「engineering」の検索結果

Nominates and assesses CRISPR off-target sites genome-wide. Enumerates candidate sites by mismatch and bulge tolerance with Cas-OFFinder/CRISPRitz, ranks them with the published CFD score (SpCas9-only, relative ranker) or MIT/CRISTA/energy models, runs variant-aware screening against gnomAD/individual genomes (CRISPRme), and frames the empirical genome-wide discovery assays (GUIDE-seq, CIRCLE-seq, CHANGE-seq, DISCOVER-seq, Digenome-seq) and high-fidelity nuclease choice (HiFi Cas9, Sniper-Cas9, eSpCas9, SpCas9-HF1). Use when assessing guide RNA specificity, choosing among candidate guides, screening a therapeutic guide against population variation, or planning empirical off-target validation. Distinguishes predicted vs detected vs validated. On-target activity scoring and deaminase (Cas-independent) base/prime-editor off-targets are separate skills.

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Designs and ranks guide RNAs (sgRNAs) for CRISPR-Cas9/Cas12a gene knockout by scanning a target for PAM sites (NGG SpCas9, NNGRRT SaCas9, TTTV Cas12a, NG SpCas9-NG, near-PAMless SpRY), enumerating candidate spacers, applying hard filters (Pol-III TTTT terminator, 5' G, GC), ranking on-target activity with the context-appropriate model (Rule Set 2/Azimuth for U6/lentiviral, CRISPRscan for T7/embryo, DeepHF for high-fidelity variants, DeepCpf1 for Cas12a), and predicting the indel/frameshift outcome (Bae out-of-frame score, inDelphi, FORECasT, Lindel). Use when selecting sgRNAs to knock out a gene, choosing a nuclease/PAM for a constrained locus, picking which exon to target, or shortlisting guides before an off-target check. Off-target specificity, base/prime editing, and HDR donors are separate skills.

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Build a differential-ready consensus peakset from per-replicate ATAC-seq peaks using iterative overlap removal, fixed-width re-centering, and majority-rule overlap. Use when generating a stable peak coordinate system for downstream differential accessibility, ML feature engineering, cross-sample comparison, or fixed-width peak counts; covers Corces 2018 iterative overlap (501 bp), DiffBind summit re-centering, and ENCODE consistency rules.

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Design, implement, and review web interface layout, component states, feedback, and motion within the current CodeConductor workflow. Use for concrete web UI work or requested UI audits, not backend-only tasks or native mobile apps.

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Web Performance Engineering — analyzes Core Web Vitals using the PageSpeed Insights API (PSI v5) and applies the 80/20 principle: identify the 20% of changes that produce 80% of the performance gain. Produces a prioritized markdown report with quantified estimates and framework-specific code. Trigger: When auditing page speed, analyzing Core Web Vitals, or optimizing web performance for any URL.

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Analyze binaries or protocols you own (or have license to inspect) to improve security, compatibility, or incident response. Not for cracking, DRM bypass, or malware creation.

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Core UI/UX engineering skill for building highly interactive, spatial, weightless, and glassmorphism-based web interfaces using GSAP and 3D CSS.

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Systematic improvement of existing agents through performance analysis, prompt engineering, and continuous iteration.

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Forces the laziest solution that actually works, simplest, shortest, most minimal. Channels a senior dev who has been paged at 3am for a factory class that wrapped one function: question whether the task needs to exist at all, reach for the standard library before custom code, native platform features before dependencies, one line before fifty. Supports intensity levels: lite, full, ultra. The default is full. Use on ANY coding task: writing, adding, refactoring, fixing, reviewing, or designing code, and choosing libraries or dependencies. Also use whenever the user says "ponytail", "be lazy", "lazy mode", "simplest solution", "minimal solution", "yagni", "do less", or "shortest path", or complains about over-engineering, bloat, boilerplate, or unnecessary dependencies. Do NOT use for non-coding requests such as general knowledge, prose, translation, summaries, recipes.

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React and Next.js performance optimization guidelines from Vercel Engineering. This skill should be used when writing, reviewing, or refactoring React/Next.js code to ensure optimal performance patterns. Triggers on tasks involving React components, Next.js pages, data fetching, bundle optimization, or performance improvements.

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When the user wants to plan, evaluate, or build a free tool for marketing purposes — lead generation, SEO value, or brand awareness. Also use when the user mentions "engineering as marketing," "free tool," "marketing tool," "calculator," "generator," "interactive tool," "lead gen tool," "build a tool for leads," "free resource," "ROI calculator," "grader tool," "audit tool," "should I build a free tool," or "tools for lead gen." Use this whenever someone wants to build something useful and give it away to attract leads or earn links. For downloadable content lead magnets (ebooks, checklists, templates), see lead-magnets.

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React and Next.js performance optimization guidelines from Vercel Engineering. This skill should be used when writing, reviewing, or refactoring React/Next.js code to ensure optimal performance patterns. Triggers on tasks involving React components, Next.js pages, data fetching, bundle optimization, or performance improvements.

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Route code cleanup, maintainability, React diagnostics, and over-engineering review to focused review modes. Use when auditing code quality or asking for a particular review lens.

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Sets up an `## Agent skills` block in AGENTS.md/CLAUDE.md and `docs/agents/` so the engineering skills know this repo's issue tracker (GitHub or local markdown), triage label vocabulary, and domain doc layout. Run before first use of `to-issues`, `to-prd`, `triage`, `diagnose`, `tdd`, `improve-codebase-architecture`, or `zoom-out` — or if those skills appear to be missing context about the issue tracker, triage labels, or domain docs.

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Forces the laziest solution that actually works, simplest, shortest, most minimal. Channels a senior dev who has seen everything: question whether the task needs to exist at all (YAGNI), reach for the standard library before custom code, native platform features before dependencies, one line before fifty. Supports intensity levels: lite, full (default), ultra. Use on ANY coding task: writing, adding, refactoring, fixing, reviewing, or designing code, and choosing libraries or dependencies. Also use whenever the user says "ponytail", "be lazy", "lazy mode", "simplest solution", "minimal solution", "yagni", "do less", or "shortest path", or complains about over-engineering, bloat, boilerplate, or unnecessary dependencies. Do NOT use for non-coding requests (general knowledge, prose, translation, summaries, recipes).

日本語の概要は準備中です。原文の説明を表示しています。

React and Next.js performance optimization guidelines from Vercel Engineering. This skill should be used when writing, reviewing, or refactoring React/Next.js code to ensure optimal performance patterns. Triggers on tasks involving React components, Next.js pages, data fetching, bundle optimization, or performance improvements.

日本語の概要は準備中です。原文の説明を表示しています。

計算型閘門 SKILL — Harness Engineering 的確定性驗證核心。在 Agent 每次完成代碼修改後自動執行一組計算型感測器（Computational Sensors），產生 Agent 友善的錯誤修正提示。USE FOR: 任何代碼修改後的自動品質驗證。DO NOT USE FOR: 僅文件修改、純美術資產生成（無 TypeScript 改動）。

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Run a structured discovery interview and produce a complete, developer-ready Product Requirements Document. Load when the user asks to write a PRD, create product requirements, document a feature, define user stories with acceptance criteria, or turn a rough idea into a formal product requirements document. Also triggers on "document this feature", "write requirements for", "create a one-pager", "turn this into a PRD", "I need a PRD for", or any request to produce a structured product document for stakeholder alignment or engineering handoff. Supports Full PRD, Lean PRD, and One-Pager formats. Note: for executable feature specifications (FRs, NFRs, ACs as Given/When/Then consumable by AI coding agents), route to `feature-spec` instead — PRDs frame the product, feature-specs encode the implementable contract.

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Improve agent reliability over time — diagnose why agents fail and fix the setup. Triggers on: agent keeps failing, same mistake again, agent not improving, make agent smarter, agent quality plateau, agents ignore skills, agent skips tests, fix agent behavior, agent unreliable, improve agent setup, self-improving harness, agents worse over time, tune agent instructions, agent going in circles, agent ignores AGENTS.md, repeated agent errors. Requires harness v0 and eval harness. AUTO-ROUTED from harness-engineering on symptoms. Not first setup — harness-generation first.

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Create a detailed, step-by-step implementation plan for a feature or project. Load when the user asks to plan a feature, create a technical roadmap, break down a PRD into tasks, design an implementation strategy, or sequence engineering work. Also triggers on "how should we build this", "implementation plan for", "technical breakdown", "task list for", or any request to turn a high-level requirement into a concrete execution plan. Supports phased rollouts, architecture-first, and MVP-focused planning.

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Orchestrate one or more thinking frameworks to work through any problem, decision, document, or idea rigorously. Diagnoses which frameworks fit — inversion, pre-mortem, assumption-mapping, socratic, adversarial-hat — then guides the user through them in the right sequence. Load when the user asks for deep thinking, says "help me think through this properly", "apply your best thinking frameworks", "I need to think carefully before deciding", or "what thinking tools should I use here". Also the entry point for any complex problem where the right framework is unclear. Covers product decisions, engineering tradeoffs, personal decisions, strategy, creative challenges — any domain.

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ClickHouse database patterns, query optimization, analytics, and data engineering best practices for high-performance analytical workloads.

日本語の概要は準備中です。原文の説明を表示しています。

Core UI/UX engineering skill for building highly interactive, spatial, weightless, and glassmorphism-based web interfaces using GSAP and 3D CSS.

日本語の概要は準備中です。原文の説明を表示しています。

You know AI wrappers get a bad rap, but the good ones solve real problems. You build products where AI is the engine, not the gimmick. You understand prompt engineering is product development. You balance costs with user experience. You create AI products people actually pay for and use daily.

日本語の概要は準備中です。原文の説明を表示しています。