributes (iOS 17+), or when integrating Core Data threading with Swift Concurrency. For Core Data + SwiftData coexistence or migration, see the swiftdata skill instead.

日本語の概要は準備中です。原文の説明を表示しています。

Read and write NFC tags using CoreNFC. Use when scanning NDEF tags, reading ISO7816/ISO15693/FeliCa/MIFARE tags, writing NDEF messages, handling NFC session lifecycle, configuring NFC entitlements, or implementing background tag reading in iOS apps.

日本語の概要は準備中です。原文の説明を表示しています。

Debug iOS apps and profile performance using LLDB, the interactive Memory Graph Debugger, and Instruments. Use for crashes, retain-cycle inspection, hangs, build failures, and generic CPU, memory, energy, or network profiling. Use ios-memgraph-analysis for .memgraph capture, leaks CLI ownership paths, or persistent heap growth; use ios-ettrace-performance for ETTrace capture and JSON.

日本語の概要は準備中です。原文の説明を表示しています。

Manages MongoDB Atlas Stream Processing (ASP) workflows. Handles workspace provisioning, data source/sink connections, processor lifecycle operations, debugging diagnostics, and tier sizing. Supports Kafka, Atlas clusters, S3, HTTPS, and Lambda integrations for streaming data workloads and event processing. NOT for general MongoDB queries or Atlas cluster management. Requires MongoDB MCP Server with Atlas API credentials.

日本語の概要は準備中です。原文の説明を表示しています。

MongoDB schema design patterns and anti-patterns. Use when designing data models, reviewing schemas, migrating from SQL, or troubleshooting performance issues caused by schema problems. Triggers on "design schema", "embed vs reference", "MongoDB data model", "schema review", "unbounded arrays", "one-to-many", "tree structure", "16MB limit", "schema validation", "JSON Schema", "time series", "schema migration", "polymorphic", "TTL", "data lifecycle", "archive", "index explosion", "unnecessary indexes", "approximation pattern", "document versioning".

日本語の概要は準備中です。原文の説明を表示しています。

This skill should be used when working on Polar billing system, Stripe integration, subscription lifecycle, checkout flows, or benefit provisioning.

日本語の概要は準備中です。原文の説明を表示しています。